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Breast Cancer

Breast Cancer

Correlation Between Family History and Characteristics of Breast Cancer

Herein, study investigators researched the link between family history and breast cancer features to elucidate the importance of family history in the diagnosis and treatment of breast cancer. 

Scientific Reports
03/18/2021
Germline BRCA1/2 and Other Predisposition Genes in Patients With Metastatic Breast Cancer: Prevalence and Association With Prognosis

Fasching and colleagues identify the prevalence of germline mutations in BRCA1/2 and other breast cancer risk genes in patients with metastatic disease and found similar prognosis with pre

The ASCO Post
04/06/2021
Comparison of Radiation With or Without Concurrent Trastuzumab for HER2-Positive Ductal Carcinoma In Situ Resected by Lumpectom

The primary aim of the B-43 trial is to assess the efficacy of RT alone vs concurrent RT plus T in preventing recurrence of ipsilateral breast cancer in women with ductal carcinoma in situ.

Journal of Clinical Oncology
03/19/2021

Treating Metastatic TNBC: Where Are We Now?

Experts have started to make headway identifying and targeting different molecular features of advanced TNBC. These approaches often focus on targeting cell surface proteins or oncogenes...

Medscape
03/29/2021
Risk Factors for Breast Cancer Development by Tumor Characteristics Among Women With Benign Breast Disease

In the general population, risk factors differ in their associations by clinical pathologic features; however, whether women with BBD show etiologic heterogeneity in the types of breast cancers...<

Breast Cancer Research
03/18/2021
Multi‐Modal Meta‐Analysis of Cancer Cell Line Omics Profiles Identifies ECHDC1 as a Novel Breast Tumor Suppressor

Study investigators demonstrate the power of the integrative analyses by identifying a novel driver gene, ECHDC1, with tumor suppressive role validated both in breast cancer cells and patient tumor

03/22/2021
Improving the Prognostic Accuracy of Residual Cancer Burden After Neoadjuvant Chemotherapy for Breast Cancer

An analysis of 546 patients with breast cancer who received neoadjuvant chemotherapy demonstrates that residual cancer burden is prognostic for OS, recurrence-free survival, and...

The ASCO Post
03/18/2021
Association of Race/Ethnicity and the 21-Gene Recurrence Score With Breast Cancer–Specific Mortality Among US Women

This retrospective cohort study finds that compared with non-Hispanic White women, Black women are more likely to have a high-risk recurrence score and had higher breast cancer–specific mortality..

JAMA Oncology
Molecular Features of Untreated Breast Cancer and Initial Metastatic Event Inform Clinical Decision-Making and Predict Outcome: Long-Term Results of ESOPE, a Single-Arm Prospective Multicenter Study

The genomic landscape of metastatic breast cancer has mostly been described in very advanced, pretreated disease, limiting the findings transferability to clinical use.

Genome Medicine
03/15/2021
Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer

Here, literature is reviewed that regards the accuracy of conventional imaging modalities in obese and diabetic women, the potential role of anti-inflammatory agents to improve detection, and...

International Journal of Molecular Sciences
03/09/2021
The Emerging Role of Extracellular Vesicles in Endocrine Resistant Breast Cancer

Understanding the EV-mediated molecular mechanisms involved in hormonal resistance can provide the rationale for novel and effective treatment modalities and allow for the identification...

Cancers
03/08/2021
Annexin A1 Is Required for Efficient Tumor Initiation and Cancer Stem Cell Maintenance in a Model of Human Breast Cancer

Study investigators seek to clarify the functions of a ubiquitous protein, Annexin A1, in the development and progression of TNBC. 

Cancers
03/08/2021
Fatty Acid Synthase Confers Tamoxifen Resistance to ER+/HER2+ Breast Cancer

Overactivation of the human epidermal growth factor receptor 2 is one of the main drivers of tamoxifen resistance in estrogen receptor-positive breast cancer patients.

Cancers
03/06/2021
Most Breast Cancer Screening Centers Not Following Guidelines

 

Most breast cancer screening centers in the United States are not following national guidelines, say researchers reporting a new analysis.

Medscape
03/18/2021
Effectiveness of One-Stop Screening for Colorectal, Breast, and Prostate Cancers

Study investigators aim to investigate the effectiveness and compliance of a one-stop screening service for CRC, PC and BC.

Frontiers in Oncology
02/25/2021
Risk and Prognostic Factors of Breast Cancer With Liver Metastases

The purpose of this study is to determine the risk and prognostic factors of breast cancer with liver metastases.

BMC Cancer
03/06/2021
The Long Noncoding RNA TINCR Promotes Breast Cancer Cell Proliferation and Migration by Regulating OAS1

This study focuses on terminal differentiation-induced non-coding RNA and explore its role in the pathogenesis of breast cancer.

Cell Death Discovery
03/01/2021
Histopathological Analysis of Mucinous Breast Cancer Subtypes and Comparison With Invasive Carcinoma of No Special Type

This study introduces the last 2-year experience regarding MBC pathological diagnostics in the documented clinical center and comparison of the obtained data with invasive breast carcinoma...

Scientific Reports
03/11/2021
Mutation Analysis Using Cell-Free DNA for Endocrine Therapy in Patients With HR+ Metastatic Breast Cancer

This study evaluates the utility of ESR1 and PIK3CA mutation analysis with cfDNA using droplet digital PCR for the efficacy of endocrine therapy in HR+ metastatic breast cancer pa

Scientific Reports
03/10/2021
The Overexpression of DNA Repair Genes in Invasive Ductal and Lobular Breast Carcinomas: Insights on Individual Variations and Precision Medicine

Study investigators explore transcriptional differences between two invasive breast cancer subtypes; infiltrating ductal carcinoma and lobular carcinoma using...

