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Translational Oncology

Translational Oncology
Exosomal miR-193a and let-7g accelerate cancer progression on primary colorectal cancer and paired peritoneal metastatic cancer

This study confirmed the possibility of using this as a diagnostic and prognostic marker for colorectal cancer by measuring the expression levels of exosomal miR-193a and let-7g in blood.

Translational Oncology
12/20/2020
Autoantibodies against tumor-associated antigens in sputum as biomarkers for lung cancer

This study provides the first evidence that sputum TAAbs could be used as biomarkers for the early detection of lung cancer.

Translational Oncology
12/14/2020
Clinical significance and prognostic value of Porphyromonas gingivalis infection in lung cancer

This study analyzed the correlation between P. gingivalis infection and clinicopathological features and survival prognosis of patients with lung cancer.

Translational Oncology
12/03/2020
Combination therapy: Future directions of immunotherapy in small cell lung cancer.

This review focused on the completed and ongoing trials of the combination therapy for immunotherapy of SCLC to find out the rational combination strategies which may improve the outcomes for SCLC.

Translational Oncology
01/01/2021
Melatonin increases the chemosensitivity of diffuse large B-cell lymphoma cells to epirubicin by inhibiting P-glycoprotein expression via the NF-κB pathway.

Epirubicin is a first-line chemotherapeutic drug for the clinical treatment of DLBCL, but the overexpression of multidrug resistance transporter proteins, especially P-glycoprotein...

Translational Oncology
01/01/2021
Anti-epidermal growth factor vaccine antibodies increase the antitumor activity of kinase inhibitors in ALK and RET rearranged lung cancer cells

This study investigated the effects of anti-EGF antibodies generated by vaccination, TKIs and combinations in EML4-ALK and CCDC6-RET NSCLC cell lines.

Translational Oncology
01/01/2021
Emerging roles for HMGA2 in colorectal cancer.

In this review, the authors address the roles of HMGA2 in the oncogenic networks of CRC based on recent advances. 

Translational Oncology
01/01/2021
NF-κB2 and RELB offer prognostic information in colorectal cancer and NFKB2 rs7897947 represents a genetic risk factor for disease development.

This study focused on NF-κB2 and RELB of the alternative pathway of NF-κB, which remains largely underexplored in colorectal cancer.

Translational Oncology
01/01/2021
Rova-T enhances the anti-tumor activity of anti-PD1 in a murine model of small cell lung cancer with endogenous Dll3 expression.

Rovalpituzumab tesirine offers a targeted therapy for ~85% of SCLC patients whose tumors express DLL3, but clinical dosing is limited due to off-target toxicities.

Translational Oncology
01/01/2021
Successful application of anti-CD19 CAR-T therapy with IL-6 knocking down to patients with central nervous system B-cell acute lymphocytic leukemia

In this study, CAR-Ts targeting CD19 with short hairpin RNA (shRNA)-IL-6 gene silencing technology were prepared.

Translational Oncology
11/01/2020
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