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Ovarian Cancer

Ovarian Cancer

Racial Disparities Persist in Ovarian Cancer Treatment

Black patients with ovarian cancer were less likely than their White counterparts to receive adjuvant chemotherapy after primary surgery, according to a study published in Gynecologic Oncology.

Cancer Therapy Advisor
01/19/2022
Reduced RBPMS Levels Promote Cell Proliferation and Decrease Cisplatin Sensitivity in Ovarian Cancer Cells

Internet search tools and an ovarian cancer tissue array, investigators studied correlations between RBPMS expression levels and ovarian cancer patient outcomes.

International Journal of Molecular Sciences
01/04/2022
Plasma circN4BP2L2 is a Promising Novel Diagnostic Biomarker for Epithelial Ovarian Cancer

Researchers evaluate the diagnostic value of plasma circN4BP2L2 in EOC.

BMC Cancer
01/03/2022

Biodegradable HMONs as a Versatile Platform for Multimodal Imaging and Phototherapeutic-Triggered Endolysosomal Disruption in Ovarian Cancer

Researchers show that these well-synthesized nanoplatforms are likely promising anticancer agents to treat ovarian cancer and show great potential for biomedical applications.

Drug Delivery
12/30/2021
Application of Deep Convolutional Neural Networks for Discriminating Benign, Borderline, and Malignant Serous Ovarian Tumors From Ultrasound Images

This study aimed to evaluate the performance of the DCNN to discriminate between benign, borderline, and malignant SOTs on ultrasound images.

Frontiers in Oncology
12/20/2021
Platelet-Activating Factor Acetyl Hydrolase IB2 Dysregulated Cell Proliferation in Ovarian Cancer

In this study, the TCGA dataset and clinical cancer tissue microarray were utilized to investigate abnormal overexpression of PAF-AH IB2 in ovarian cancer.

Cancer Cell International
12/20/2021
The Prognostic Factor for Recurrence in Advanced-Stage High-Grade Serous Ovarian Cancer After Complete Clinical Remission

Scientists evaluate further characteristics of relapsed HGSOC patients with advanced disease who had achieved complete clinical remission after primary treatment.

Journal of Ovarian Research
12/20/2021
Mirvetuximab Soravtansine Active in Previously Treated Ovarian Cancer

Mirvetuximab soravtansine induced confirmed objective response in about one-third of women with folate receptor alpha-high platinum-resistant ovarian cancer who previously received bevacizumab...

Healio
12/01/2021
Identification and Validation of Immune-Related Gene for Predicting Prognosis and Therapeutic Response in Ovarian Cancer

Researchers investigated the ability to predict disease prognosis based on immune-related genes differentially expressed in the tumor microenvironment. 

Frontiers in Immunology
11/22/2021
Maintenance Olaparib Provides Long-Term PFS Benefit in Ovarian Cancer

The PFS benefit observed with olaparib maintenance persists after treatment completion in patients with advanced ovarian cancer, according to research published in The Lancet Oncology.

Cancer Therapy Advisor
11/17/2021
Recurrence Monitoring for Ovarian Cancer Using a Cell Phone-Integrated Paper Device to Measure the Ovarian Cancer Biomarker HE4/CRE Ratio in Urine

The development of an at-home paper-based test to measure both HE4 and creatinine in one device was presented by researchers to increase recurrence detection. 

Scientific Reports
11/09/2021
Gemogenovatucel-T Maintenance Provides Lasting Benefit in HRP Ovarian Cancer

Maintenance with gemogenovatucel-T provides a durable survival benefit in patients with homologous recombination proficient ovarian cancer, according to results published in Gynecologic Oncology.

Cancer Therapy Advisor
11/10/2021
Model Constructions of Chemosensitivity and Prognosis of High Grade Serous Ovarian Cancer Based on Evaluation of Immune Microenvironment and Immune Response

Investigators constructed a model to predict chemosensitivity and prognosis, and provided novel biomarkers for immunotherapy and prognosis evaluation of high grade serous ovarian cancer.

Cancer Cell International
11/04/2021
Single-Cell Analysis Revealed That IL4I1 Promoted Ovarian Cancer Progression

Investigators comprehensively analyzed an ovarian cancer single-cell RNA sequencing dataset, GSE118828, and identified nine major cell types.

Journal of Translational Medicine
10/30/2021
Attributions of Survival and Methods of Coping of Long-Term Ovarian Cancer Survivors

Researchers conducted open-ended, semi-structured interviews of patients with primarily high-grade, advanced-stage ovarian cancer who had survived 10 years or longer after initial diagnosis.

BMC Women's Health
10/28/2021
Pre-Existing CHIP Variants Tied to Therapy-Related Neoplasms in Ovarian Cancer

Pre-existing clonal hematopoiesis of indeterminate potential variants are associated with therapy-related myeloid neoplasms in ovarian cancer patients treated with rucaparib.

