Top Stories
Addition of Diet and Lifestyle Factors to Recurrence and Mortality Prediction Models for Patients With Stage III Colon Cancer

Investigators found the addition of patient-reported diet and lifestyle factors to prediction models improved predictions of disease recurrence and mortality among patients with Stage III CRC.

The ASCO Post
Automatic Segmentation of Head and Neck Primary Tumors on MRI Using a Multi-View CNN

The aim of this study was to introduce and evaluate an automatic segmentation pipeline for head and neck squamous cell cancer using a multi-view CNN. 

Cancer Imaging

Head And Neck Cancer

New National Study Finds Oropharyngeal Cancer Incidence and Mortality Is Rising in the United States

Oropharyngeal cancer incidence among men is continuing to rise rapidly in nearly all 50 US states and among women living in states in the Midwest and Southeast regions. 

The ASCO Post
An Immune Feature-Based, Three-Gene Scoring System for Prognostic Prediction of Head-and-Neck Squamous Cell Carcinoma

This study works to identify the involvement of immune response in the lymphatic metastasis of HNSCC. 

Frontiers in Oncology
Automatic Segmentation of Head and Neck Primary Tumors on MRI Using a Multi-View CNN

The aim of this study was to introduce and evaluate an automatic segmentation pipeline for head and neck squamous cell cancer using a multi-view CNN. 

Cancer Imaging
AhR Antagonist Promotes Differentiation of Papillary Thyroid Cancer via Regulating circSH2B3/miR-4640-5P/IGF2BP2 Axis

Researchers offer a novel therapeutic approach and a potential marker for differentiation of PTC for the first time. 

Frontiers in Pharmacology
Oropharyngeal Cancer Up About 3% Among Men

Researchers analyzed oropharyngeal cancer trends for the first time in all 50 states, showing the condition is increasingly common among older men.


FDA Approvals

FDA Grants Orphan Drug Designation to NKX101 for Acute Myeloid Leukemia

The FDA granted orphan drug designation to NKX101 for treatment of AML.

FDA Approves Pembrolizumab for the Adjuvant Treatment of Stage IIB or IIC Melanoma

The US FDA approved pembrolizumab for the adjuvant treatment of adult and pediatric patients aged 12 years and older with stage IIB or IIC melanoma following complete resection. 

The ASCO Post
FDA Clears IND Application for Allogeneic CAR-T to Treat Certain Solid Tumors

The FDA cleared an investigational new drug application, a chimeric antigen receptor T-cell therapy, designed to treat adults with locally advanced or metastatic epithelial-derived solid tumors.

FDA Approves Rituximab for Multiple Pediatric Cancers

The US FDA approves Rituximab in combination with chemotherapy for pediatric patients with previously untreated, advanced stage, CD20-positive DLBCL, BL, BLL, or mature B-AL. 

FDA Grants Fast Track Designation to Natural Killer Cell Therapy for Advanced AML

The FDA granted fast track designation to CYNK-001 for the treatment of adults with relapsed or refractory acute myeloid leukemia.



Pharmacogenomics in Pediatric Oncology: Mitigating Adverse Drug Reactions While Preserving Efficacy

Major developments in drugs such as thiopurines and optimization in clinical trial protocols for treating cancer in children have led to a remarkable improvement in survival, from approximately...<

Annual Review of Pharmacology and Toxicology
Selecting Image-Guided Surgical Technologies in Oncology: A Surgeon's Perspective.

This study aimed to select the most promising IG technology per oncologic indication.

Journal of Surgical Research
The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology.

Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges medicine.

Acta Pharmaceutica
Review of Oncology and Transplant Literature for the Management of Hepatic and Pancreatic Resections in Jehovah's Witnesses.

Jehovah's Witnesses undergoing liver or pancreas surgery represent a unique medical and ethical challenge.

Cancer medicine journal
Development and Optimization of Clinical Informatics Infrastructure to Support Bioinformatics at an Oncology Center.

Translational bioinformatics for therapeutic discovery requires the infrastructure of clinical informatics.

Methods of Molecular Biology

Lung Cancer

Blood Test Better Predicts Who Can Benefit From Lung Cancer Screening

A new blood-based biomarker panel combined with a model assessing risk factors of lung cancer better predicted who could benefit most from lung cancer screening, according to new findings.

