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Hematologic Malignancies

Hematologic Malignancies

Treatment of Acute Leukemia During COVID-19

The risk of severe COVID-19 and mortality is markedly raised in patients with cancer, prompting several collaborative groups to issue guidelines to mitigate the risk of infection...

01/12/2021
Clinical Significance of Occult Central Nervous System Disease in Adult Acute Lymphoblastic Leukemia

This study retrospectively evaluates the incidence of occult CNS disease and its impact on outcome in 240 adult patients with newly diagnosed ALL.

Haematologica
01/01/2021
Alignment-Free Method for Functional Annotation of Amino Acid Substitutions: Application on Epigenetic Factors Involved in Hematologic Malignancies

Genes coding for epigenetic regulators have important roles in cancer pathogenesis and mutations in these genes show great potential as clinical biomarkers, especially in HMs.

PLOS ONE
01/04/2021

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Weathering the Storm: COVID-19 Infection in Patients with Hematological Malignancies

Owing to their immunosuppressive status, patients with hematological malignancies are at an increased risk of infection and have a worse prognosis than patients without HMs.

12/21/2020
Mitochondrial Bioenergetics at the Onset of Drug Resistance in Hematological Malignancies

In hematological malignancies, there is a strong relationship between cellular metabolism, mitochondrial bioenergetics, interconnections with supportive microenvironment and drug resistance.

Frontiers in Oncology
12/21/2020
Analysis of Risk Factors and Clinical Indicators in Bloodstream Infections Among Patients with Hematological Malignancy

The present study is aimed to describe the epidemiology, clinical indexes, and antibiotic use for in-hospital bloodstream infections of hematological malignancy patients.

12/31/2020
Hematopoeitic Cell Transplantation and CAR T-Cell Therapy: Complements or Competitors?

The advent of both technologies revolutionized treatment of many hematologic malignancies, both offering the chance at sustained remissions for patients who would otherwise...

Frontiers in Oncology
12/22/2020
Targeting Chromatin Complexes in Myeloid Malignancies and Beyond: From Basic Mechanisms to Clinical Innovation

This review summarizes some of the current concepts on the role epigenetic modifiers in malignant chromatin states with a specific focus on myeloid malignancies and...

Cells
12/21/2020
Decisional involvement and information preferences of patients with hematologic malignancies

This study described and examined factors associated with preferences of patients with hematologic malignancies for decisional involvement, information sources, and presentation of information.

Blood Advances
11/09/2020
Radioprotective Agents and Enhancers Factors. Preventive and Therapeutic Strategies for Oxidative Induced Radiotherapy Damages in Hematological Malignancies

The purpose of this review was to examine the data in the literature on the possible use of old and new substances to increase the efficacy of radiation treatment in hematological diseases...

11/12/2020
CD123 as a Biomarker in Hematolymphoid Malignancies: Principles of Detection and Targeted Therapies

This review provides an overview of CD123 biology and in-depth discussion of clinical laboratory techniques used to determine CD123 expression in various hematolymphoid neoplasms.

Cancers
10/23/2020
Immunotherapy in Hematologic Malignancies: Emerging Therapies and Novel Approaches

In this review, immunotherapies for each type of hematologic malignancy will be introduced, and novel targets that are under investigation will be described.

International Journal of Molecular Sciences
10/27/2020
Heterozygous germ line CSF3R variants as risk alleles for development of hematologic malignancies

Heterozygous pathogenic germ line CSF3R variants increase risk for developing both myeloid and lymphoid malignancies.

Blood Advances
10/27/2020
Evaluation of the Relationship of Glasdegib Exposure and Safety End Points in Patients With Refractory Solid Tumors and Hematologic Malignancies.

The relationship between glasdegib exposure and adverse event cluster terms of clinical concern was explored in this analysis.

The Journal of Clinical Pharmacology
09/24/2020
Haploidentical stem cell transplantation vs matched unrelated donor transplantation in adults with hematologic malignancies: a systematic review and meta-analysis.

Haploidentical hematopoietic stem cell transplantation and matched unrelated donor transplantation are two important options when a matched sibling donor is unavailable.

