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Diabetes Drug Reduces Acute GVHD After Stem Cell Transplant

A new study shows that adding the diabetes drug sitagliptin to usual immunsuppression therapies substantially reduces the risk for this adverse event.

Cervical Cancer: Epidemiology, Risk Factors and Screening

Although cervical cancer threatens female health, it could be the first cancer that would be eliminated by human beings with comprehensive preventive and control strategy.

Identification of Hub Genes as Potential Prognostic Biomarkers in Cervical Cancer Using Comprehensive Bioinformatics Analysis and Validation Studies

This study examines the microarray datasets using comprehensive bioinformatics tools and identified novel biomarkers associated with the prognosis of patients with cervical cancer.


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Exploring the Potential of Drug Response Assays for Precision Medicine in Ovarian Cancer

This review highlights several drug-response assays developed in ovarian cancer and discussed the current challenges and future prospects of these assays in the...

International Journal of Molecular Sciences
Calculating the Dose of Cisplatin That is Actually Utilized in Hyperthermic Intraperitoneal Chemotherapy Among Ovarian Cancer Patients

Hyperthermic intraperitoneal chemotherapy is an important treatment for ovarian cancer. This study explores how much cisplatin is actually utilized and its prognostic influence.

Reflections on the Role of Malat1 in Gynecological Cancer

Malat1, as one of the most extensively studied ncRNAs, is believed to be not only a potential biomarker for disease diagnosis and prognosis, but also a candidate drug target for...

Carboplatin Sensitivity in Epithelial Ovarian Cancer Cell Lines: The Impact of Model Systems

Epithelial ovarian cancer is the most lethal gynecologic malignancy in North America, underscoring the need for the development of new therapeutic strategies for...

ESMO-Magnitude of Clinical Benefit Scale of Adjuvant Colon Cancer Trials and Meta-Analyses

Form 1 of the European Society for Medical Oncology-Magnitude of Clinical Benefit Scale serves to grade therapies with curative intent.

Gastric/GE Junction Cancer – Geoffrey Ku, MD, and Robert Figlin, MD

 Geoffrey Ku, MD, and Robert Figlin, MD, discuss recent clinical developments in gastric and esophageal cancer.

Lenvatinib Plus Pembrolizumab for Patients With Advanced Gastric Cancer

This week the discussion surrounds the efficacy of the combination of lenvatinib and pembrolizumab for patients with advanced gastric cancer.

ASCO 2020: New Developments in the Treatment of Hard to Treat Cancers

Drs Hofland and Massacesi discuss the company’s partnerships with Daiichi Sankyo in developing a very targeted drug  for the treatment of patients with HER2+ advanced gastric cancer.

ESMO Open - ASCO - Practice Changing Studies in Gastrointestinal Cancer

In this podcast new, practice-changing research in GI cancer is considered.

Dr. S. Lindsey Davis Highlights Key Abstracts on GI Cancers from the #ASCO20 Virtual Scientific Program

Dr. S. Lindsey Davis, medical oncologist and assistant professor at the University of Colorado Cancer Center, highlights key abstracts on GI cancers that were featured at ASCO20.

Time-Dependent Treatment Effects of Metronomic Chemotherapy in Unfit AML Patients

This study examines the presence of the time-dependent effect of metronomic chemotherapy for the treatment of older patients with AML who were unfit for standard chemotherapy...

The Metabolic Reprogramming in Acute Myeloid Leukemia Patients Depends on Their Genotype and is a Prognostic Marker

Leukemic cells display some alterations in metabolic pathways, which play a role in leukemogenesis and in patients’ prognosis.

Blood Advances
Outcomes of Pediatric Acute Myeloid Leukemia Patients With FLT3-ITD Mutations in the Pre-FLT3 Inhibitor Era

This study aims to analyze the outcomes of pediatric AML patients with FLT3-ITD mutations in the pre-FLT3 inhibitor era.

Role of gut microbiome in regulating the effectiveness of metformin in reducing colorectal cancer in type 2 diabetes

This study tries to find the common grounds of initiation of T2DM and CRC and the reason why metformin reduces the risk of CRC in patients with T2DM.

Targeting aurora kinases as a potential prognostic and therapeutical biomarkers in pediatric acute lymphoblastic leukaemia

The aim of this study was evaluated the mRNA expression profile of pediatric ALL patients and the efficacy of two AURKA and AURKB designed inhibitors in a...

