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Solid Tumors

Solid Tumors

Aberrant Factors of Fibrinolysis and Coagulation in Pancreatic Cancer

This review provides a brief highlight of existing studies that the fibrinolysis and coagulation systems were activated in pancreatic cancer patients...

01/06/2021
Autophagy-Mediated Tumor Cell Survival and Progression of Breast Cancer Metastasis to the Brain

This review outlines the molecular mechanisms underlying autophagy-mediated breast cancer cell survival and metastasis to the brain.

01/01/2021
Dysphagia and its Impact on the Quality of Life of Head and Neck Cancer Patients: Institution-Based cross-sectional study

Impaired swallowing is a primary medical concern in HNC patientsThis cross-sectional study aimed to assess swallowing function and its impact on QoL.

01/07/2021

Circulating Exosomal miRNAs as Biomarkers for the Diagnosis and Prognosis of Colorectal Cancer

This study reports the potential of circulating exosomal miRNAs to act as biomarkers for the diagnosis and prognosis of CRC.

International Journal of Molecular Sciences
12/31/2020
Dysphagia and its Impact on the Quality of Life of Head and Neck Cancer Patients: Institution-Based cross-sectional study

Impaired swallowing is a primary medical concern in HNC patientsThis cross-sectional study aimed to assess swallowing function and its impact on QoL.

01/07/2021
Utilization of Circulating Cell-Free DNA Profiling to Guide First-Line Chemotherapy in Advanced Lung Squamous Cell Carcinoma

This study investigates the predictive and monitoring role of circulating cell-free DNA profiling for the outcome of first-line chemotherapy in patients with advanced lung squamous cell carcinoma.<

01/01/2021
Anti-Stem Cell Property of Pterostilbene in Gastrointestinal Cancer Cells

This study examined the potential mechanism of this contrasting effect of PTE using three gastrointestinal cancer cell lines, namely CT26, HT29, and MKN74.

International Journal of Molecular Sciences
12/08/2020
NDRG1 Expression Is an Independent Prognostic Factor in Inflammatory Breast Cancer

This study found that the level of expression of NDRG1 in tumor tissues predicts the survival outcome of patients with IBC.

Cancers
12/10/2020
Gene and Protein Expression of mTOR and LC3 in Hepatocellular Carcinoma, Colorectal Liver Metastasis and “Normal” Liver Tissues

The physiological role of autophagy in the progression of liver diseases is still debated.

PLOS ONE
12/23/2020
Artificial Intelligence in Medical Imaging and Its Application in Sonography for the Management of Liver Tumor

This study summarizes AI development in medical images with challenges to task setting, data curation, and focus on the application of AI for the managements of liver tumor...

Frontiers in Oncology
12/21/2020
Integrative Analysis of Long Extracellular RNAs Reveals a Detection Panel of Noncoding RNAs for Liver Cancer

Among other developments, study investigators use machine learning models to identify a signature of 3 noncoding RNAs for the detection of liver cancer.

01/01/2021
Fentanyl Inhibits Lung Cancer Viability and Invasion via Upregulation of miR-331-3p and Repression of HDAC5

The current study aimes to investigate the effects and the mechanisms underlying the effects of fentanyl on NSCLC.

12/23/2020
Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes

Estrogen and estrogen receptor-regulated gene transcriptional events have been well known to be involved in ER-positive breast carcinogenesis.

01/01/2021
Uncovering Emperature‐Dependent Extracellular Vesicle Secretion in Breast Cancer

Pathological studies in breast cancer have implied that temperature is associated with disease progression.

12/31/2020
Breast Cancer During Pregnancy: A Marked Propensity to Triple-Negative Phenotype

This study reviews recent progress in understanding the development of breast cancer during pregnancy and their unique subtype of triple negative which is the...

Frontiers in Oncology
12/23/2020
Efficacy of Local Treatments for Hepatocellular Carcinoma Involving the Inferior Vena Cava and/or Right Atrium

The most commonly involved major vessel is the portal vein; however, approximately 4% of patients with HCC have inferior vena cava and/or right atrium invasion.

