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Gynecologic Cancer

Gynecologic Cancer

Hsp90 Up-Regulates PD-L1 to Promote HPV-Positive Cervical Cancer via HER2/PI3K/AKT Pathway

The therapeutic effect of heat shock protein 90 knockdown on HPV16+ cervical cancer progression and the underlying mechanism is investigated.

Molecular Medicine
10/19/2021
Clinicopathological Features and Survival of Adolescent and Young Adults with Cervical Cancer

Researchers explore the clinicopathological characteristics and find a meaningful method to predict the prognosis of young women with cervical cancer.

Cancer Control
10/14/2021
Cervical Cancer Screening is Overused—and Underused, As Well

Researchers have found that many women are screened too often, leading to unnecessary procedures that may carry their own harms, while some women are not getting tested often enough...

Medical Xpress
10/13/2021

Attenuated Salmonella Carrying Plasmid Co-Expressing HPV16 L1 and siRNA-E6 for Cervical Cancer Therapy

This study suggests that pcDNA3.1-HPV16-L1-siE6 carried by attenuated Salmonella has a synergistic effect of immune regulation and RNA interference in cervical cancer treatment.

Scientific Reports
10/11/2021
Ovarian Function Preservation in Patients With Cervical Cancer Undergoing Hysterectomy and Ovarian Transposition Before Pelvic Radiotherapy

Research explores the factors associated with ovarian failure and evaluates the effectiveness of OT before pelvic irradiation for preserving ovarian function in patients with cervical cancer...

Technology in Cancer Research & Treatment
10/09/2021
Barriers and Strategies for Cervical Cancer Screening: What Do Female University Students Know and Want?

Researchers work to identify the distinct barriers and knowledge level of cervical cancer screening among female university students and establish intervention strategies to overcome these barriers

PLOS ONE
10/05/2021
The Profile Analysis of Circular RNAs in Cervical Cancer

The aim of this study was to identify the circRNAs significantly associated with CSCC, in order to discover novel diagnostic markers and elucidate their mechanistic basis.

Medicine
10/01/2021
Development and Validation of a SEER-Based Prognostic Nomogram for Cervical Cancer Patients Below the Age of 45 Years

Researchers establish a nomogram for the prognostic prediction of patients with early-onset cervical cancer (EOCC) for both overall survival (OS) and cancer-specific survival (CSS).

BJBMS
10/01/2021
Prevalence of HER2 Overexpression and Amplification in Cervical Cancer

Researchers work to estimate the pooled prevalence of the HER2 amplification and overexpression in patients with invasive CC, globally and according to the HER2 scoring system...

PLOS ONE
09/30/2021
TP53 Mutants and Non-HPV16/18 Genotypes are Poor Prognostic Factors for Concurrent Chemoradiotherapy in Locally Advanced Cervical Cancer

Scientists evaluated the pattern of genomic or actionable mutations in patients with FIGO stage III to IVA cervical cancer who received CCRT. 

Scientific Reports
09/28/2021
Vaginal-Assisted Gasless Laparoendoscopic Single-Site Radical Hysterectomy for Early Cervical Cancer

Scientists aimed to evaluate the feasibility and safety of this surgical procedure and observe the early oncologic outcomes.

World Journal of Surgical Oncology
09/27/2021
FDA Grants Priority Review to Libtayo for Advanced Cervical Cancer

The FDA granted priority review to cemiplimab-rwlc for use of the agent by women with recurrent or metastatic cervical cancer whose disease progressed on or after chemotherapy.

Healio
09/28/2021
The Impact of the COVID-19 Pandemic on the Rate of Newly Diagnosed Gynecological and Breast Cancers

The aim of this study was to assess the impact of the COVID-19 pandemic and its management throughout the year 2020 on the rate of newly diagnosed gynecological and breast cancers...

Gynecologic Oncology
09/24/2021
Impact of Computed Tomography-Based, Artificial Intelligence-Driven Volumetric Sarcopenia on Survival Outcomes in Early Cervical Cancer

This study aims to investigate the impact of sarcopenia and body composition change during primary treatment on survival outcomes in patients with early cervical cancer.

Frontiers in Oncology
09/24/2021
High Prevalence of Germline BRCA Mutations in Indian Women With Ovarian Cancer

Scientists found that Indian women with ovarian cancer not selected for study based on clinical factors had a high prevalence of germline pathogenic or likely pathogenic BRCA variants

The ASCO Post
09/10/2021
Comparison Between Laparoscopic and Robotic Surgery in Elderly Patients With Endometrial Cancer

The aim of this study was to evaluate the peri-operative and oncological outcomes of EEC patients who had undergone laparoscopic (LS) or robotic surgery (RS).

Frontiers in Oncology
09/22/2021
Integration of scRNA-Seq and Bulk RNA-Seq to Analyse the Heterogeneity of Ovarian Cancer Immune Cells and Establish a Molecular Risk Model

In this study, a series of tissue-specific clusters were constructed to predict immune cell compositions from two OC scRNA-seq datasets in the GEO database.

