Solid Tumors

Solid Tumors

Bioinformatics Screening of Biomarkers Related to Liver Cancer

Scientists took original data was downloaded from the TCGA database, and the R software to screen the DEGs in the gene expression profile of liver cancer tissues and adjacent tissues. 

BMC Bioinformatics
A Immune-Related Signature Associated with TME Can Serve as a Potential Biomarker for Survival and Sorafenib Resistance in Liver Cancer

This research team worked to develop a robust TME-related prognostic signature that could independently predict both RFS and OS of LIHC. 

OncoTargets and Therapy
Tiny Worms Sniff Out Early-Stage Pancreatic Cancer

Early research shows C elegans are attracted to the odor certain chemicals give off that may include scents of human cancer cell secretions, cancer tissues, and urine from patients...


Evaluation of Preoperative Diagnostic Methods for Resectable Pancreatic Cancer

Researchers evaluate the diagnostic ability of EUS-FNA and its effect on the preoperative diagnosis, surgical outcome, and prognosis of pancreatic cancer.

BMC Gastroenterology
Targeting CDC7 Potentiates ATR-CHK1 Signaling Inhibition Through Induction of DNA Replication Stress in Liver Cancer

Researchers use integrated bioinformatics and functional genetics approaches to study the therapeutic options for the use of ATR or CHK1 inhibitors in liver cancer.

Genome Medicine
Hepatic Artery Infusion Pump Combined With Systemic Chemotherapy for Patients With Liver Metastases From Breast Carcinoma

The efficacy and safety of HAI combined with systemic chemotherapy in patients with breast carcinoma liver metastases is evaluated through this study. 

Technology in Cancer Research & Treatment
PKI-587 Enhances Radiosensitization of Hepatocellular Carcinoma by Inhibiting the PI3K/AKT/mTOR Pathways and DNA Damage Repair

Researchers evaluate the role of the dual PI3K/mTOR inhibitor, PKI-587, on radiosensitization of HCC and its possible mechanism. 

GNG7 and ADCY1 as Diagnostic and Prognostic Biomarkers for Pancreatic Adenocarcinoma Through Bioinformatic-Based Analyses

Researchers work to screen out the genes that have diagnostic and prognostic significance for PAAD through downloading the GSE55643 and GSE15471 mRNA expression profiles from the GEO database. 

Scientific Reports
Plasma Lipidomic Profiles of Kidney, Breast and Prostate Cancer Patients Differ From Healthy Controls

Lipidomic changes are investigated and visualized using various MDA tools, such as PCA, orthogonal projection to latent structures discriminant analysis, and ROC. 

Scientific Reports
The Mechanism of miR-141 Regulating the Proliferation and Metastasis of Liver Cancer Cells by Targeting STAT4

The expression of miRNA-141 in hepatocellular carcinoma cells & the effect of targeting STAT4 on the proliferation, migration, & invasion on those cells were detected using qRT-PCR, MTT.

Journal of Oncology
ctDNA Reduction After Tebentafusp Predicts OS in Uveal Melanoma

Reduction in circulating tumor DNA appeared correlated with longer OS among patients with previously treated metastatic uveal melanoma who received tebentafusp. 

ctDNA: An Emerging Neoadjuvant Biomarker in Resectable Solid Tumors

Scientists evaluate ctDNA as a tool capable of predicting complete pCR in LARC and MIBC, to focus on evaluating its response as a response biomarker in early-stage solid tumors. 

PLOS Medicine
Neoadjuvant Therapy for Pancreatic Cancer

 This research offers a state-of-the-art review on neoadjuvant treatments in the setting of pancreatic ductal adenocarcinoma.

Updates in Surgery
Clinical Impact of Pathogenic Germline Variants in Pancreatic Cancer

This study aimed to report the prevalence and outcomes of unselected PC patients with pathogenic/likely PGVs detected using a universal testing approach.

Clinical and translational gastroenterology
Novel Genomic Alteration in Superficial Esophageal Squamous Cell Neoplasms in Non-Smoker Non-Drinker Females

Researchers explore clinical characteristics and genomic alterations of the esophageal epithelium in patients with superficial ESCC with respect to risk factors.

Scientific Reports
Rising Rates of Esophageal Cancer in Young Adults; Lifestyle May Be to Blame

Increased rates of esophageal adenocarcinoma could reflect changes in lifestyle-related risk factors for the disease, with rises in unhealthy habits including smoking, poor diet...