Scientific Reports
Impact of Time to Castration Resistance on Cytoreductive Radiotherapy in Metastatic Castration-Resistant Prostate Cancer

This study aimed to identify the value of local radiotherapy and potential candidates for metastatic castration-resistant prostate cancer.

Frontiers in Oncology
The evolving landscape of predictive biomarkers in immuno‐oncology with a focus on spatial technologies

This review aims to provide an overview of the current methodologies that are used to profile the TME, which may provide insights into the immunopathology associated...

Duration of Lead Time in Screening for Lung Cancer

Screening for lung cancer has used chest radiography, low dose computed tomography and sputum cytology.

Photodynamic Therapy for Basal Cell Carcinoma: The Clinical Context for Future Research Priorities

This study summarized the clinical relevance and expose areas of research need in the BCC context, ultimately to facilitate improvements in PDT treatment.

Aberrant Factors of Fibrinolysis and Coagulation in Pancreatic Cancer

This review provides a brief highlight of existing studies that the fibrinolysis and coagulation systems were activated in pancreatic cancer patients...

A Novel Prognosis Marker Based on Combined Preoperative Carcinoembryonic Antigen and Systemic Inflammatory Response for Resectable Gastric Cancer

Carcinoembryonic antigen is one of the important indexes for the diagnosis and prognosis of gastrointestinal cancer.

Preoperative Improvement in Physical Function by Comprehensive Rehabilitation Leads to Decreased Postoperative Complications in Gastrointestinal Cancer Patients

This study investigates how baseline laboratory data and changes in physical function due to preoperative rehabilitation training in GIC patients can influence the frequency of PCs.

Treatment of Acute Leukemia During COVID-19

The risk of severe COVID-19 and mortality is markedly raised in patients with cancer, prompting several collaborative groups to issue guidelines to mitigate the risk of infection...

Clinical Significance of Occult Central Nervous System Disease in Adult Acute Lymphoblastic Leukemia

This study retrospectively evaluates the incidence of occult CNS disease and its impact on outcome in 240 adult patients with newly diagnosed ALL.

Alignment-Free Method for Functional Annotation of Amino Acid Substitutions: Application on Epigenetic Factors Involved in Hematologic Malignancies

Genes coding for epigenetic regulators have important roles in cancer pathogenesis and mutations in these genes show great potential as clinical biomarkers, especially in HMs.

Autophagy-Mediated Tumor Cell Survival and Progression of Breast Cancer Metastasis to the Brain

This review outlines the molecular mechanisms underlying autophagy-mediated breast cancer cell survival and metastasis to the brain.

A Novel Immune Prognostic Index for Stratification of High-Risk Patients With Early Breast Cancer

Using public gene expression microarray datasets, study investigators classify breast cancer patients into three risk groups according to clinical risk and proliferation risk.

Scientific Reports
Melatonin as an Oncostatic Molecule Based on its Anti-Aromatase Role in Breast Cancer

This review summarizes the inhibitory role of melatonin in aromatase action, suggesting its role as a possible oncostatic molecule in breast cancer.

International Journal of Molecular Sciences
MCM3 Upregulation Confers Endocrine Resistance in Breast Cancer and is a Predictive Marker of Diminished Tamoxifen Benefit

Resistance to endocrine therapy in estrogen receptor-positive breast cancer is a major clinical problem with poorly understood mechanisms.

MicroRNA Regulation of Cancer Stem Cells in the Pathogenesis of Breast Cancer

In breast cancer, miRNAs appear to be multi-faceted since they can act as either suppressors or oncogenes to regulate breast cancer progression.

Clinical, Pathological, and PAM50 Gene Expression Features of HER2-Low Breast Cancer

This study emphasizes the large biological heterogeneity of HER2-low BC, and the need to implement reproducible and sensitive assays to measure low HER2 expression.

A Novel Therapeutic Approach for Colorectal Cancer Stem Cells: Blocking the PI3K/Akt Signaling Axis With Caffeic Acid

This study finds caffeic acid effectively suppresses self-renewal capacity, stem-like characteristics, and migratory capacity of CD44+ and CD133+ colorectal CSCs in vitro and in vivo.<

Circulating Exosomal miRNAs as Biomarkers for the Diagnosis and Prognosis of Colorectal Cancer

This study reports the potential of circulating exosomal miRNAs to act as biomarkers for the diagnosis and prognosis of CRC.

