Head And Neck Cancer

Head And Neck Cancer

Identification of Immune Subtypes for Predicting the Prognosis of Patients in Head and Neck Squamous Cell Carcinoma

A series of bioinformatic approaches were used to identify HNSCC immune subtypes and investigate their underlying immune characteristics that detects potentially targetable ICB subtypes. 

Technology in Cancer Research & Treatment
Knowledge-Based Planning for Robustly Optimized Intensity-Modulated Proton Therapy of Head and Neck Cancer Patients

Doctors assess the performance of a proton-specific KBP model in the creation of robustly optimized IMPT plans for treatment of advanced head and neck cancer patients.

Frontiers in Oncology
A New Prognostic Score for Predicting Survival in Patients Treated With Robotic Stereotactic Radiotherapy for Brain Metastases

Independent pretreatment factors associated with overall survival are identified to create an easy-to-use prognostic score for patients with brain metastases irrespective of primary tumor location.

Scientific Reports

Detection of Inaccessible Head and Neck Lesions Using Human Saliva and Fluorescence Spectroscopy

Scientists use fluorescence spectroscopy from human saliva to help bridge gaps in head and neck cancer detection. 

Lasers in Medical Science
Swallowing, Nutritional Status, and Salivary Flow in Patients After Head and Neck Cancer Treatment

This study confirms the relationship between swallowing & nutritional status and how appropriate protein intake influences muscle activity during swallowing in head & neck cancer survivors.

Scientific Reports
Prognostic Utility of Pretreatment Neutrophil-Lymphocyte Ratio in Advanced Larynx Cancer

Scientists identify an optimal NLR cutoff point and examine the prognostic utility of this biomarker in patients with locoregionally advanced larynx cancer treated with curative intent.

Biomarker Insights
Influence of Modulation Factor on Treatment Plan Quality and Irradiation Time in Hippocampus-Sparing Whole-Brain Radiotherapy Using Tomotherapy

This research investigates if changing the MF in HS-WBRT, its possible to shorten the irradiation time while maintaining the quality of the radiotherapy plan.

Technology in Cancer Research & Treatment
Immunotherapy Combination Could Be Alternative to 'Extreme' Chemotherapy in Some Head and Neck Cancers

Nivolumab and Ipilimumab helped some patients with advanced head & neck cancer live longer, compared to standard treatment consisting of an aggressive cocktail of two chemotherapy drugs...

Medical Xpress
Effect of Programmed Death-Ligand 1 in Cancer-Associated Fibroblasts on Advanced Laryngeal Squamous Cell Carcinoma

Researchers explore the effect of programmed death-ligand 1 (PD-L1) in cancer-associated fibroblasts (CAFs) on advanced laryngeal squamous cell carcinoma (LSCC).

Technology in Cancer Research & Treatment
miR-17-5p Drives G2/M-Phase Accumulation by Directly Targeting CCNG2 and is Related to Recurrence of Head and Neck Squamous Cell Carcinoma

This study aims to clarify the role of miR-17-5p in the cell cycle process of HNSCC and the correlation with clinical characteristics of patients with HNSCC...

BMC Cancer
Short-Term Response Might Influence the Treatment-Related Benefit of Adjuvant Chemotherapy After Concurrent Chemoradiotherapy for Esophageal Squamous Cell Carcinoma Patients

Scientists decide to investigate the potential benefit of AC after CCRT for ESCC and to identify biomarkers predictive of a clinical benefit.

Radiation Oncology
Prognostic Association of Starvation-Induced Gene Expression in Head and Neck Cancer

Researchers placed HNSCC cells under serum-free conditions to induce growth retardation and autophagy, subjecting them to transcriptome analysis to investigate the dynamics of expression of genes

Scientific Reports
Analysis of T cell Receptor Clonotypes in Tumor Microenvironment Identifies Shared Cancer-Type-Specific Signatures

Scientists sought to determine the extent of shared TCR clonotypes in the intra-tumor microenvironment of two different head and neck cancer types: EBV-linked NPC and non-virally linked HNSCC.

Cancer Immunology, Immunotherapy
Nuclear HER3 Expression Improves the Prognostic Stratification of Patients With HER1 Positive Advanced Laryngeal Squamous Cell Carcinoma

Scientists conducted this retrospective observational study on two series of locoregionally advanced LSCC patients treated with BioRT with cetuximab and salvage or upfront surgery...

Journal of Translational Medicine
Low Expression of CIP4 in Predicting Worse Overall Survival: A Potential Biomarker for Laryngeal Cancer

Scientists examine the TCGA profile geared towards evaluating the potential prognostic value and clinical correlation of CIP4 expression in LC. 

