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Head And Neck Cancer

Detection of Inaccessible Head and Neck Lesions Using Human Saliva and Fluorescence Spectroscopy

Scientists use fluorescence spectroscopy from human saliva to help bridge gaps in head and neck cancer detection.

Lasers in Medical Science

10/12/2021

https://link.springer.com/article/10.1007%2Fs10103-021-03437-4

Knowledge-Based Planning for Robustly Optimized Intensity-Modulated Proton Therapy of Head and Neck Cancer Patients

Doctors assess the performance of a proton-specific KBP model in the creation of robustly optimized IMPT plans for treatment of advanced head and neck cancer patients.

Frontiers in Oncology

10/19/2021

https://www.frontiersin.org/articles/10.3389/fonc.2021.737901/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FONC_XXXXXXXX_auto-dlvrit

Identification of Immune Subtypes for Predicting the Prognosis of Patients in Head and Neck Squamous Cell Carcinoma

A series of bioinformatic approaches were used to identify HNSCC immune subtypes and investigate their underlying immune characteristics that detects potentially targetable ICB subtypes.

Technology in Cancer Research & Treatment

10/16/2021

https://journals.sagepub.com/doi/10.1177/15330338211045823

Prognostic Utility of Pretreatment Neutrophil-Lymphocyte Ratio in Advanced Larynx Cancer

Scientists identify an optimal NLR cutoff point and examine the prognostic utility of this biomarker in patients with locoregionally advanced larynx cancer treated with curative intent.

Biomarker Insights

10/11/2021

https://journals.sagepub.com/doi/10.1177/11772719211049848

Swallowing, Nutritional Status, and Salivary Flow in Patients After Head and Neck Cancer Treatment

This study confirms the relationship between swallowing & nutritional status and how appropriate protein intake influences muscle activity during swallowing in head & neck cancer survivors.

Scientific Reports

10/12/2021

https://www.nature.com/articles/s41598-021-99208-w

A New Prognostic Score for Predicting Survival in Patients Treated With Robotic Stereotactic Radiotherapy for Brain Metastases

Independent pretreatment factors associated with overall survival are identified to create an easy-to-use prognostic score for patients with brain metastases irrespective of primary tumor location.

Scientific Reports

10/13/2021

https://www.nature.com/articles/s41598-021-98847-3

FDA Approvals

FDA Approves Pembrolizumab Plus Chemo as First-Line Therapy for Advanced, Recurrent Cervical Cancer

The FDA has approved the checkpoint inhibitor pembrolizumab alongside standard chemotherapy, as first-line therapy for patients with PD-L1-expressing cervical cancer.

Medscape

10/13/2021

https://www.medscape.com/viewarticle/960819?src=soc_tw_211013_mscpedt_news_onc_cervicalcancer&faf=1

FDA Grants Breakthrough Device Designation to Alpha DaRT for Glioblastoma

Alpha DaRT is proposed as an adjunct to standard medical therapies for patients with glioblastoma multiforme or as standalone therapy for patients who have exhausted standard therapies.

Healio

10/08/2021

https://www.healio.com/news/hematology-oncology/20211008/fda-grants-breakthrough-device-designation-to-alpha-dart-for-glioblastoma

Keytruda Approved as First-Line Treatment for Persistent, Recurrent or Metastatic Cervical Cancer

The FDA approves keytruda in combination with chemotherapy, with or without bevacizumab, for patients with persistent, recurrent, or metastatic cervical cancer whose tumors express PD-L1...

Cancer Therapy Advisor

10/14/2021

https://www.cancertherapyadvisor.com/home/cancer-topics/gynecologic-cancer/keytruda-approved-as-first-line-treatment-for-persistent-recurrent-or-metastatic-cervical-cancer/?utm_medium=social&utm_source=twitter&utm_content=01dcec4124f64e51bab725dc2e82e7a9-

FDA Approves Verzenio for Certain Patients With Early Breast Cancer

The approval applies to use of the agent by adults with hormone receptor-positive, HER2-negative, node-positive disease at high risk for recurrence who have a Ki-67 score of at least 20%.

