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Gynecologic Cancer

Gynecologic Cancer

Choline Kinase Alpha Impairment Overcomes TRAIL Resistance in Ovarian Cancer Cells

ChoKα/CHKA overexpression and hyper-activation sustain altered choline metabolism conferring the cholinic phenotype to epithelial ovarian cancer...

01/04/2021
Early Clearance of Serum HE4 and CA125 in Predicting Platinum Sensitivity and Prognosis in Epithelial Ovarian Cancer

The objectives of this study are to assess the clinical value of early clearance of HE4 and CA125 for platinum sensitivity and prognosis in patients with ovarian cancer.

01/04/2021
Microscopic Peritoneal Residual Disease after Complete Macroscopic Cytoreductive Surgery for Advanced High Grade Serous Ovarian Cancer

The aim of this study is to assess and quantify the prevalence of residual mPM after complete macroscopic CRS in patients with advanced high-grade serous ovarian cancer.

12/25/2020

DACH1 Mutation Frequency in Endometrial Cancer is Associated With High Tumor Mutation Burden

This study utilizes the Oncology Research Information Exchange Network Avatar database to determine the frequency of DACH1 mutations in patients with endometrial cancer...

PLOS ONE
12/30/2020
Inflammatory Proteins HMGA2 and PRTN3 as Drivers of Vulvar Squamous Cell Carcinoma Progression

This study aims to advance the understanding of vulvar squamous cell carcinoma biology by recognizing biological pathways that drive the progression of this disease.

Cancers
12/23/2020
Pegylated Liposomal Doxorubicin in Patients With Epithelial Ovarian Cancer

This study evaluates the efficacy and safety of PLD in treating of in patients who experience epithelial ovarian, fallopian tubal, and peritoneal cancer progression...

01/11/2021
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Advanced Cervical Cancer in Young Women: Imaging Study of Late and Very Late Radiation-Related Side Effects After Successful Treatment by Combined Radiotherapy

Radical combined radiotherapy is a standard treatment for advanced cervical cancer.

01/01/2021
Lower dietary mineral intake is significantly associated with cervical cancer risk in a population-based cross-sectional study

Population-based studies investigating the association between dietary mineral intake and risk of cervical intraepithelial neoplasia or cervical cancer in Chinese women are few.

01/01/2021
Roles and Mechanisms of the Long Noncoding RNAs in Cervical Cancer

This review summarizes the current literature regarding the knowledge known about the roles and mechanisms of the lncRNAs in cervical neoplasia.

International Journal of Molecular Sciences
12/21/2020
New novel non-MHC genes were identified for cervical cancer with an integrative analysis approach of transcriptome-wide association study

Although genome-wide association studies have successfully identified multiple genetic variants associated with cervical cancer, the functional role of those variants is not well understood.

01/01/2021
Screening for the prevention and early detection of cervical cancer: protocol for systematic reviews to inform Canadian recommendations

This study's purpose is to inform recommendations by the Canadian Task Force on Preventive Health Care on screening in primary care for the prevention and early detection of cervical cancer by...

01/02/2021
Postoperative Adjuvant Chemotherapy Improved the Prognosis in Locally Advanced Cervical Cancer Patients With Optimal Response to Neoadjuvant Chemotherapy

Few studies investigated the effectiveness of adjuvant chemotherapy in patients with optimal response to neoadjuvant chemotherapy, and an optimal number of treatment...

Frontiers in Oncology
12/07/2020
Association of Neoadjuvant Chemotherapy With Overall Survival in Women With Metastatic Endometrial Cancer

The objective of this study is to determine the use of and outcomes associated with NACT for women with stage IV endometrial cancer.

12/09/2020
Challenges Posed by Embryonic and Anatomical Factors in Systematic Lymphadenectomy for Endometrial Cancer

The present review summarizes the current evidence on the role of lymph node surgery in endometrial cancer, focusing on the embryological, anatomical, and technical aspects.

12/19/2020
Ovarian Cancer and Pregnancy—A Current Problem in Perinatal Medicine: A Comprehensive Review

The aim of this review is to bring ovarian cancer as a complication of pregnancy to the attention of doctors and other medical professionals who have to cope with these rare cases.

Cancers
12/16/2020
Epigenomic Reprogramming toward Mesenchymal-Epithelial Transition in Ovarian-Cancer-Associated Mesenchymal Stem Cells Drives Metastasis

This study shows that in addition to cancer cell EMT, ovarian cancer cell metastasis relies on an epigenomic mesenchymal-to-epithelial transition in host mesenchymal stem cells.

