Prostate Cancer

Prostate Cancer

Artificial Intelligence Combined With Big Data to Predict Lymph Node Involvement in Prostate Cancer

Scientists use machine learning to create a more accurate preoperative prediction of LNI in PCa, which would improve clinical treatment and follow-up strategies of this disease.

Frontiers in Oncology
Nomogram Incorporating Contrast-Enhanced Ultrasonography Predicting Time to the Development of Castration-Resistant Prostate Cancer

Scientists build and validate a nomogram incorporating the clinicopathologic characteristics and the parameters of CEUS to predict the time to CRPC after ADT.

Clinical Medicine Insights: Oncology
Reciprocal Deregulation of NKX3.1 and AURKA Axis in Castration-Resistant Prostate Cancer and NEPC Models

Researchers uncover a reciprocal loop between AURKA and NKX3.1 in CRPC and NEPC cells. 

Journal of Biomedical Science

Minimally Important Differences for the EORTC QLQ-C30 in Prostate Cancer Clinical Trials

This study estimates the MID for interpreting group-level change over time, both within a group and between groups, for the EORTC QLQ-C30 scores in patients with prostate cancer.

BMC Cancer
Stroma-Derived Extracellular Vesicle mRNA Signatures Inform Histological Nature of Prostate Cancer

Research presents a characterisation of normal vs disease-associated prostate stromal cell EVs, highlighting several differences in the encapsulated EV RNA cargo.

Journal of Extracellular Vesicles
Magnetic Resonance Imaging of PSMA-Positive Prostate Cancer by a Targeted and Activatable Gd(III) MR Contrast Agent

Research finds a targeted and activatable MR contrast agent that can be systemically administered in vivo to highlight PSMA+ prostate tumors...

Surgery vs Radiation May Lower Risk of Death From High-Risk Prostate Cancer

A new study finds that radical prostatectomy is associated with improved cancer-specific survival compared with external beam radiation therapy among men with high-risk prostate cancer.

Cancer Therapy Advisor
Androgen Signaling Inhibitors Appear More Effective in Luminal mCRPC

Among patients with mCRPC, androgen signaling inhibitors may be more beneficial for patients with luminal tumors than for those with basal tumors.

Cancer Therapy Advisor
Initial Dose Reduction of Enzalutamide Does Not Decrease the Incidence of Adverse Events in Castration-Resistant Prostate Cancer

Scientists investigate whether the initial dose of enzalutamide affects the incidence of AEs and oncological outcome in patients with CRPC by propensity score matching (PSM).

Apalutamide plus Abiraterone Acetate and Prednisone versus Placebo Plus Abiraterone and Prednisone in Metastatic, Castration-Resistant Prostate Cancer

Scientists investigate the combination treatment using apalutamide plus abiraterone acetate, each of which suppresses the androgen signalling axis in a different way, versus standard care in mCRPC.

The Lancet Oncology
Evaluation of a Rapid One-step PSA Test for Primary Prostate Cancer Screening

Researchers evaluated a rapid, one-step, qualitative PSA test, called the PSA SPOT test, as a possible way to enhance the convenience and reduce the cost of PC screening in a large population.

BMC Urology
Suppressor Effect of Catechol-O-Methyltransferase Gene in Prostate Cancer

Researchers determined the functional effects and regulation of COMT in prostate cancer.

Differentiating Prostate Cancer from Benign Prostatic Hyperplasia Using Whole-Lesion Histogram and Texture Analysis of Diffusion- and T2-Weighted Imaging

This study aimed to explore the usefulness of ADC map and T2W image histogram and texture analyses to distinguish PCa from BPH using histopathology as the reference.

Cancer Imaging
Bergamottin a CYP3A Inhibitor Found in Grapefruit Juice Inhibits Prostate Cancer Cell Growth by Downregulating Androgen Receptor Signaling and Promoting G0/G1 Cell Cycle Block and Apoptosis

Researchers focused on furanocoumarin bergamottin, a natural product found in grapefruit juice and a potent CYP3A inhibitor to improve the outcome of prostate cancer therapies. 

NCCN Guidelines Embrace PSMA-PET Imaging for Prostate Cancer

A reference in the newly updated prostate cancer guidelines from the NCCN has prostate cancer specialists excited about the prospects for incorporating PSMA-PET into daily practice.

Health-Related Quality of Life in Men With Localized Prostate Cancer Treated With Radiotherapy

This study aimed to measure the impact of radiotherapy on HRQoL and to further validate the Spanish version of the 16-item EPIC-16 in routine clinical practice.

