Lung Cancer

Lung Cancer

Duration of Lead Time in Screening for Lung Cancer

Screening for lung cancer has used chest radiography, low dose computed tomography and sputum cytology.

Bisphosphonates and Risk of Lung Cancer

This study conducts a meta-analysis to figure out the relationship between bisphosphonates and lung cancer.

Comparative Analysis of Target Gene Exon Sequencing by Cognitive Technology Using a Next Generation Sequencing Platform in Patients with Lung Cancer

Next generation sequencing technology is an increasingly important clinical tool for therapeutic decision-making.


Infections and Immunotherapy in Lung Cancer: A Bad Relationship?

This analysis aims to review the current evidence in order to clarify the complex correlation between infections and lung cancer.

International Journal of Molecular Sciences
Immunogenomic Gene Signature of Cell-Death Associated Genes with Prognostic Implications in Lung Cancer

In this study, variations in the expression of genes involved in cell death pathways and resulting infiltration of immune cells are explored in lung adenocarcinoma.

The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients?

This article discusses the links between the lung microbiota and cancer, with particular focus on immune responses, metabolism and strategies to target the lung microbiome for cancer prevention.

Volatile Organic Compounds in Exhaled Breath as Fingerprints of Lung Cancer, Asthma and COPD

Lung cancer, chronic obstructive pulmonary disease and asthma are inflammatory diseases that have risen worldwide, posing a major public health issue...

Sex Difference and Smoking Effect of Lung Cancer Incidence in Asian Population

This study analyzes the sex difference in the effect of smoking exposure on lung cancer in terms of absolute and relative risks despite the increasing lung cancer...

A Population-Based Analysis of Spirometry Use and the Prevalence of Chronic Obstructive Pulmonary Disease in Lung Cancer

This study assesses the diagnosis of COPD with lung cancer in a large public healthcare system.

BMC Cancer
Connexins in Lung Cancer and Brain Metastasis

This review discusses junctional or non-junctional hemichannel studies in lung cancer development and brain metastasis, highlighting important unanswered questions...

Frontiers in Oncology
Durvalumab and Tremelimumab With or Without Stereotactic Body Radiation Therapy in Relapsed Small Cell Lung Cancer

Study investigators conducted this signal-finding study to assess the efficacy of ICB with or without radiation in relapsed SCLC.

Predictive value of tumor mutation burden with targeted next-generation sequencing in immunocheckpoint inhibitors for non-small cell lung cancer

This study evaluates the clinical predictive value of tumor mutation burden for immune checkpoint inhibitor therapy in patients with NSCLC.

Overexpression of CENPF is Associated With Progression and Poor Prognosis of Lung Adenocarcinoma

This study explored the role of Centromere protein F in lung adenocarcinoma. 

Acquired Resistance to PD-1/PD-L1 Blockade in Lung Cancer: Mechanisms and Patterns of Failure

This review discusses mechanisms and clinical outcomes of acquired resistance in NSCLCs and explores future directions for research to understand and address this important question.

GINS2 attenuates the development of lung cancer by inhibiting the STAT signaling pathway

This study's results suggest that GINS2 inhibits the proliferation of lung cancer cells by inhibiting the STAT signaling pathway, which may be a potential biomarker for the diagnosis or prognosis..

Cutaneous Metastasis as the First Presentation of Non-Small-Cell Lung Cancer with a BRAF Mutation

Distant metastases at the time of non-small-cell lung cancer presentation are a frequent clinical problem.

Three metachronous primary lung cancers in a chronic smoker

This report involves a rare case of triple metachronous lung cancer and review of literature of patients with triple metachronous cancers.

Clinical significance and prognostic value of Porphyromonas gingivalis infection in lung cancer

This study analyzed the correlation between P. gingivalis infection and clinicopathological features and survival prognosis of patients with lung cancer.

Translational Oncology
Response evaluation after immunotherapy in NSCLC

The present study aimed to evaluate the role of early FDG PET/CT in non-small cell lung cancer patients undergoing immune checkpoint inhibitor treatment.

Microbiome Dysbiosis in Lung Cancer: From Composition to Therapy

This study summarized the recent progresses about microbiome in lung cancer and further discussed the role of microbial communities in promoting lung cancer progression...

Evolution of Systemic Treatment Uptake and Survival in Advanced Non-Small Cell Lung Cancer

Non-small cell lung cancer commonly presents at advanced stage.

Current Oncology
Germline variation networks in the PI3K/AKT pathway corresponding to familial high-incidence lung cancer pedigrees

Investigators conducted a study with whole-exome sequencing of pedigrees with familial lung cancer to analyze the potential genetic susceptibility.

