Colorectal Cancer

Colorectal Cancer

Proteomics-Based Identification of Candidate Exosomal Glycoprotein Biomarkers and Their Value for Diagnosing Colorectal Cancer

Researchers screen for differences in glycoproteins associated with tumor-derived exosomes and validate their clinical value to serve as liquid biopsy biomarkers to diagnose early CRC.

Frontiers in Oncology
Blood Microbiota Diversity Determines Response of Advanced Colorectal Cancer to Chemotherapy Combined With Adoptive T Cell Immunotherapy

This study explored the effect of blood microbiota on clinical efficacy, represented by PFS and OS, of combined CT and adoptive cellular therapy in advanced colon cancer patients.

Inhibitory Immune Checkpoints PDCD-1 and LAG-3 Hypermethylation May Reduce the Risk of Colorectal Cancer

This study investigated the effect of PDCD-1LAG-3 methylation statuses in peripheral blood leukocytes on colorectal cancer risk.

Molecular Medicine

COVID-19 Lockdown May Be Associated With Higher Tumor Burden in Newly Diagnosed Patients With Metastatic Colorectal Cancer

Investigators found that tumor burden assessed as plasma ctDNA was significantly higher among patients with newly diagnosed metastatic colorectal cancer screened for a clinical trial...

The ASCO Post
Role of Phenotypes of Circulating Tumor Cells in the Diagnosis and Treatment of Colorectal Cancer

The aim of this study was to investigate the relationship between circulating tumor cells and their subpopulations and colorectal cancer. 

Cancer Management and Research
The Clinical Significance of Mesenteric Lymphocytes in Human Colorectal Cancer

Study investigators examine the immune landscape of the mesentery, particularly the role of lymphocytes and its association with the clinicopathological characteristics of colorectal cancer.

Frontiers in Oncology
Identification of the Effects of Chondroitin Sulfate on Inhibiting CDKs in Colorectal Cancer Based on Bioinformatic Analysis and Experimental Validation

In the present study, the importance of cyclin-dependent kinases on the occurrence of CRC is identified by data mining of The Cancer Genome Atlas and Gene Expression Omnibus.

Frontiers in Oncology
Tripartite Motif Protein 6 Promotes Colorectal Cancer Cell Migration and Metastasis via SOCS2-STAT3 Signaling

In this study, investigators use CRC cell lines with TRIM6 knockdown and overexpression to investigate the function of TRIM6 in CRC metastasis.

Frontiers in Oncology
Low-Dose Apatinib Combined With S-1 in Refractory Metastatic Colorectal Cancer

The aim of this prospective, single-arm, multicenter, phase 2 study is to assess the efficacy and safety of low-dose apatinib combined with S-1 in the treatment of refractory mCRC.

Frontiers in Oncology
Japanese Study Examines How Intervention Encourages Screening for Colorectal Cancer Among Patients With Schizophrenia

Researchers from Okayama University, Japan, conducted a randomized trial to assess the benefits of interventions for early cancer screening in patients with schizophrenia.

The ASCO Post
Liquid Biopsy Is Changing Colon Cancer Management

The measurement of circulating tumor DNA is changing the way gastrointestinal cancers are managed, according to Dr Bassel F. El-Rayes.

The ASCO Post
Identification and Verification of HCAR3 and INSL5 as New Potential Therapeutic Targets of Colorectal Cancer

This study identifies novel biomarkers related to the pathogenesis of CRC based upon a bioinformatics analysis, and further verifies the biomarkers in clinical tumor samples and CRC cell lines.

World Journal of Surgical Oncology
Nestin Expression as a Diagnostic and Prognostic Marker in Colorectal Cancer and Other Tumors

This literature focuses on nestin as a new biomarker of possible clinical importance in the early diagnosis and monitoring of cancer.

Clinical Medicine Insights: Oncology
Colorectal Polyps Often Recur After Incomplete Resection

A new study indicates that incomplete resection, compared with complete resection, substantially increases the likelihood that a polyp will be found during follow-up colonoscopy.

Detection of Molecular Residual Disease Using Personalized Circulating Tumor DNA Assay in Patients With Colorectal Cancer Undergoing Resection of Metastases

This study evaluates the prognostic value of ctDNA, correlating MRD status postsurgery with clinical outcomes by using a personalized and tumor-informed ctDNA assay.

JCO Precision Oncology
Downregulated ARID1A by miR-185 Is Associated With Poor Prognosis and Adverse Outcomes in Colon Adenocarcinoma

This study aims to explore ncRNA-dependent mechanism that regulates ARID1A expression in COAD regarding miR-185.

