Follicular Lymphoma

Follicular Lymphoma

Engineering a Reporter Cell Line to Mimic the High Oligomannose Presenting Surface Immunoglobulin of Follicular Lymphoma B Cells

From deep sequencing of the variable heavy and light chain sequences of follicular lymphoma involved tissue sections, this study identified the consensus variable sequences possessing...

Scientific Reports
Clinical impact of bendamustine exposure on lymphopenia risk after bendamustine and rituximab combination therapy for follicular lymphoma

Bendamustine produces long-lasting objective responses in patients with indolent non-Hodgkin lymphoma, including follicular lymphoma.

Annals of Hematology
C(h)AR-ting a new course in incurable lymphomas: CAR T cells for mantle cell and follicular lymphomas

CD19 CAR T cells have since been tested in largely incurable lymphomas, including mantle cell lymphoma, follicular lymphoma, and marginal zone lymphoma, with promising...

Blood Advances

How Do I Sequence Therapy for Follicular Lymphoma?

In the past decade, many new agents have been introduced for the management of follicular lymphoma, and therapeutic strategies have evolved over time.

Identification of Recurrent Mutations in the microRNA-Binding Sites of B-Cell Lymphoma-Associated Genes in Follicular Lymphoma

Using whole-genome sequencing data from FL tumors, this study discovered 544 mutations located in bioinformatically predicted microRNA-binding sites.

International Journal of Molecular Sciences
Follicular lymphoma t(14;18)-negative is genetically a heterogeneous disease

Fifty-five cases of t(14;18)− follicular lymphoma were genetically characterized by targeted sequencing and copy number arrays.

Blood Advances
MiR-7e-5p downregulation promotes transformation of low-grade follicular lymphoma to aggressive lymphoma by modulating an immunosuppressive stroma through the upregulation of FasL in M1 macrophages

In FL, histologic transformation to high-grade FL and DLBCL is a critical adverse step in disease progression. Activation of the oncogene c-MYC and tumor microenvironment...

Human Lymphoid Stromal Cells Contribute to Polarization of Follicular T Cells Into IL-4 Secreting Cells

Previous studies revealed that CXCR5hiPD1hi GC-Tfh are abundant within FL lymph nodes and support directly and indirectly FL B cell survival.

Frontiers in Immunology
Prolonged rituximab maintenance in follicular lymphoma patients: long-term results of the SAKK 35/03 randomized trial

The Swiss Group for Clinical Cancer Research conducted the SAKK 35/03 randomized trial to investigate different rituximab monotherapy schedules in patients with follicular lymphoma.

Blood Advances
Integrative Analysis of Cell Crosstalk within Follicular Lymphoma Cell Niche: Towards a Definition of the FL Supportive Synapse

Follicular lymphoma, the most frequent indolent non-Hodgkin’s B cell lymphoma, arises from a germinal center B cell proliferation supported by...

Efficacy and Safety of ABP 798: Results from the JASMINE Trial in Patients with Follicular Lymphoma in Comparison with Rituximab Reference Product

ABP 798 is being developed as a biosimilar to rituximab reference product, a CD20-directed cytolytic antibody that is approved in the US and EU for the treatment of NHL.

Zanubrutinib (BGB-3111) plus obinutuzumab in patients with chronic lymphocytic leukemia and follicular lymphoma

Zanubrutinib plus obinutuzumab was safely administered to patients with CLL/SLL and FL, and deep responses were observed.

Blood Advances

Rectal follicular lymphoma is difficult to diagnose due to limited available data, low clinical suspicion and non-specific symptoms.

Primary Gastric Follicular Lymphoma Presenting as a Submucosal Tumor

A 59-year-old man was referred for the detailed examination of a gastric submucosal tumor that had gradually enlarged from a previous examination 4 years ago.

Single-nucleotide variants in TGFB1, TGFBR2, IL17A, and IL17F immune response genes contribute to follicular lymphoma susceptibility and aggressiveness

This present study aimed to test whether 16 SNVs in eight immune-response genes affected FL susceptibility.

Immune Monitoring of Patients With Primary Immune Regulation Disorders Unravels Higher Frequencies of Follicular T Cells With Different Profiles That Associate With Alterations in B Cell Subsets

To improve the understanding of these conditions, this work analyzed the T and B cell compartments of 15 PID patients with dysregulation, including...

Frontiers in Immunology
Primary cutaneous follicle center lymphoma of the breast: Management of an exceedingly rare malignancy

Primary cutaneous follicle center lymphoma is defined as a low-grade B-cell non- Hodgkins lymphoma, which primarily occurs and remains confined to the skin, without evidence of...


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