BMC Cancer
Tumor Differentiation and EGFR Mutation Associated with Disease-Free Survival in Stage IA Lung Adenocarcinoma Patients with Curative Surgery

This study aimed to predict stage IA lung adenocarcinoma patients who underwent radical resection with a high risk of recurrence or metastasis.

Clinically relevant prognostic and predictive markers for immune-checkpoint-inhibitor (ICI) therapy in non-small cell lung cancer (NSCLC)

ICI either alone or in combination with chemotherapy have expanded our choice of agents for the palliative treatment of non-small cell lung cancer patients.

BMC Cancer
Multi-Window CT Based Radiological Traits for Improving Early Detection in Lung Cancer Screening

This study evaluated the ability of radiological semantic traits assessed on multi-window computed tomography to predict lung cancer risk.

Evaluation of the association between vitamin D and lung cancer skin metastasis

This study aims to investigate the association between vitamin D and lung cancer skin metastasis.

EZH2 inhibitors reverse resistance to gefitinib in primary EGFR wild-type lung cancer cells

This study aimed to investigate whether the EZH2 inhibitors, GSK343 and DZNep when combined with gefitinib can reverse EGFR-TKIs resistance in EGFR wild-type NSCLC cells.

BMC Cancer
Lung cancer screening by low-dose computed tomography: a cost-effectiveness analysis of alternative programmes in the UK using a newly developed natural history-based economic model

This systematic review of economic evaluations for lung cancer identified no economic models of the UK setting based on disease natural history.

Association of Mutation Profiles with Postoperative Survival in Patients with Non–Small Cell Lung Cancer

This study comprehensively and synthetically analyzed mutations in lung cancer based on the next generation sequencing data of lung tumors surgically removed...

Increased PARP Activity and DNA Damage in NSCLC Patients: The Influence of COPD

This study aimed to assess PARP-1 and PARP-2 expression and activity and DNA damage in tumors and non-tumor lungs from patients with/without COPD.

Continuous Versus 1-Year Fixed-Duration Nivolumab in Previously Treated Advanced Non–Small-Cell Lung Cancer: CheckMate 153

This study presents an exploratory analysis of CheckMate 153, a largely community-based phase IIIb/IV study, to evaluate the impact of 1-year fixed-duration...

Journal of Clinical Oncology
Approach to Resectable N1 Non-Small Cell Lung Cancer: An Analysis of the National Cancer Database

In patients with clinical N1 disease, minimally invasive surgery has potentially better perioperative outcome compared to open thoracotomy. 

Journal of Surgical Research
Blood cadmium levels as a marker for early lung cancer detection.

This study assessed whether blood cadmium levels were associated with incident lung cancer and could be used in the context of a screening program for early-stage lung cancer.

Journal of Trace Elements in Medicine and Biology
Long Noncoding RNA PTPRG Antisense RNA 1 Reduces Radiosensitivity of Nonsmall Cell Lung Cancer Cells Via Regulating MiR-200c-3p/TCF4

This is an in-depth investigation into the underlying mechanism of radioresistance in NSCLC cells is highly desirable to improve survival rate and help to determine optimized treatment for NSCLC.

MicroRNA-126: A new and promising player in lung cancer

In the present review, the current knowledge of the role of miR-126 in lung cancer growth, metastasis, diagnosis and prognosis as well as therapy was summarized...

Defining timeliness in care for patients with lung cancer: protocol for a scoping review

The aim of this scoping review is to identify and critically synthesise the operational definitions and terminologies used to describe the timely initiation of care and consequent treatments...

BMJ Open
Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity

This study performed whole exome sequencing, RNA sequencing, methylation microarray, and immunohistochemistry on 8 pairs of NSCLC primary tumors and matched distant metastases.

Genome Biology
9G TestTM Cancer/Lung: A Desirable Companion to LDCT for Lung Cancer Screening

The present study evaluated the applicability of 9G testTM Cancer/Lung test to detect stage 0~IV lung cancer.

Licochalcone A inhibits interferon-gamma-induced programmed death-ligand 1 in lung cancer cells.

The aim of this study is to further clarify the effect and the mechanism of LCA on inhibiting IFN-γ-induced PD-L1 in lung cancer cells.

Combination therapy: Future directions of immunotherapy in small cell lung cancer.

This review focused on the completed and ongoing trials of the combination therapy for immunotherapy of SCLC to find out the rational combination strategies which may improve the outcomes for SCLC.

Translational Oncology
Functional proteomic analysis reveals that fungal immunomodulatory protein reduced expressions of heat shock proteins correlates to apoptosis in lung cancer cells.

