Prostate Cancer

Prostate Cancer

"Liquid Biopsies" Allow Non-Invasive Diagnosis of Metastatic Cancers

Newly identified biomarkers could be used alongside imaging techniques for the non-invasive diagnosis of patients with advanced prostate cancer. 

Medical Xpress
Large International Evaluation Shows AI Accurately Diagnoses Prostate Cancer

Researchers suggest AI systems are ready to be responsibly introduced as a complementary tool in prostate cancer care. 

Medical Xpress
MiR-423-5p Prevents MALAT1-Mediated Proliferation and Metastasis in Prostate Cancer

Scientists investigate the interaction between MALAT1 and miR-423-5p, defined as a target with in silico prediction analysis, in PCa.

Journal of Experimental & Clinical Cancer Research

Addition of Abiraterone Acetate and Prednisolone With or Without Enzalutamide to ADT in High-Risk Nonmetastatic Prostate Cancer

The addition of abiraterone acetate and prednisolone with or without enzalutamide to ADT was associated with improved metastasis-free survival in patients with high-risk nonmetastatic disease.

The ASCO Post
For Equality in Prostate Cancer Outcomes, Seek Equality in Treatment

A new study revealed a surprising twist: Black men who received RT for localized prostate cancer fared better.

Relationship Between Biodosimetric Parameters and Treatment Volumes in Three Types of Prostate Radiotherapy

Researchers showed that various types of CAs 9 months after LDR BT, 3 months after HDR BT and in a long time-range after EBRT positively correlated with ISVs.

Scientific Reports
Predictive Value of Neutrophil-to-Lymphocyte Ratio in Diagnosis of Early Prostate Cancer Among Men Who Underwent Robotic Transperineal Prostate Biopsy

This study evaluates the predicted value of NLR in the diagnosis of early prostate cancer by using standardized FBC performed within 4 weeks before biopsy and histology results from RTPB.

FDA Approves New Imaging Product for Prostate Cancer

The FDA approves Illuccix for the preparation of 68Ga gozetotide injection, a radioactive diagnostic agent indicated for PET of PSMA positive lesions in patients with prostate cancer.

MRI Radiomics in Prostate Cancer

Researchers work to investigate the reliability of radiomics in PCa MRI.

Frontiers in Oncology
Defining 'Cured' for Prostate Cancer

Prostate cancer patients with 4-year PSA levels at 0.2 ng/mLl or less after LDR prostate brachytherapy can be considered cured, according to a study led by the Edinburgh Cancer Centre.

Addition of Darolutamide to ADT, Docetaxel Extends Survival in Prostate Cancer Subset

The addition of darolutamide to docetaxel and androgen deprivation therapy significantly prolonged OS among men with metastatic hormone-sensitive prostate cancer. 

Addition of Ipatasertib to Abiraterone Plus Prednisolone Improves Radiographic Progression–Free Survival in Metastatic Castration-Resistant Prostate Cancer With PTEN Loss

A phase III trial found that the addition of the AKT inhibitor ipatasertib to abiraterone and prednisolone produced a significant improvement in radiographic progression-free survival... 

The ASCO Post
Alpha-L-Fucosidase Has Diagnostic Value in Prostate Cancer With “Gray-Zone PSA” and Inhibits Cancer Progression via Regulating Glycosylation

This study explores the diagnostic value of AFU in PCa patients with “gray-zone PSA” and the correlation between AFU expression and clinicopathological characteristics of PCa patients.

Frontiers in Oncology
Discovery Proteomics Defines Androgen-Regulated Glycoprotein Networks in Prostate Cancer Cells, as Well as Putative Biomarkers of Prostatic Diseases

Researchers discover that androgens elicited dose-dependent changes in the expression of glycoprotein networks related to cell growth and differentiation in PCa cells. 

Scientific Reports
TMPRSS4 Promotes Cancer Stem–Like Properties in Prostate Cancer Cells Through Upregulation of SOX2 by SLUG and TWIST1

Study authors investigated whether TMPRSS4 confers cancer stem–like properties to prostate cancer cells and characterized the underlying mechanisms.

Journal of Experimental & Clinical Cancer Research
Exploration of the Tumor Mutational Burden as a Prognostic Biomarker and Related Hub Gene Identification in Prostate Cancer

Investigators examined the correlations of the tumor mutational burden with clinical prognosis and antitumor immunity in prostate cancer, and compared the gene sets of high-TMB and...

