Early Breast Cancer

Early Breast Cancer

Dense Breasts, High BMI May Interact to Up Breast Cancer Risk

Breast density and BMI may interact synergistically to heighten breast cancer risk, with a stronger association found among postmenopausal women. 

Cancer Therapy Advisor
Re-Wiring and Gene Expression Changes of AC025034.1 and ATP2B1 Play Complex Roles in Early-to-Late Breast Cancer Progression

Scientists reconstruct differential co-expression networks for four stages of breast cancer to assess the dynamic patterns of cancer progression.

BMC Genomic Data
Multimodal Imaging of Target Detection Algorithm under Artificial Intelligence in the Diagnosis of Early Breast Cancer

Researchers analyze the diagnostic value of multimodal images based on AI target detection algorithms for early breast cancer. 

Journal of Health Care Engineering

Development and Validation of the New HER2DX Assay for Predicting Pathological Response and Survival Outcome in Early-Stage HER2-Positive Breast Cancer

Researchers develop and validate a new HER2DX risk score, and a new HER2DX pCR score, both based on a 27-gene expression plus clinical feature-based classifier.

Addition of Capecitabine to Taxane/Anthracycline Adjuvant Chemotherapy for Early Breast Cancer

15-year OS results showed that the addition of capecitabine to taxane/anthracycline adjuvant chemotherapy was associated with improved OS among patients with early breast cancer.

The ASCO Post
The Blood Level of Thioredoxin 1 as a Supporting Biomarker in the Detection of Breast Cancer

Scientists validate the clinical utility of Trx1 to identify BC by testing sera from biopsy-confirmed cancer patients and women without cancer.

BMC Cancer
The Effects of the COVID-19 Pandemic on Psychological Stress in Breast Cancer Patients

The level of psychological distress currently experienced by a defined group of breast cancer patients is analyzed in this study. 

BMC Cancer
Discriminative Localized Sparse Approximations for Mass Characterization in Mammograms

Scientists use CADe and CADx methods to screen breast cancer mammograms for earlier detection and diagnosis of this disease. 

Frontiers in Oncology
Antioxidant Vitamin Supplement Use in Breast Cancer Not Supported by Recent Studies

A systematic review and meta-analysis found contradictory evidence, casting doubt on AVS use after receiving a breast cancer diagnosis. 

Cancer Therapy Advisor
No Benefit of Adjuvant Palbociclib Plus Endocrine Therapy in Early Breast Cancer

The phase III PALLAS trial shows no benefit of palbociclib plus endocrine therapy in the adjuvant breast cancer setting. 

The ASCO Post
Physical Fitness and Chemotherapy Tolerance in Patients with Early-Stage Breast Cancer

Researchers explore the role of physical fitness in attaining an adequate RDI in patients with early stage breast cancer.

Medicine & Science in Sports & Exercise
Final Analysis of PALLAS Shows No Benefit With Palbociclib Plus Endocrine Therapy in Early Breast Cancer

Adding palbociclib to adjuvant endocrine therapy did not improve survival when compared with endocrine therapy alone among patients with early-stage, HR+ and HER2- breast cancer. 

Cancer Therapy Advisor
Data Further Support Pembrolizumab Regimen for Early Triple-Negative Breast Cancer

The addition of pembrolizumab to neoadjuvant chemotherapy and as monotherapy in the adjuvant setting extended EFS for patients with early triple-negative breast cancer. 

Surgical Staging Affects Some QOL Scores in Early Breast Cancer

SLNB and SLNB with ALND negatively affected some QOL measures among patients with early-stage breast cancer. 

Cancer Therapy Advisor
FDA Approves Verzenio for Certain Patients With Early Breast Cancer

The FDA approved abemaciclib in combination with endocrine therapy for adjuvant treatment of certain patients with early breast cancer.

Long-Term Benefit With Abemaciclib in High-Risk Early Breast Cancer

Adding abemaciclib to ET reduced the risk of disease recurrence in patients with early breast cancer, and that benefit persisted beyond the 2-year treatment period. 

Cancer Therapy Advisor
Metformin Does Not Improve Outcomes in Early Breast Cancer

Metformin did not improve outcomes for most patients with early breast cancer, according to study results presented at San Antonio Breast Cancer Symposium.

Aromatase Inhibitors Benefit Certain Premenopausal Women With Early Breast Cancer

Aromatase inhibitors may reduce breast cancer recurrence compared with tamoxifen for certain premenopausal women with breast cancer, according to study results presented at SABCS.

Fatigue and Endocrine Symptoms Among Women With Early Breast Cancer Randomized to Endocrine versus Chemoendocrine Therapy

TAILORx prospectively assessed fatigue and endocrine symptoms among women with early-stage hormone receptor–positive breast cancer. 

Postmenopausal Women With Early Breast Cancer Can Go Chemo-Free

Mounting evidence shows most postmenopausal women with early-stage breast cancer derive no added benefits from chemotherapy and can be effectively treated with endocrine therapy alone.


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