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Haematologica

Haematologica
Outcomes After Late Bone Marrow and Very Early Central Nervous System Relapse of Childhood B-Acute Lymphoblastic Leukemia

Outcomes after relapse of childhood B-acute lymphoblastic leukemia are poor, and optimal therapy is unclear.

Haematologica
01/01/2021
Clinical Significance of Occult Central Nervous System Disease in Adult Acute Lymphoblastic Leukemia

This study retrospectively evaluates the incidence of occult CNS disease and its impact on outcome in 240 adult patients with newly diagnosed ALL.

Haematologica
01/01/2021
Differentiation Therapy of Myeloid Leukemia

AML is characterized by arrested differentiation, and agents that overcome this block are therapeutically useful, as shown by the efficacy of all-trans retinoic acid in...

Haematologica
01/01/2021
SIRPαFc Treatment Targets Human Acute Myeloid Leukemia Stem Cells

Hematologic and solid tumors can upregulate expression of CD47, a self-marker that binds to SIRPα, an immunoglobulin superfamily receptor expressed on...

Haematologica
01/01/2021
Measurable Residual Disease Monitoring Provides Insufficient Lead-Time to Prevent Morphological Relapse in the Majority of Patients with Core-Binding Factor Acute Myeloid Leukemia

Core-binding factor acute myeloid leukemia is characterized by t(8;21) or inv(16) and the fusion proteins RUNX1-RUNX1T1 and CBFB-MYH11.

Haematologica
01/01/2021
FcγRIIb-BCR Coligation Inhibits B-cell Receptor Signaling in Chronic Lymphocytic Leukemia

Considering the major role of BCR in the pathogenesis of CLL and the activated nature of the leukemic cells, this study investigates whether FcγRIIb could regulate BCR signaling...

Haematologica
01/01/2021
Genomic Arrays Identify High-Risk Chronic Lymphocytic Leukemia With Genomic Complexity

Complex karyotype identified by chromosome-banding analysis has been shown to have prognostic value in chronic lymphocytic leukemia.

Haematologica
01/01/2021
Analysis of Retrotransposon Subfamily DNA Methylation Reveals Novel Early Epigenetic Changes in Chronic Lymphocytic Leukemia

While global hypomethylation of these elements has been widely reported in solid tumors, their epigenetic dysregulation is yet to be characterized in CLL, and...

Haematologica
01/01/2021
Dasatinib response in acute myeloid leukemia is correlated with FLT3/ITD, PTPN11 mutations and a unique gene expression signature

This study aimed to predict in vitro response to targeted therapies, based on molecular markers, with subsequent validation in leukemic stem cells.

Haematologica
12/01/2020
Chronic lymphocytic leukemias with trisomy 12 show a distinct DNA methylation profile linked to altered chromatin activation

The landscape of genetic alterations of CLL is well characterized and found to be extremely heterogeneous, with multiple chromosomal aberrations and dozens of driver genes...

Haematologica
12/01/2020
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