Technology in Cancer Research & Treatment
CD8-Positive T Cells and CD204-Positive M2-like Macrophages Predict Postoperative Prognosis of Very High-Risk Prostate Cancer

This study investigated the clinical, pathological and immunological significance of the tumor immune microenvironment of very high-risk prostate cancer with seminal vesicle invasion.

Scientific Reports
Association of Treatment Modality, Functional Outcomes, and Baseline Characteristics With Treatment-Related Regret Among Men With Localized Prostate Cancer

Treatment-related regret is common among patients with localized prostate cancer, and rates appear to differ among treatment approaches associated with outcomes and patient expectations.

JAMA Oncology
No Survival Benefit but Improved Secondary Endpoints With Radiotherapy Plus Androgen Suppression in Intermediate-Risk Prostate Cancer

The phase III RTOG 0815 study finds both dose-escalated RTand short-course ADT improve outcomes in intermediate-risk prostate cancer. 

The ASCO Post
Urine Test for Prostate Cancer Signals Amount of Aggressive Tumor

A potential new urine biomarker for prostate cancer not only spots the presence of aggressive tumors, it also indicates the amount of these tumors, according to a recent report.

Protocol for GET FIT Prostate: A Randomized, Controlled Trial of Group Exercise Training for Fall Prevention and Functional Improvements During and After Treatment for Prostate Cancer

This trial compared the relative efficacy of strength training versus tai ji quan training against each other and to a stretching control group on falls, frailty, and physical functioning...

Type of Treatment, Symptoms and Patient Satisfaction Play an Important Role in Primary Care Contact During Prostate Cancer Follow-Up

This study investigates factors associated with GP contact during follow-up of prostate cancer survivors, such as patient, treatment and symptom variables, and satisfaction with GPs.

BMC Family Practice
Findings Support Targeted PSA Screening for Prostate Cancer

Patients with pathogenic variants in MSH2 and MSH6 have a significantly higher incidence of prostate cancer than do patients without these variants... 

Cancer Therapy Advisor
HYPORT in Prostate Cancer: New Standard After Surgery?

The long-term side effects of HYPORT for prostate cancer are similar to those of conventional radiotherapy, a new study concludes.

ASTRO: Long-Term AEs Similar for Shorter-Course RT After Prostatectomy

For patients who undergo prostatectomy for prostate cancer, hypofractionated postoperative prostate bed radiotherapy is similar to conventionally fractionated postoperative radiotherapy with...

Cancer Therapy Advisor
Study Zeros in on Why Men Abandon Prostate Cancer Active Surveillance

The appearance of higher-risk tumor features often triggers the conversion from active surveillance or watchful waiting of prostate cancer to treatment, a new study finds. 

Cancer Therapy Advisor
Doctors Disagree With Update to NCCN Guidelines for Prostate Cancer

The National Comprehensive Cancer Network recently updated its guidelines for the treatment of prostate cancer, and one change has some physicians concerned. 

Cancer Therapy Advisor
PIM1 Phosphorylation of the Androgen Receptor and 14-3-3 ζ Regulates Gene Transcription in Prostate Cancer

This research works to indicate a coordinated response in which PIM1 phosphorylation of AR and 14-3-3 ζ alters AR-dependent gene expression.

Communications Biology
Optimization of Training and Measurement Protocol for eNose Analysis of Urine Headspace Aimed at Prostate Cancer Diagnosis

Scientists describe the approach aimed at improving the experimental protocol for eNose application for PCa diagnosis through exploring the effects of the portion of urine analysed...

Scientific Reports
In Nonmetastatic Castration-Sensitive Prostate Cancer, Abiraterone Added to Androgen-Deprivation Therapy Improves Survival

According to a primary analysis of two comparisons from the STAMPEDE trial, adding two years of AAP to androgen-deprivation therapy improves metastasis-free survival and overall survival.

The ASCO Post
Prostate Cancer Observation Varies With MRI, Genomic Testing Availability

The availability of prostate MRI and genomic testing is associated with increased adoption of observation rather than treatment as an initial management strategy for localized prostate cancer.

Cancer Therapy Advisor
Detecting and Grading Prostate Cancer in Radical Prostatectomy Specimens Through Deep Learning Techniques

This study aims to evaluate the ability of deep learning algorithms to detect and grade prostate cancer in radical prostatectomy specimens.

Small Extracellular Vesicle-Derived microRNAs Stratify Prostate Cancer Patients According to Gleason Score, Race and Associate with Survival of African American and Caucasian Men

Researchers determine the diagnostic and prognostic utility of sEV-associated miRs in identifying aggressive PCa in African American and Caucasian men.


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