Radioimmunotherapy for Solid Tumors: Spotlight on Glypican-1 as a Radioimmunotherapy Target

Research shows the current treatment paradigm for several solid tumors expressing GPC-1 & suggests the potential clinical utility of a GPC-1 directed radioimmunotherapy for these tumors.

Therapeutic Advances in Medical Oncology
The Clinical Significance of Preoperative Serum Fibrinogen Levels and Platelet Counts in Patients with Gallbladder Carcinoma

Scientists investigate the clinical significance of preoperative serum fibrinogen levels and platelet counts in GBC patients.

BMC Gastroenterology
Identification of Phosphoenolpyruvate Carboxykinase 1 as a Potential Therapeutic Target for Pancreatic Cancer

Scientists show that PCK1 is required for pancreatic cancer cell growth both in vitro and in vivo through this research study. 

Cell Death & Disease
Metabolic Syndrome and its Component Traits Present Gender-Specific Association with Liver Cancer Risk

Researchers explore the gender-specific effect and potential role of non-linear associations between MetS components and liver cancer risk.

BMC Cancer
Elevated Expression of Nuclear Receptor-Binding SET Domain 3 Promotes Pancreatic Cancer Cell Growth

Researchers show that long full-length NSD3 is overexpressed in pancreatic cancer.

Cell Death & Disease
Blood Volume as a New Functional Image-Based Biomarker of Progression in Metastatic Renal Cell Carcinoma

Scientists examine whether BV, identified by DCE-CT, could be used as an image-based biomarker of therapy progression in patients with mRCC.

Scientific Reports
The Application of the CRISPR/Cas9 System in the Treatment of Hepatitis B Liver Cancer

Scientists discuss CRISPR/Cas as a treatment for patients with liver cancer caused by hepatitis B virus infection, and reviewed the challenges incurred by this effective gene-editing technology.

Technology in Cancer Research & Treatment
Interferon-Inducible Protein, IFIX, has Tumor-Suppressive Effects in Oral Squamous Cell Carcinoma

Researchers explore the function of IFIX in OSCC cells by determining the relationship between IFIX expression and OSCC invasiveness or migration.

Scientific Reports
Establishment and Drug Screening of Patient-Derived Extrahepatic Biliary Tract Carcinoma Organoids

Researchers establish a series of PDOs from eBTC to determine whether the physiological structure and genetic profiles are maintained in these cultures. 

Cancer Cell International
Non-Pegylated Liposomal Doxorubicin as Palliative Chemotherapy in Pre-Treated Advanced Pancreatic Cancer

Due to the lack of established treatment regimens beyond second line, we offered nonpegylated liposomal doxorubicin to pretreated pancreatic cancer patients requesting systemic therapy.

Technology in Cancer Research & Treatment
Cytochrome P450-2D6: A Novel Biomarker in Liver Cancer Health Disparity

Scientists identified key genes that may decrease ethnic-driven health disparities and may serve as valuable prognostic and therapeutic targets that can stop the development of liver cancer. 

Serum GGT/ALT Ratio Predicts Vascular Invasion in HBV-Related HCC

Research determines the role of the GGT/ALT ratio in the prediction of vascular invasion and survival outcomes in patients with HBV-related HCC.

Cancer Cell International
Renalase is a Novel Tissue and Serological Biomarker in Pancreatic Ductal Adenocarcinoma

Scientists characterized renalase expression in premalignant and malignant PDAC tissue and investigated whether plasma renalase levels corresponded to clinical PDAC characteristics.

ALDOA Inhibits Cell Cycle Arrest Induced by DNA Damage via the ATM-PLK1 Pathway in Pancreatic Cancer Cells

Researchers probed the potential role of ALDOA in the cell cycle arrest induced by DNA damage in pancreatic tumour cells and discovered that ALDOA participated in regulating the DDR...

Cancer Cell International
The Risk and Prognostic Factors for Brain Metastases in Esophageal Cancer Patients

Scientists summarize the incidence, the risk factors, and the prognostic factors of brain metastases in esophageal cancer patients using the SEER database. 

BMC Cancer
CDT1 Is a Novel Prognostic and Predictive Biomarkers for Hepatocellular Carcinoma

Scientists work to comprehensively and systematically explore the expression of CDT1 in HCC through bioinformatics analysis.

Frontiers in Oncology
PTP4A3 Is a Prognostic Biomarker Correlated With Immune Infiltrates in Papillary Renal Cell Carcinoma

Scientists developed a comprehensive analysis across multiple databases to elucidate the role of PTP4A3 in ccRCC and pRCC & analyzed PTP4A3 and immune cell tumor infiltration (TIMER). 

Frontiers in Immunology

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