A Prognostic Molecular Signature of N6-Methyladenosine Methylation Regulators for Soft-Tissue Sarcoma from The Cancer Genome Atlas Database

This study aims to identify the molecular signatures of N6-methyladenosine methylation regulators associated with patient prognosis using The Cancer Genome Atlas database.

Actual Long-Term Survival After Resection of Stage III Soft Tissue Sarcoma

This study aims to characterize the clinicopathological characteristics associated with actual long-term survival in patients with stage III soft tissue sarcoma.

BMC Cancer
Multimodal Risk-Adapted Treatment in Surgical Patients With Synovial Sarcoma: A Preoperative Nomogram-Guided Adjuvant Treatment Strategy

Study investigators established an effective preoperative nomogram to predict CSS and present a risk-adapted adjuvant treatment strategy in surgical patients with synovial sarcoma.


Will Virtual Multidisciplinary Team Meetings Become the Norm for Musculoskeletal Oncology Care Following the COVID-19 Pandemic?

Like with all cancers, multidisciplinary team meetings are the norm in bone and soft tissue tumour management too.

Intrapulmonary Solitary Fibrous Tumor With Adenofibromatous Pattern With Features of Pleomorphic High Grade Sarcoma

This study reports a case of an intrapulmonary SFT with an adenofibromatous pattern and areas with high grade histology resembling pleomorphic sarcoma.

Efficacy of hyperthermic isolated limb perfusion in the treatment of locally recurrent high-grade soft tissue sarcoma of the extremities

This novel study compared the use of tumor necrosis factor-alpha and melphalan-based isolated limb perfusion to the standard treatment of locally recurrent soft tissue extremity sarcoma.

Eribulin as a first-line treatment for soft tissue sarcoma patients with contraindications for doxorubicin

This study retrospectively analyzed the efficacy and safety of first-line eribulin therapy for patients with advanced STS unable to receive doxorubicin.

Scientific Reports
Eltrombopag inhibits the proliferation of Ewing sarcoma cells via iron chelation and impaired DNA replication

There is an urgent need to identify novel therapies that will improve outcomes for children and adults with Ewing sarcoma tumors while also decreasing treatment-related toxicities.

BMC Cancer
Assessing immune infiltration and the tumor microenvironment for the diagnosis and prognosis of sarcoma

This study characterized infiltrating immune cells and analyze immune scores to identify the molecular mechanism of immunologic response to sarcomas.

Psychological adaptation and recovery in youth with sarcoma: a qualitative study with practical implications for clinical care and research

This study explored factors that play a role in psychological adaptation and recovery of young people with sarcoma.

BMJ Open
Continuous 14 Day Infusional Ifosfamide for Management of Soft-Tissue and Bone Sarcoma: A Single Centre Retrospective Cohort Analysis

This study describes the efficacy and toxicity profile of 14-day continuous infusional ifosfamide in adult and teenage young adult patients with relapsed or metastatic soft-tissue and bone sarcoma.

Unravelling the heterogeneity of soft tissue and bone sarcoma patients’ health-related quality of life: a systematic literature review with focus on tumour location

This review aims to unravel the heterogeneity of HRQoL of patients with sarcoma with regard to tumor location and to summarize the used measures in research.

Relationship between PDGFR expression and the response to pazopanib in intimal sarcoma of the pulmonary artery: A case report.

The present study reports findings related to two cases of PAIS with PDGF and VEGF expression following treatment with pazopanib.

Current Opinion in Clinical Nutrition and Metabolic Care
Incidence of radiation induced sarcoma attributable to radiotherapy in adults: A retrospective cohort study in the SEER cancer registries across 17 primary tumor sites.

Previous studies have noted the incidence of radiation-induced sarcomas but have not investigated the relative risk of developing RIS based on primary tumor organ disease site.

Cancer Epidemiology
A Fatal Case of Kaposi Sarcoma Immune Reconstitution Syndrome Complicated by Kaposi Sarcoma Inflammatory Cytokine Syndrome or Multicentric Castleman Disease

Kaposi sarcoma-associated herpesvirus or human herpesvirus 8 is the etiological agent for a heterogeneous group of human disorders. 

American Journal of Case Reports
GDF6-CD99 Signaling Regulates Src and Ewing Sarcoma Growth

This study reported the autocrine signaling mediated by growth and differentiation factor 6, a member of the bone morphogenetic protein family of cytokines, maintains...