12/21/2020
Roles of Lysyl Oxidase Family Members in the Tumor Microenvironment and Progression of Liver Cancer

Study investigators review the clinical value and novel biological roles of LOX family members in tumor progression and the TME of liver cancers.

International Journal of Molecular Sciences
12/21/2020
Evaluation of Variant Frequency in SARS-CoV-2 Infection-Related Genes Utilizing Lung Cancer Genomic Database

Study investigators analyzed the coding variants of ACE2 and TMPRSS2 and their allele frequencies in 350 Japanese patients with advanced-stage lung cancer using whole-exome...

12/24/2020
Microphthalmia-Associated Transcription Factor-Dependent Melanoma Cell Adhesion Molecule Activation Promotes Peritoneal Metastasis of Ovarian Cancer

This study investigates the function of microphthalmia-associated transcription factor, which contributes to the development of melanoma, in epithelial ovarian cancer. 

International Journal of Molecular Sciences
12/21/2020
Immunohistochemical Analysis of PGC-1α and ERRα Expression Reveals Their Clinical Significance in Human Ovarian Cancer

The purpose of this study was to investigate whether the PGC-1α/ERRα axis could serve as an effective prognostic marker in ovarian cancer. 

12/22/2020
Obesity Epidemic—The Underestimated Risk of Endometrial Cancer

This work provides an overview of pathophysiological interactions and pathways in obese women initiating tumorigenesis.

Cancers
12/21/2020
The Added Value of CA125 Normalization Before Interval Debulking Surgery to the Chemotherapy Response Score for the Prognostication of Ovarian Cancer patients Receiving Neoadjuvant Chemotherapy for Advanced Disease

Investigators studied whether CA125 normalization following neoadjuvant chemotherapy can complement the chemotherapy response system in the prognostication of patients with tubo-ovarian HGSC.

01/01/2021
Bioinformatics Analysis of Key Genes and Pathways of Cervical Cancer

The purpose of this study is to find new genes that can be used as potential biomarkers for the prognosis of cervical cancer.

12/29/2020
Alterations in Urobiome in Patients With Bladder Cancer and Implications for Clinical Outcome: A Single-Institution Study

This study was performed to characterize the alterations in urobiome and explore its implications of clinical outcome in male patients with bladder cancer.

12/15/2020
A Noninvasive Assessment of Tumor Proliferation in Lung cancer Patients using Intravoxel Incoherent Motion Magnetic Resonance Imaging

Ki-67 is a nuclear antigen widely used in routine pathologic analyses as a tumor cell proliferation marker for lung cancer.

01/01/2021
Herbal Medicines for Anorexia in Lung Cancer

This review discusses with the clinical evidence of herbal medicine use for reducing anorexia in lung cancer patients.

12/24/2020
CAFs affect the proliferation and treatment response of head and neck cancer spheroids during co-culturing in a unique in vitro model

This study aims to create a biologically relevant HNSCC in vitro model consisting of both tumor cells and CAFs cultured in 3D to establish predictive biomarkers for treatment response...

12/22/2020
Tumor Mutation Burden, Immune Cell Infiltration, and Construction of Immune-Related Genes Prognostic Model in Head and Neck Cancer

This study aimed to investigate the TMB and immune cell infiltration in these patients and construct an immune-related genes prognostic model.

01/01/2021
The Detection of Plasma Soluble Podoplanin of Patients with Breast Cancer and Its Clinical Signification

This study investigates the clinical significance of plasma soluble PDPN levels in patients with breast cancer and its significance in the diagnosis and metastasis.

12/23/2020
MYC dysfunction modulates stemness and tumorigenesis in breast cancer

Study investigators found that the expression of MYC varies in different subtypes of breast cancer, with relatively high frequency in TNBC.

01/01/2021
Putting the BRK on Breast Cancer: From Molecular Target to Therapeutics

This review highlights recent advances in BRK biology in contributing to the “hallmarks of cancer”, as well as BRK's therapeutic significance.