PLOS ONE
03/04/2021
Breast Cancer Brain Metastasis—Overview of Disease State, Treatment Options and Future Perspectives

This review presents the latest information on the pathophysiology, diagnosis, and local and systemic treatment of brain metastases from breast cancer, with a focus on recent publications.

Cancers
03/03/2021
Breast Cancer and Occupational Exposures: An Integrative Review of the Literature

The objective of this study is to search the relevant literature for information on the association between breast cancer and exposure to occupational risk factors.

Revista Brasileira De Medicina Do Trabalho
03/03/2021
Miami Breast Cancer Conference: Genomic Assays Show Utility in Predicting Pathologic Complete Response Rate in Pre- and Postmenopausal Patients With Breast Cancer

This analysis reinforces both tests’ utility in better tailoring preoperative treatment and in determining the best timing for surgery for patients of all ages with breast cancer.

The ASCO Post
03/11/2021
Miami Breast Cancer Conference: Study Examines Response to Neoadjuvant Chemotherapy in Hispanic and Black Patients

A single-institution study reported at PER's virtual Miami Breast Cancer Conference confirms neoadjuvant CT improved axillary disease in Hispanic women and reduced tumor size in Black women.

The ASCO Post
03/04/2021
Role of Alpelisib in the Treatment of PIK3CA-Mutated Breast Cancer: Patient Selection and Clinical Perspectives

The PI3K/AKT/mTOR pathway has long been known to play a major role in the growth and survival of cancer cells.

Therapeutics and Clinical Risk Management
03/05/2021
The Biogenesis and Functions of circRNAs and Their Roles in Breast Cancer

This review describes current knowledge about the functions of circRNAs and generalize their roles in various aspects of breast cancer, including cell proliferation, cell cycle, apoptosis...

Frontiers in Oncology
02/25/2021
The Effect of Subsequent Pregnancy on Prognosis in Young Breast Cancer Patients According to Hormone Receptor Status

This study aims to examine the effect of pregnancy on prognosis in young breast cancer patients with hormone receptor positive after surgery and the safety of interrupting ET.

Cancer Management and Research
02/15/2021
Clinical Development of New Antibody–Drug Conjugates in Breast Cancer

This review discusses the clinical development of ADCs for the treatment of breast cancer, focusing on two recently FDA-approved agents and the ongoing efforts exploring new agents.

BioDrugs
03/05/2021
Evolution of Angiogenic Factors in Pregnant Patients With Breast Cancer Treated With Chemotherapy

Anthracyclines and taxanes are being used as a standard treatment for breast cancer diagnosed during pregnancy.

Cancers
02/23/2021
Nanosized Drug Delivery Systems for Breast Cancer Stem Cell Targeting

This review introduces the strategies and agents used against BCSCs and then highlight the mechanism of action and therapeutic efficacy of several state-of-the-art NDDSs that can be used...

02/23/2021
Miami Breast Cancer Conference: Updated DESTINY-Breast01 Results Show Trastuzumab Deruxtecan-nxki Delivers Durable Responses

In updated results from the pivotal DESTINY-Breast01 trial, trastuzumab deruxtecan-nxki demonstrated high rates of durable responses consistent with prior results...

The ASCO Post
03/09/2021
Role of the V1G1 Subunit of V-ATPase in Breast Cancer Cell Migration

Study investigators observe a decrease of V1G1 and RAB7 in highly invasive breast cancer cells, suggesting a key role of these proteins in controlling cancer progression.

Scientific Reports
02/25/2021
Invasive Ductal Breast Cancer with Osteoclast-Like Giant Cells: A Case Report Based on the Gene Expression Profile for Changes in Management

This study reports the case of a 49-year-old woman diagnosed with a rare histotype of early breast cancer, invasive ductal carcinoma with osteoclast-like giant cells, from the perspective of gene p

02/23/2021
Clinical Perspectives in Addressing Unsolved Issues in (Neo)Adjuvant Therapy for Primary Breast Cancer

In this study, current clinical perspectives are summarized to address unsolved issues in (neo)adjuvant therapy for primary breast cancer.

Cancers
02/23/2021
Recent Advances in Integrative Multi-Omics Research in Breast and Ovarian Cancer

This review focuses on the impact of historical and recent advances in single platform and integrative proteogenomic studies in breast and ovarian cancer.

02/19/2021
Regulating the Immunosuppressive Tumor Microenvironment to Enhance Breast Cancer Immunotherapy Using pH-Responsive Hybrid Membrane-Coated Nanoparticles

The combination of an immuno-metabolic adjuvant and immune checkpoint inhibitors holds great promise for effective suppression of tumor growth and invasion.

Journal of Nanobiotechnology
02/25/2021
Discovery of Breast Cancer Risk Genes and Establishment of a Prediction Model Based on Estrogen Metabolism Regulation

This study looks at the relationship between estrogen levels and the genetic polymorphism of estrogen metabolism-related enzymes in breast cancer and...

BMC Cancer
02/25/2021
Tumor Co-Expression of Progranulin and Sortilin as a Prognostic Biomarker in Breast Cancer

In this retrospective biomarker analysis, it is determined whether tumor co-expression of progranulin and sortilin has prognostic and treatment predictive values for breast cancer patients.

BMC Cancer
02/22/2021
Regulatory T Lymphocyte Infiltration in Metastatic Breast Cancer—An Independent Prognostic Factor That Changes With Tumor Progression

The great majority of breast cancer research has focused on the primary tumor and less is known about metastatic breast cancer and the prognostic impact of the metastatic tumor microenvironment.

02/18/2021
Network Pharmacology-Based Approach to Investigate the Molecular Targets of Sinomenine for Treating Breast Cancer

This study aims to search for molecular targets of sinomenine for treating breast cancer via network pharmacology.

