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Circulating RNA Biomarkers in Diffuse Large B-Cell Lymphoma

The aim of this systematic review is to present the current understanding of circulating RNA molecules as biomarker in DLBCL and to discuss their future potential.

Experimental Hematology & Oncology
02/16/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885416/
Risk of Gastrointestinal Cancer in Patients With an Elevated Level of Gamma-Glutamyltransferase

The aim of this study is to assess the relationship between GGT level and risk of GI cancer, and the contribution of the interaction of hyperglycemia with elevated GGT level...

PLOS ONE
02/05/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864398/
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Head And Neck Cancer

Deep Learning in Head and Neck Tumor Multiomics Diagnosis and Analysis

Study investigators review multiomics image analysis of head and neck tumors using CNN and other DL neural networks.

Frontiers in Genetics
02/10/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902873/
Novel Diagnostic Approaches for Assessment of the Clinically Negative Neck in Head and Neck Cancer Patients

This review discusses the potential of several innovative diagnostic approaches to guide customized management of the clinically negative neck in head and neck cancer patients.

Frontiers in Oncology
02/05/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901951/
The Incidence of Myocardial Infarction and Stroke in Head and Neck Cancer Patients

This study analyzes the incidence and risks of myocardial infarction and stroke by cancer site and treatment modality in 22,737 patients newly diagnosed with HNC registered...

Scientific Reports
02/18/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892553/
Oral and Ocular Late Effects in Head and Neck Cancer Patients Treated With Radiotherapy

This study demonstrates that HNC patients treated with IMRT experience late effects in terms of xerostomia and ocular dryness underlining the importance of interdisciplinary approach...

Scientific Reports
02/17/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7889862/
Integrated Analysis Reveals ENDOU as a Biomarker in Head and Neck Squamous Cell Carcinoma Progression

This study identifies genes with clinical significance by integrated bioinformatics analysis and investigate their function in HNSCC.

Frontiers in Oncology
02/05/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7894080/
The Prospective Evaluation and Risk Factors of Dysphagia After Surgery in Patients With Oral Cancer

This prospective study investigates the change of swallowing ability using the Swallowing Ability Scale System and swallowing-related QOL by PSS-H&N.

01/25/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7830751/

FDA Approvals

FDA OKs New CAR T- Cell Tx for Large B-cell Lymphomas

The FDA has approved lisocabtagene maraleucel (Breyanzi), a CAR T-cell product for the treatment of adults with certain types of R/R large B-cell lymphoma who relapse or...

Medscape
02/05/2021
https://www.medscape.com/viewarticle/945417?src=soc_tw_210210_mscpedt_news_onc_lymphoma&faf=1
FDA Updates Highlighting the Latest Cancer Treatments

Read more about the FDA's latest updates in cancer treatment.

Oncology Times - Latest Articles
02/05/2021
https://journals.lww.com/oncology-times/Fulltext/2021/02050/FDA_Updates_Highlighting_the_Latest_Cancer.23.aspx
FDA Updates Highlighting the Latest Cancer Treatments

The FDA approved margetuximab-cmkb in combination with chemotherapy for the treatment of adult patients with metastatic HER2-positive breast cancer who have received...

Oncology Times - Latest Articles
01/20/2021
https://journals.lww.com/oncology-times/Fulltext/2021/01200/FDA_Updates_Highlighting_the_Latest_Cancer.22.aspx
FDA Approves First and Only Treatment for AL Amyloidosis

The first and only treatment for a rare and often fatal blood cell disorder has been approved in the United States.

Medscape
01/20/2021
https://www.medscape.com/viewarticle/944380?src=soc_tw_210123_mscpedt_news_mdscp_amyloidosis&faf=1
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FDA Approval of Immunotherapy Drugs Brings Hope to Mesothelioma Patients

The drugs—nivolumab and ipilimumab—have now been approved by the FDA for first-line treatment of adult patients who suffer from malignant pleural mesothelioma.

Oncology Times - Latest Articles
12/20/2020
https://journals.lww.com/oncology-times/Fulltext/2020/12200/FDA_Approval_of_Immunotherapy_Drugs_Brings_Hope_to.2.aspx

Oncology

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Selecting Image-Guided Surgical Technologies in Oncology: A Surgeon's Perspective.

