The Implications of Clinical Risk Factors, CAR Index, and Compositional Changes of Immune Cells on Hyperprogressive Disease in Non-Small Cell Lung Cancer Patients Receiving Immunotherapy

This study aims to investigate implications of clinical factors and immune cell composition on different tumor responses to immunotherapy in patients with NSCLC.

BMC Cancer
MEK Inhibitors for the Treatment of Non-Small Cell Lung Cancer

Concomitant mutations in both KRAS and BRAF genes have been identified in non-small cell lung cancer.

Functional Signatures in Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis of Sex-Based Differences in Transcriptomic Studies

This study aims to assess the molecular mechanisms underlying those differences through functional profiling and meta-analysis of lung adenocarcinoma expression datasets. 


Long Term Results of Single-Fraction Carbon-Ion Radiotherapy for Non-small Cell Lung Cancer

This study suggests that single-fraction passive carbon-ion radiotherapy can serve as an alternate treatment for patients with early-stage non-small cell lung cancer...

CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung Cancer

This study evaluates immune cells markers in 100 NSCLC specimens. Immunohistochemical analysis reveals no prognostic value for the markers studied, except CD163 and CD206.

International Journal of Molecular Sciences
Multiple microarray analyses identify key genes associated with the development of Non-Small Cell Lung Cancer from Chronic Obstructive Pulmonary Disease

This study aims to analyze the key genes and potential molecular mechanisms that are involved in the development from COPD to NSCLC.

Mutation Profile of Non-Small Cell Lung Cancer Revealed by Next Generation Sequencing

Precision therapy for lung cancer requires comprehensive genomic analyses.

NUCKS1 Promotes Proliferation, Invasion and Migration of Non-Small Cell Lung Cancer by Upregulating CDK1 Expression

The aim of this study is to investigate the roles of nuclear casein kinase and cyclin-dependent kinase substrate 1 in NSCLC and to identify the potential mechanisms.

Dyspnea in Patients Receiving Radical Radiotherapy for Non-Small Cell Lung Cancer

This study investigates the relationship between dose-volume parameters and subjective changes in dyspnea as a measure of RILI and the relationship to spirometry.

Frontiers in Oncology
Cutaneous Metastasis as the First Presentation of Non-Small-Cell Lung Cancer with a BRAF Mutation

BRAF mutations are emerging therapeutic targets in non-small-cell lung cancer, as they are present in 2–4% of NSCLC cases.

Predictive Value of Tumor Mutation Burden With Targeted Next-Generation Sequencing in Immunocheckpoint Inhibitors for Non-Small Cell Lung Cancer

To evaluate the clinical predictive value of tumor mutation burden for immune checkpoint inhibitor therapy in patients with non-small cell lung cancer.

Nogo-B Receptor is Required for Stabilizing TGF-β Type I Receptor and Promotes the TGF-β1-Induced Epithelial-to-Mesenchymal Transition of Non-Small Cell Lung Cancer

Metastasis is the leading cause of death in patients with advanced NSCLC, and epithelial-mesenchymal transition is a crucial event in the metastasis of NSCLC.

Alpha Thalassemia/Intellectual Disability X-Linked Deficiency Sensitizes Non-Small Cell Lung Cancer to Immune Checkpoint Inhibitors

The immune checkpoint inhibitors have achieved great success in the treatment of NSCLC patients. However, the response rate is low.

Frontiers in Oncology
Impact of Programmed Death Ligand 1 Expression in Advanced Non-Small–Cell Lung Cancer Patients, Treated by Chemotherapy

This study prospectively assesses the prognostic value of tumor-cell and immune-cell PD-L1 expressions for advanced NSCLC patients.

Prognostic Implication of Glycolysis Related Gene Signature in Non-Small Cell Lung Cancer

This study is devoted to identify glycolysis related genes as prognostic biomarkers for non-small cell lung cancer. 

Brain Metastases of Non-Small Cell Lung Cancer: Magnetic Resonance Spectroscopy for Clinical Outcome Assessment in Patients with Stereotactic Radiotherapy

The primary aim of this study is to explore the application of MRS in the assessment of tumor prognosis after stereotactic radiotherapy in NSCLC patients with BM.

Aberrant Splicing Isoforms Detected by Full-Length Transcriptome Sequencing as Transcripts of Potential Neoantigens in Non-Small Cell Lung Cancer

This study uses a long-read sequencer to construct a comprehensive catalog of aberrant splicing isoforms in non-small-cell lung cancers...

Genome Biology
Effective Treatment of NSCLC with Surgery After Nivolumab Combined with Chemotherapy

This study reports a case of the patient with resectable non-small cell lung cancer showing a complete response to nivolumab combined with chemotherapy.

Evolution of Systemic Treatment Uptake and Survival in Advanced Non-Small Cell Lung Cancer

Study findings show systemic treatment rose across three time periods, reflecting the introduction of rapid diagnostic pathways, reflex molecular testing, ICI, and targeted therapies. 

Current Oncology
Clinically Relevant Prognostic and Predictive Markers for Immune-Checkpoint-Inhibitor Therapy in Non-Small Cell Lung Cancer

Immune checkpoint inhibitors either alone or in combination with chemotherapy have expanded our choice of agents for the palliative treatment of NSCLC patients.

BMC Cancer
Response Evaluation after Immunotherapy in NSCLC

The present study aims to evaluate the role of early F-18 2-deoxy-2-FDG PET/CT in non-small cell lung cancer patients undergoing immune checkpoint inhibitor treatment.

Association of Mutation Profiles with Postoperative Survival in Patients with Non–Small Cell Lung Cancer

Study investigators analyze mutations in lung cancer based on the next generation sequencing data of lung tumors surgically removed from the patients, and identified...


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