Cancer Management and Research
02/09/2021
Lymphocyte-to-Monocyte Ratio is Associated with the Poor Prognosis of Breast Cancer Patients Receiving Neoadjuvant Chemotherapy

The purpose of this study is to evaluate the predictive value of inflammatory markers for pathological response and prognosis in breast cancer patients receiving neoadjuvant chemotherapy.

Cancer Management and Research
02/16/2021
Association Between Single-Nucleotide Polymorphisms in Breast Cancer Susceptibility Genes and Clinicopathological Characteristics

The purpose of the present study is to evaluate the associations between seven tagging single nucleotide polymorphisms and risk of breast cancer assessed by tumor pathological characteristics and B

Clinical Epidemiology
02/16/2021
Genetically Predicted C-Reactive Protein Associated With Postmenopausal Breast Cancer Risk: Interrelation With Estrogen and Cancer Molecular Subtypes Using Mendelian Randomization

Immune-related etiologic pathways that influence breast cancer risk are incompletely understood and may be confounded by lifestyles or reverse causality.

Frontiers in Oncology
02/03/2021
The Adverse Effects of Bisphosphonates in Breast Cancer

Bisphosphonate drugs can be used to improve the outcomes of women with breast cancer.

PLOS ONE
02/05/2021
Phase II Study of Liposomal Doxorubicin, Docetaxel and Trastuzumab in Combination With Metformin as Neoadjuvant Therapy for HER2-Positive Breast Cancer

This study's aim is to improve activity over single human epidermal growth factor receptor 2 (HER2)-blockade sequential neaodjuvant regimens for HER2-positive breast cancer.

02/09/2021
Quinolinate Phosphoribosyltransferase Promotes Invasiveness of Breast Cancer Through Myosin Light Chain Phosphorylation

These results indicate that QPRT enhanced breast cancer invasiveness probably through purinergic signaling and might be a potential prognostic indicator and therapeutic target in breast cancer.

02/04/2021
A Phenomic Perspective on Factors Influencing Breast Cancer Treatment: Integrating Aging and Lifestyle in Blood and Tissue Biomarker Profiling

Understanding and managing heterogeneity in the clinical response exhibited by patients with breast cancer remains a challenge.

Frontiers in Immunology
02/01/2021
Primary Neuroendocrine Neoplasms of the Breast: Still Open Issues

This study's aim is to understand whether neuroendocrine neoplasms of the breast can be considered a definite clinical entity and if neuroendocrine differentiation of breast tumors...

01/26/2021
Novel Immune-Related Genes in the Tumor Microenvironment With Prognostic Value in Breast Cancer

Alterations in the tumor microenvironment have been increasingly recognized as key in the development and progression of breast cancer in recent years.

BMC Cancer
02/06/2021
Hair Chemicals May Increase Breast Cancer Risk

The aim of this work is to investigate the association between the use of hair care products and breast cancer risk in women.

PLOS ONE
02/04/2021
Sympathetic Activity in Breast Cancer and Metastasis

This review assembles current knowledge on complex interactions that take place in the tumor microenvironment, with a special emphasis on sympathetic modulation of breast cancer and stromal cells.<

02/05/2021
Computational Analysis of Cyclin D1 Gene SNPs and Association With Breast Cancer

In this study, the impact of CCND1 SNPs on structure and/or function of Cyclin D1 protein using in silico tools is investigated.

01/29/2021
Breast Cancer in Adolescent and Young Adult Women Under the Age of 40 Years

To provide optimal care for AYAs with breast cancer, clinicians should engage multidisciplinary teams that offer fertility preservation, genetic counseling, physical and occupational therapy...

01/15/2021
The Breast Cancer Stem Cells Traits and Drug Resistance

Accumulating studies indicate that breast cancer stem cells are responsible for the BC drugs resistance, causing relapse and metastasis in BC patients.

Frontiers in Pharmacology
01/28/2021
Increased Risk of Cardiovascular Death in Breast Cancer Patients Without Chemotherapy or (and) Radiotherapy

This study evaluates the correlation between breast cancer and CVD risk independent of chemotherapy or (and) radiotherapy.

Frontiers in Oncology
01/28/2021
CircNR3C2 Promotes HRD1-Mediated Tumor-Suppressive Effect via Sponging miR-513a-3p in Triple-Negative Breast Cancer

E3 ubiquitin ligase HRD1 was found downregulated and acting as a tumor suppressor in breast cancer, while the exact expression profile of HRD1 in different breast cancer subtypes remains unknown.

02/02/2021
Role of Twitter in Identifying Barriers to Care Among Patients With Metastatic Breast Cancer

Information shared by women with metastatic breast cancer on social media platforms like Twitter may be a timely source of data for policymakers hoping to improve care...

The ASCO Post
02/08/2021
A Meta-Analysis of the Efficacy and Safety of Accelerated Partial Breast Irradiation Versus Whole-Breast Irradiation for Early-Stage Breast Cancer

This meta-analysis evaluates the efficacy and safety of accelerated partial breast irradiation versus whole-breast irradiation for early-stage breast cancer after breast-conserving surgery.

02/02/2021
A Multilevel Assessment of the Social Determinants Associated With the Late Stage Diagnosis of Breast Cancer

This study analyzes the prevalence of advanced breast cancer and its relationship with individual and contextual socioeconomic indicators and offer of health service.

Scientific Reports
02/01/2021
Molecular Profiling of Nucleocytoplasmic Transport Factor Genes in Breast Cancer

While earlier studies have focussed on individual transport related molecules, a collective overview of how these molecules may be dysregulated in breast cancer is lacking.

