Cutaneous Squamous-Cell Carcinoma

Cutaneous Squamous-Cell Carcinoma

Serial Excision for Treatment of Non-Melanoma Skin Cancer

The objective of this study is to investigate outcomes of serial excision as an alternative excision modality for NMSC.

Plastic and Reconstructive Surgery-Global Open
Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors

Study investigators examine the expression profiles of ASIC1, ASIC2, TRPV1 and TRPV4 in malignant melanoma, squamous cell carcinoma, basal cell carcinoma and in nevus cell nevi. 

International Journal of Molecular Sciences
Effect of the COVID-19 Pandemic on Delayed Skin Cancer Services

Investigators aim to summarize evidenced-based recommendations for the surgical management and prioritization of three skin cancer categories during the COVID-19 pandemic.


Exosomal Circular RNA RNA-seq Profiling and the Carcinogenic Role of Exosomal circ-CYP24A1 in Cutaneous Squamous Cell Carcinoma

Based on RNA-seq, study investigators systematically uncover the expression and implication of exosomal circRNAs in cSCC.

Frontiers in Medicine
Topical Arginase Inhibition Decreases Growth of Cutaneous Squamous Cell Carcinoma

This study demonstrates the therapeutic potential of transcutaneous arginase inhibition in cSCC.

Scientific Reports
Reflectance Confocal Microscopy of Aging Skin and Skin Cancer

Skin aging is a complex process that causes morphologic variations. Some of these variations have been hypothesized to be involved in skin cancer development. 

Delayed Response After Confirmed Progression and Other Unique Immunotherapy-Related Treatment Concepts in Cutaneous Squamous Cell Carcinoma

This study highlights treatment issues distinct to the management of the disease including expansion of the traditional concept of pseudoprogression and describes delayed responses after...

Frontiers in Oncology
Possible Link Between High Risk SCC Tumors and Statins in Men

Adult men taking statins may be at greater risk for larger and more advanced CSCC tumors, according to study results presented at the AAD VMX 2021.

Risk for Cutaneous Squamous Cell Carcinoma Increases With Age

Although the diagnosis of actinic keratosis has been associated with developing CSCC, patient age is shown to have a greater association with the long-term development of CSCC.

Cancer Therapy Advisor
Cutaneous Squamous Cell Carcinoma Arising From the Ulcer of the Lesions of Dupuytren’s Disease on the Palm

This is a case of a 52-year-old female with squamous cell carcinoma arising from the ulcer of the lesions of Dupuytren’s disease on the left palm.

Frontiers in Oncology
Small Molecules in the Treatment of Squamous Cell Carcinomas: Focus on Indirubins

This review discusses the genetic landscape of squamous cell carcinoma and the related to the potential targets of indirubin-based small molecules in cancer therapy.

Identification of a Gene Prognostic Signature for Oral Squamous Cell Carcinoma by RNA Sequencing and Bioinformatics

Study investigators aim to identify new biomarkers or potential therapeutic targets for OSCC.

BioMed Research International
Nectin Cell Adhesion Molecule 4 (NECTIN4) Expression in Cutaneous Squamous Cell Carcinoma: A New Therapeutic Target?

The aim of this study is to determine the expression and function of NECTIN4 in cSCC.

Efficacy and Toxicity of Definitive ChemoRadiation and ImmunOtherapy in Locally and/or Regionally Advanced Unresectable Cutaneous Squamous Cell Carcinoma

This single arm phase 2 prospective study aims to investigate the combination of curative intent chemoradiation and durvalumab (anti-PD-L1 checkpoint inhibitor) for this patient cohort.

Radiation Oncology
Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors

Study investigators determine the sensitivity of four patient-derived cSCC cell lines to isoform-specific PI3K inhibitors to start investigating their potential therapeutic value in cSCC.

International Journal of Molecular Sciences
Mutually Exclusive Lymphangiogenesis or Perineural Infiltration in Human Skin Squamous-Cell Carcinoma

Although anti-PD-1 therapy is beneficial for some patients with advanced sSCC, a greater understanding of disease mechanisms is still needed to develop better therapies.

