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Breast Cancer

Breast Cancer

A Novel Immune Prognostic Index for Stratification of High-Risk Patients With Early Breast Cancer

Using public gene expression microarray datasets, study investigators classify breast cancer patients into three risk groups according to clinical risk and proliferation risk.

Scientific Reports
01/08/2021
Melatonin as an Oncostatic Molecule Based on its Anti-Aromatase Role in Breast Cancer

This review summarizes the inhibitory role of melatonin in aromatase action, suggesting its role as a possible oncostatic molecule in breast cancer.

International Journal of Molecular Sciences
01/04/2021
MCM3 Upregulation Confers Endocrine Resistance in Breast Cancer and is a Predictive Marker of Diminished Tamoxifen Benefit

Resistance to endocrine therapy in estrogen receptor-positive breast cancer is a major clinical problem with poorly understood mechanisms.

01/04/2021

MicroRNA Regulation of Cancer Stem Cells in the Pathogenesis of Breast Cancer

In breast cancer, miRNAs appear to be multi-faceted since they can act as either suppressors or oncogenes to regulate breast cancer progression.

01/07/2021
Clinical, Pathological, and PAM50 Gene Expression Features of HER2-Low Breast Cancer

This study emphasizes the large biological heterogeneity of HER2-low BC, and the need to implement reproducible and sensitive assays to measure low HER2 expression.

01/04/2021
Physical Activity as an Imperative Support in Breast Cancer Management

The field of exercise and physical activity have expanded prominently, not only for the prevention but also for the management of different pathologies, including breast cancer.

Cancers
12/28/2020
NRG1 Fusions in Breast Cancer

The NRG1 fusion expressed in the breast cancer cell line MDA-MB-175 serves as a model example of such fusions, showing the proposed autocrine loop and exceptional drug sensitivity.

01/07/2021
The Effect of Family History on Screening Procedures and Prognosis in Breast Cancer Patients

The potential benefit of additional breast cancer screening examinations in moderate risk patients (patients with history of breast cancer in one or two family members) remains unclear.

12/24/2020
The Association Between ATM Variants and Risk of Breast Cancer

Study investigators conduct a systematic review and meta-analysis to clarify the pooled association between various ATM variants and the risk of breast cancer.

BMC Cancer
01/05/2021
PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects

The main purpose of this review is to present general aspects of breast cancer, the components of the AKT signaling pathway, the factors that activate...

International Journal of Molecular Sciences
12/26/2020
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High Expression of NRF2 Is Associated with Increased Tumor-Infiltrating Lymphocytes and Cancer Immunity in ER-Positive/HER2-Negative Breast Cancer

The clinical relevance of Nuclear factor erythroid 2-Related Factor 2 in human breast cancer remains unclear.

Cancers
12/21/2020
Prevalence of RECQL Germline Variants in Pakistani Early-Onset and Familial Breast Cancer Patients

This study investigates the contribution of pathogenic RECQL germline variants to hereditary breast cancer in early-onset and familial breast cancer patients from Pakistan.

12/20/2020
Establishment and Validation of a Preoperative MRI-based Nomogram for Predicting the Risk of Malignancy in Patients with Breast Tumor

This study establishes a preoperative nomogram incorporating morphological and DCE features to individually predict the risk of malignancy in patients with breast tumor.

01/01/2021
Feasibility and Acceptability of Personalised Breast Cancer Screening (DECIDO Study): Protocol of a Single-Arm Proof-of-Concept Trial

The objective of the DECIDO study is to assess the acceptability and feasibility of offering risk-based personalised breast cancer screening and...

BMJ Open
12/23/2020
Racial Disparities in Triple Negative Breast Cancer: A Review of the Role of Biologic and Non-biologic Factors

African-American women have high prevalence of TNBC with worse clinical outcomes than European-American women.

12/22/2020
The Tumor Microenvironment as a Driving Force of Breast Cancer Stem Cell Plasticity

This review summarizes the studies providing links between the TME and the breast cancer stem cell phenotype and we discuss their specific interactions with immune cell subsets...

Cancers
12/21/2020
Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells

Breast cancer preferentially develops osteolytic bone metastasis, which makes patients suffer from pain, fractures and spinal cord compression.

01/01/2021
Background parenchymal enhancement on contrast-enhanced spectral mammography does not represent an influencing factor for breast cancer

This study compares the relationship between BPE on contrast-enhanced spectral mammography, mammographic breast density, age, in the group with benign vs malignant breast lesions.

