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Follicular Lymphoma

Follicular Lymphoma

Engineering a Reporter Cell Line to Mimic the High Oligomannose Presenting Surface Immunoglobulin of Follicular Lymphoma B Cells

From deep sequencing of the variable heavy and light chain sequences of follicular lymphoma involved tissue sections, this study identified the consensus variable sequences possessing...

Scientific Reports
01/08/2021
Clinical impact of bendamustine exposure on lymphopenia risk after bendamustine and rituximab combination therapy for follicular lymphoma

Bendamustine produces long-lasting objective responses in patients with indolent non-Hodgkin lymphoma, including follicular lymphoma.

Annals of Hematology
01/03/2021
C(h)AR-ting a new course in incurable lymphomas: CAR T cells for mantle cell and follicular lymphomas

CD19 CAR T cells have since been tested in largely incurable lymphomas, including mantle cell lymphoma, follicular lymphoma, and marginal zone lymphoma, with promising...

Blood Advances
11/24/2020

How Do I Sequence Therapy for Follicular Lymphoma?

In the past decade, many new agents have been introduced for the management of follicular lymphoma, and therapeutic strategies have evolved over time.

Hematology
12/04/2020
Identification of Recurrent Mutations in the microRNA-Binding Sites of B-Cell Lymphoma-Associated Genes in Follicular Lymphoma

Using whole-genome sequencing data from FL tumors, this study discovered 544 mutations located in bioinformatically predicted microRNA-binding sites.

International Journal of Molecular Sciences
11/21/2020
Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease

Fifty-five cases of t(14;18)− follicular lymphoma were genetically characterized by targeted sequencing and copy number arrays.

Blood Advances
11/24/2020
MiR-7e-5p downregulation promotes transformation of low-grade follicular lymphoma to aggressive lymphoma by modulating an immunosuppressive stroma through the upregulation of FasL in M1 macrophages

In FL, histologic transformation to high-grade FL and DLBCL is a critical adverse step in disease progression. Activation of the oncogene c-MYC and tumor microenvironment...

11/09/2020
Human Lymphoid Stromal Cells Contribute to Polarization of Follicular T Cells Into IL-4 Secreting Cells

Previous studies revealed that CXCR5hiPD1hi GC-Tfh are abundant within FL lymph nodes and support directly and indirectly FL B cell survival.

Frontiers in Immunology
10/02/2020
Prolonged rituximab maintenance in follicular lymphoma patients: long-term results of the SAKK 35/03 randomized trial

The Swiss Group for Clinical Cancer Research conducted the SAKK 35/03 randomized trial to investigate different rituximab monotherapy schedules in patients with follicular lymphoma.

Blood Advances
12/04/2020
Integrative Analysis of Cell Crosstalk within Follicular Lymphoma Cell Niche: Towards a Definition of the FL Supportive Synapse

Follicular lymphoma, the most frequent indolent non-Hodgkin’s B cell lymphoma, arises from a germinal center B cell proliferation supported by...

Cancers
10/05/2020
Efficacy and Safety of ABP 798: Results from the JASMINE Trial in Patients with Follicular Lymphoma in Comparison with Rituximab Reference Product

ABP 798 is being developed as a biosimilar to rituximab reference product, a CD20-directed cytolytic antibody that is approved in the US and EU for the treatment of NHL.

10/12/2020
Zanubrutinib (BGB-3111) plus obinutuzumab in patients with chronic lymphocytic leukemia and follicular lymphoma

Zanubrutinib plus obinutuzumab was safely administered to patients with CLL/SLL and FL, and deep responses were observed.

Blood Advances
10/13/2020
FOLLICULAR LYMPHOMA OF THE RECTUM

Rectal follicular lymphoma is difficult to diagnose due to limited available data, low clinical suspicion and non-specific symptoms.

10/21/2020
Primary Gastric Follicular Lymphoma Presenting as a Submucosal Tumor

A 59-year-old man was referred for the detailed examination of a gastric submucosal tumor that had gradually enlarged from a previous examination 4 years ago.

11/19/2020
Single-nucleotide variants in TGFB1, TGFBR2, IL17A, and IL17F immune response genes contribute to follicular lymphoma susceptibility and aggressiveness

This present study aimed to test whether 16 SNVs in eight immune-response genes affected FL susceptibility.

10/06/2020
Immune Monitoring of Patients With Primary Immune Regulation Disorders Unravels Higher Frequencies of Follicular T Cells With Different Profiles That Associate With Alterations in B Cell Subsets

To improve the understanding of these conditions, this work analyzed the T and B cell compartments of 15 PID patients with dysregulation, including...

Frontiers in Immunology
10/29/2020
Primary cutaneous follicle center lymphoma of the breast: Management of an exceedingly rare malignancy

Primary cutaneous follicle center lymphoma is defined as a low-grade B-cell non- Hodgkins lymphoma, which primarily occurs and remains confined to the skin, without evidence of...

11/02/2020

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