Blood Advances

Blood Advances
Immune Reconstitution and Infectious Complications Following Axicabtagene Ciloleucel Therapy for Large B-Cell Lymphoma

This study evaluates the long-term course of hematologic recovery, immune reconstitution, and infectious complications in 41 patients with LBCL treated with axicabtagene ciloleucel at a single cent

Blood Advances
Overcoming Resistance to Targeted Therapies in Chronic Lymphocytic Leukemia

Recent advances that have contributed to the understanding of resistance to targeted therapies in CLL are discussed in this study.

Blood Advances
Notch Activation is Pervasive in SMZL and Uncommon in DLBCL: Implications For Notch Signaling in B-Cell Tumors

Notch receptors participate in a signaling pathway in which ligand-induced proteolysis frees the NICD, allowing it to translocate to the nucleus, form a transcription complex...

Blood Advances
The Metabolic Reprogramming in Acute Myeloid Leukemia Patients Depends on Their Genotype and is a Prognostic Marker

Leukemic cells display some alterations in metabolic pathways, which play a role in leukemogenesis and in patients’ prognosis.

Blood Advances
Genomic heterogeneity in core-binding factor acute myeloid leukemia and its clinical implication

Both CBF-AML entities are characterized by chromosomal rearrangements involving the CBF transcriptional complex, leading to abnormal fusion proteins that block myeloid differentiation.

Blood Advances
IGFBP7 activates retinoid acid–induced responses in acute myeloid leukemia stem and progenitor cells

Study results suggest a potential clinical utility of IGFBP7 and ATRA combination treatment to eliminate primary AML cells and reduce relapse in AML patients.

Blood Advances
A pragmatic multi-institutional approach to understanding transplant-associated thrombotic microangiopathy after stem cell transplant

Transplant-associated thrombotic microangiopathy is a severe complication of hematopoietic stem cell transplantation.

Blood Advances
CAR T cells or allogeneic transplantation as standard of care for advanced large B-cell lymphoma: an intent-to-treat comparison

The prognosis for patients with LBCL, such as DLBCL, high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements/double-hit lymphoma, and primary mediastinal B-cell....

Blood Advances
Application of machine learning in the management of acute myeloid leukemia: current practice and future prospects

This comprehensive review highlights and discusses recent advances in ML techniques in the management of AML as a model disease of hematologic neoplasms...

Blood Advances
Prolonged rituximab maintenance in follicular lymphoma patients: long-term results of the SAKK 35/03 randomized trial

The Swiss Group for Clinical Cancer Research conducted the SAKK 35/03 randomized trial to investigate different rituximab monotherapy schedules in patients with follicular lymphoma.

Blood Advances
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