12/24/2020
Adipocyte-Derived Leptin Promotes PAI-1-Mediated Breast Cancer Metastasis in a STAT3/miR-34a Dependent Manner

This study revealed that adipocyte coculture stimulated PAI-1 expression in breast cancer cells to potentiate cell motility.

Cancers
12/21/2020
Breast Cancer Stem Cells: Biomarkers, Identification and Isolation Methods, Regulating Mechanisms, Cellular Origin, and Beyond

This study reviews recent advances in breast cancer stem cell studies in terms of available biomarkers, identification and isolation methods, molecular mechanisms, and...

Cancers
12/14/2020
Current Status of Circulating Tumor Cells, Circulating Tumor DNA, and Exosomes in Breast Cancer Liquid Biopsies

This study reviews the most recent studies on breast cancer, demonstrating the clinical potential and utility of CTCs and ctDNA.

International Journal of Molecular Sciences
12/11/2020
Neutrophil-to-lymphocyte ratio predicts early mortality in females with metastatic triple-negative breast cancer

The aim of this study was to determine the utility of the neutrophil-to-lymphocyte ratio as a biomarker for predicting early-mortality among females with metastatic triple-negative breast cancer.

PLOS ONE
12/07/2020
Spindle cell carcinoma of the breast managed with neoadjuvant AIM: A case report

Metaplastic carcinomas of the breast are rare but are thought to be more aggressive than invasive ductal carcinomas. Due to their rarity, there are few randomized trials that...

12/11/2020
Plasma levels and tissue expression of soluble TGFβrIII receptor in women with early-stage breast cancer and in healthy women: a prospective observational study

This prospective observational study assessed tissue expression and plasma levels of sTGFβrIII in healthy women, women with benign breast lesions and in early-stage breast cancer patients.

12/11/2020
Drug resistance gene expression and chemotherapy sensitivity detection in Chinese women with different molecular subtypes of breast cancer

The aim of the study was to identify specific chemosensitivity drugs for various molecular subtypes of breast tumors in Chinese women, by detecting the expression...

12/15/2020
The Role of Regular Mammograms in Finding Interval Breast Cancer

Strategies beyond current mammographic screening practices are needed to reduce incidence, improve detection, and reduce deaths from interval breast cancers...

Oncology Times - Latest Articles
12/20/2020
Axillary Hibernoma in woman with Lobular breast cancer and MEN1 syndrome: A case report

The present study reports the case of an axillary hibernoma in a patient with lobular homolateral breast cancer and multiple endocrine neoplasia type1.

11/27/2020
Breast cancer mortality trends in Peruvian women

This study aims to estimate the mortality rates from breast cancer in Peruvian women and to assess mortality trends over 15 years.

BMC Cancer
12/01/2020
The Gut Microbiota: A Potential Gateway to Improved Health Outcomes in Breast Cancer Treatment and Survivorship

This review provided an overview of the current understanding of the relationship between the gut microbiota and breast cancer and to highlight potential strategies for...

International Journal of Molecular Sciences
12/03/2020
Integrative genomic analysis implicates ERCC6 and its interaction with ERCC8 in susceptibility to breast cancer

Up to 30% of all breast cancer cases may be inherited and up to 85% of those may be due to segregation of susceptibility genes with low and moderate risk for breast cancer. 

Scientific Reports
12/04/2020
Prognostic value of programmed cell death ligand-1 expression in breast cancer

This meta-analysis was about to explore PD-L1 expression as well as its prognostic role in BC.

12/04/2020
Manual lymphatic drainage for lymphedema in patients after breast cancer surgery

This systematic review and meta-analysis summarized the current evidence to assess the effectiveness of MLD in preventing and treating lymphedema in patients after breast cancer surgery.

12/04/2020
Cancer Stem Cell-Associated Pathways in the Metabolic Reprogramming of Breast Cancer

This review summarizes the links between the metabolic adaptations of breast cancer cells and CSC-associated pathways. 

International Journal of Molecular Sciences
11/30/2020
Breast Cancer and Microcalcifications: An Osteoimmunological Disorder?

This review compares microenvironments and molecular characteristics in the most frequent osteoimmunological disorders with major events...

International Journal of Molecular Sciences
11/15/2020
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

This review summarizes the main findings concerning the relationship between Wnt signaling and breast cancer and provide an overview of existing mechanisms, challenges...