01/30/2021
Methodological Quality Evaluation of Systematic Reviews or Meta-Analysis of Trastuzumab-Based Therapy for Breast Cancer

This review evaluates the methodological quality of systematic reviews or meta-analysis of trastuzumab-based therapy for breast cancer.

01/29/2021
MicroRNA-3613-3p Functions as a Tumor Suppressor and Represents a Novel Therapeutic Target in Breast Cancer

Novel microRNAs need to be identified and investigated to guide the clinical prognosis or therapy for breast cancer.

01/25/2021
Triple Negative Breast Cancer: A Review of Present and Future Diagnostic Modalities

This review discusses the overview of breast cancer with emphasis on TNBC subtypes and the current diagnostic approaches of TNBC along with its challenges.

01/12/2021
Clinical Implications of Intrinsic Molecular Subtypes of Breast Cancer for Sentinel Node Status

Study investigators examine if consecutively derived molecular subtypes from primary breast cancers provide additional predictive value for SLNB status.

Scientific Reports
01/26/2021
Effects of Systemic Inflammation on Relapse in Early Breast Cancer

Chronic inflammation has been a proposed mechanism of resistance to aromatase inhibitors in breast cancer.

01/22/2021
Knockdown of NIR Suppresses Breast Cancer Cell Proliferation via Promoting FOXO3

The role of NIR in the progression of breast cancer remains elusive.

01/22/2021
IQGAP3 Overexpression Correlates With Poor Prognosis and Radiation Therapy Resistance in Breast Cancer

This study explores the correlation between IQGAP3 expression profile and the clinicopathological features in breast cancer.

Frontiers in Pharmacology
01/14/2021
Tiny miRNAs Play a Big Role in the Treatment of Breast Cancer Metastasis

Through a review of multiple studies, this paper identifies the key regulatory roles of oncogenic miRNAs in breast cancer metastasis including the potentiation of angiogenesis...

Cancers
01/18/2021
MicroRNA Regulation of Cancer Stem Cells in the Pathogenesis of Breast Cancer

In breast cancer, miRNAs appear to be multi-faceted since they can act as either suppressors or oncogenes to regulate breast cancer progression.

01/07/2021
Determining Factors in the Therapeutic Success of Checkpoint Immunotherapies against PD-L1 in Breast Cancer: A Focus on Epithelial-Mesenchymal Transition Activation

Study investigators compile the most recent studies evaluating PD-1/PD-L1 checkpoint inhibitors in breast cancer.

01/07/2021
Obesity, Leptin, and Deregulation of microRNA in Lipid Metabolisms: Their Contribution to Breast Cancer Prognosis

This literature review examines recent publications on the role of obesity, leptin, and microRNA deregulation in adverse prognosis of breast cancer. 

01/22/2021
The Role of Capecitabine-Based Neoadjuvant and Adjuvant Chemotherapy in Early-Stage Triple-Negative Breast Cancer

This study's meta-analysis is designed to further elucidate the effects of capecitabine on survival in early-stage TNBC patients and its safety.

BMC Cancer
01/19/2021
Association of Variably Methylated Tumour DNA Regions With Overall Survival for Invasive Lobular Breast Cancer

This study investigates the genome-wide variability of DNA methylation levels across ILBC tumours and assessed the association between methylation levels at the...

01/18/2021
Recent Discoveries of Macromolecule- and Cell-Based Biomarkers and Therapeutic Implications in Breast Cancer

This review focuses on the recent discoveries of promising macromolecules and cell-based biomarkers for the diagnosis and prognosis of breast cancer and provide implications for therapeutic strateg

International Journal of Molecular Sciences
01/10/2021
The Metabolic Mechanisms of Breast Cancer Metastasis

Understanding the metabolic mechanisms underlying breast cancer metastasis will provide important clues to develop novel therapeutic approaches for treatment of metastatic breast cancer.

Frontiers in Oncology
01/07/2021
The Immunomodulatory Effects of Endocrine Therapy in Breast Cancer

This is a comprehensive review of the immunomodulatory effect of endocrine therapy and its potential applications in combination with immune checkpoint inhibitors in breast cancer treatment.

01/07/2021
A Novel Immune Prognostic Index for Stratification of High-Risk Patients With Early Breast Cancer

Using public gene expression microarray datasets, study investigators classify breast cancer patients into three risk groups according to clinical risk and proliferation risk.

Scientific Reports
01/08/2021
Characteristics and Outcome of Breast Cancer-Related Microangiopathic Haemolytic Anaemia

This study sets up a retrospective multicentre study focusing on breast cancer-related microangiopathic haemolytic anaemia.

01/19/2021
Identification of Prognostic Biomarkers and Molecular Targets Among JAK Family in Breast Cancer

Janus kinases are a family of non-receptor tyrosine kinases involved in multiple malignancies.

01/14/2021
IL20RA Signaling Enhances Stemness and Promotes the Formation of an Immunosuppressive Microenvironment in Breast Cancer

Previous studies revealed the possible role of IL20RA signaling in the progression of several types of tumors. Its regulatory effects on the stemness and microenvironment of breast cancer...

01/01/2021
Melatonin as an Oncostatic Molecule Based on its Anti-Aromatase Role in Breast Cancer

This review summarizes the inhibitory role of melatonin in aromatase action, suggesting its role as a possible oncostatic molecule in breast cancer.

International Journal of Molecular Sciences
01/04/2021
High B3GALT5 Expression Confers Poor Clinical Outcome and Contributes to Tumor Progression and Metastasis in Breast Cancer

Little is known about the prognostic significance of B3GALT5 in breast cancer.