Healio

10/13/2021

https://www.healio.com/news/hematology-oncology/20211013/fda-approves-verzenio-for-certain-patients-with-early-breast-cancer

FDA Approves Tecentriq for New Lung Cancer Indication

The FDA expanded the approval of atezolizumab to include adjuvant treatment of certain patients with NSCLC.

Healio

10/15/2021

https://www.healio.com/news/hematology-oncology/20211015/fda-approves-tecentriq-for-new-lung-cancer-indication

Oncology

Selecting Image-Guided Surgical Technologies in Oncology: A Surgeon's Perspective.

This study aimed to select the most promising IG technology per oncologic indication.

Journal of Surgical Research

01/01/2021

https://www.journalofsurgicalresearch.com/article/S0022-4804(20)30543-6/fulltext

The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology.

Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges medicine.

Acta Pharmaceutica

03/01/2021

https://content.sciendo.com/view/journals/acph/71/1/article-p1.xml?language=en

Pharmacogenomics in Pediatric Oncology: Mitigating Adverse Drug Reactions While Preserving Efficacy

Major developments in drugs such as thiopurines and optimization in clinical trial protocols for treating cancer in children have led to a remarkable improvement in survival, from approximately...<

Annual Review of Pharmacology and Toxicology

01/06/2021

https://www.annualreviews.org/doi/10.1146/annurev-pharmtox-031320-104151

Review of Oncology and Transplant Literature for the Management of Hepatic and Pancreatic Resections in Jehovah's Witnesses.

Jehovah's Witnesses undergoing liver or pancreas surgery represent a unique medical and ethical challenge.

Cancer medicine journal

04/01/2021

https://www.ncbi.nlm.nih.gov/pubmed/32601622

Development and Optimization of Clinical Informatics Infrastructure to Support Bioinformatics at an Oncology Center.

Translational bioinformatics for therapeutic discovery requires the infrastructure of clinical informatics.

Methods of Molecular Biology

01/01/2021

https://pubmed.ncbi.nlm.nih.gov/32926358/

Lung Cancer

Assessment of the Clinical Utility of Circulating Tumor Cells at Different Time Points in Predicting Prognosis of Patients With Small Cell Lung Cancer

Scientists investigate the prognostic significance of different time points of CTCs in SCLC.

Cancer Control

10/15/2021

https://journals.sagepub.com/doi/10.1177/10732748211050581

A Mixed Methods Population Health Approach to Explore Radon-Induced Lung Cancer Risk Perception in Canada

Researchers employe a MM approach to understand determinant perceptions of the risk as well as the micro & macro level factors that motivate residents to adopt preventive actions.

Cancer Control

10/12/2021

https://journals.sagepub.com/doi/10.1177/10732748211039764

M6A Associated TSUC7 Inhibition Contributed to Erlotinib Resistance in Lung Adenocarcinoma Through a Notch Signaling Activation Dependent Way

Researchers tentatively explored the supporting role of TUSC7 in cancer suppression, trying to establish the m6A correlated lncRNA functions in modulating the TKIs therapies resistance.

Journal of Experimental & Clinical Cancer Research

10/16/2021

https://jeccr.biomedcentral.com/articles/10.1186/s13046-021-02137-9

Influence of Autophagy Inhibition on Lung Adenocarcinoma Cell Migration and Invasion Ability, and Efficacy of Gefitinib

3 types of lung adenocarcinoma cells are selected to explore the influence of autophagy inhibition on the migration and invasion of lung adenocarcinoma cells...

Technology in Cancer Research & Treatment

10/16/2021

https://journals.sagepub.com/doi/10.1177/15330338211049000

Identifying Modifiable Risk Factors of Lung Cancer

While lung cancer incidence rate has recently declined, it is still far from satisfactory and its potential modifiable risk factors should be explored.