Cancer Therapy Advisor
10/28/2021
Laparoscopic Splenectomy Both for Primary Cytoreductive Surgery for Advanced Ovarian Cancer and for Secondary Surgery for Isolated Spleen Recurrence

The feasibility and safety of laparoscopic splenectomy was conducted in the contexts of both laparoscopic secondary surgery for isolated recurrence in the spleen..

BMC Surgery
10/28/2021
Cytotoxic Lymphocytes-Related Gene ITK from a Systematic CRISPR Screen Could Predict Prognosis of Ovarian Cancer Patients With Distant Metastasis

Researchers collect 6,722 significant genes correlated with metastasis within CRISPR/Cas9 library and identified ITK as a key factor to predict clinical outcomes...

Journal of Translational Medicine
10/26/2021
MiR-425-5p Accelerated the Proliferation, Migration, and Invasion of Ovarian Cancer Cells via Targeting AFF4

Researchers demonstrate that miR-425-5p was upregulated in OC, and it was negatively regulated by MAGI2-AS3. 

Journal of Ovarian Research
10/22/2021
Molecular Response to PARP1 Inhibition in Ovarian Cancer Cells as Determined by Mass Spectrometry Based Proteomics

Researchers work to comprehensively assess the cellular response PARP1i in HGSOC cells using quantitative MS-based proteomics and data-driven protein network analysis. 

Journal of Ovarian Research
10/22/2021
Precision Oncology of High-Grade Ovarian Cancer Defined through Targeted Sequencing

Genomic characterization was applied to tumour material from women with ovarian cancer to identify women that might benefit from PARP inhibitor therapy...

Cancers
10/19/2021
Identification of Tumor Antigens in Ovarian Cancers Using Local and Circulating Tumor-Specific Antibodies

Scientists use antibodies produced locally in tumor-draining lymph nodes (ASC probes) of individual ovarian cancer patients to screen two separate protein microarray platforms...

International Journal of Molecular Sciences
10/18/2021
Replication Catastrophe is Responsible for Intrinsic PAR Glycohydrolase Inhibitor-Sensitivity in Patient-Derived Ovarian Cancer Models

Scientists explore the use of a transcript-based biomarker, and provide insight into the design of future clinical trials of PARGi in patients with ovarian cancer.

Journal of Experimental & Clinical Cancer Research
10/16/2021
Neoadjuvant Chemotherapy May Reduce Short-Term Mortality in Advanced Ovarian Cancer

Neoadjuvant chemotherapy may decrease short-term mortality in patients with advanced ovarian cancer, according to recently published research.

Cancer Therapy Advisor
10/12/2021
Targeting Ovarian Carcinoma With TSP-1:CD47 Antagonist TAX2 Activates Anti-Tumor Immunity

Study investigators aimed at providing an extensive molecular characterization of TAX2 mode of action, while evaluating its potential in ovarian cancer therapy.

Cancers
10/07/2021
Niraparib Exhibits a Synergistic Anti-Tumor Effect With PD-L1 Blockade by Inducing an Immune Response in Ovarian Cancer

In this study, investigators examined the dynamic changes and responses of immune cells and cytokines during Niraparib treatment for ovarian cancer.

Journal of Translational Medicine
10/07/2021
TTK is a Potential Therapeutic Target for Cisplatin-Resistant Ovarian Cancer

In this study, cisplatin-resistant ovarian cancer cell line A2780 (A2780cis) was established to explore the relationship between TTK expression and cisplatin-resistance.

Journal of Ovarian Research
10/02/2021
Induction of Mitochondria Mediated Apoptosis in Human Ovarian Cancer Cells by Folic Acid Coated Tin Oxide Nanoparticles

This study aims to prepare FA-SnO2 NPs for specifically targeting human ovarian cancer cells with minimum side effects against normal cells.

PLOS ONE
10/01/2021
Risk Reduction Strategies for BRCA1/2 Hereditary Ovarian Cancer Syndromes

Researchers make recommendations regarding the care of women who harbour a pathogenic or likely pathogenic variant in BRCA1 and BRCA2.

Hereditary Cancer in Clinical Practice
09/26/2021
Galectin-1 as a Predictive Biomarker in Ovarian Cancer

In this study, investigators tested the clinical implications of serum Galectin-1 levels in patients with ovarian tumors.

Journal of Ovarian Research
09/23/2021
Up-Regulation of GSTT1 in Serous Ovarian Cancer Associated With Resistance to TAXOL / Carboplatin

To overcome this shortcoming of chemotherapy, investigators established taxol and carboplatin resistant serous ovarian cancer cell lines for the understandings of the...

Journal of Ovarian Research
09/17/2021
The Immune-Related Gene ELF3 is a Novel Biomarker for the Prognosis of Ovarian Cancer

This comprehensive study determined the role of ELF3 in ovarian cancer through bioinformatic analysis.

International Journal of General Medicine
09/10/2021
Multiple Genetic Variants Predict the PFS of Bevacizumab Plus Chemotherapy in Advanced Ovarian Cancer

Here, tumor tissues from patients with advanced ovarian cancer receiving BV-based regimens are analyzed with a 150-gene targeted panel for next generation sequencing.

Medicine
09/03/2021

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