12/18/2020
Matrix Drug Screen Identifies Synergistic Drug Combinations to Augment SMAC Mimetic Activity in Ovarian Cancer

Recurrent ovarian cancer is difficult to treat due to the development of chemotherapy resistance. This resistance develops through multiple mechanisms to include the avoidance...

Cancers
12/15/2020
Gynecologic Oncology Sub-Specialty Training in Ghana: A Model for Sustainable Impact on Gynecologic Cancer Care in Sub-Saharan Africa

 In Ghana, most women with gynecological malignancies present with advanced-stage disease when treatment is less effective.

12/03/2020
Ovarian Cancer Cells Cooperate to Metastasize

The team isolated subpopulations of cells from human ovarian tumors and found that none had the ability to form metastatic tumors on its own. 

Oncology Times - Latest Articles
12/20/2020
Emerging Targets of Immunotherapy in Gynecologic Cancer

Immune targets can be divided into stimulating and inhibiting molecules according to their function after receptor–ligand binding.

11/18/2020
Propensity score-matched analysis of systemic chemotherapy versus salvage hysterectomy for persistent cervical cancer after definitive radiotherapy/concurrent chemoradiotherapy

This study evaluated oncologic outcomes of patients who were treated with salvage HT, compared to systemic CT for persistent cervical cancer after definitive RT/ CCRT.

BMC Cancer
11/30/2020
Association of the hOGG1 Ser326Cys polymorphism with gynecologic cancer susceptibility: a meta-analysis

Investigators performed a comprehensive meta-analysis to precisely estimate of the impact of the hOGG1 Ser326Cys polymorphism on gynecologic cancer susceptibility. 

11/26/2020
Short- and long-term outcomes for single-port risk-reducing salpingo-oophorectomy with and without hysterectomy for women at risk for gynecologic cancer.

This study examines the outcomes after single-port risk-reducing salpingo-oophorectomy with or without hysterectomy for reduction of ovarian, breast, or endometrial cancer risk.

International Journal of Gynecological Cancer
09/18/2020
Sources of palliative care knowledge among patients with advanced or metastatic gynecologic cancer.

The objective of this study was to identify sources used by patients with advanced or metastatic gynecologic cancer to learn about palliative care and...

Journal of Pain and Symptom Management
09/22/2020
The caring experience and supportive care needs of male partners for women with gynecologic cancer: a qualitative literature review.

The objective of the study was to systematically review male partners' caring experience and supportive care needs when for women with gynecologic cancer.

Journal of Clinical Nursing
09/19/2020
An increase in multi-site practices: The shifting paradigm for gynecologic cancer care delivery.

The purpose of this study was to assess whether the number of practice sites per gynecologic oncologist and geographic access to GOs has changed over time.

Gynecologic Oncology
11/24/2020
TWIST1 expression and clinical significance in type I endometrial cancer and premalignant lesions

The aim of this study was to assess the correlation of TWIST1 expression with clinical parameters and the prognosis of type I endometrial cancer.

11/25/2020
Obesity in Gynecologic Oncology

Studies have provided solid evidence for an independent, linear, positive correlation between a pathologically increased body mass index and the probability of developing endometrial...

12/03/2020
Integrin-Linked Kinase Is a Novel Therapeutic Target in Ovarian Cancer

The objective of this study is to identify and validate novel therapeutic target(s) in ovarian cancer.

11/26/2020
Adapting and avoiding coping strategies for women with ovarian cancer during the COVID-19 pandemic

This study aim to assess coping strategies employed by women with ovarian cancer during the COVID-19 pandemic.

11/19/2020
Evaluating the effect of a group pre-treatment chemotherapy psycho-education session for chemotherapy-naive gynecologic cancer patients and their caregivers.

The objective was to evaluate the effects of a pre-chemotherapy education class on chemotherapy-naïve patients diagnosed with gynecologic cancer and their informal caregivers.

Gynecologic Oncology
10/16/2020
COVID-19 outcomes of patients with gynecologic cancer in New York City.

Characterization of COVID-19 infection in patients with gynecologic cancer is important for guiding decision making regarding critical care and anticancer treatment because the...

Cancer
10/01/2020
GOG 244 - The Lymphedema and Gynecologic cancer (LeG) study: The impact of lower-extremity lymphedema on quality of life, psychological adjustment, physical disability, and function.

This prospective cooperative group study demonstrated LLE symptoms were associated with poorer outcomes on PRO/QOL measures.

Gynecologic Oncology
10/24/2020
Emergency department utilization by patients with gynecologic cancer in the United States.