Hematology
12/01/2020
Total Hip Arthroplasty in Adolescents and Young Adults for Management of Advanced Corticosteroid-Induced Osteonecrosis Secondary to Treatment for Hematologic Malignancies

This study examined clinical outcomes of THA in adolescents and young adults treated for hematologic malignancies who developed advanced ONFH.

Journal of Arthroplasty
10/19/2020
Discovery of CA-4948, an Orally Bioavailable IRAK4 Inhibitor for Treatment of Hematologic Malignancies

Small molecule potent IRAK4 inhibitors from a novel bicyclic heterocycle class were designed and synthesized based on hits identified Aurigene’s compound library.

ACS Medicinal Chemistry Letters
10/14/2020
Revisiting Early Palliative Care for Patients With Hematologic Malignancies and Bone Marrow Transplant: Why the Delay?

The aim of this literature review is to analyze and discuss the possible barriers to care and delayed referrals for hematologic malignancies and bone marrow transplant patients.

Cureus
09/17/2020
Primary Palliative Care for Patients with Advanced Hematologic Malignancies: A Pilot Trial of the SHARE Intervention.

The objective of this study was to develop and pilot-test a nurse-led primary palliative care intervention for patients with advanced hematologic malignancies.

Journal of Palliative Medicine
10/19/2020
Revisiting the treatment of anemia in the setting of chronic kidney disease, hematologic malignancies and cancer: perspectives with opinion and commentary.

A review of anemia in the context of chronic kidney disease, hematologic malignancies and cancer is presented with focus on the establishment of ESAs as integral in the treatment of anemia.

Expert Review of Hematology
10/08/2020
Impact of a Clostridioides difficile testing computerized clinical decision support on an adult stem cell transplant and hematologic malignancies unit.

Clostridioides difficile infection rates in hospitalized hematopoietic stem cell transplant (HSCT) and hematologic malignancy (HM) patients are higher than the general population.

Biology of Blood and Marrow Transplantation
10/09/2020
Multiple myeloma (MM) therapy within a Medicare-insured patient population: Role of care setting and oncologist sub-specialization in hematologic malignancies.

Dramatic increases in oncology practice consolidation with hospitals may affect care setting and whether patients see oncologists that specialize in their cancer, with downstream effects on...

Journal of Clinical Oncology
10/08/2020
Acute Respiratory Failure Outcomes in Patients with Hematologic Malignancies and Hematopoietic Cell Transplant: A Secondary Analysis of the EFRAIM Study

Patients with allogeneic HCT who develop acute respiratory failure are perceived to have worse outcomes than autologous HCT and non-transplant patients with hematologic malignancy.

Biology of Blood and Marrow Transplantation
10/01/2020
Effects of treatments on gonadal function in long-term survivors of pediatric hematologic malignancies: A cohort study.

This study aims to evaluate the prevalence of gonadal dysfunction and the most important associated risk factors in a cohort of hematologic malignancy survivors.

Pediatric Blood &amp
09/12/2020
Strong association between herpes simplex virus-1 and chemotherapy-induced oral mucositis in patients with hematologic malignancies.

A link between oral cavity infections and CIOM in patients with hematological malignancies undergoing intensive chemotherapy or hematopoietic stem cell transplantation has been suggested.

The Korean Journal of Internal Medicine
09/01/2020
Hematologic malignancies of the gastrointestinal luminal tract.

Hematologic malignancies include several lymphoproliferative and myeloproliferative disorders, many of which are frequently encountered in current health care settings.

Abdominal Radiology
10/01/2020
Sex representation in clinical trials associated with FDA cancer drug approvals differs between solid and hematologic malignancies.

This study aimed to assess the...

Oncologist
09/22/2020
Impact of a Clostridioides difficile testing computerized clinical decision support on an adult stem cell transplant and hematologic malignancies unit.

Clostridioides difficile infection rates in hospitalized HSCT and HM patients are higher than in the general population.

Biology of Blood and Marrow Transplantation
10/09/2020
Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor.

GCTs are the most common cancer in men between the ages of 15-40. While most patients are cured, those with disease arising in the mediastinum have distinctly poor outcomes.

Journal of Clinical Investigation
09/08/2020
Hematologic malignancies of the gastrointestinal luminal tract.

Hematologic malignancies include several lymphoproliferative and myeloproliferative disorders, many of which are frequently encountered in current health care settings.

Abdominal Radiology
10/01/2020

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