This study determines the changes in the proteomic profile for tumor lesions of LLC1 cell-bearing mouse received with LZ-8 and the potential mechanism for FIPs in anti-lung cancer cells.

Stress-induced upregulation of TNFSF4 in cancer-associated fibroblast facilitates chemoresistance of lung adenocarcinoma through inhibiting apoptosis of tumor cells

The present study explored transcriptome changes in lung fibroblasts under chemotherapeutics, irradiation, and hypoxia, which were induced by chemotherapy, radiotherapy, and...

Cancer Letters
DFD-Net: lung cancer detection from denoised CT scan image using deep learning

The availability of pulmonary nodules in CT scan image of lung does not completely specify cancer.

Frontiers of Computer Science in China
Risk Prediction Model Versus United States Preventive Services Task Force Lung Cancer Screening Eligibility Criteria: Reducing Race Disparities

This study evaluated whether the PLCOm2012 risk prediction model more effectively selects African American ever-smokers for screening.

Anti-epidermal growth factor vaccine antibodies increase the antitumor activity of kinase inhibitors in ALK and RET rearranged lung cancer cells

This study investigated the effects of anti-EGF antibodies generated by vaccination, TKIs and combinations in EML4-ALK and CCDC6-RET NSCLC cell lines.

Translational Oncology
The high expression of MTH1 and NUDT5 promotes tumor metastasis and indicates a poor prognosis in patients with non-small-cell lung cancer.

The present study reported that MTH1 and NUDT5 were upregulated in NSCLC cell lines and tissues, and higher levels of MTH1 or NUDT5 were associated with tumor metastasis and...

Biochimica et Biophysica Acta
Synergistic co-loading of vincristine improved chemotherapeutic potential of pegylated liposomal doxorubicin against triple negative breast cancer and non-small cell lung cancer.

The current work aims to explore the biological characteristics of vincristine synergistic co-loading into pegylated liposomal doxorubicin in non-indicated modalities of NSCLC and TNBC.

Nanomedicine: Nanotechnology, Biology and Medicine
Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer

Cisplatin is the first-in-class drug for advanced and non-targetable NSCLC.

AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.

In this study, CRISPR/Cas9-mediated loss-of-function screen revealed that PPP2R2A downregulation suppressed cell growth in NSCLC cells.

Biochimica et Biophysica Acta
Mechanisms of Fritillariae Thunbergii Flos in lung cancer treatment from a systems pharmacology perspective.

Fritillariae Thunbergii Flos included in the Chinese Pharmacopoeia (1977 Edition) is a Chinese medicinal herb traditionally used to treat bronchitis.

Journal of Ethnopharmacology
Rova-T enhances the anti-tumor activity of anti-PD1 in a murine model of small cell lung cancer with endogenous Dll3 expression.

Rovalpituzumab tesirine offers a targeted therapy for ~85% of SCLC patients whose tumors express DLL3, but clinical dosing is limited due to off-target toxicities.

Translational Oncology
Interprovincial trade driven relocation of polycyclic aromatic hydrocarbons and lung cancer risk in China

This study assesses the PAHs environmental contamination and associated lung cancer risk attributable to interprovincial trade in goods and services in China.

Journal of Cleaner Production
Sericin microparticles enveloped with metal-organic networks as a pulmonary targeting delivery system for intra-tracheally treating metastatic lung cancer.

Chemotherapy is one of the major approaches for the treatment of metastatic lung cancer. However, systemic chemotherapy is limited by poor therapeutic efficiency...

Bioactive Materials
Usefulness of Rapid Desensitization Therapy for Severe Rash Caused by Molecularly Targeted Drugs Used in the Treatment of Non-small-cell Lung Cancer.

Molecular-targeted drugs, such as epidermal growth factor receptor tyrosine kinase inhibitors and anaplastic lymphoma kinase inhibitors, are used to treat NSCLC. 

Internal Medicine
Targeted inhibition of c-MET by podophyllotoxin promotes caspase-dependent apoptosis and suppresses cell growth in gefitinib-resistant non-small cell lung cancer cells.

In the present study, the authors investigated the underlying mechanisms of PPT-induced apoptosis in NSCLC cells and found that the inhibition of c-MET kinase activity...

A Case of Anti-CRMP5 Paraneoplastic Neurological Syndrome Induced by Atezolizumab for Small Cell Lung Cancer.

This case report discusses a 76-year-old man who developed irritability and forgetfulness 5 months after the introduction of atezolizumab for the treatment of small cell lung cancer.

Internal Medicine
Pre-treatment CT imaging in stage IIIA lung cancer: Can we predict local recurrence after definitive chemoradiotherapy?