This study aimed to select the most promising IG technology per oncologic indication.

Journal of Surgical Research
01/01/2021
https://www.journalofsurgicalresearch.com/article/S0022-4804(20)30543-6/fulltext
Pharmacogenomics in Pediatric Oncology: Mitigating Adverse Drug Reactions While Preserving Efficacy

Major developments in drugs such as thiopurines and optimization in clinical trial protocols for treating cancer in children have led to a remarkable improvement in survival, from approximately...<

Annual Review of Pharmacology and Toxicology
01/06/2021
https://www.annualreviews.org/doi/10.1146/annurev-pharmtox-031320-104151
Review of Oncology and Transplant Literature for the Management of Hepatic and Pancreatic Resections in Jehovah's Witnesses.

Jehovah's Witnesses undergoing liver or pancreas surgery represent a unique medical and ethical challenge.

Cancer medicine journal
04/01/2021
https://www.ncbi.nlm.nih.gov/pubmed/32601622
The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology.

Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges medicine.

Acta Pharmaceutica
03/01/2021
https://content.sciendo.com/view/journals/acph/71/1/article-p1.xml?language=en
Development and Optimization of Clinical Informatics Infrastructure to Support Bioinformatics at an Oncology Center.

Translational bioinformatics for therapeutic discovery requires the infrastructure of clinical informatics.

Methods of Molecular Biology
01/01/2021

Lung Cancer

Relationship Between Nutritional Status and Quality of Life in Patients with Lung Cancer

This study assesses the relationship between nutritional status and QoL in patients with lung cancer.

Cancer Management and Research
02/12/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886085/
Front Line Applications and Future Directions of Immunotherapy in Small-Cell Lung Cancer

This article reviews the use of ICIs in SCLC as well as other emerging immunotherapy strategies.

Cancers
01/29/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865814/
DNA Methylation Profiles of Bronchoscopic Biopsies for the Diagnosis of Lung Cancer

This study aims at determining the value of DNA methylation analysis applied to specimens obtained by bronchoscopic biopsy for the diagnosis of lung cancer...

Clinical Epigenetics
02/17/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7890863/
Competing Endogenous RNAs in Lung Cancer

This study reviews the research progress in the field of non-coding and protein-coding RNAs as ceRNAs in lung cancer, and highlighted validated ceRNAs involved in biological lung cancer functions.<

Cancer Biology & Medicine
02/15/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7877185/
Identification of Primary and Metastatic Lung Cancer-Related lncRNAs and Potential Targeted Drugs Based on ceRNA Network

This study analyzes the competitive relationships and regulatory mechanism of the repeatedly dysregulated lncRNAs in lung cancer carcinogenesis and metastasis, and provided...

Frontiers in Oncology
02/03/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886985/
A Multi-Omics-Based Serial Deep Learning Approach to Predict Clinical Outcomes of Single-Agent Anti-PD-1/PD-L1 Immunotherapy in Advanced Stage Non-Small-Cell Lung Cancer

The SimTA-based multi-omics serial deep learning provides a promising methodology for predicting response of advanced NSCLC patients to anti-PD-1/PD-L1 monotherapy.

American Journal of Translational Research
02/15/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868825/

Immuno Oncology

Preclinical Models of Pancreatic Ductal Adenocarcinoma and Their Utility in Immunotherapy Studies

Efforts to understand mechanisms of resistance and increase efficacy of immune checkpoint blockade in pancreatic cancer require the use of appropriate preclinical models in the laboratory.

Cancers
01/25/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865443/
A Small-Molecule P2RX7 Activator Promotes Anti-Tumor Immune Responses and Sensitizes Lung Tumor to Immunotherapy

Only a subpopulation of NSCLC patients responds to immunotherapies, highlighting the urgent need to develop therapeutic strategies to improve patient outcome.

01/28/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843983/
Radiotherapy–Immunotherapy Combination: How Will We Bridge the Gap Between Pre-Clinical Promise and Effective Clinical Delivery?

This review assesses the important clinical questions that need to be addressed to successfully combine radiotherapy and immunotherapy treatments by rethinking approaches to...