Health and Quality of Life Outcomes
Expression and Subcellular Localization of Discoidin Domain Receptor 1 (DDR1) Define Prostate Cancer Aggressiveness

Scientists examined the expression of DDR1 in prostate cancer (PCa), and assessed its potential value as a prognostic marker, as a function of grade, stage and other clinicopathologic parameters.

Cancer Cell International
Abiraterone Also Ups Survival in Nonmetastatic Prostate Cancer

Scientists find clinical use for the combination of abiraterone acetate and ADT for the treatment of men with high-risk, nonmetastatic prostate cancer.

Prognosis Associated With Luminal and Basal Subtypes of Metastatic Prostate Cancer

Researchers developed an approach specific to the metastatic prostate cancer disease state to identify luminal (B) and basal subtypes in 634 mCRPC samples from 4 independent clinical cohorts.

JAMA Oncology
Olaparib Regimen Extends Radiographic PFS in Metastatic Prostate Cancer

Scientists assessed the addition of olaparib to abiraterone as first-line treatment for men with metastatic castration-resistant prostate cancer. 

Metastatic Castration-Resistant Prostate Cancer Remains Dependent on Oncogenic Drivers Found in Primary Tumors

Scientists question if targeted sequencing of hormone-sensitive primary PC identify drivers of metastasis that are targetable in advanced CRPC. 

Journal of Clinical Oncology
Prediction of Biochemical Recurrence-Free Survival of Prostate Cancer Patients Leveraging Multiple Gene Expression Profiles in Tumor Microenvironment

In this study, the dataset from TCGA-PRAD project and the dataset E-MTAB-6128 were used to develop and validate a prognostic model...

Frontiers in Oncology
Biologically Informed Deep Neural Network for Prostate Cancer Discovery

Scientists develop a deep-learning predictive model that incorporates previous biologically established hierarchical knowledge in a neural network language... 

FDA Grants Marketing Authorization for Software to Detect Prostate Cancer

The FDA authorized Paige Prostate, the first artificial intelligence-based software designed to identify areas on the prostate biopsy with the greatest likelihood of containing cancer.

Androgen Deprivation Alone No Longer Acceptable for mCSPC

New results from the PEACE-1 trial show that regardless of the standard-of-care regimen used, the addition of abiraterone (Zytiga) has a "clinically meaningful impact on survival."

Employing a Mobile Health Decision Aid to Improve Decision-Making for Patients with Advanced Prostate Cancer and Their Decision Partners/Proxies: The CHAMPION Randomized Controlled Trial Study Design

This study assess the effectiveness of a decision intervention (DI) compared to enhanced usual care (EUC) alone.

Cancer Management and Research
Prostate Cancer Risk Up for World Trade Center Rescue Workers

The risk for prostate cancer appears to be significantly elevated among World Trade Center rescue/recovery workers, with heightened incidence beginning in 2007, according to a study published in...

Cancer Therapy Advisor
Enzalutamide Plus ADT Prolongs Survival in Metastatic Hormone-Sensitive Prostate Cancer

Combining enzalutamide with ADT provides a long-term survival benefit, when compared with ADT alone, in patients with mHSPC, according to final results from the phase 3 ARCHES trial.

Cancer Therapy Advisor
The Protein Arginine Methyltransferases PRMT1 and CARM1 as Candidate Epigenetic Drivers in Prostate Cancer Progression

Using immunohistochemistry, investigators examined the expression of PRMT1 and CARM1 in patients across the spectrum of prostate cancer and correlated them with markers of AR signaling...

Clinical Outcomes of Salvage Treatment in Lymph Node-Positive Prostate Cancer Patients After Radical Prostatectomy

Study investigators compare the clinical outcomes of two different salvage treatments, androgen deprivation therapy alone versus ADT with radiotherapy.

Radium-223 in Combination With Enzalutamide in Metastatic Castration-Resistant Prostate Cancer

This phase II study enrolled patients with mCRPC and bone metastases. Patients received six cycles of radium-223 in combination with enzalutamide, followed by enzalutamide alone.

Therapeutic Advances in Medical Oncology
A Novel Risk Factor Model Based on Glycolysis-Associated Genes for Predicting the Prognosis of Patients With Prostate Cancer

Investigators aim to develop a novel glycolysis-associated multifactor prediction model for better predicting the prognosis of prostate cancer.

Frontiers in Oncology
Unique Subset of Prostate Cancers May Benefit From Immunotherapies

The need for improved therapies for treating prostate cancer and the positive results of ICI in advanced cancers, such as lung cancer and melanoma, created the rationale for...

Oncology Times - Latest Articles

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