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PLOS ONE

PLOS ONE
Carboplatin Sensitivity in Epithelial Ovarian Cancer Cell Lines: The Impact of Model Systems

Epithelial ovarian cancer is the most lethal gynecologic malignancy in North America, underscoring the need for the development of new therapeutic strategies for...

PLOS ONE
12/31/2020
Alignment-Free Method for Functional Annotation of Amino Acid Substitutions: Application on Epigenetic Factors Involved in Hematologic Malignancies

Genes coding for epigenetic regulators have important roles in cancer pathogenesis and mutations in these genes show great potential as clinical biomarkers, especially in HMs.

PLOS ONE
01/04/2021
DACH1 Mutation Frequency in Endometrial Cancer is Associated With High Tumor Mutation Burden

This study utilizes the Oncology Research Information Exchange Network Avatar database to determine the frequency of DACH1 mutations in patients with endometrial cancer...

PLOS ONE
12/30/2020
Novel Sunprotection Interventions to Prevent Skin Cancer

In Denmark, 16,500 cases of melanoma and keratinocyte cancers were registered in 2015, of which 90% could have been avoided by behavioral changes.

PLOS ONE
12/31/2020
Evaluation of Productivity Losses Due to Premature Mortality from Colorectal Cancer

The purpose of this study is to assess the productivity losses from premature deaths due to colorectal cancer over a ten year period (2008–2017).

PLOS ONE
12/23/2020
Gene and Protein Expression of mTOR and LC3 in Hepatocellular Carcinoma, Colorectal Liver Metastasis and “Normal” Liver Tissues

The physiological role of autophagy in the progression of liver diseases is still debated.

PLOS ONE
12/23/2020
New fecal bacterial signature for colorectal cancer screening reduces the fecal immunochemical test false-positive rate in a screening population

This work aimed to develop a new, noninvasive CRC screening tool based on fecal bacterial markers capable of decreasing FIT false-positive rates in a FIT-positive population.

PLOS ONE
12/01/2020
Neutrophil-to-lymphocyte ratio predicts early mortality in females with metastatic triple-negative breast cancer

The aim of this study was to determine the utility of the neutrophil-to-lymphocyte ratio as a biomarker for predicting early-mortality among females with metastatic triple-negative breast cancer.

PLOS ONE
12/07/2020
Bone marrow stromal cells induce an ALDH+ stem cell-like phenotype and enhance therapy resistance in AML through a TGF-β-p38-ALDH2 pathway

The bone marrow microenvironment in acute myeloid leukemia consists of various cell types that support the growth of AML cells and protect them from chemotherapy. 

PLOS ONE
11/30/2020
Blood pressure and bladder cancer risk in men by use of survival analysis and in interaction with NAT2 genotype, and by Mendelian randomization analysis

The association between blood pressure and bladder cancer risk remains unclear with confounding by smoking being of particular concern.

PLOS ONE
11/25/2020
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