11/24/2020
Evaluation of Inhibitory Effects of Geniposide on a Tumor Model of Human Breast Cancer based on 3D Printed Cs/Gel Hybrid Scaffold

This study aimed to inspect whether GEN could inhibit proliferation and promote the apoptosis of human breast cancer cells (MCF-7).

Materials Science and Engineering: C
02/01/2021
Efficacy of cognitive behavioral therapy for insomnia in breast cancer: A meta-analysis

Although cognitive behavioral therapy for insomnia is available in integrative oncology settings, it poses unique challenges for BC survivors.

Sleep Medicine Reviews
02/01/2021
Predicting the likelihood of recurrence of pregnancy-associated breast cancer: Nomogram based on analysis of the French cancer network: Cancer Associé à La Grossesse.

The aim of this study is to build a nomogram based on selected clinical and histological variables to predict recurrence.

Journal of gynecology obstetrics and human reproduction
03/01/2021
Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment.

This study was conducted to assess the antitumor activity of tryptanthrin in breast cancer models both in vitro and in vivo, and to explore the important role of the inflammatory

Acta Pharmaceutica
06/01/2021
Currently Applied Molecular Assays for Identifying ESR1 Mutations in Patients with Advanced Breast Cancer

With respect to diagnosis and treatment, breast cancer is one of the most heterogeneous and complex diseases.

International Journal of Molecular Sciences
11/20/2020
Mutation screening of germline TP53 mutations in high-risk Chinese breast cancer patients

TP53 gene mutation screening was performed in 2538 Chinese breast cancer patients who tested negative for BRCA mutations.

BMC Cancer
11/02/2020
An optimized K-Nearest Neighbor based breast cancer detection

In this research, a grid search is employed to find the optimal parameter and an optimized KNN based breast cancer detection model proposed.

Journal of Robotics and Control (JRC)
05/05/2021
The HMGB1/RAGE axis induces bone pain associated with colonization of 4T1 mouse breast cancer in bone

Bone pain is a common complication of breast cancer bone metastasis and is a major cause of increased morbidity and mortality.

Journal of bone oncology
02/01/2021
The secretome of non-tumorigenic mammary cells MCF-10A elicits DNA damage in MCF-7 and MDA-MB-231 breast cancer cells.

This study evaluated the effect of the secretome of non-tumorigenic mammary cells (MCF-10A) on proliferation and DNA damage in breast cancer cells.

Toxicology in Vitro
02/01/2021
Sevoflurane Suppresses the Migration, Invasion, and Epithelial-Mesenchymal Transition of Breast Cancer Cells Through the miR-139-5p/ARF6 Axis

Sevoflurane (SEV) has been reported to inhibit the metastasis of multiple cancers, however, the role of SEV in the metastasis of BC cells remains poorly understood.

Journal of Surgical Research
02/01/2021
Preoperative breast MR imaging in newly diagnosed breast cancer: Comparison of outcomes based on mammographic modality, breast density and breast parenchymal enhancement.

This study's purpose was to compare the role of MR for assessment of extent of disease in women newly diagnosed with breast cancer imaged with digital mammography alone versus DBT.

Clinical Imaging
02/01/2021
Graphene-Based Field Effect Transistor Biosensors for Breast Cancer Detection: A Review on Biosensing Strategies

This review will present the latest strategies in graphene-based FETs for BC biosensing, and compare the different graphene-based transducers, biomarkers, bioreceptor materials...

Carbon
02/01/2021
Aptasensor based on screen-printed electrode for breast cancer detection in undiluted human serum

This study reports the development and optimization of an electrochemical aptasensor for the detection of HER2 protein, a breast cancer biomarker.

Bioelectrochemistry
02/01/2021
Presentation of self-detected breast mass in minority women with limited access to care: Can self-examination assist in early cancer detection?

This retrospective cohort study included women newly diagnosed with breast cancer from 1/1/2016 to 1/1/2018 in an inner city public community hospital.

Clinical Imaging
02/01/2021
A Multifaceted Approach to Opioid Education, Prescribing, and Disposal for Patients with Breast Cancer Undergoing Surgery.

This quality improvement project and analysis evaluated implementation of standardized prescribing, opioid education, and a narcotic disposal system.

Journal of Surgical Research
01/01/2021
Effect of weimaining on apoptosis and Caspase-3 expression in a breast cancer mouse model.