01/01/2021
Microbiome Related Cytotoxically Active CD8+ TIL Are Inversely Associated With Lung Cancer Development

This study evaluated the effect of inhalation of bronchoalveolar fluid in the lung cancer cell growth.

Frontiers in Oncology
12/09/2020
Cerebrospinal Fluid Penetration and Combination Therapy of Entrectinib for Disseminated ROS1/NTRK-Fusion Positive Pediatric High-Grade Glioma

Targeting oncogenic fusion-genes in pediatric high-grade gliomas with entrectinib has emerged as a highly promising therapeutic approach.

12/18/2020
Pregnancy‐specific glycoprotein 9 acts as both a transcriptional target and a regulator of the canonical TGF‐β/Smad signaling to drive breast cancer progression

This study reports PSG9 expression levels were elevated in tumor tissues and plasma specimens from breast cancer patients, and were associated with poor prognosis.

12/12/2020
Mechanisms of Resistance to Chemotherapy in Breast Cancer and Possible Targets in Drug Delivery Systems

This systematic review aims to bring the molecular mechanisms involved in BC chemoresistance and extract from the previous literature information regarding the use of nanoparticles...

12/09/2020
Primary and Acquired Resistance to Immunotherapy in Lung Cancer: Unveiling the Mechanisms Underlying of Immune Checkpoint Blockade Therapy

Immuno-oncology has redefined the treatment of lung cancer, with the ultimate goal being the reactivation of the anti-tumor immune response.

Cancers
12/11/2020
Salivary Metabolic Profile of Patients with Lung Cancer, Chronic Obstructive Pulmonary Disease of Varying Severity and Their Comorbidity: A Preliminary Study

The aim of the work was to study the features of the salivary biochemical composition in the combined pathology of lung cancer and chronic obstructive pulmonary disease of varying severity.

12/15/2020
Systemic and intravesical adoptive cell therapy of tumor-reactive T cells can decrease bladder tumor growth in vivo

The therapeutic armamentarium of bladder cancer has been recently enriched with the introduction of new therapies including ICIs, receptor TKIs and antibody drug conjugates...

12/10/2020
Neuroendocrine and Aggressive-Variant Prostate Cancer

This review provides an overview of neuroendocrine prostate cancer focusing on the AVPC subtype and we approach current treatment options as well as ongoing research efforts.

Cancers
12/16/2020
The efficacy and safety of sunscreen use for the prevention of skin cancer

Several well-conducted randomized controlled trials with long follow-up showed that sunscreen use reduces the risk of squamous cell and melanoma skin cancers.

12/14/2020
Identification of Incidental Skin Cancers Among Adults Referred to Dermatologists for Suspicious Skin Lesions

The findings of this study suggest that total body skin examinations may be useful for detecting incidental skin cancers and that patients with suspicious index lesions should be prioritized.

12/16/2020
Development and Validation of an Immune-Related Gene Pair Signature in Skin Cutaneous Melanoma

In this study, investigators established a prognostic immune-related gene pair signature for predicting the survival of SKCM patients.

12/15/2020
Molecular Alterations in Metastatic Ovarian Cancer From Gastrointestinal Cancer

This article provides new insights into the metastatic pathway and generates novel therapeutic targets for effective treatment and satisfactory outcomes in GIC patients.

Frontiers in Oncology
12/10/2020
Evolving Role of Artificial Intelligence in Gastrointestinal Endoscopy

This review discusses AI and associated various technological terminologies, evolving role in gastrointestinal endoscopy, and future possibilities.

12/14/2020
Liquid Biomarkers for Pediatric Brain Tumors: Biological Features, Advantages and Perspectives

This review summarizes current knowledge on liquid biopsy markers and technologies in pediatric brain tumors, their advantages and drawbacks...

11/27/2020
Autoantibodies against tumor-associated antigens in sputum as biomarkers for lung cancer

This study provides the first evidence that sputum TAAbs could be used as biomarkers for the early detection of lung cancer.

Translational Oncology
12/14/2020
Integrative multi-omics analysis of muscle-invasive bladder cancer identifies prognostic biomarkers for frontline chemotherapy and immunotherapy

Only a subgroup of patients with muscle-invasive bladder cancer are responders toward cisplatin-based chemotherapy and PD-L1 blockade immunotherapy.

