Gastrointestinal Cancer

Gastrointestinal Cancer

Effects and Prognostic Values of miR-30c-5p Target Genes in Gastric Cancer via a Comprehensive Analysis Using Bioinformatics

Potential diagnostic and prognostic values of miR-30c-5p target genes in gastric cancer by using a filtration step analysis and integrated bioinformatics tools are explored.

Scientific Reports
Comprehensive Analysis of IGFBPs as Biomarkers in Gastric Cancer

This study aimed to explore IGFBPs and their prognostic value as markers in gastric cancer.

Frontiers in Oncology
Peripheral Blood-Based DNA Methylation of Long Non-Coding RNA H19 and Metastasis-Associated Lung Adenocarcinoma Transcript 1 Promoters are Potential Non-Invasive Biomarkers for Gastric Cancer Detection

Bioinformatic analysis was utilized to verify the reported association between MALAT1 and H19 expression and the occurrence, development, and prognosis of GC. 

Cancer Control

Circular RNA UBE2Q2 Promotes Malignant Progression of Gastric Cancer by Regulating Signal Transducer and Activator of Transcription 3-Mediated Autophagy and Glycolysis

Scienists proved that circUBE2Q2 is upregulated in GC tissues and cell lines, sponges miR-370-3p to activate the STAT3 pathway, and promotes tumor metastasis...

Cell Death & Disease
Comparison of Long-Term Efficacy in S-1 and Capecitabine With Oxaliplatin as Adjuvant Chemotherapy for Patients With Gastric Cancer After Curative Surgery

Research compares the long-term survival rates of patients who received TS-1 or XELOX during adjuvant chemotherapy and clinical indications that could guide clinicians in selecting regimens.

Technology in Cancer Research & Treatment
Phase II Feasibility Study of Adjuvant Chemotherapy with Docetaxel/Cisplatin/S-1 Followed by S-1 for Stage III Gastric Cancer

This phase II trial evaluates the feasibility, safety, and efficacy of postoperative adjuvant therapy with DCS following S-1 therapy in patients with stage IIIA, IIIB, and IIIC gastric cancer...

BMC Cancer
Development of a Two-Circular RNA Panel as Potential Prognostic Biomarker for Gastric Cancer

Scientists attempted to screen circRNAs that can be used to predict postoperative recurrence and survival in patients with GC.

Journal of Translational Medicine
Effect of Lockdown on Digestive System Cancer Care Among Older Patients During the First Wave of COVID-19

Scientists see if the effects of lockdown on cancer care and the short-term mortality rate in older patients differed when comparing the very oldest individuals with younger individuals.

Digestive and Liver Disease
Expression of NEDD9 and Connexin-43 in Neoplastic and Stromal Cells of Gastric Adenocarcinoma

Researchers determine the expression of Cx43 and NEDD9 in node-positive and node-negative gastric cancer at gastrectomy tissue...

RNF144A-AS1, a TGF-β1- and Hypoxia-Inducible Gene That Promotes Tumor Metastasis and Proliferation via Targeting the miR-30c-2-3p/LOX Axis in Gastric Cancer

This research intends to explore the function and characterize the underlying mechanism of long noncoding RNA RNF144A-AS1 in GC metastasis and outgrowth.

Cell & Bioscience
Health Care Utilization Among Patients with Oesophageal and Gastric Cancer

Researchers describe individuals’ health care use from the time of treatment decision until death & investigate the impact of the initial treatment strategy and assignment of a CN...

BMC Health Services Research
T Stage and Venous Invasion are Crucial Prognostic Factors for Long-Term Survival of Patients With Remnant Gastric Cancer

Researchers investigated the clinicopathological factors associated with the long-term outcomes of RGC.

World Journal of Surgical Oncology
mGWAS Identification of Six Novel Single Nucleotide Polymorphism Loci With Strong Correlation to Gastric Cancer

Researchers combined genome-wide and metabolome-wide datasets generated from 233 GC patients and 233 healthy controls to identify the GC-associated mQTLs. 

Cancer & Metabolism
Effect of Helicobacter Pylori on Plasma Metabolic Phenotype in Patients With Gastric Cancer

Scientists use Hp as the bacteria & host agents for increasing the risk of gastric cancer to find profound implications for earlier detection of early cancer...

Cancer Control
Adding First-Line Nivolumab to Chemotherapy Improves Survival in Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinomas

Scientists show that the addition of first-line nivolumab to chemotherapy resulted in improved overall and progression-free survival among patients...

The ASCO Post
OTUB2 Facilitates Tumorigenesis of Gastric Cancer Through Promoting KDM1A-Mediated Stem Cell-Like Properties

Researchers demonstrate that OTUB2 may serve as a vital driver in GC tumorigenesis by enhancing KDM1A-mediated stem cell-like properties.