01/07/2021
ADAM10 is Involved in the Oncogenic Process and Chemo-Resistance of Triple-Negative Breast Cancer via Regulating Notch1 Signaling Pathway, CD44 and PrPc

This study investigates the potential roles of ADAM10 on TNBC cells and the effects of combining ADAM10 expression and NACT to improve the overall survival in breast cancer patients.

01/07/2021
Interplay Between p53 and Non-Coding RNAs in the Regulation of EMT in Breast Cancer

This review presents an overview of miRNA/lncRNA-dependent mechanisms that control interplay between p53 and master-regulators of EMT and their importance for breast cancer.

01/04/2021
A Psychosocial Genomics Pilot Study in Oncology for Verifying Clinical, Inflammatory and Psychological Effects of Mind-Body Transformations-Therapy in Breast Cancer Patients

Study preliminary results indicate that a specific mind-body therapy could induce a significant reduction of the release of different cytokines and chemokines.

01/03/2021
The Impact of Immunofunctional Phenotyping on the Malfunction of the Cancer Immunity Cycle in Breast Cancer

The cancer-immunity cycle is a series of self-sustaining stepwise events to fight cancer growth by the immune system.

Cancers
12/31/2020
The Association Between ATM Variants and Risk of Breast Cancer

Study investigators conduct a systematic review and meta-analysis to clarify the pooled association between various ATM variants and the risk of breast cancer.

BMC Cancer
01/05/2021
MCM3 Upregulation Confers Endocrine Resistance in Breast Cancer and is a Predictive Marker of Diminished Tamoxifen Benefit

Resistance to endocrine therapy in estrogen receptor-positive breast cancer is a major clinical problem with poorly understood mechanisms.

01/04/2021
Clinical, Pathological, and PAM50 Gene Expression Features of HER2-Low Breast Cancer

This study emphasizes the large biological heterogeneity of HER2-low BC, and the need to implement reproducible and sensitive assays to measure low HER2 expression.

01/04/2021
Physical Activity as an Imperative Support in Breast Cancer Management

The field of exercise and physical activity have expanded prominently, not only for the prevention but also for the management of different pathologies, including breast cancer.

Cancers
12/28/2020
NRG1 Fusions in Breast Cancer

The NRG1 fusion expressed in the breast cancer cell line MDA-MB-175 serves as a model example of such fusions, showing the proposed autocrine loop and exceptional drug sensitivity.

01/07/2021
The Effect of Family History on Screening Procedures and Prognosis in Breast Cancer Patients

The potential benefit of additional breast cancer screening examinations in moderate risk patients (patients with history of breast cancer in one or two family members) remains unclear.

12/24/2020
PI3K/AKT/mTOR Signaling Pathway in Breast Cancer: From Molecular Landscape to Clinical Aspects

The main purpose of this review is to present general aspects of breast cancer, the components of the AKT signaling pathway, the factors that activate...

International Journal of Molecular Sciences
12/26/2020
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High Expression of NRF2 Is Associated with Increased Tumor-Infiltrating Lymphocytes and Cancer Immunity in ER-Positive/HER2-Negative Breast Cancer

The clinical relevance of Nuclear factor erythroid 2-Related Factor 2 in human breast cancer remains unclear.

Cancers
12/21/2020
Prevalence of RECQL Germline Variants in Pakistani Early-Onset and Familial Breast Cancer Patients

This study investigates the contribution of pathogenic RECQL germline variants to hereditary breast cancer in early-onset and familial breast cancer patients from Pakistan.

12/20/2020
Establishment and Validation of a Preoperative MRI-based Nomogram for Predicting the Risk of Malignancy in Patients with Breast Tumor

This study establishes a preoperative nomogram incorporating morphological and DCE features to individually predict the risk of malignancy in patients with breast tumor.

01/01/2021
Feasibility and Acceptability of Personalised Breast Cancer Screening (DECIDO Study): Protocol of a Single-Arm Proof-of-Concept Trial

The objective of the DECIDO study is to assess the acceptability and feasibility of offering risk-based personalised breast cancer screening and...

BMJ Open
12/23/2020
Racial Disparities in Triple Negative Breast Cancer: A Review of the Role of Biologic and Non-biologic Factors

African-American women have high prevalence of TNBC with worse clinical outcomes than European-American women.

12/22/2020
The Tumor Microenvironment as a Driving Force of Breast Cancer Stem Cell Plasticity

This review summarizes the studies providing links between the TME and the breast cancer stem cell phenotype and we discuss their specific interactions with immune cell subsets...

Cancers
12/21/2020
Breast cancer exosomes contribute to pre-metastatic niche formation and promote bone metastasis of tumor cells

Breast cancer preferentially develops osteolytic bone metastasis, which makes patients suffer from pain, fractures and spinal cord compression.

01/01/2021
Background parenchymal enhancement on contrast-enhanced spectral mammography does not represent an influencing factor for breast cancer

This study compares the relationship between BPE on contrast-enhanced spectral mammography, mammographic breast density, age, in the group with benign vs malignant breast lesions.

12/24/2020
Adipocyte-Derived Leptin Promotes PAI-1-Mediated Breast Cancer Metastasis in a STAT3/miR-34a Dependent Manner

This study revealed that adipocyte coculture stimulated PAI-1 expression in breast cancer cells to potentiate cell motility.

Cancers
12/21/2020
Breast Cancer Stem Cells: Biomarkers, Identification and Isolation Methods, Regulating Mechanisms, Cellular Origin, and Beyond

This study reviews recent advances in breast cancer stem cell studies in terms of available biomarkers, identification and isolation methods, molecular mechanisms, and...

Cancers
12/14/2020
Current Status of Circulating Tumor Cells, Circulating Tumor DNA, and Exosomes in Breast Cancer Liquid Biopsies

This study reviews the most recent studies on breast cancer, demonstrating the clinical potential and utility of CTCs and ctDNA.