Comparison of Efficiency of USPSTF vs PLCO Criteria in Determining Eligibility for Lung Cancer Screening

PLCOm2012 may be more efficient than USPSTF2013 criteria in selecting individuals who should be considered eligible for computed tomography lung cancer screening. 

The ASCO Post
Generation of a Lung Squamous Cell Carcinoma Three-Dimensional Culture Model With Keratinizing Structures

Scientists developed a 3D culture model that retains the hierarchical plasticity of LUSC using tumor cell lines PLR327F-LD41 and MCC001F, established from LUSC patient-derived xenografts. 

Scientific Reports
Method Improves Risk Assessment for Lung Cancer Screening

Risk assessment for lung cancer screening can be improved by combining a blood biomarker test and a risk prediction model, as explored by new research. 

Cancer Therapy Advisor
A Success Targeted Nano Delivery to Lung Cancer Cells With Multi-Walled Carbon Nanotubes Conjugated to Bromocriptine

A targeted nano-drug delivery system was designed and evaluated based on neurotransmitter pathways to show that it may be useful in the treatment of lung cancer.

Scientific Reports
Incidence of Advanced Lung Cancer Continues to Decline in the US

Continued progress is seen in decreasing the incidence of advanced lung cancer in US adults, according to the Cancer Statistics, 2022 report. 

Cancer Therapy Advisor

Immuno Oncology

A Data Portal for Predicting Response to Immune Checkpoint Blockade Immunotherapy

A new data portal called Cancer-Immu can help cancer clinicians and researchers predict which patients will respond to immune checkpoint inhibitors.

Medical Xpress
An Integrative Pan-Cancer Analysis Revealing LCN2 as an Oncogenic Immune Protein in Tumor Microenvironment

This research aimed to investigate the correlation between LCN2 expression and immunity and visualize its prognostic landscape in pan-cancer.

Frontiers in Oncology
Second-Line Tisagenlecleucel vs Standard of Care in Aggressive B-Cell Lymphoma

New trial results show no improvement in EFS with second-line tisagenlecleucel vs standard of care including salvage chemotherapy and autologous HSCT in patients with aggressive B-cell lymphoma.

The ASCO Post
Immunotherapy Combination Confers Durable Benefit in Advanced Renal Cell Carcinoma

First-line nivolumab plus ipilimumab conferred greater long-term clinical benefit than sunitinib for patients with advanced renal cell carcinoma, according to new study results. 

Talk Between Immune Cells Could Lead to New Cancer Vaccine

Yale scientists helped identify crucial ways that immune system cells congregate and communicate with each other to identify and eradicate tumors, an insight that can help improve these outcomes.

Medical Xpress
Physicians May Be Overprescribing Immunotherapy for Unfit Cancer Patients

The use of immune checkpoint inhibitors for cancer patients with advanced disease may be contradictory and cause more harm than good, according to a new study in JAMA Oncology. 


Gastrointestinal Cancer

Addition of Nivolumab to Oxaliplatin-Based CT for HER2- Unresectable, Advanced or Recurrent Gastric or GEJ

Dr Kang and colleagues found the addition of nivolumab to oxaliplatin-based chemotherapy improved PFS—but not OS—as first-line treatment of HER2-...

The ASCO Post
Sensitivity to Chemotherapy May Guide Treatment of Patients With Stomach Cancer

Chemotherapy after surgery for gastric adenocarcinoma is associated with longer survival in patients with chemosensitive disease, but not in those with sensitive or refractory disease. 

Medical Xpress
Economic Cost–Utility Analysis of Stage-Directed Gastric Cancer Treatment

Doctors examine treatment costs related to life-years gained in patients having potentially curative treatment and those receiving BSC.

BJS Open
Anxiety and Depression in Recurrent Gastric Cancer

Researchers investigate the prevalence and risk factors for anxiety and depression in recurrent gastric cancer patients.

AI System Improves Early Gastric Cancer Detection

An AI system, "ENDOANGEL" was effective for real-time monitoring of endoscopic "blind spots" and improved detection of early EGC during EGD, according to research published recently.

PHLPP1 Overexpression was Associated With a Good Prognosis With Decreased AKT Activity in Gastric Cancer

Scientists perform a clinicopathologic analysis of PHLPP1 expression in gastric cancer patients and analyze AKT activity with chemotherapy drug treatment in cancer subtypes.