The aim of this study was to delineate computed tomography features of stage IIIA non-small cell lung cancers on pre-treatment staging studies and identify features that could...

Clinical Imaging
Relationship between Patient Characteristics and the Timing of Provision of Explanation about DNAR to Patients with Advanced Lung Cancer.

The aim of the present study was to analyze the relationship between the patient characteristics and the timing of provision of an explanation about “Do Not Attempt Resuscitation”...

Internal Medicine
Surface plasmon resonance signal enhancement based on erlotinib loaded magnetic nanoparticles for evaluation of its interaction with human lung cancer cells

In the present study, signal enhancement of erlotinib conjugated magnetic nanoparticles compared to erlotinib was evaluated...

Optics and Laser Technology
Fucoxanthin extracted from Laminaria Japonica inhibits metastasis and enhances the sensitivity of lung cancer to Gefitinib.

The aim of this study was to demonstrate the effects of Fucoxanthin, a major active component extracted from Laminaria japonica on metastasis and Gefitinib sensitivity in...

Journal of Ethnopharmacology
Targeted Delivery of Quercetin by Nanoparticles Based on Chitosan Sensitizing Paclitaxel-Resistant Lung Cancer Cells to Paclitaxel

This study explores whether QUE could reverse the resistance of NSCLC to paclitaxel-based therapy.

Materials Science and Engineering: C
A k-NN Method for Lung Cancer Prognosis with the Use of a Genetic Algorithm for Feature Selection

In this paper, a k-Nearest-Neighbors technique, for which a genetic algorithm is applied for the efficient feature selection to reduce the dataset dimensions and enhance the classifier pace...

Expert Systems With Applications
Polydopamine nanoparticles-assisted impedimetric sensor towards label-free lung cancer cell detection

Herein, this study demonstrated the first evaluation of the PDA NPs for the electrochemical determination of lung cancer cells.

Materials Science and Engineering: C
Differential expression profiling of transcripts of IDH1, CEA, Cyfra21-1, and TPA in stage IIIa non-small cell lung cancer (NSCLC) of smokers and non-smokers cases with air quality index

The aim of the study is to compare chronic smokers and non-smokers living in areas with air quality categorized as poor or moderate.

Artesunate exhibits synergistic anti-cancer effects with cisplatin on lung cancer A549 cells by inhibiting MAPK pathway.

This study was aimed to explore the anti-cancer activity of ART in combination with CIS on A549 cells.

Complementary and integrative medicine mention and recommendations: A systematic review and quality assessment of lung cancer clinical practice guidelines.

The purpose of this study was to identify the quantity and assess the quality of CIM recommendations in clinical practice guidelines (CPGs) for the treatment and/or management of lung cancer.

Integrative medicine research
The More, The Better?
ASCO: Journal of Clinical Oncology: Table of Contents
Hybrid Screening Model Proves Beneficial for Lung Cancer Patient Outcomes
Journal of Clinical Pathways
Volume-Based Care Regionalization: Pitfalls and Challenges
ASCO: Journal of Clinical Oncology: Table of Contents
RET Inhibitor Selpercatinib Achieves Durable Responses in Lung Cancer
Oncology Times - Latest Articles
Even 'Light' Smoking Ups Lung Cancer Risk
MedPage Today
Decreases in Lung Cancer Deaths May Be Due to Advances in Treatment
MedPage Today
BMS' Opdivo Garners Positive Draft Recommendation From UK's NICE in Second-Line NSCLC
Precision Oncology News
Precision Therapy in Lung Cancer
Oncology Times - Latest Articles
Second Liquid Biopsy OK'd for Tumor Profiling in All Solid Cancers
MedPage Today
FDA Approves Pralsetinib for Lung Cancer With RET Gene Fusions
Oncology Nursing Society
Selective MET Inhibitor Tepotinib in Patients With Advanced NSCLC and MET Exon 14–Skipping Mutation
The ASCO Post
Research Shows ‘Social Smoking’ Raises Risk of Death From Lung Disease and Lung Cancer
The ASCO Post
Pralsetinib: Second Drug for RET+ NSCLC Approved in US
UK's NICE Backs Tagrisso for First-, Second-Line EGFR-Positive Lung Cancer
Precision Oncology News
FDA Approves Gavreto for Treatment of RET-Positive, Metastatic NSCLC
Clinical Oncology News
Libtayo First-line Treatment Prolongs Survival in Advanced NSCLC, Early Trial Data Show
Immuno-Oncology News
First-line Keytruda Doubles 5-Year Survival in Certain Lung Cancer Patients, Data Show
Immuno-Oncology News
Barriers to Guideline-Concordant Treatment for Lung Cancer
Journal of Clinical Pathways

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