International Journal of Molecular Sciences
12/11/2020
Neutrophil-to-lymphocyte ratio predicts early mortality in females with metastatic triple-negative breast cancer

The aim of this study was to determine the utility of the neutrophil-to-lymphocyte ratio as a biomarker for predicting early-mortality among females with metastatic triple-negative breast cancer.

PLOS ONE
12/07/2020
Spindle cell carcinoma of the breast managed with neoadjuvant AIM: A case report

Metaplastic carcinomas of the breast are rare but are thought to be more aggressive than invasive ductal carcinomas. Due to their rarity, there are few randomized trials that...

12/11/2020
Plasma levels and tissue expression of soluble TGFβrIII receptor in women with early-stage breast cancer and in healthy women: a prospective observational study

This prospective observational study assessed tissue expression and plasma levels of sTGFβrIII in healthy women, women with benign breast lesions and in early-stage breast cancer patients.

12/11/2020
Drug resistance gene expression and chemotherapy sensitivity detection in Chinese women with different molecular subtypes of breast cancer

The aim of the study was to identify specific chemosensitivity drugs for various molecular subtypes of breast tumors in Chinese women, by detecting the expression...

12/15/2020
The Role of Regular Mammograms in Finding Interval Breast Cancer

Strategies beyond current mammographic screening practices are needed to reduce incidence, improve detection, and reduce deaths from interval breast cancers...

Oncology Times - Latest Articles
12/20/2020
Axillary Hibernoma in woman with Lobular breast cancer and MEN1 syndrome: A case report

The present study reports the case of an axillary hibernoma in a patient with lobular homolateral breast cancer and multiple endocrine neoplasia type1.

11/27/2020
Breast cancer mortality trends in Peruvian women

This study aims to estimate the mortality rates from breast cancer in Peruvian women and to assess mortality trends over 15 years.

BMC Cancer
12/01/2020
The Gut Microbiota: A Potential Gateway to Improved Health Outcomes in Breast Cancer Treatment and Survivorship

This review provided an overview of the current understanding of the relationship between the gut microbiota and breast cancer and to highlight potential strategies for...

International Journal of Molecular Sciences
12/03/2020
Integrative genomic analysis implicates ERCC6 and its interaction with ERCC8 in susceptibility to breast cancer

Up to 30% of all breast cancer cases may be inherited and up to 85% of those may be due to segregation of susceptibility genes with low and moderate risk for breast cancer. 

Scientific Reports
12/04/2020
Prognostic value of programmed cell death ligand-1 expression in breast cancer

This meta-analysis was about to explore PD-L1 expression as well as its prognostic role in BC.

12/04/2020
Manual lymphatic drainage for lymphedema in patients after breast cancer surgery

This systematic review and meta-analysis summarized the current evidence to assess the effectiveness of MLD in preventing and treating lymphedema in patients after breast cancer surgery.

12/04/2020
Cancer Stem Cell-Associated Pathways in the Metabolic Reprogramming of Breast Cancer

This review summarizes the links between the metabolic adaptations of breast cancer cells and CSC-associated pathways. 

International Journal of Molecular Sciences
11/30/2020
Breast Cancer and Microcalcifications: An Osteoimmunological Disorder?

This review compares microenvironments and molecular characteristics in the most frequent osteoimmunological disorders with major events...

International Journal of Molecular Sciences
11/15/2020
Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

This review summarizes the main findings concerning the relationship between Wnt signaling and breast cancer and provide an overview of existing mechanisms, challenges...

11/24/2020
Evaluation of Inhibitory Effects of Geniposide on a Tumor Model of Human Breast Cancer based on 3D Printed Cs/Gel Hybrid Scaffold

This study aimed to inspect whether GEN could inhibit proliferation and promote the apoptosis of human breast cancer cells (MCF-7).

Materials Science and Engineering: C
02/01/2021
Efficacy of cognitive behavioral therapy for insomnia in breast cancer: A meta-analysis

Although cognitive behavioral therapy for insomnia is available in integrative oncology settings, it poses unique challenges for BC survivors.

Sleep Medicine Reviews
02/01/2021
Predicting the likelihood of recurrence of pregnancy-associated breast cancer: Nomogram based on analysis of the French cancer network: Cancer Associé à La Grossesse.

The aim of this study is to build a nomogram based on selected clinical and histological variables to predict recurrence.

Journal of gynecology obstetrics and human reproduction
03/01/2021
Tryptanthrin exerts anti-breast cancer effects both in vitro and in vivo through modulating the inflammatory tumor microenvironment.

This study was conducted to assess the antitumor activity of tryptanthrin in breast cancer models both in vitro and in vivo, and to explore the important role of the inflammatory

Acta Pharmaceutica
06/01/2021
Currently Applied Molecular Assays for Identifying ESR1 Mutations in Patients with Advanced Breast Cancer

With respect to diagnosis and treatment, breast cancer is one of the most heterogeneous and complex diseases.

International Journal of Molecular Sciences
11/20/2020
Mutation screening of germline TP53 mutations in high-risk Chinese breast cancer patients

TP53 gene mutation screening was performed in 2538 Chinese breast cancer patients who tested negative for BRCA mutations.

BMC Cancer
11/02/2020
An optimized K-Nearest Neighbor based breast cancer detection

In this research, a grid search is employed to find the optimal parameter and an optimized KNN based breast cancer detection model proposed.

Journal of Robotics and Control (JRC)
05/05/2021
The HMGB1/RAGE axis induces bone pain associated with colonization of 4T1 mouse breast cancer in bone

Bone pain is a common complication of breast cancer bone metastasis and is a major cause of increased morbidity and mortality.