DIAPH1 Promotes Laryngeal Squamous Cell Carcinoma Progression Through Cell Cycle Regulation

Researchers suggest that DIAPH1 influences the expression of genes in several signaling pathways and promotes LSCC progression by regulating the cell cycle.

Frontiers in Oncology
Cathepsins B, D, and G Are Expressed in Metastatic Head and Neck Cutaneous Squamous Cell Carcinoma

This study investigated the expression of cathepsins B, D and G and their localization in relation to the CSC subpopulations we have recently identified in mHNcSCC.

Frontiers in Oncology
Different Primary Sites of Hypopharyngeal Cancer Have Different Lymph Node Metastasis Patterns: A Retrospective Analysis From Multi-Center Data

Scientists reassessed the features of the primary tumor (tumor size, primary location, and extent of invasion) and the involvement of lymph nodes at each level.

Frontiers in Oncology
Evaluating Predictive Factors for Toxicities Experienced by Head & Neck Cancer Patients Undergoing Radiotherapy

The purpose of this study is to evaluate if HPV status serves as an independent predictor of early and late dysphagia outcomes when considered alongside standard patient characteristics...

Journal of Translational Medicine
Upregulated Glycolysis Correlates With Tumor Progression and Immune Evasion in Head and Neck Squamous Cell Carcinoma

Here, study investigators perform a comprehensive analysis of the glycolytic activity in head and neck squamous cell carcinoma. 

Scientific Reports
The Role of Akt in Acquired Cetuximab Resistant Head and Neck Squamous Cell Carcinoma

This study aims to characterize acquired cetuximab resistance mechanisms in HNSCC cell lines by protein phosphorylation profiling.

Frontiers in Oncology
Projected Association of HPV Vaccination With Oropharynx Cancer Incidence in the US, 2020-2045

This study examines the association of HPV vaccination with future oropharynx cancer incidence in the US.

JAMA Oncology
Gene Model Related to m6A Predicts the Prognostic Effect of Immune Infiltration on Head and Neck Squamous Cell Carcinoma

This study focuses on the relationship between N6-methyladenosine and the prognosis of HNSCC in the tumor immune microenvironment.

Journal of Oncology
Novel Prognostic Score For Recurrent or Metastatic Head and Neck Cancer Patients Treated With Nivolumab

Study investigators conducted a multicenter retrospective cohort study to investigate the impact of clinico-hematological factors on survival in RM-HNC patients treated with nivolumab.

Scientific Reports
First-Line Cisplatin Plus Gemcitabine or Fluorouracil for Advanced Nasopharyngeal Carcinoma

The final OS analysis of the phase III GEM20110714 trial shows a significant benefit with gemcitabine/cisplatin vs fluorouracil/cisplatin as first-line treatment for...

The ASCO Post
No Progression-Free Survival Benefit With First-Line Avelumab Plus Chemoradiotherapy in Squamous Cell Carcinoma of the Head and Neck

The phase III JAVELIN Head and Neck 100 trial has shown no improvement in PFS with the addition of the PD-L1 inhibitor avelumab to CRT in patients with previously untreated locally advanced HNSCC.<

The ASCO Post
New Therapies on the Horizon for Elderly or Frail Patients With Head and Neck Cancer

Two treatment regimens have shown promise for treating elderly or frail patients with head and neck squamous cell carcinoma, according to researchers.

Cancer Therapy Advisor
FOXM1 Promotes Head and Neck Squamous Cell Carcinoma via Activation of the Linc-ROR/LMO4/AKT/PI3K Axis

The current study aims to elucidate the function and regulatory mechanism of FOXM1 in HNSCC.

Frontiers in Oncology
Weekly Outpatient Palliative Care Interventions Among Patients With Head and Neck Cancer

Over 90% of patients with head and neck cancer receiving curative-intent chemoradiation therapy found weekly palliative care visits to be a valuable addition to their treatment.

The ASCO Post
Molecular Interplays Between Cell Invasion and Radioresistance That Lead to Poor Prognosis in Head-Neck Cancer

In this study, investigators hypothesize that HNC cells might exhibit a cross-phenotypic attribute between cell invasion and radioresistance.

Frontiers in Oncology
Predictive Value of Skeletal Muscle Mass in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma Patients Treated With Immune Checkpoint Inhibitors

Study investigators evaluate the impact of skeletal muscle index on prognosis and immune-related adverse events in a cohort of recurrent/metastatic HNSCC treated with ICIs.

Frontiers in Oncology
Systematic Analysis of Survival-Associated Alternative Splicing Signatures in Thyroid Carcinoma

Study investigators use TCGA to generate AS maps in patients with thyroid cancer.

Frontiers in Oncology
Patterns of Technology Use Among Patients With Head and Neck Cancer and Implications for Telehealth

The objective of this study is to describe baseline technology use within the head and neck cancer population prior to the COVID-19 pandemic.

OTO Open

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