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SABCS 2021: Updates in HER2+

SABCS 2021: Updates in HER2+

Trastuzumab Deruxtecan Improved PFS Across HER2+ Breast Cancer Subgroups

The significant improvement in PFS seen in the DESTINY-Breast03 trial with the HER2-targeting antibody-drug conjugate trastuzumab deruxtecan compared with trastuzumab emtansine was...

Cancer Therapy Advisor
12/09/2021
Pyrotinib/Capecitabine vs Lapatinib/Capecitabine for Previously Treated Patients With HER2+ Metastatic Breast Cancer

Among previously treated patients with HER2+ metastatic breast cancer, those who received pyrotinib plus capecitabine had longer OS than those who received lapatinib plus capecitabine.

The ASCO Post
12/09/2021
Patients With HR+ Breast Cancer and Emergent ESR1 Mutations May Benefit From Early Switch to Fulvestrant/Palbociclib

Among patients with HR+ breast cancer treated with an aromatase inhibitor plus palbociclib, those who displayed a rising ESR1 mutation detected in their blood before disease progression...

The ASCO Post
12/09/2021

SimBioSys Presents New Studies on its Precision Medicine Software Platform at the 2021 San Antonio Breast Cancer Symposium

CHICAGO & SAN ANTONIO--(BUSINESS WIRE)--SimBioSys®, the technology company that predicts tumor responses to therapy, presented new research on the accuracy and specificity of their simulation software, TumorScope®, for breast cancer treatment planning during the 2021 San Antonio Breast Cancer Symposium (SABCS). 

12/01/2021
Premenopausal Women May Benefit From Chemotherapy for Node-Positive Breast Cancer

Premenopausal women with node-positive breast cancer and low recurrence scores benefited from adjuvant chemo, whereas postmenopausal women did not, according to results of a study published in TNEJ

Healio
12/01/2021
Intensity Therapeutics Announces New Clinical Data Presentation for its Lead Asset, INT230-6, in Breast Cancer, at the 2021 San Antonio Breast Cancer Symposium® in December

WESTPORT, Conn., Nov. 30, 2021 /PRNewswire/ -- Intensity Therapeutics, Inc. ("Intensity"), a clinical-stage biotechnology company focused on the discovery and development of proprietary, novel immune-based intratumoral cancer therapies designed to kill tumors and increase immune system recognition of cancers, today announced that new breast cancer data from its phase 1/2 study IT-01 using novel lead asset, INT230-6, will be presented at the SABCS being held virtually and in-person at the Henry B. Gonzales Convention Center in San Antonio, Texas from December 7-10, 2021.

11/30/2021
Large-Scale Genomic Sequencing Reveals Adaptive Opportunity of Targeting Mutated-PI3Kα in Early and Advanced HER2+ Breast Cancer

Study authors characterized the adaptive roles of PI3Kα mutations among HER2+ tumor progression.

Clinical and Translational Medicine
12/04/2021

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