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Actual Long-Term Survival After Resection of Stage III Soft Tissue Sarcoma

This study aims to characterize the clinicopathological characteristics associated with actual long-term survival in patients with stage III soft tissue sarcoma.

BMC Cancer
01/05/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786893/
Physical Activity as an Imperative Support in Breast Cancer Management

The field of exercise and physical activity have expanded prominently, not only for the prevention but also for the management of different pathologies, including breast cancer.

Cancers
12/28/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7796347/
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Head And Neck Cancer

Endoscopic Surveillance for Metachronous Esophageal Squamous Cell Neoplasms among Head and Neck Cancer Patients

This study recommends image enhanced endoscopy including Lugol chromoendoscopy as the screening tool for incident HNSCC patients.

Cancers
12/18/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7766780/
Risk Factors for Osteoradionecrosis of the Jaw in Patients with Head and Neck Squamous Cell Carcinoma

This study evaluates factors associated with ORNJ in patients with HNSCC, focusing on jaw-related dose–volume histogram parameters.

01/05/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7786900/
Prehabilitation in Head and Neck Cancer Patients

Dysphagia is one consequence of head and neck cancer that has a significant impact on quality of life for head and neck cancer survivors.

01/06/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7789666/
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Landscape of natural killer cell activity in head and neck squamous cell carcinoma

This study reviews the activity of NK cells in HNSCC, paying special attention to the role of environmental and genetic determinants of NK cell antitumor function.

12/21/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7754625/
Research progress of radiation-induced hypothyroidism in head and neck cancer

This paper reviews the factors related to hypothyroidism after radiotherapy in patients with head and neck cancer to facilitate the prevention of radiation-induced hypothyroidism and...

01/01/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738994/

FDA Approvals

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FDA Approval of Immunotherapy Drugs Brings Hope to Mesothelioma Patients

The drugs—nivolumab and ipilimumab—have now been approved by the FDA for first-line treatment of adult patients who suffer from malignant pleural mesothelioma.

Oncology Times - Latest Articles
12/20/2020
https://journals.lww.com/oncology-times/Fulltext/2020/12200/FDA_Approval_of_Immunotherapy_Drugs_Brings_Hope_to.2.aspx
The quality of reporting general safety parameters and immune-related adverse events in clinical trials of FDA-approved immune checkpoint inhibitors

This methodological review compared the quality of reporting of safety information and in particular, serious irAEs, in publications and ClinicalTrials.gov for all current FDA-approved ICIs.

BMC Cancer
11/23/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682068/
FOCR Meeting Highlights Modernization of Expedited FDA Drug Approvals

The Friends of Cancer Research held the first of a two-part virtual annual meeting, which focused on ways of updating expedited drug approvals at the FDA.

Oncology Times - Latest Articles
12/20/2020
https://journals.lww.com/oncology-times/Fulltext/2020/12200/FOCR_Meeting_Highlights_Modernization_of_Expedited.16.aspx
A New Strategy in Treating Patients With CAR T-Cell Therapy

A novel “switchable” CAR T-cell therapy for blood cancers moved into early clinical trials recently after gaining Fast Track designation from the FDA. 

Oncology Times - Latest Articles
12/20/2020
https://journals.lww.com/oncology-times/Fulltext/2020/12200/A_New_Strategy_in_Treating_Patients_With_CAR.12.aspx
FDA and EMA Approvals of New Breast Cancer Drugs-A Comparative Regulatory Analysis.

This study examines new drug approvals for breast cancer by the FDA and the EMA, based on an analysis of regulatory documents from both agencies for the period from 1995 to 2018.

Cancers
02/13/2020
https://www.mdpi.com/2072-6694/12/2/437/pdf

Oncology

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Selecting Image-Guided Surgical Technologies in Oncology: A Surgeon's Perspective.

This study aimed to select the most promising IG technology per oncologic indication.

Journal of Surgical Research
01/01/2021
https://www.journalofsurgicalresearch.com/article/S0022-4804(20)30543-6/fulltext
Pharmacogenomics in Pediatric Oncology: Mitigating Adverse Drug Reactions While Preserving Efficacy

Major developments in drugs such as thiopurines and optimization in clinical trial protocols for treating cancer in children have led to a remarkable improvement in survival, from approximately...<

Annual Review of Pharmacology and Toxicology
01/06/2021
https://www.annualreviews.org/doi/10.1146/annurev-pharmtox-031320-104151
Review of Oncology and Transplant Literature for the Management of Hepatic and Pancreatic Resections in Jehovah's Witnesses.

Jehovah's Witnesses undergoing liver or pancreas surgery represent a unique medical and ethical challenge.

Cancer medicine journal
04/01/2021
https://www.ncbi.nlm.nih.gov/pubmed/32601622
The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology.

Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges medicine.

Acta Pharmaceutica
03/01/2021
https://content.sciendo.com/view/journals/acph/71/1/article-p1.xml?language=en
Development and Optimization of Clinical Informatics Infrastructure to Support Bioinformatics at an Oncology Center.