Cancers
01/26/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7865752/
Comprehensive Characterization of Immunological Profiles and Clinical Significance in Hepatocellular Carcinoma

Therapies targeting immune molecules have rapidly been adopted and advanced the treatment of hepatocellular carcinoma. 

Frontiers in Oncology
01/22/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862794/
Immuno-oncology: Are TAM Receptors in Glioblastoma Friends or Foes?

In this study, investigators aim to cast a spotlight on the potential multidirectional effects of TAM receptors in glioblastoma and provide a better understanding for TAM receptor-related targeted

01/28/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841914/
The New Immuno-Oncology-Based Therapies and Their Perspectives in Hepatocellular Carcinoma

The aim of this review article is to characterize the profile of efficacy and safety of immuno-oncology-based monotherapies that failed to demonstrate significant benefit...

Cancers
01/11/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826922/

Gastrointestinal Cancer

Risk of Gastrointestinal Cancer in Patients With an Elevated Level of Gamma-Glutamyltransferase

The aim of this study is to assess the relationship between GGT level and risk of GI cancer, and the contribution of the interaction of hyperglycemia with elevated GGT level...

PLOS ONE
02/05/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864398/
A Universal Molecular Prognostic Score for Gastrointestinal Tumors

This study concludes that mPS_colon is a universal prognostic classifier for patients with GI cancers and that it should prove informative for optimization of personalized therapy for such patients

02/04/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7862603/
Methyladenosine Modification in RNAs: Classification and Roles in Gastrointestinal Cancers

This review highlights the multitude of epigenetic changes of RNA methlyadenosine modifications in gene expression, and their roles in GIC tumorigenesis, progression, and...

Frontiers in Oncology
02/01/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7883673/
The Importance of Addressing the Burden of Stomach Cancer

Ongoing efforts to improve early detection, as well as continued treatment advancements, are crucial to address stomach cancer around the world.

Oncology Times - Latest Articles
02/05/2021
https://journals.lww.com/oncology-times/Fulltext/2021/02050/The_Importance_of_Addressing_the_Burden_of_Stomach.10.aspx
Epidemiology, Diagnosis, Staging and Multimodal Therapy of Esophageal and Gastric Tumors

Future directions for diagnosis of esophageal and gastric malignancies are evolving rapidly and will involve advances in endoscopic and endosonographic techniques including...

Cancers
02/02/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867245/
Challenges in Crohn’s Disease Management after Gastrointestinal Cancer Diagnosis

This review provides a comprehensive overview of the current evidence for an adequate diagnostic pathway and medical and surgical management of CD patients after gastrointestinal cancer onset.

Cancers
02/02/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7867285/

Skin Cancer

Checkpoint Inhibitor Therapy for Skin Cancer May be Safe in Patients With Asymptomatic COVID-19

An ongoing area of uncertainty during the SARS-CoV-2 pandemic is the safety of ICI therapy for cancer, and the theoretical possibility of exacerbated irAEs secondary to COVID-19 inflammatory pathol

02/16/2021
https://www.annalsofoncology.org/article/S0923-7534(21)00125-3/pdf
Anti-BRAF/Anti-MEK Targeted Therapies for Metastatic Melanoma Patients During the COVID-19 Outbreak: Experience From an Italian Skin Cancer Unit

Although melanoma has been increasing at a constant rate in the past few decades, mortality has been low, and only a small percentage of patients have developed metastatic disease.

Future Oncology
02/03/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874884/
Muffin Technique Micrographic Surgery for Non-Melanoma Skin Cancer

This study describes the implementation and the preliminary results of MTMS in an academic dermatology center.

01/21/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859636/
Construction and Validation of a Nomogram for Patients with Skin Cancer

Study investigators use patient data collected from the surveillance, epidemiology, and end results program database to construct and validate the model for clinical prediction of skin cancer.

01/29/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850664/
Sun Exposure During Water Sports: Do Elite Athletes Adequately Protect Their Skin Against Skin Cancer?

This study examines whether elite athletes in water sports take appropriate measures to protect their skin from the sun, and whether there are differences in this respect according to...