PLOS ONE

10/18/2021

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0258498

Challenges in Advanced Lung Cancer Diagnosis During the COVID-19 Pandemic

Doctors and researchers collaborate to create individualized management for lung cancer patients to protect them from COVID-19.

Technology in Cancer Research & Treatment

10/16/2021

https://journals.sagepub.com/doi/10.1177/15330338211050764

Immuno Oncology

Standardization & Harmonization of Immuno-Oncology Toxicities

A report from the Association of Community Cancer Centers shows that IO treatment is increasingly being given to patients in community settings, not just in academic cancer centers.

Oncology Times - Latest Articles

04/05/2021

https://journals.lww.com/oncology-times/Fulltext/2021/04050/Standardization___Harmonization_of_Immuno_Oncology.2.aspx

Role of Immunotherapy in Localized Muscle Invasive Urothelial Cancer

Study investigators report results from clinical trials using single agent ICI, ICI/ICI and ICI/chemo combination therapies in the neoadjuvant setting for non-metastatic MIBC.

Therapeutic Advances in Medical Oncology

09/22/2021

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8461126/

Comprehensive Transcriptomic Analysis Reveals the Role of the Immune Checkpoint HLA-G Molecule in Cancers

The aim of this study is to systematically identify the roles of checkpoint HLA-G molecules across various types of cancer.

Frontiers in Immunology

07/01/2021

https://www.frontiersin.org/articles/10.3389/fimmu.2021.614773/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FIMMU_XXXXXXXX_auto-dlvrit

mRNA in Cancer Immunotherapy: Beyond a Source of Antigen

Many novel immunotherapeutic strategies focus on the use of mRNA beyond its use as the source of tumor antigens.

Molecular Cancer

03/03/2021

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926200/

Response Endpoints Deemed ‘Poor Surrogates’ for Overall Survival in Trials of Immune Checkpoint Inhibitors

Tumor response endpoints are “poor surrogate endpoints” for OS in trials of immune checkpoint inhibitors, according to research published in JCO Precision Oncology.

Cancer Therapy Advisor

08/05/2021

https://www.cancertherapyadvisor.com/home/cancer-topics/general-oncology/cancer-poor-surrogate-response-endpoint-immune-checkpoint-risk/?utm_medium=social&utm_source=twitter&utm_content=3979dc286fd148b795cdce882c9a8820-429091341&utm_campaign=cta_daily_pos

Cardiovascular Risks Associated With Checkpoint Inhibitors and CAR T-Cell Therapy

Leveraging the immune system to treat cancer, however, also increases the potential for serious off-target effects.

The ASCO Post

04/10/2021

https://ascopost.com/issues/april-10-2021/cardiovascular-risks-associated-with-checkpoint-inhibitors-and-car-t-cell-therapy/

Gastrointestinal Cancer

Comparison of Long-Term Efficacy in S-1 and Capecitabine With Oxaliplatin as Adjuvant Chemotherapy for Patients With Gastric Cancer After Curative Surgery

Research compares the long-term survival rates of patients who received TS-1 or XELOX during adjuvant chemotherapy and clinical indications that could guide clinicians in selecting regimens.

Technology in Cancer Research & Treatment

10/04/2021

https://journals.sagepub.com/doi/10.1177/15330338211039679

Peripheral Blood-Based DNA Methylation of Long Non-Coding RNA H19 and Metastasis-Associated Lung Adenocarcinoma Transcript 1 Promoters are Potential Non-Invasive Biomarkers for Gastric Cancer Detection

Bioinformatic analysis was utilized to verify the reported association between MALAT1 and H19 expression and the occurrence, development, and prognosis of GC.

Cancer Control

10/06/2021

https://journals.sagepub.com/doi/10.1177/10732748211043667

Circular RNA UBE2Q2 Promotes Malignant Progression of Gastric Cancer by Regulating Signal Transducer and Activator of Transcription 3-Mediated Autophagy and Glycolysis

Scienists proved that circUBE2Q2 is upregulated in GC tissues and cell lines, sponges miR-370-3p to activate the STAT3 pathway, and promotes tumor metastasis...