12/17/2020
A novel imaging based Nomogram for predicting post-surgical biochemical recurrence and adverse pathology of prostate cancer from pre-operative bi-parametric MRI

Study investigators developed and validated an integrated radiomic-clinicopathologic nomogram for post-surgical bRFS and adverse pathology prediction in men with prostate cancer.

12/13/2020
Diagnostic value of microRNA-25 in patients with non-small cell lung cancer in Chinese population

This meta-analysis aims to explore diagnostic value of miR-25 in NSCLC in Chinese population.

12/18/2020
CD44 in Ovarian Cancer Progression and Therapy Resistance—A Critical Role for STAT3

This review summarizes currently available evidence about functional crosstalk between CD44 and STAT3 in human malignancies with an emphasis on ovarian cancer.

Frontiers in Oncology
12/01/2020
Updates and New Options in Advanced Epithelial Ovarian Cancer Treatment

Although primary epithelial ovarian cancer is still treated with a combination of surgery and systemic therapy, more complex surgical procedures and novel therapeutics have emerged...

12/01/2020
Progress of Artificial Intelligence in Gynecological Malignant Tumors

The purpose of this paper is to describe the progress of AI in gynecological malignant tumors and discuss some problems in its application.

12/14/2020
Perceptions of care after end-of-treatment among younger women with different gynecologic cancer diagnoses

The aim of this study was to explore how care following end-of-treatment was perceived by women treated for different gynecologic cancer diagnoses during younger adulthood.

12/22/2020
Unplanned hospitalizations in patients with locoregionally advanced head and neck cancer treated with (chemo)radiotherapy with and without prophylactic percutaneous endoscopic gastrostomy

Current studies about percutaneous endoscopic gastrostomy tube placement report equivalent patient outcomes with prophylactic PEG tubes versus common nutritional support. 

12/14/2020
Comparison of Tumor Infiltrating Lymphocyte Density with Histopathological Parameters and Effect on Prognosis in Head and Neck Squamous Cell Cancers

The study aims to determine the ratio of the TIL in the tumor microenvironment in squamous cell carcinoma of H&N and its effect on prognosis using histopathological parameters.

12/11/2020
Hypofractionated chemoradiation for head and cancer: Data from the PET NECK trial

There has been increased interest in hypofractionated accelerated chemoradiation for head and neck cancer during the recent first peak of the COVID-19 pandemic.

Oral Oncology
12/13/2020
Improving quality of life through the routine use of the patient concerns inventory for head and neck cancer patients

The patient concerns inventory is a prompt list allowing head and neck cancer patients to discuss issues that otherwise might be overlooked. 

12/21/2020
Bone marrow mesenchymal stem cells interact with head and neck squamous cell carcinoma cells to promote cancer progression and drug resistance

This study demonstrated that the recognized recruitment of MSC to tumors could impart multiple protumorigenic properties including chemotherapy resistance like that observed...

Neoplasia
12/10/2020
Urinary charged metabolite profiling of colorectal cancer using capillary electrophoresis-mass spectrometry

To understand the metabolomic profiles of different stages of CRC, study investigators conducted metabolomic profiling of urinary samples. 

Scientific Reports
12/03/2020
New fecal bacterial signature for colorectal cancer screening reduces the fecal immunochemical test false-positive rate in a screening population

This work aimed to develop a new, noninvasive CRC screening tool based on fecal bacterial markers capable of decreasing FIT false-positive rates in a FIT-positive population.

PLOS ONE
12/01/2020
The Intestinal Microbiota and Colorectal Cancer

The roles for intestinal microorganisms that initiated and facilitated the CRC process are becoming increasingly clear.

Frontiers in Immunology
11/30/2020
Depressed Colorectal Cancer: A New Paradigm in Early Colorectal Cancer

This study hypothesized that depressed colorectal neoplasms have unique clinicopathological features different that are different from those of protruded and flat colorectal neoplasms.

Clinical and translational gastroenterology
12/09/2020

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