The aim of this study was to investigate the effect of WMN on the cellular activity and apoptosis of mouse breast cancer 4T1-luc2 cells, and caspase-3 and cleaved-caspase-3 expression.

Journal of Ethnopharmacology
01/01/2021
Identification of blood protein biomarkers for breast cancer staging by integrative transcriptome and proteome analyses.

In this study, the authors identified blood protein biomarkers for each stage of breast cancer by analyzing transcriptome and proteome data from patients.

Journal of Proteomics
01/01/2021
Comparative analysis of intact glycopeptides from mannose receptor among different breast cancer subtypes using mass spectrometry

This work analyzed the intact glycopeptides of the mannose receptors in serum from breast cancer patients using isobaric tags for relative and absolute quantitation and LC-MS/MS.

Talanta
02/01/2021
Proximity-constructed bifunctional DNA probes for identification of stem-like biomarker in breast cancer

Herein, the authors designed an effective sensing method using proximity-constructed bifunctional DNA probes for electrochemical identification of CD44.

Sensors and Actuators B-chemical
02/01/2021
LncRNA OIP5-AS1 Promotes Breast Cancer Progression by Regulating miR-216a-5p/GLO1

This study aimed to explore the role of OIP5-AS1 and the mechanism of its action in the progression of breast cancer.

Journal of Surgical Research
01/01/2021
Correlation between numerical and categorical immunohistochemical score of Ki-67 and HER2 with clinicopathological parameters of breast cancer.

This study evaluated the relationship between numerical and categorical immunohistochemical score of Ki-67 and human epidermal growth factor of receptor 2 with...

Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
02/01/2021
The effect of Poria cocos ethanol extract on the intestinal barrier function and intestinal microbiota in mice with breast cancer.

The aim of this study was to investigate the effect and the mechanism of ethanol extract of Poria cocos on intestinal barrier function and intestinal microbiota in the mice with...

Journal of Ethnopharmacology
02/01/2021
SANT, a novel Chinese herbal monomer combination, decreasing tumor growth and angiogenesis via modulating autophagy in heparanase overexpressed triple-negative breast cancer.

This study aimed at evaluating the anti-tumor potential of SANT in treating HPSE related TNBC both in-vitro and in-vivo.

Journal of Ethnopharmacology
02/01/2021
Mitochondria-targeted magnetic gold nanoheterostructure for multi-modal imaging guided photothermal and photodynamic therapy of triple-negative breast cancer

In the present work, a multifunctional magnetic gold nanoheterostructure with photosensitizer Ce6 loading was designed and synthesized for synergistic photothermal and photodynamic therapy of TNBC.

Chemical Engineering Journal
01/01/2021
Disulfiram-loaded functionalized magnetic nanoparticles combined with copper and sodium nitroprusside in breast cancer cells

In this study, it was aimed to prepare a drug carrier system based on magnetic mesoporous silica nanoparticles which are non-toxic, biocompatible, and have a mesoporous structure.

Materials Science and Engineering: C
02/01/2021
Comparison of surface enhanced Raman spectroscopy and Raman spectroscopy for the detection of breast cancer based on serum samples.

In this study, surface enhanced Raman spectroscopy and Raman spectroscopy are employed for the classification of different stages of breast cancer using clinically...

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
02/01/2021
Aptamer modified MoS2 nanosheets application in targeted photothermal therapy for breast cancer

To ensure photothermal nanosheets have high specific recognition and can effectively enrich to tumor cells, controlling the size of nanosheets and lowering the potential toxicity...

Colloids and Surfaces A: Physicochemical and Engineering Aspects
01/05/2021
The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer

This review summarizes reports related to signaling pathways and potential therapeutic targets mediated by TCM and natural medicine to provide references for subsequent research in this field.

Journal of Ethnopharmacology
01/10/2021
A hybrid feature selection on AIRS method for identifying breast cancer diseases

In this study, a new hybrid feature selection fast correlation based feature and information gain was used to select features on identifying breast cancer using AIRS algorithm.

International Journal of Electrical and Computer Engineering
02/01/2021
The toxicity mechanism of different sized iron nanoparticles on human breast cancer (MCF7) cells.

The toxicity mechanism of superparamagnetic iron oxide nanoparticles (SPIONs) were examined multidimensionally to reduce the risks.

Food Chemistry
03/01/2021
Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis.

In this study, the proprotein convertase furin is targeted due to its critical roles in both tumor cell invasion and osteoclast function.