Frontiers in Oncology
A Novel and Rapid Serum Detection Technology for Non-Invasive Screening of Gastric Cancer Based on Raman Spectroscopy Combined With Different Machine Learning Methods

In this study, scientists analyzed the differences in serum Raman spectra of GC patients and normal subjects, and explored the metabolic differences between them. 

Frontiers in Oncology
Prediction of Locoregional Recurrence-Free Survival of Oesophageal Squamous Cell Carcinoma After Chemoradiotherapy Based on an Enhanced CT-Based Radiomics Model

Scientists establish a predictive model based on enhanced computed tomography examination, and evaluate its clinical value for detecting LRFS in cases of oesophageal squamous cell carcinoma.

Frontiers in Oncology
Clinicopathological Characteristics and Response to Chemotherapy in Treatment-Naive Epstein–Barr Virus Associated Gastric Cancer

Scientists investigate the treatment response of chemotherapy both in advanced stage and metastatic EBVaGC.

Frontiers in Oncology
Knockdown of m6A Reader IGF2BP3 Inhibited Hypoxia-Induced Cell Migration and Angiogenesis by Regulating Hypoxia Inducible Factor-1α in Stomach Cancer

The roles of IGF2BP3 in hypoxia-induced cell migration and angiogenesis together with its m6A-dependent targets were investigated in SC in vitro and in vivo.

Frontiers in Oncology
CT Radiomics for the Preoperative Prediction of Ki67 Index in Gastrointestinal Stromal Tumors

This study establishes and verifies a radiomics model for the preoperative prediction of the Ki67 index of gastrointestinal stromal tumors.

Frontiers in Oncology
Neoadjuvant Chemotherapy Versus Direct Surgery for Locally Advanced Gastric Cancer With Serosal Invasion

This study examines patients with cT4NxM0 gastric cancer who underwent D2 gastrectomy.

Frontiers in Oncology
Screening and Identification of Key Biomarkers of Gastric Cancer: Three Genes Jointly Predict Gastric Cancer

The differentially expressed genes between gastric cancer and adjacent normal tissues were detected to explore biomarkers that may play an important role in gastric cancer.

Frontiers in Oncology
Avapritinib Versus Regorafenib in Locally Advanced Unresectable or Metastatic GI Stromal Tumor

This study evaluates efficacy and safety of avapritinib versus regorafenib as third-line or later treatment in patients with unresectable or metastatic GIST.

Journal of Clinical Oncology
A Parallel Comparison Method of Early Gastric Cancer: The Light Transmission-Assisted Pathological Examination of Specimens of Endoscopic Submucosal Dissection

Investigators perform a parallel comparison between the light transmission-assisted pathological examination under endoscopy and the histological examination for the diagnosis of early gastric...

Frontiers in Oncology
Disease-Specific Survival of AJCC 8th Stage II Gastric Cancer Patients After D2 Gastrectomy

The purpose of this study is to investigate the independent risk factors for treatment failure in stage II gastric cancer.

Frontiers in Oncology
KIT Inhibitor Combination Shows Efficacy in Refractory GIST

Investigators find that the combination of a type I KIT inhibitor, PLX9486, with the type II inhibitor sunitinib produces clinical benefit and improves PFS rates in patients with GIST.

The ASCO Post
Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer

In May 2021, nivolumab was approved for adjuvant treatment of patients with completely resected esophageal or GEJ cancer with residual pathologic disease after neoadjuvant chemoradiotherapy.

The ASCO Post
Identification and Validation of the Immune Regulator CXCR4 as a Novel Promising Target for Gastric Cancer

This study has determined the prognostic value of 11 immunomodulatory factors in gastric cancer.

Frontiers in Immunology
Association of Combination of Conformation-Specific KIT Inhibitors With Clinical Benefit in Patients With Refractory Gastrointestinal Stromal Tumors

This study seeks to answer the question: Is cotargeting the active and inactive conformations of KIT associated with clinical benefit in refractory GIST?

JAMA Oncology
Aberrant Non-Coding RNA Expressed in Gastric Cancer and Its Diagnostic Value

Study investigators measure miRNA, lncRNA and cirRNA expression profiles of gastric cancer patients by using microarray and RNA-sequencing data from tissue samples.

Frontiers in Oncology
Addition of Neoadjuvant Chemotherapy to Surgery and Adjuvant S-1 in Locally Advanced Gastric Cancer

Dr Kang and colleagues find the addition of neoadjuvant docetaxel, oxaliplatin, and S-1 to D2 gastrectomy followed by adjuvant S-1 is associated with improved PFS in patients...

The ASCO Post
Addition of First-Line Nivolumab to Chemotherapy in Advanced Gastric Cancers

The phase III CheckMate 649 trial shows that the addition of first-line nivolumab to CT results in improved overall and PFS among patients with advanced HER2- gastric, GEJ, and...

The ASCO Post

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