Technology in Cancer Research & Treatment

Skin Cancer

Pioneering Test Predicts Return of Malignant Melanoma

Researchers describe how early-stage melanomas secretingTGFβ2, cause the reduction of AMBRA1 and Loricrin, both of which are found in the skin overlaying the tumor. 

Chemotherapy ‘Has Limited Role’ After ICI Failure in Metastatic Melanoma

In patients with metastatic melanoma whose disease progressed ICI treatment, chemotherapy produces low response rates and short PFS.

Cancer Therapy Advisor
Early Readout on Overall Survival of Patients With Melanoma Treated With Immunotherapy Using a Novel Imaging Analysis

Scientists explore radiomics and machine learning to analyze computed tomographic scans to improve clinical decision making for patients with melanoma treated with immunotherapy.

JAMA Oncology
Interim Radiographic Assessment for Adaptive Dosing of Combination Immunotherapy in Advanced Melanoma

Findings on interim CT allowed patients to avoid the third and fourth doses of combination nivolumab/ipilimumab for the treatment of advanced melanoma.

The ASCO Post
High-Fiber Diet Linked to Immunotherapy Response Among Patients With Melanoma

A high-fiber diet appeared associated with increased PFS among patients with melanoma who started treatment with immune checkpoint inhibitors, according to study results published in Science.


Gynecologic Cancer

Comprehensive Analysis to Identify SPP1 as a Prognostic Biomarker in Cervical Cancer

Researchers demonstrate the relationship between SPP1 expression and pan-cancer using TCGA database.

Frontiers in Genetics
Study Finds Guideline-Concordant Cervical Cancer Screening Dropped From 2005 to 2019 Among Women in the United States

Cervical cancer screening rates have dropped in the US, with screening rates lowest among Asian and Hispanic women, those who live in rural areas, are uninsured, or are sexual minorities. 

The ASCO Post
PI3K Pathway Activation May Underlie Tamoxifen-Associated Uterine Cancer

New research suggests that the mechanism by which uterine cancers develop is tamoxifen-induced P13K pathway activation.

The ASCO Post
Coffee Consumption May Reduce Endometrial Cancer Risk

Coffee consumption may reduce the risk for endometrial cancer, according to a study published in The Journal of Obstetrics and Gynaecology Research.

The Impact of Medical Tourism on Cervical Cancer Screening Among Immigrant Women in the US

This study examines the association between medical tourism and cervical cancer screening among immigrant women and whether the association varies across years in the US. 

BMC Women's Health
Researchers Unlock Immune Cell Contributions That Could Lead to New Therapies for Endometrial Cancer

Researchers provide insight on the role of B cell immunity in endometrial cancer.

Medical Xpress
New Study Examines Septic Shock in Patients With Hematologic Malignancies

Scientists found that the mortality rate was 67.8% at 28 days, and only 19.4% of patients remained alive after 90 days, when HM patients underwent septic shock. 

The ASCO Post


KB-68A7.1 Inhibits Hepatocellular Carcinoma Development Through Binding to NSD1 and Suppressing Wnt/β-Catenin Signalling

Researchers revealed that KB-68A7.1 is lowly expressed in HCC, and its low expression is correlated with poor survival.

Frontiers in Oncology
"Liquid Biopsies" Allow Non-Invasive Diagnosis of Metastatic Cancers

Newly identified biomarkers could be used alongside imaging techniques for the non-invasive diagnosis of patients with advanced prostate cancer. 

Medical Xpress
Clinical Score May Assist in Guiding Peptide Receptor Radionuclide Therapy Decisions for Patients With Neuroendocrine Tumors

A clinical score system developed by researchers at Vanderbilt-Ingram Cancer Center that can guide PRRT decisions has been validated. 

The ASCO Post
Coffee Consumption May Reduce Endometrial Cancer Risk

Coffee consumption may reduce the risk for endometrial cancer, according to a study published in The Journal of Obstetrics and Gynaecology Research.

Radiotherapy Did Not Improve Upon Immunotherapy in Metastatic NSCLC

Adding RT to treatment with durvalumab and tremelimumab did not improve outcomes in patients with metastatic NSCLC resistant to anti-PD-1/L1 therapy. 

Cancer Therapy Advisor
Could Probiotics Reduce 'Chemo Brain' in Breast Cancer Patients?

Patients treated with chemotherapy who also took a probiotics supplement had significantly fewer symptoms of CRCI compared to a control group taking placebo capsules. 


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