Bioactive Materials
03/01/2021
Hypofractionated Versus Standard Fractionated Radiotherapy in Patients With Early Breast Cancer or Ductal Carcinoma In Situ in a...

Given the poor results using hypofractionated radiotherapy for early breast cancer, a dose of 50 Gy in 25 fractions (fr) has been the standard regimen used by the Danish Breast Cancer Group (DBCG)

Journal of Clinical Oncology
09/18/2020
Considerations for the Use of Scalp Cooling Devices in Black Patients
ASCO: Journal of Clinical Oncology: Table of Contents
Cost Differences Identified for Older Patients With Breast Cancer Undergoing Various Treatments
Journal of Clinical Pathways
Similar Breast Cancer Outcomes With WBI, APBI
MedPage Today
Can Earlier Mammographic Screenings Affect Mortality Rates?
Oncology Nurse Advisor
Randomized Controlled Trial of Trastuzumab With or Without Chemotherapy for HER2-Positive Early Breast Cancer in Older Patients
ASCO: Journal of Clinical Oncology: Table of Contents
Are We RESPECTing Older Patients With Breast Cancer?
ASCO: Journal of Clinical Oncology: Table of Contents
Abbreviated Breast Magnetic Resonance Imaging for Supplemental Screening of Women With Dense Breasts and Average Risk
ASCO: Journal of Clinical Oncology: Table of Contents
US Patients With Breast Cancer Report Care Delays Amid COVID-19
Medscape
ACA Led to Higher Rates of Early Breast Cancer Diagnoses
Oncology Nursing Society
FDA Warns on Tecentriq-Paclitaxel Combo in Breast Cancer
MedPage Today
Win for PARP Inhibitor in BRCA Breast Cancer
MedPage Today
CDK4/6 Inhibition in Early-Stage Breast Cancer: The New Standard?
Journal of Clinical Oncology
Bayer Pays Systems Oncology $25M Upfront to License ER-Positive Breast Cancer Drug
Precision Oncology News
Developing Precise Medicines for Triple-Negative Breast Cancer
Oncology Times - Latest Articles
Intraoperative RT Matches EBRT for Early Breast Cancer
MedPage Today
Lymphedema Prevention Surgery Shows Promise
Clinical Oncology News
Three Nomograms Reviewed in Study
Clinical Oncology News
New TKI May be a Game Changer for Breast Cancer
Clinical Oncology News
Developing Pathway to Cure: A Multimodal Clinical Pathway Platform to Support Timely and Appropriate Care of Women Under 50 Diagnosed With Breast Cancer
Journal of Clinical Pathways
Gene Testing for Patients With Breast Cancer and Second Cancer
Medscape
ONS Guidelines™ Offer Framework for Managing Treatment-Related Hot Flashes
Oncology Nursing Society
Zion Pharma Begins Phase I Study of ZN-A-1041 in HER2-Positive Solid Tumors, Breast Cancer
Precision Oncology News
FDA Informs on Lack of Efficacy and Safety of Atezolizumab/Paclitaxel in mTNBC
Atezolizumab TNBC Indication 'in Jeopardy' From Phase 3 Results
Medscape
FDA Rejects Atezolizumab in Combination With Paclitaxel as Treatment for Breast Cancer 
Oncology Nursing Society
Divergent Findings With Paclitaxel and Nab-Paclitaxel in TNBC
Medscape
Local Recurrence With Radiation Boost in HER2-Positive Breast Cancer: HERA Trial Analysis
The ASCO Post
More Evidence of Interval Breast Cancers' Aggressive Nature
MedPage Today
Adjuvant Anti-CDK Thwarts Early Breast Cancer Recurrence
MedPage Today
Abemaciclib Combined With Endocrine Therapy for the Adjuvant Treatment of HR+, HER2−, Node-Positive, High-Risk, Early Breast Cancer (monarchE)
ASCO: Journal of Clinical Oncology: Table of Contents
Should Older Women With Early HER2+ Breast Cancer Avoid Chemo?
MedPage Today
Risks Seen With Continued Opioid Use in Older Breast Cancer Survivors
MedPage Today
Coronavirus Shedding; Airborne Transmission: It's TTHealthWatch!
MedPage Today
FDA: Efficacy, Safety Concerns With Breast Cancer Combo Therapy
Cancer Therapy Advisor
Exploring Overall Survival Results for Verzenio Plus Fulvestrant in Metastatic Breast Cancer
Journal of Clinical Pathways

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