International Journal of Molecular Sciences
Choline Kinase Alpha Impairment Overcomes TRAIL Resistance in Ovarian Cancer Cells

ChoKα/CHKA overexpression and hyper-activation sustain altered choline metabolism conferring the cholinic phenotype to epithelial ovarian cancer...

Endoscopic Surveillance for Metachronous Esophageal Squamous Cell Neoplasms among Head and Neck Cancer Patients

This study recommends image enhanced endoscopy including Lugol chromoendoscopy as the screening tool for incident HNSCC patients.

Dysphagia and its Impact on the Quality of Life of Head and Neck Cancer Patients: Institution-Based cross-sectional study

Impaired swallowing is a primary medical concern in HNC patientsThis cross-sectional study aimed to assess swallowing function and its impact on QoL.

Risk Factors for Osteoradionecrosis of the Jaw in Patients with Head and Neck Squamous Cell Carcinoma

This study evaluates factors associated with ORNJ in patients with HNSCC, focusing on jaw-related dose–volume histogram parameters.

Prehabilitation in Head and Neck Cancer Patients

Dysphagia is one consequence of head and neck cancer that has a significant impact on quality of life for head and neck cancer survivors.

Early Clearance of Serum HE4 and CA125 in Predicting Platinum Sensitivity and Prognosis in Epithelial Ovarian Cancer

The objectives of this study are to assess the clinical value of early clearance of HE4 and CA125 for platinum sensitivity and prognosis in patients with ovarian cancer.

Deciphering the Complex Circulating Immune Cell Microenvironment in Chronic Lymphocytic Leukaemia Using Patient Similarity Networks

This study reveals high inter-individual heterogeneity in the distribution and activation of bystander immune cells in CLL, depending on the bulk of the CLL cells.

Scientific Reports
The Implications of Clinical Risk Factors, CAR Index, and Compositional Changes of Immune Cells on Hyperprogressive Disease in Non-Small Cell Lung Cancer Patients Receiving Immunotherapy

This study aims to investigate implications of clinical factors and immune cell composition on different tumor responses to immunotherapy in patients with NSCLC.

BMC Cancer
MEK Inhibitors for the Treatment of Non-Small Cell Lung Cancer

Concomitant mutations in both KRAS and BRAF genes have been identified in non-small cell lung cancer.

Functional Signatures in Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis of Sex-Based Differences in Transcriptomic Studies

This study aims to assess the molecular mechanisms underlying those differences through functional profiling and meta-analysis of lung adenocarcinoma expression datasets. 

Long Term Results of Single-Fraction Carbon-Ion Radiotherapy for Non-small Cell Lung Cancer

This study suggests that single-fraction passive carbon-ion radiotherapy can serve as an alternate treatment for patients with early-stage non-small cell lung cancer...

CHID1 Is a Novel Prognostic Marker of Non-Small Cell Lung Cancer

This study evaluates immune cells markers in 100 NSCLC specimens. Immunohistochemical analysis reveals no prognostic value for the markers studied, except CD163 and CD206.

International Journal of Molecular Sciences
Multiple microarray analyses identify key genes associated with the development of Non-Small Cell Lung Cancer from Chronic Obstructive Pulmonary Disease

This study aims to analyze the key genes and potential molecular mechanisms that are involved in the development from COPD to NSCLC.

Treatment of Non-melanoma Skin Cancers in the Absence of Mohs Micrographic Surgery

This study discusses the management of non-melanoma skin cancers in settings where Mohs micrographic surgery is not readily available.

Surgical Oncology of the Head and Neck District During COVID-19 Pandemic

Health care workers who come into contact with the upper aero-digestive tract during diagnostic and therapeutic procedures, such as otolaryngologists...

Utilization of Circulating Cell-Free DNA Profiling to Guide First-Line Chemotherapy in Advanced Lung Squamous Cell Carcinoma

This study investigates the predictive and monitoring role of circulating cell-free DNA profiling for the outcome of first-line chemotherapy in patients with advanced lung squamous cell carcinoma.<

Novel Sunprotection Interventions to Prevent Skin Cancer

In Denmark, 16,500 cases of melanoma and keratinocyte cancers were registered in 2015, of which 90% could have been avoided by behavioral changes.