Translational bioinformatics for therapeutic discovery requires the infrastructure of clinical informatics.

Methods of Molecular Biology
01/01/2021

Lung Cancer

Duration of Lead Time in Screening for Lung Cancer

Screening for lung cancer has used chest radiography, low dose computed tomography and sputum cytology.

01/06/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788818/
Bisphosphonates and Risk of Lung Cancer

This study conducts a meta-analysis to figure out the relationship between bisphosphonates and lung cancer.

01/08/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793382/
Comparative Analysis of Target Gene Exon Sequencing by Cognitive Technology Using a Next Generation Sequencing Platform in Patients with Lung Cancer

Next generation sequencing technology is an increasingly important clinical tool for therapeutic decision-making.

12/24/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783722/
Infections and Immunotherapy in Lung Cancer: A Bad Relationship?

This analysis aims to review the current evidence in order to clarify the complex correlation between infections and lung cancer.

International Journal of Molecular Sciences
12/22/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793072/
Immunogenomic Gene Signature of Cell-Death Associated Genes with Prognostic Implications in Lung Cancer

In this study, variations in the expression of genes involved in cell death pathways and resulting infiltration of immune cells are explored in lung adenocarcinoma.

Cancers
01/05/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795632/
The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients?

This article discusses the links between the lung microbiota and cancer, with particular focus on immune responses, metabolism and strategies to target the lung microbiome for cancer prevention.

Cancers
12/22/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7792810/

Immuno Oncology

The evolving landscape of predictive biomarkers in immuno‐oncology with a focus on spatial technologies

This review aims to provide an overview of the current methodologies that are used to profile the TME, which may provide insights into the immunopathology associated...

11/22/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7680923/
Society for Immunotherapy of Cancer Clinical Practice Guideline on Immunotherapy for the Treatment of Lymphoma

The recent development and clinical implementation of novel immunotherapies for the treatment of Hodgkin and non-Hodgkin lymphoma have improved patient outcomes across subgroups.

12/24/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7768967/
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Noninvasive Imaging of Cancer Immunotherapy

This study reviews recent developments in the field of noninvasive cancer imaging with a focus on immunotherapeutics and nuclear imaging technologies.

01/01/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738948/
Chimeric antigen receptor-engineered natural killer cells for cancer immunotherapy

Exciting data from recent clinical trials have renewed interest in the field of cancer immunotherapy due to the potential of CAR NK cells in the production of “off-the-shelf” anti-cancer...

12/07/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720606/
Defining best practices for tissue procurement in immuno-oncology clinical trials: consensus statement from the Society for Immunotherapy of Cancer Surgery Committee

Immunotherapy is now a cornerstone for cancer treatment, and much attention has been placed on the identification of prognostic and predictive biomarker.

11/16/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7670953/

Gastrointestinal Cancer

A Novel Prognosis Marker Based on Combined Preoperative Carcinoembryonic Antigen and Systemic Inflammatory Response for Resectable Gastric Cancer

Carcinoembryonic antigen is one of the important indexes for the diagnosis and prognosis of gastrointestinal cancer.

01/01/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7778548/
Preoperative Improvement in Physical Function by Comprehensive Rehabilitation Leads to Decreased Postoperative Complications in Gastrointestinal Cancer Patients

This study investigates how baseline laboratory data and changes in physical function due to preoperative rehabilitation training in GIC patients can influence the frequency of PCs.

01/08/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7788086/
Emerging roles of RNA methylation in gastrointestinal cancers

Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression, particularly in GI cancers.

12/07/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7720447/
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Downregulation of CDH11 Promotes Metastasis and Resistance to Paclitaxel in Gastric Cancer Cells

This study explores the mechanisms that mediate PTX-resistance and metastasis in GC with peritoneal metastasis.

01/01/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7738820/
A non-lab nomogram of survival prediction in home hospice care patients with gastrointestinal cancer

This study aimed to develop a gastrointestinal cancer-specific non-lab nomogram predicting survival time in home-based hospice.

BMC Palliative Care
12/07/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7722330/

Skin Cancer

Treatment of Non-melanoma Skin Cancers in the Absence of Mohs Micrographic Surgery

This study discusses the management of non-melanoma skin cancers in settings where Mohs micrographic surgery is not readily available.

12/22/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7787325/
Novel Sunprotection Interventions to Prevent Skin Cancer

In Denmark, 16,500 cases of melanoma and keratinocyte cancers were registered in 2015, of which 90% could have been avoided by behavioral changes.

PLOS ONE
12/31/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7774952/
Novel Functions of CD147 in the Mitochondria Exacerbates Melanoma Metastasis

In this study, investigators showed that CD147 was translocated from the cell membrane to the mitochondria in advanced melanoma.

01/01/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757041/
Optical Technologies for the Improvement of Skin Cancer Diagnosis

This paper reviews a variety of the optical modalities that have been used in the last years in order to improve non-invasive diagnosis of skin cancer...