Frontiers in Oncology
The Survival Effect of Radiotherapy on Stage II/III Rectal Cancer in Different Age Groups

This study investigates whether radiotherapy exhibits disparate effects in different age groups of patients with stage II/III rectal cancer.

Frontiers in Oncology
Gankyrin as Potential Biomarker for Colorectal Cancer With Occult Liver Metastases

In this study, the expression of Gankyrin in colorectal cancer patients with liver metastases is investigated to determine its prognosis value.

Frontiers in Oncology
Task Force Finalizes New Colorectal Cancer Screening Recommendation

The US Preventive Services Task Force has published a final recommendation statement calling for individuals to get their first CRC screening at age 45 instead of waiting until age 50.

Oncology Times - Latest Articles
Benefits From Moving More, Sitting Less for CRC Survivors

A study shows that CRC survivors experienced better quality of life and less fatigue if they engaged in more moderate to vigorous physical activity and reduced their sedentary behavior.

Better Responses to Hepatic Arterial Infusion Therapy Among Patients With KRAS Wild-Type Metastatic Colorectal Cancer

Patients with CRC and unresectable liver metastases and KRAS wild-type disease experienced better responses to hepatic arterial infusion pump CT than did patients with KRAS mutations...

The ASCO Post
Is There a Link Between Use of Antibiotics and Early-Onset Colorectal Cancer?

Study findings presented by Perrott et al at the ESMO World Congress on Gastrointestinal Cancer showed that the use of antibiotics may be linked to colon tumor formation across all patient age grou

The ASCO Post
Poorer Survival in CRC With Obesity: Is Chemo Dose Too Low?

Patients with CRC who are also obese have poorer survival than those who are not obese. A new study suggests that they may be receiving a lower cumulative dose of adjuvant CT...

Predicting Treatment Response of Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer Using Amide Proton Transfer MRI Combined With Diffusion-Weighted Imaging

This study evaluates amide proton weighted MRI combined with diffusion-weighted imaging in predicting NCRT response in patients with locally advanced rectal cancer.

Frontiers in Oncology
Development and Validation of a Prognostic Nomogram for Colorectal Cancer Patients With Synchronous Peritoneal Metastasis

In this study, investigators aim to use a multicenter data to identify the factors associated with S-PM of CRC to construct a nomogram for predicting the overall survival of these patients.

Frontiers in Oncology
Early-Onset CRC Associated With Longer Survival

Individuals diagnosed with primary CRC at less than 50 years of age have better survival outcomes than individuals diagnosed at 51-55 years, based on data from more than 750,000 patients.

CRC Mortality Risk Correlates With Adenoma Detection Rate

Low adenoma detection rates are associated with a greater risk of death in CRC patients, especially among those with high-risk adenomas, based on a review of more than 250,000 colonoscopies.

PDE2 Inhibits PKA-Mediated Phosphorylation of TFAM to Promote Mitochondrial Ca2+-Induced Colorectal Cancer Growth

In this study, the regulatory effects of mitochondrial Ca2+ on PDE2/cAMP/PKA axis and the phosphorylation of mitochondrial TFAM as well as the growth of CRC cells are systematically investigated.

Frontiers in Oncology
Alkylating Signature in Colorectal Cancer Linked to High Red Meat Intake

According to the study’s results, high red meat consumption may cause alkylating damage in colon cells that lead to cancer-causing mutations in KRAS and PIK3CA genes...

The ASCO Post
The Novel Curcumin Derivative 1g Induces Mitochondrial and ER-Stress-Dependent Apoptosis in Colon Cancer Cells by Induction of ROS Production

In the present study, the novel curcumin derivative, 1g, is found to inhibit tumor growth in colon cancer cells both in vitro and in vivo. 

Frontiers in Oncology
Perioperative Systemic Therapy for Patients With Resectable Colorectal Peritoneal Metastases

Rovers et al find the addition of perioperative systemic therapy to CRS-HIPEC is feasible and safe for the treatment of patients with resectable colorectal peritoneal metastases.   

The ASCO Post
LncRNA DLEU1 Contributes to the Growth and Invasion of Colorectal Cancer via Targeting miR-320b/PRPS1

Here, the level of DLEU1 in CRC tissues is investigated by qRT-PCR.

Frontiers in Oncology
Standard Multigene Testing Could Detect More Hereditary Cancer Syndromes in Patients With Colorectal Cancer

Up to 38.6% of people with colon cancer who have a hereditary cancer syndrome could have their conditions remain undetected with current universal tumor-screening methods...

The ASCO Post

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