The objective of this study was to differentiate how patients with gynecologic cancers use emergency care, and to assess the characteristics associated with potentially avoidable treat-and-release

International Journal of Gynecological Cancer
10/12/2020
Predictors of Response to Immune Checkpoint Inhibition in a Real World Gynecologic Cancer Population

This retrospective study aimed to identify prognostic factors associated with improved overall response rate and progression free survival in gynecologic cancer patients receiving at least two cycl

Gynecologic oncology reports
11/06/2020
Cancer awareness in the general population varies with sex, age and media coverage: A population-based survey with focus on gynecologic cancers

This study employed a research-purpose population-based citizen panel to assess how often people recall gynecologic cancers compared to other cancer types and to explore the relative importance...<

European Journal of Obstetrics &amp
11/01/2020
Panorama of Gynecologic Cancer in Brazil

This article describes the incidence, morbidity, and mortality of women in Brazil affected with GC between the years of 2000 and 2017.

JCO Global Oncology
10/27/2020
Patterns of social media use and associations with psychosocial outcomes among breast and gynecologic cancer survivors

We sought to characterize the use of social media (SM) among breast and gynecologic cancer survivors, as well associations between patterns SM psychosocial outcomes.

Journal of Cancer Survivorship
11/08/2020
Can Fried Frailty Score predict postoperative morbidity and mortality in gynecologic cancer surgery? Results of a prospective study.

The aim of this study is to evaluate the predictive ability of Fried Frailty Score for surgical outcomes in patients undergoing gynecologic cancer surgery.

Journal of Geriatric Oncology
10/06/2020
Using the Risk Assessment Index to predict mortality and quality of life in breast and gynecologic cancer patients.

To aid oncologists in identifying patients with highest risk for adverse outcomes, the study investigated the RAI, a validated tool used to assess frailty in patients prior to elective surgery.

Journal of Clinical Oncology
10/08/2020
Role of vaginal brachytherapy boost following adjuvant external beam radiotherapy in cervical cancer: Turkish Society for Radiation Oncology Gynecologic Group Study (TROD 04-002).

The aim of this study was to assess the impact of the addition of vaginal brachytherapy boost to adjuvant external beam radiotherapy on oncological outcomes and toxicity in patients with...

International Journal of Gynecological Cancer
09/30/2020
Undergoing active treatment for gynecologic cancer during COVID-19: A qualitative study of the impact on healthcare and social support.

This qualitative study captured the perspectives of women undergoing active treatment for gynecologic malignancy at an academic medical center.

Gynecologic oncology reports
10/21/2020
Provision of smartphones in a symptom monitoring program of gynecologic and breast cancer patients during active therapy.

With advances in technology, smartphones are being used for multiple research and clinical care functions. However, not all patients have these devices, leading to disparities in participation.

Journal of Clinical Oncology
10/08/2020
Characteristics of immediate hypersensitivity reaction to paclitaxel-based chemotherapy in gynecologic cancer patients.

This study's objective was to investigate the incidence, patterns, and risk factors for paclitaxel-related IHRs and management of IHRs in gynecologic malignancy patients.

Asian Pacific Journal of Allergy and Immunology
10/17/2020
Increased ultrasonographic endometrial thickness is associated with poor survival in patients with endometrial cancer: An Israel gynecologic oncology group study.

The authors aimed to assess the association of pre-operatively evaluated ultrasonographic endometrial thickness with outcomes of patients with endometrial cancer.

Ejso
10/14/2020
Diet and gut microbiome interactions in gynecologic cancer.

This study explores the mechanisms by which alterations in the gut and reproductive tract microbiome contribute to carcinogenesis focusing on obesity, hyperestrogenism, inflammation and...

Gynecologic Oncology
09/12/2020
Clinical implications of plasma circulating tumor DNA in gynecologic cancer patients.

This study describes the molecular landscape identified on ctDNA, ctDNA concordance with tissue‐based analysis, and factors associated with OS in gynecologic cancer patients with ctDNA analysis.

Molecular Oncology
09/17/2020
Gynecologic cancer surveillance in the era of SARS-CoV-2 (COVID-19).

The SARS-CoV-2 (COVID-19) pandemic has significantly impacted the management of patients with gynecologic cancers.

International Journal of Gynecological Cancer
10/05/2020
Prophylactic Gynecologic Surgery at Time of Colectomy Benefits Women with Lynch Syndrome and Colon Cancer: A Markov Cost-Effectiveness Analysis.

This study aimed to compare the cost, quality of life, and likelihood of being alive and free from colon, endometrial, and ovarian cancer between operative choices for patients with Lynch syndrome

Diseases of The Colon &amp
10/01/2020
Oncology Drug Reference Sheet: Rucaparib
Oncology Nursing Society
Gynecologic Cancer Patients at No Greater Risk of Dying From COVID-19
Oncology Times - Latest Articles

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