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Clinical Characteristics and Outcomes of Extranodal Stage I Diffuse Large B-Cell Lymphoma in the Rituximab Era

This retrospective study aimed to better define the characteristics and outcomes of extranodal stage I diffuse large B-cell lymphoma in the rituximab era.

Blood
01/07/2021
Impact of Gemtuzumab Ozogamicin on MRD and Relapse Risk in Patients With NPM1-Mutated AML

Measurable residual disease monitoring is of prognostic relevance in NPM1mut acute myeloid leukemia patients.

Blood
12/24/2020
Short telomere length predicts nonrelapse mortality after stem cell transplantation for myelodysplastic syndrome

The effect of telomere length on NRM was most prominent after higher intensity conditioning and in patients with severe acute graft-versus-host disease.

 

Blood
12/24/2020
CD22-Directed CAR T-Cell Therapy Induces Complete Remissions in CD19-Directed CAR-Refractory Large B-Cell Lymphoma

This study reports on the first three consecutive patients with autologous CAR19-refractory LBCL treated with a single infusion of autologous 1×106 CAR+ T-cells/kg targeting...

Blood
12/18/2020
Clinical effects of administering leukemia-specific donor T cells to patients with AML/MDS post-allogeneic transplant.

However as the infused lymphocytes are not selected for leukemia-specificity, the GVL effect is often accompanied by life-threatening GVHD due to the concurrent transfer of allo-reactive lymphocyte

Blood
12/03/2020
Obinutuzumab versus Rituximab in young patients with advanced DLBCL, a PET-guided and randomized phase 3 study by LYSA

Obinutuzumab does not provide any significant additional tumor control in newly diagnosed transplant-eligible DLBCL compared to rituximab.

Blood
11/19/2020
Adaptive T-cell immunity controls senescence-prone MyD88- or CARD11-mutant B-cell lymphomas

Aberrant B-cell receptor (BCR)/NF-kB signaling is a hallmark feature of B-cell non-Hodgkin lymphomas, especially in diffuse large B-cell lymphoma.

Blood
11/24/2020
Identifying potential germline variants from sequencing hematopoietic malignancies

Next-generation sequencing of bone marrow and peripheral blood increasingly guides clinical care in hematological malignancies.

Blood
11/26/2020
Is the CNS-PINK the new CNS risk model in ENKTL?

Apart from these specific subtypes, additional risk factors associated with CNS relapse have been most extensively explored in diffuse large B-cell lymphoma.

Blood
11/26/2020
A phase 1b study of AFM13 in combination with pembrolizumab in patients with relapsed or refractory Hodgkin lymphoma

In R/R HL, immunotherapies such as the anti-programmed death-1 inhibitor pembrolizumab have demonstrated efficacy as monotherapy and are playing an increasingly prominent role in treatment.

Blood
11/19/2020
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