Journal of bone oncology
02/01/2021
The secretome of non-tumorigenic mammary cells MCF-10A elicits DNA damage in MCF-7 and MDA-MB-231 breast cancer cells.

This study evaluated the effect of the secretome of non-tumorigenic mammary cells (MCF-10A) on proliferation and DNA damage in breast cancer cells.

Toxicology in Vitro
02/01/2021
Sevoflurane Suppresses the Migration, Invasion, and Epithelial-Mesenchymal Transition of Breast Cancer Cells Through the miR-139-5p/ARF6 Axis

Sevoflurane (SEV) has been reported to inhibit the metastasis of multiple cancers, however, the role of SEV in the metastasis of BC cells remains poorly understood.

Journal of Surgical Research
02/01/2021
Preoperative breast MR imaging in newly diagnosed breast cancer: Comparison of outcomes based on mammographic modality, breast density and breast parenchymal enhancement.

This study's purpose was to compare the role of MR for assessment of extent of disease in women newly diagnosed with breast cancer imaged with digital mammography alone versus DBT.

Clinical Imaging
02/01/2021
Graphene-Based Field Effect Transistor Biosensors for Breast Cancer Detection: A Review on Biosensing Strategies

This review will present the latest strategies in graphene-based FETs for BC biosensing, and compare the different graphene-based transducers, biomarkers, bioreceptor materials...

Carbon
02/01/2021
Aptasensor based on screen-printed electrode for breast cancer detection in undiluted human serum

This study reports the development and optimization of an electrochemical aptasensor for the detection of HER2 protein, a breast cancer biomarker.

Bioelectrochemistry
02/01/2021
Presentation of self-detected breast mass in minority women with limited access to care: Can self-examination assist in early cancer detection?

This retrospective cohort study included women newly diagnosed with breast cancer from 1/1/2016 to 1/1/2018 in an inner city public community hospital.

Clinical Imaging
02/01/2021
A Multifaceted Approach to Opioid Education, Prescribing, and Disposal for Patients with Breast Cancer Undergoing Surgery.

This quality improvement project and analysis evaluated implementation of standardized prescribing, opioid education, and a narcotic disposal system.

Journal of Surgical Research
01/01/2021
Effect of weimaining on apoptosis and Caspase-3 expression in a breast cancer mouse model.

The aim of this study was to investigate the effect of WMN on the cellular activity and apoptosis of mouse breast cancer 4T1-luc2 cells, and caspase-3 and cleaved-caspase-3 expression.

Journal of Ethnopharmacology
01/01/2021
Identification of blood protein biomarkers for breast cancer staging by integrative transcriptome and proteome analyses.

In this study, the authors identified blood protein biomarkers for each stage of breast cancer by analyzing transcriptome and proteome data from patients.

Journal of Proteomics
01/01/2021
Comparative analysis of intact glycopeptides from mannose receptor among different breast cancer subtypes using mass spectrometry

This work analyzed the intact glycopeptides of the mannose receptors in serum from breast cancer patients using isobaric tags for relative and absolute quantitation and LC-MS/MS.

Talanta
02/01/2021
Proximity-constructed bifunctional DNA probes for identification of stem-like biomarker in breast cancer

Herein, the authors designed an effective sensing method using proximity-constructed bifunctional DNA probes for electrochemical identification of CD44.

Sensors and Actuators B-chemical
02/01/2021
LncRNA OIP5-AS1 Promotes Breast Cancer Progression by Regulating miR-216a-5p/GLO1

This study aimed to explore the role of OIP5-AS1 and the mechanism of its action in the progression of breast cancer.

Journal of Surgical Research
01/01/2021
Correlation between numerical and categorical immunohistochemical score of Ki-67 and HER2 with clinicopathological parameters of breast cancer.

This study evaluated the relationship between numerical and categorical immunohistochemical score of Ki-67 and human epidermal growth factor of receptor 2 with...

Medicinski glasnik : official publication of the Medical Association of Zenica-Doboj Canton, Bosnia and Herzegovina
02/01/2021
The effect of Poria cocos ethanol extract on the intestinal barrier function and intestinal microbiota in mice with breast cancer.

The aim of this study was to investigate the effect and the mechanism of ethanol extract of Poria cocos on intestinal barrier function and intestinal microbiota in the mice with...

Journal of Ethnopharmacology
02/01/2021
SANT, a novel Chinese herbal monomer combination, decreasing tumor growth and angiogenesis via modulating autophagy in heparanase overexpressed triple-negative breast cancer.

This study aimed at evaluating the anti-tumor potential of SANT in treating HPSE related TNBC both in-vitro and in-vivo.

Journal of Ethnopharmacology
02/01/2021
Mitochondria-targeted magnetic gold nanoheterostructure for multi-modal imaging guided photothermal and photodynamic therapy of triple-negative breast cancer

In the present work, a multifunctional magnetic gold nanoheterostructure with photosensitizer Ce6 loading was designed and synthesized for synergistic photothermal and photodynamic therapy of TNBC.

Chemical Engineering Journal
01/01/2021
Disulfiram-loaded functionalized magnetic nanoparticles combined with copper and sodium nitroprusside in breast cancer cells

In this study, it was aimed to prepare a drug carrier system based on magnetic mesoporous silica nanoparticles which are non-toxic, biocompatible, and have a mesoporous structure.

Materials Science and Engineering: C
02/01/2021
Comparison of surface enhanced Raman spectroscopy and Raman spectroscopy for the detection of breast cancer based on serum samples.

In this study, surface enhanced Raman spectroscopy and Raman spectroscopy are employed for the classification of different stages of breast cancer using clinically...