Frontiers in Oncology
09/21/2021
A SMYD3/ITGB6/TGFβ1 Positive Feedback Loop Promotes the Invasion and Adhesion of Ovarian Cancer Spheroids

This study found that SMYD3 and ITGB6 could promote the release and activation of latent TGFβ1 and increase the phosphorylation of Smad3 activated by TGFβ1 in ovarian cancer spheroids.

Frontiers in Oncology
09/21/2021
Identification and Experimental Validation of Immune-Associate lncRNAs for Predicting Prognosis in Cervical Cancer

This study aimed to identify an immune-related lncRNA signature for the prospective assessment of prognosis in CC patients.

OncoTargets and Therapy
09/07/2021
Radiotherapy for Vaginal Recurrences of Cervical Cancer in Patients After Prior Surgery

The aim of this study is to evaluate the efficacy and toxicity of salvage RT and explore prognostic factors associated with the survival after recurrence.

Frontiers in Oncology
09/13/2021
Radiotherapy Versus Inguinofemoral Lymphadenectomy as Treatment for Vulvar Cancer Patients With Micrometastases in the Sentinel Node

This study on Sentinel nodes in vulvar cancer investigated whether inguinofemoral RT is a safe alternative to inguinofemoral lymphadenectomy in vulvar cancer patients with a metastatic SN.

Journal of Clinical Oncology
08/25/2021
MRI-Based Radiomics Nomogram for Selecting Ovarian Preservation Treatment in Patients With Early-Stage Endometrial Cancer

Study investigators develop an MRI radiomics nomogram to assist radiologists in selecting eligible candidates for ovarian preservation treatment by assessing DMI in G 1/2-EEC patients...

Frontiers in Oncology
09/09/2021
The Role of the Metabolic Parameters of 18F-FDG PET/CT in Patients With Locally Advanced Cervical Cancer

This study evaluates the role of the pre-treatment cervical and lymph node metabolic parameters of 18F-FDG PET/CT for locally advanced cervical cancer patients...

Frontiers in Oncology
08/19/2021
The Efficacy and Safety of Continuous Intravenous Endostar Treatment Combined With Concurrent Chemoradiotherapy in Patients With Locally Advanced Cervical Squamous Cell Carcinoma

The aim of this study is to investigate the short-term efficacy and safety of Endostar combined with concurrent CRT in the treatment of locally advanced cervical squamous cell carcinoma.

Frontiers in Oncology
08/13/2021
Chemo After Chemoradiation Does Not Extend Survival in Cervical Cancer

Adding chemotherapy after standard chemoradiation treatment does not improve survival for women with locally advanced cervical cancer, and it also leads to additional side effects.

Oncology Times - Latest Articles
07/20/2021
Support Vector Machine Model Predicts Dose for Organs at Risk in High-Dose Rate Brachytherapy of Cervical Cancer

This study aims to establish a support vector machine model to predict the dose for organs at risk in intracavitary brachytherapy planning for cervical cancer with tandem and ovoid treatments.

Frontiers in Oncology
07/16/2021
Identification of Methylation-Driven Genes Prognosis Signature and Immune Microenvironment in Uterus Corpus Endometrial Cancer

This study examines whether abnormal DNA methylation can predict the prognosis of uterus corpus endometrial cancer and reflect the patient's tumor immune microenvironment.

Cancer Cell International
07/10/2021
Other HPV-Related Cancers Set to Overtake Cervical Cancer by 2025

The incidence of other HPV-associated cancers is rising and could soon surpass cervical cancer, a researcher told a press briefing held in advance of the 2021 ASCO Annual Meeting. 

Oncology Times - Latest Articles
07/05/2021
CDC Notes Sharp Declines in Breast and Cervical Cancer Screening

The data show the total number of screenings funded by the NBCCEDP declined by 87% for breast cancer screening and by 84% for cervical cancer screening in April 2020 in comparison...

Medscape
07/02/2021
Factors Influencing the Discordancy Between Intraoperative Frozen Sections and Final Paraffin Pathologies in Ovarian Tumors

Study investigators examine the pre-operative clinical factors and ultrasonographic features that influence the accuracy of the intraoperative frozen section of ovarian tumors.

Frontiers in Oncology
07/01/2021
Identifying & Managing Symptoms in Epithelial Ovarian Cancer

At the ASCO 2021 Annual Meeting, researchers highlighted the importance of a targeted approach to symptom management for epithelial ovarian cancer patients undergoing evaluation and treatment.

Oncology Times - Latest Articles
06/21/2021
Machine Learning-Based Prediction of Survival Prognosis in Cervical Cancer

The aim of this study is to improve forecasting capability by developing a miRNAs-based machine learning survival prediction model.

BMC Bioinformatics
06/16/2021
Radiation Therapy for Vaginal and Perirectal Lesions in Recurrent Ovarian Cancer

This study determines that radiation to treat locally recurrent vaginal/perirectal lesions in heavily pre-treated ovarian cancer patients is safe and may effectively provide in-field control.

Gynecology Oncology Reports
06/09/2021

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