01/19/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7832317/
Bioactive Compounds for Skin Health

The present study draws attention to bioactive substances, i.e., vitamins, minerals, fatty acids, polyphenols, and carotenoids, with a particular focus on their effects on the condition of the skin

01/12/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827176/

Gynecologic Cancer

Long-Term Quality of Life and Sexual Function of Elderly People With Endometrial or Ovarian Cancer

This study describes and compares according to age long-term HRQoL, sexual function, and social deprivation of adults with either EC or OC.

Health and Quality of Life Outcomes
02/12/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7881660/
Hydronephrosis in Patients With Cervical Cancer is an Indicator of Poor Outcome

This study shows that cervical cancer with hydronephrosis may have a higher morbidity and mortality than cervical cancer without hydronephrosis.

Medicine
02/12/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7886411/
Utility of Adjuvant Whole Abdominal Radiation Therapy in Ovarian Clear Cell Cancer: A Pragmatic Cohort Study of Women With Classic Immuno-Phenotypic Signature

This study evaluates the initial experience and clinical utility of first-line adjuvant intensity-modulated whole abdominal radiation therapy in women with OCCC referred to an academic center.

Radiation Oncology
02/06/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866446/
Practice Patterns and Results of Tumor and Germline Genetic Evaluation of Women With Endometrial Cancer in South Louisiana

Study objectives are to describe rates of MMRd or MSI-H EC tumors, the prevalence of LS, the practice patterns of EC genetic evaluation and adherence to NCCN guidelines, and to...

Gynecology Oncology Reports
02/03/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868632/
CDCA8, Targeted by MYBL2, Promotes Malignant Progression and Olaparib Insensitivity in Ovarian Cancer

This study concludes high CDCA8 expression is involved in the tumorigenesis, aggressiveness and chemoresistance of ovarian cancer.

American Journal of Cancer Research
02/01/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868764/
Pharmacological Prophylaxis and Personal Protective Equipment Practices in Gynecological Cancer Surgery During COVID-19 Pandemic

The aim of this study is to assess PPE practices during surgery on COVID-19 negative gynecological cancer patients and use of pharmacologic prophylaxis by clinicians practicing gynecologic oncology

Indian Journal of Gynecologic Oncology
01/30/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7847240/
Spotlight
Interchangeability of Light and Virtual Microscopy for Histopathological Evaluation of Prostate Cancer

Virtual microscopy holds promise to reduce subjectivity as well as intra- and inter-observer variability for the histopathological evaluation of prostate cancer. 

Scientific Reports
02/05/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7864946/

News

Deep Learning in Head and Neck Tumor Multiomics Diagnosis and Analysis

Study investigators review multiomics image analysis of head and neck tumors using CNN and other DL neural networks.

Frontiers in Genetics
02/10/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902873/
8167
Novel Diagnostic Approaches for Assessment of the Clinically Negative Neck in Head and Neck Cancer Patients

This review discusses the potential of several innovative diagnostic approaches to guide customized management of the clinically negative neck in head and neck cancer patients.

Frontiers in Oncology
02/05/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7901951/
8166
Effects of Antithrombotic Drugs on the Results of Fecal Immunochemical Test in Colorectal Neoplasms Screening

The aim of this study is to clarify the effect of antithrombotic agents on FIT accuracy in screening for colorectal neoplasms.

Scientific Reports
02/23/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7902607/
8165
Genome-Wide Analysis Identifies Critical DNA Methylations Within NTRKs Genes in Colorectal Cancer

The following study investigates the methylation and expression profiles and prognostic value of NTRKs gene in colorectal cancer.

02/16/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7885252/
8164
Understanding Cell‐Cell Communication and Signaling in the Colorectal Cancer Microenvironment

This article aims to review the current in vitro and in vivo mono‐cellular and multi‐cellular cultures models of colorectal cancer, and to explore how they can be used for single‐cell multi‐omics approaches for...

02/07/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7868082/
8163
Epigenetic Landscape of Liquid Biopsy in Colorectal Cancer

This study summarizes current knowledge of the most relevant epigenetic mechanisms associated with cancer development and progression, and the implications of their deregulation in cancer cells...

Frontiers in Cell and Developmental Biology
02/05/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7892964/
8162

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