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy
02/01/2021
Aptamer modified MoS2 nanosheets application in targeted photothermal therapy for breast cancer

To ensure photothermal nanosheets have high specific recognition and can effectively enrich to tumor cells, controlling the size of nanosheets and lowering the potential toxicity...

Colloids and Surfaces A: Physicochemical and Engineering Aspects
01/05/2021
The signaling pathways and targets of traditional Chinese medicine and natural medicine in triple-negative breast cancer

This review summarizes reports related to signaling pathways and potential therapeutic targets mediated by TCM and natural medicine to provide references for subsequent research in this field.

Journal of Ethnopharmacology
01/10/2021
A hybrid feature selection on AIRS method for identifying breast cancer diseases

In this study, a new hybrid feature selection fast correlation based feature and information gain was used to select features on identifying breast cancer using AIRS algorithm.

International Journal of Electrical and Computer Engineering
02/01/2021
The toxicity mechanism of different sized iron nanoparticles on human breast cancer (MCF7) cells.

The toxicity mechanism of superparamagnetic iron oxide nanoparticles (SPIONs) were examined multidimensionally to reduce the risks.

Food Chemistry
03/01/2021
Inhibition of furin by bone targeting superparamagnetic iron oxide nanoparticles alleviated breast cancer bone metastasis.

In this study, the proprotein convertase furin is targeted due to its critical roles in both tumor cell invasion and osteoclast function.

Bioactive Materials
03/01/2021
Hypofractionated Versus Standard Fractionated Radiotherapy in Patients With Early Breast Cancer or Ductal Carcinoma In Situ in a...

Given the poor results using hypofractionated radiotherapy for early breast cancer, a dose of 50 Gy in 25 fractions (fr) has been the standard regimen used by the Danish Breast Cancer Group (DBCG)

Journal of Clinical Oncology
09/18/2020
Considerations for the Use of Scalp Cooling Devices in Black Patients
ASCO: Journal of Clinical Oncology: Table of Contents
Cost Differences Identified for Older Patients With Breast Cancer Undergoing Various Treatments
Journal of Clinical Pathways
Similar Breast Cancer Outcomes With WBI, APBI
MedPage Today
Can Earlier Mammographic Screenings Affect Mortality Rates?
Oncology Nurse Advisor
Randomized Controlled Trial of Trastuzumab With or Without Chemotherapy for HER2-Positive Early Breast Cancer in Older Patients
ASCO: Journal of Clinical Oncology: Table of Contents
Are We RESPECTing Older Patients With Breast Cancer?
ASCO: Journal of Clinical Oncology: Table of Contents
Abbreviated Breast Magnetic Resonance Imaging for Supplemental Screening of Women With Dense Breasts and Average Risk
ASCO: Journal of Clinical Oncology: Table of Contents
US Patients With Breast Cancer Report Care Delays Amid COVID-19
Medscape
ACA Led to Higher Rates of Early Breast Cancer Diagnoses
Oncology Nursing Society
FDA Warns on Tecentriq-Paclitaxel Combo in Breast Cancer
MedPage Today
Win for PARP Inhibitor in BRCA Breast Cancer
MedPage Today
CDK4/6 Inhibition in Early-Stage Breast Cancer: The New Standard?
Journal of Clinical Oncology
Bayer Pays Systems Oncology $25M Upfront to License ER-Positive Breast Cancer Drug
Precision Oncology News
Developing Precise Medicines for Triple-Negative Breast Cancer
Oncology Times - Latest Articles
Intraoperative RT Matches EBRT for Early Breast Cancer
MedPage Today
Lymphedema Prevention Surgery Shows Promise
Clinical Oncology News
Three Nomograms Reviewed in Study
Clinical Oncology News
New TKI May be a Game Changer for Breast Cancer
Clinical Oncology News
Developing Pathway to Cure: A Multimodal Clinical Pathway Platform to Support Timely and Appropriate Care of Women Under 50 Diagnosed With Breast Cancer
Journal of Clinical Pathways
Gene Testing for Patients With Breast Cancer and Second Cancer
Medscape
ONS Guidelines™ Offer Framework for Managing Treatment-Related Hot Flashes
Oncology Nursing Society
Zion Pharma Begins Phase I Study of ZN-A-1041 in HER2-Positive Solid Tumors, Breast Cancer
Precision Oncology News
FDA Informs on Lack of Efficacy and Safety of Atezolizumab/Paclitaxel in mTNBC
Atezolizumab TNBC Indication 'in Jeopardy' From Phase 3 Results
Medscape
FDA Rejects Atezolizumab in Combination With Paclitaxel as Treatment for Breast Cancer 
Oncology Nursing Society
Divergent Findings With Paclitaxel and Nab-Paclitaxel in TNBC
Medscape
Local Recurrence With Radiation Boost in HER2-Positive Breast Cancer: HERA Trial Analysis
The ASCO Post
More Evidence of Interval Breast Cancers' Aggressive Nature
MedPage Today
Adjuvant Anti-CDK Thwarts Early Breast Cancer Recurrence
MedPage Today
Abemaciclib Combined With Endocrine Therapy for the Adjuvant Treatment of HR+, HER2−, Node-Positive, High-Risk, Early Breast Cancer (monarchE)
ASCO: Journal of Clinical Oncology: Table of Contents
Should Older Women With Early HER2+ Breast Cancer Avoid Chemo?
MedPage Today
Risks Seen With Continued Opioid Use in Older Breast Cancer Survivors
MedPage Today
Coronavirus Shedding; Airborne Transmission: It's TTHealthWatch!
MedPage Today
FDA: Efficacy, Safety Concerns With Breast Cancer Combo Therapy
Cancer Therapy Advisor
Exploring Overall Survival Results for Verzenio Plus Fulvestrant in Metastatic Breast Cancer
Journal of Clinical Pathways

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