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Acute Cutaneous Squamous-Cell Carcinoma

Acute Cutaneous Squamous-Cell Carcinoma

Cutaneous Squamous Cell Carcinoma in Lynch Syndrome — An Overlooked Association

Study investigators report a case of CSCC occurring in a patient with Lynch syndrome and explore some of the characteristic features and significance of this association.

Cureus
02/25/2021
Managing Risk Factors & Timing of Subsequent Cutaneous Squamous Cell Carcinoma

Each year in the United States, at least 200,000 to 400,000 new cases of cSCC are expected, and disease-related death occurs in more than 3,000 people with cSCC. 

Oncology Times - Latest Articles
03/01/2021
High-Risk Cutaneous Squamous Cell Carcinomas: The Present and Future

There are several unanswered questions about cutaneous squamous cell carcinoma, including which patients should undergo nodal staging, who should be surgically treated with...

The ASCO Post
02/10/2021

Gene Test Helps Inform Management of High-Risk SCC Patients

Emerging data support the clinical validity and use of DecisionDx-SCC as a prognostic 40-gene expression profile test for patients with high-risk SCC.

Medscape
02/01/2021
CD8+CD103+ Tissue-Resident Memory T Cells Convey Reduced Protective Immunity in Cutaneous Squamous Cell Carcinoma

While several memory T-cell subtypes have been reported in inflammatory and neoplastic conditions, the proportional representation of the different subsets of memory T cells and...

01/21/2021
Pembrolizumab Produces Durable Responses in Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma

The study supports the June 2020 approval of pembrolizumab in recurrent or metastatic cutaneous squamous cell carcinoma that is not curable by surgery or radiation.

The ASCO Post
An Unusual Case of Perineural Infiltration and Orbital Invasion of Squamous Cell Carcinoma Associated with Actinic Keratosis

Perineural invasion has been observed in patients with cutaneous carcinoma due to local subcutaneous tissue destruction and primarily involves the...

12/30/2020
Phenethyl Isothiocyanate-Containing Carbomer Gel for Use Against Squamous Cell Carcinoma

Study investigators prepare a topical gel containing 0.5% v/w phenethyl isothiocyanate for the treatment of SCC.

01/15/2021
Retinoids in Cutaneous Squamous Cell Carcinoma

This article reviews what is known about natural and synthetic retinoids and their metabolism in cSCC.

01/05/2021
Cemiplimab Therapy Safe, Active in Patients With Cutaneous Squamous Cell Carcinoma

Phase 2 study findings demonstrated the acceptable safety profile and antitumor activity of cemiplimab therapy for patients with locally advanced cutaneous squamous cell carcinoma.

Oncology Learning Network
Integrative transcriptomic analysis for linking acute stress responses to squamous cell carcinoma development

This study tested whether more acute molecular responses to UV and wounding overlapped with molecular signatures of cuSCC.

Scientific Reports
10/14/2020
Clinical value of high-resolution dynamic contrast-enhanced (DCE) MRI in diagnosis of cutaneous squamous cell carcinoma.

While uncomplicated cases of skin cSCC can be treated with surgery topical therapy alone, more objective and non‐invasive examination methods are needed to guide clinicians...

Skin Research and Technology
11/03/2020
Inhibitory effect of glutathione S-transferase A3 in the progression of cutaneous squamous cell carcinoma.

The present study was designed to explore the effect of GSTA3 on cSCC.

Journal of Cosmetic Dermatology
10/21/2020
The Synthetic Flavonoid Derivative GL-V9 Induces Apoptosis and Autophagy in Cutaneous Squamous Cell Carcinoma via Suppressing AKT-Regulated HK2 and mTOR Signals.

Cutaneous squamous-cell carcinoma (cSCC) is one of most common type non-black skin cancer. The malignancy degree and the death risk cSCC patients are significantly higher than basal cell patients.

Molecules
10/30/2020
Incidence of Multiple vs First Cutaneous Squamous Cell Carcinoma on a Nationwide Scale and Estimation of Future Incidences of Cutaneous Squamous Cell Carcinoma.

Given the increase in incidence rates and the frequent occurrence of subsequent cSCCs per patient, population-based data on the incidence rates of both first and multiple cSCCs are needed.

JAMA Dermatology
10/28/2020
The incidence of cutaneous squamous cell carcinoma in patients receiving voriconazole therapy for chronic pulmonary aspergillosis

The study's aim was to estimate the incidence of cSCC after voriconazole exposure in patients with chronic pulmonary aspergillosis on a background of chronic lung disease.

08/21/2020
Number of nodal metastases and the American Joint Committee on cancer staging of head and neck cutaneous squamous cell carcinoma: A multicenter study.

This study aimed to determine if the number of nodal metastases is an independent predictor of survival in HNcSCC, whether it provides additional prognostic information to the...

Oral Oncology
12/01/2020
British Association of Dermatologists guidelines for the management of people with cutaneous squamous cell carcinoma 2020.

The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for management cutaneous squamous cell carcinoma.

British Journal of Dermatology
11/04/2020
Study Finds Incidence Rates of cSCC Continue to Increase, Especially Among Females

Study investigators indicated that these results call for the need to revise skin cancer health policies to be able to handle the increasing burden of keratinocyte carcinoma management.

11/16/2020
FDA Approves Pembrolizumab for Cutaneous Squamous Cell Carcinoma

The FDA approved pembrolizumab for patients with recurrent or metastatic cutaneous squamous cell carcinoma that is not curable by surgery or radiation.

06/24/2020

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