Risk Prediction Model for Cutaneous Squamous Cell Carcinoma in Adult Cardiac Allograft Recipients

The aim of this study is to identify risk factors and predict the incidence of cSCC for heart transplant recipients.

Cutaneous Squamous Cell Carcinoma in Patients With Hidradenitis Suppurativa

Cutaneous squamous cell carcinoma is a recognized but infrequent complication of hidradenitis suppurativa.

Cutaneous Squamous Cell Carcinoma in the Age of Immunotherapy

Expanded applications of programmed death-1 (PD-1) blockade therapies have revealed cSCC to be one of the most amenable targets.

Cutaneous Squamous Cell Carcinoma in Lynch Syndrome — An Overlooked Association

Study investigators report a case of CSCC occurring in a patient with Lynch syndrome and explore some of the characteristic features and significance of this association.

Managing Risk Factors & Timing of Subsequent Cutaneous Squamous Cell Carcinoma

Each year in the United States, at least 200,000 to 400,000 new cases of cSCC are expected, and disease-related death occurs in more than 3,000 people with cSCC. 

Oncology Times - Latest Articles
High-Risk Cutaneous Squamous Cell Carcinomas: The Present and Future

There are several unanswered questions about cutaneous squamous cell carcinoma, including which patients should undergo nodal staging, who should be surgically treated with...

The ASCO Post
CD8+CD103+ Tissue-Resident Memory T Cells Convey Reduced Protective Immunity in Cutaneous Squamous Cell Carcinoma

While several memory T-cell subtypes have been reported in inflammatory and neoplastic conditions, the proportional representation of the different subsets of memory T cells and...

Gene Test Helps Inform Management of High-Risk SCC Patients

Emerging data support the clinical validity and use of DecisionDx-SCC as a prognostic 40-gene expression profile test for patients with high-risk SCC.

Pembrolizumab Produces Durable Responses in Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma

The study supports the June 2020 approval of pembrolizumab in recurrent or metastatic cutaneous squamous cell carcinoma that is not curable by surgery or radiation.

The ASCO Post
An Unusual Case of Perineural Infiltration and Orbital Invasion of Squamous Cell Carcinoma Associated with Actinic Keratosis

Perineural invasion has been observed in patients with cutaneous carcinoma due to local subcutaneous tissue destruction and primarily involves the...

Phenethyl Isothiocyanate-Containing Carbomer Gel for Use Against Squamous Cell Carcinoma

Study investigators prepare a topical gel containing 0.5% v/w phenethyl isothiocyanate for the treatment of SCC.

Retinoids in Cutaneous Squamous Cell Carcinoma

This article reviews what is known about natural and synthetic retinoids and their metabolism in cSCC.

Cemiplimab Therapy Safe, Active in Patients With Cutaneous Squamous Cell Carcinoma

Phase 2 study findings demonstrated the acceptable safety profile and antitumor activity of cemiplimab therapy for patients with locally advanced cutaneous squamous cell carcinoma.

Oncology Learning Network
Inhibitory effect of glutathione S-transferase A3 in the progression of cutaneous squamous cell carcinoma.

The present study was designed to explore the effect of GSTA3 on cSCC.

Journal of Cosmetic Dermatology
The Synthetic Flavonoid Derivative GL-V9 Induces Apoptosis and Autophagy in Cutaneous Squamous Cell Carcinoma via Suppressing AKT-Regulated HK2 and mTOR Signals.

Cutaneous squamous-cell carcinoma (cSCC) is one of most common type non-black skin cancer. The malignancy degree and the death risk cSCC patients are significantly higher than basal cell patients.

Integrative transcriptomic analysis for linking acute stress responses to squamous cell carcinoma development

This study tested whether more acute molecular responses to UV and wounding overlapped with molecular signatures of cuSCC.

Scientific Reports
The incidence of cutaneous squamous cell carcinoma in patients receiving voriconazole therapy for chronic pulmonary aspergillosis

The study's aim was to estimate the incidence of cSCC after voriconazole exposure in patients with chronic pulmonary aspergillosis on a background of chronic lung disease.


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