01/02/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795742/
pH-Responsive Nanostructures Based on Surface Active Fatty Acid-Protic Ionic Liquids for Imiquimod Delivery in Skin Cancer Topical Therapy

For topical treatment of skin cancer, the design of pH-responsive nanocarriers able to selectively release the drug in the tumor acidic microenvironment represents a reliable option for targeted de

11/11/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7697672/
A Brief Dermatology Curriculum in Skin Cancer Detection and Prevention to Improve Medical Student Knowledge and Confidence

While the incidence of skin cancers continues to rise, there remains a disproportionate lack of introductory training on skin cancer screening and identification of modifiable...

12/29/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780741/

Gynecologic Cancer

Choline Kinase Alpha Impairment Overcomes TRAIL Resistance in Ovarian Cancer Cells

ChoKα/CHKA overexpression and hyper-activation sustain altered choline metabolism conferring the cholinic phenotype to epithelial ovarian cancer...

01/04/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780408/
Early Clearance of Serum HE4 and CA125 in Predicting Platinum Sensitivity and Prognosis in Epithelial Ovarian Cancer

The objectives of this study are to assess the clinical value of early clearance of HE4 and CA125 for platinum sensitivity and prognosis in patients with ovarian cancer.

01/04/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7780648/
Microscopic Peritoneal Residual Disease after Complete Macroscopic Cytoreductive Surgery for Advanced High Grade Serous Ovarian Cancer

The aim of this study is to assess and quantify the prevalence of residual mPM after complete macroscopic CRS in patients with advanced high-grade serous ovarian cancer.

12/25/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7795826/
DACH1 Mutation Frequency in Endometrial Cancer is Associated With High Tumor Mutation Burden

This study utilizes the Oncology Research Information Exchange Network Avatar database to determine the frequency of DACH1 mutations in patients with endometrial cancer...

PLOS ONE
12/30/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7773279/
Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression

This study aims to advance the understanding of vulvar squamous cell carcinoma biology by recognizing biological pathways that drive the progression of this disease.

Cancers
12/23/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7793473/
Pegylated Liposomal Doxorubicin in Patients With Epithelial Ovarian Cancer

This study evaluates the efficacy and safety of PLD in treating of in patients who experience epithelial ovarian, fallopian tubal, and peritoneal cancer progression...

01/11/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7798203/
Spotlight
CD44 in Ovarian Cancer Progression and Therapy Resistance—A Critical Role for STAT3

This review summarizes currently available evidence about functional crosstalk between CD44 and STAT3 in human malignancies with an emphasis on ovarian cancer.

Frontiers in Oncology
12/01/2020
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7736609/

News

Gastric Cancer Deep Dive

This podcast briefly reviews the historical gastric cancer classifications and explains how this has drastically changed over the past 5-10 years with the advent of next-generation...

https://www.stitcher.com/show/surg-onc-files/episode/gastric-cancer-deep-dive-56821530
7550
Colon and Rectal Cancer – David Ilson, MD, and Robert Figlin, MD

Drs David Ilson and Robert Figlin discuss recent clinical advances in colon and rectal cancer from ASCO20 Virtual.

06/08/2020
https://obroncology.com/podcasts/colon-and-rectal-cancer-david-ilson-md-and-robert-figlin-md-discuss-recent-clinical-advances-in-colon-and-rectal-cancer-from-asco20-virtual/
7549
Gastric/GE Junction Cancer – Geoffrey Ku, MD, and Robert Figlin, MD

 Geoffrey Ku, MD, and Robert Figlin, MD, discuss recent clinical developments in gastric and esophageal cancer.

10/16/2020
https://obroncology.com/podcasts/gastric-ge-junction-cancer-geoffrey-ku-md-and-robert-figlin-md-discuss-recent-clinical-developments-in-gastric-and-esophageal-cancer/
7548
Lenvatinib Plus Pembrolizumab for Patients With Advanced Gastric Cancer

This week the discussion surrounds the efficacy of the combination of lenvatinib and pembrolizumab for patients with advanced gastric cancer.

07/27/2020
7547
ASCO 2020: New Developments in the Treatment of Hard to Treat Cancers

Drs Hofland and Massacesi discuss the company’s partnerships with Daiichi Sankyo in developing a very targeted drug  for the treatment of patients with HER2+ advanced gastric cancer.

07/11/2020
https://podcasts.google.com/feed/aHR0cHM6Ly93d3cuc3ByZWFrZXIuY29tL3Nob3cvMjc4NjE1Ni9lcGlzb2Rlcy9mZWVk/episode/aHR0cHM6Ly9hcGkuc3ByZWFrZXIuY29tL2VwaXNvZGUvMzg4MzkzMjk
7546
ESMO-Magnitude of Clinical Benefit Scale of Adjuvant Colon Cancer Trials and Meta-Analyses

Form 1 of the European Society for Medical Oncology-Magnitude of Clinical Benefit Scale serves to grade therapies with curative intent.

09/15/2020
7545

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American Journal of Hospice and Palliative Medicine
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Asian Pacific Journal of Allergy and Immunology
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