Multi-omics analysis of copy number variations of RNA regulatory genes in soft tissue sarcoma

RNA regulatory genes were closely associated with tumorigenesis and prognosis in multiple tumors. Copy number variation is a frequent characteristic in soft tissue sarcomas.

Life Sciences
Primary cardiac synovial sarcoma: a clinicopathological, immunohistochemical, and molecular genetics study of five clinical cases.

Primary cardiac synovial sarcoma was an exceedingly rare tumor that less reported.

Cardiovascular Pathology
Targeted RNA expression profiling identifies high-grade endometrial stromal sarcoma as a clinically relevant molecular subtype of uterine sarcoma.

High-grade endometrial stromal sarcoma may harbor YWHAE-NUTM2A/B fusion, ZC3H7B-BCOR fusion, and BCOR internal tandem duplication.

Modern Pathology
Femoral Fracture in Primary Soft Tissue Sarcoma Treated with Intensity-Modulated Radiation Therapy with and Without Dose Constraints.

In the current study, the authors sought to evaluate the effect of radiation dose constraints on the rate of femoral fracture in a more contemporary cohort.

Annals of Surgical Oncology
Has the Outcome for Patients Who Undergo Resection of Primary Retroperitoneal Sarcoma Changed Over Time? A Study of Time Trends During the Past 15 years.

This study aimed to investigate changes in treatment strategy and outcome for patients with primary retroperitoneal sarcoma undergoing resection at referral centers during a recent period.

Annals of Surgical Oncology
Incidence of Kaposi Sarcoma in Sweden is Decreasing.

Using data from the Swedish Cancer Registry, this study examined the incidence rates and survival for Kaposi sarcoma in Sweden from 1993 to 2016.

Acta Dermato-venereologica
Identification of a survival-related signature for sarcoma patients through integrated transcriptomic and proteomic profiling analyses.

SARC represents a group of highly histological and molecular heterogeneous rare malignant tumors with poor prognosis. There are few proposed classifiers for predicting patient’s outcome.

Adrenal crisis and death following transarterial chemoembolization of sarcoma liver metastases.

A report on a case of a patient with metastatic sarcoma and adrenal insufficiency who underwent right hepatic artery chemoembolization to control his intrahepatic metastases.

Clinical Imaging
Radiotherapy is Associated With Improved Survival in Patients With Synovial Sarcoma Undergoing Surgery: A National Cancer Database Analysis

In this study, the authors sought to further analyze this association using a hospital-based data set where data on chemotherapy administration and surgical margin status are available.

Journal of Surgical Research
Evaluation of immune-biomarker expression in high-grade soft-tissue sarcoma: HLA-DQA1 expression as a prognostic marker.

The present study was performed to evaluate the expression of immune‑associated genes and to elucidate the association between these genes and the prognosis in high‑grade STS.

Experimental and Therapeutic Medicine
Paraneoplastic Pemphigus Associated with Bilateral Corneal Perforations in Follicular Dendritic Cell Sarcoma.

The study's purpose is to describe a case of PNP presenting as spontaneous bilateral corneal perforations in a patient with follicular dendritic cell sarcoma.

Ocular Immunology and Inflammation
Uterine sarcoma with posterior reversible encephalopathy syndrome associated with pazopanib.

The case objective is to report on a case of posterior reversible encephalopathy syndrome associated with pazopanib.

Journal of Clinical Pharmacy and Therapeutics
A case report of rare isolated Ewing sarcoma of left maxillary sinus

Ewing sarcoma is a malignant round cell neoplasm and categorized as part of family tumor (EFT).

The Egyptian Journal of Otolaryngology
Treatment Patterns and Distance to Treatment Facility for Soft Tissue Sarcoma of the Extremity

The impact that distance traveled to receive treatment has on treatments and outcomes among patients with STS of the extremity has yet to be thoroughly investigated.

Journal of Surgical Research
Assessment of Doxorubicin and Pembrolizumab in Patients With Advanced Anthracycline-Naive Sarcoma: A Phase 1/2 Nonrandomized Clinical Trial

In this nonrandomized phase 1/2 clinical trial of 37 patients with advanced sarcoma, the combination of doxorubicin and pembrolizumab was well tolerated.

JAMA Oncology
Nivolumab/Ipilimumab Established as New Standard in Frontline sRCC

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