Cell Death & Disease

10/05/2021

https://www.nature.com/articles/s41419-021-04216-3

Phase II Feasibility Study of Adjuvant Chemotherapy with Docetaxel/Cisplatin/S-1 Followed by S-1 for Stage III Gastric Cancer

This phase II trial evaluates the feasibility, safety, and efficacy of postoperative adjuvant therapy with DCS following S-1 therapy in patients with stage IIIA, IIIB, and IIIC gastric cancer...

BMC Cancer

10/01/2021

https://bmccancer.biomedcentral.com/articles/10.1186/s12885-021-08795-4

Comprehensive Analysis of IGFBPs as Biomarkers in Gastric Cancer

This study aimed to explore IGFBPs and their prognostic value as markers in gastric cancer.

Frontiers in Oncology

10/21/2021

https://www.frontiersin.org/articles/10.3389/fonc.2021.723131/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FONC_XXXXXXXX_auto-dlvrit

Effects and Prognostic Values of miR-30c-5p Target Genes in Gastric Cancer via a Comprehensive Analysis Using Bioinformatics

Potential diagnostic and prognostic values of miR-30c-5p target genes in gastric cancer by using a filtration step analysis and integrated bioinformatics tools are explored.

Scientific Reports

10/18/2021

https://www.nature.com/articles/s41598-021-00043-w

Skin Cancer

HSP105 Expression in Cutaneous Malignant Melanoma: Correlation with Clinicopathological Characteristics

Scientists analyzed the relationship between HSP105 expression and the clinicopathological characteristics of CMM.

PLOS ONE

10/07/2021

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0258053

Nobiletin-Loaded Composite Penetration Enhancer Vesicles Restore the Normal miRNA Expression and the Chief Defence Antioxidant Levels in Skin Cancer

This study is the first attempt to evaluate the effect of nobiletin on antioxidant enzymes and mi-RNAs in the treatment of skin cancer.

Scientific Reports

10/12/2021

https://www.nature.com/articles/s41598-021-99756-1

DLEU1 Promotes Oral Squamous Cell Carcinoma Progression by Activating Interferon-Stimulated Genes

Scientists find that DLEU1 exerts its oncogenic effects, at least in part, through activation of a series ISGs in OSCC cells.

Scientific Reports

10/14/2021

https://www.nature.com/articles/s41598-021-99736-5

Adjuvant Pembrolizumab Shows Efficacy in High-Risk Stage II Melanoma in Adults and Children Older Than 12

According to a late-breaking interim analysis of the phase III KEYNOTE-716 trial, adjuvant pembrolizumab reduced the risk of recurrence in adults and children older than age 12...

The ASCO Post

10/11/2021

https://ascopost.com/issues/october-10-2021/adjuvant-pembrolizumab-shows-efficacy-in-high-risk-stage-ii-melanoma-in-adults-and-children-older-than-12/

Integrative Characterization of the Role of IL27 In Melanoma Using Bioinformatics Analysis

Scientists work to uncover the multifaceted roles of IL27 and provide evidence for future cytokine-based immunotherapy against melanoma.

Frontiers in Immunology

10/18/2021

https://www.frontiersin.org/articles/10.3389/fimmu.2021.713001/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FIMMU_XXXXXXXX_auto-dlvrit

Integration Analysis of m6A Related Genes in Skin Cutaneous Melanoma and the Biological Function Research of the SPRR1B

Research provides a new view for the comprehensive action of m6A regulatory factors & for the first time finds SPRR1B can promote the proliferation, invasion & migration of melanoma cells <

Frontiers in Oncology

10/19/2021

https://www.frontiersin.org/articles/10.3389/fonc.2021.729045/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FONC_XXXXXXXX_auto-dlvrit

Gynecologic Cancer

Ovarian Function Preservation in Patients With Cervical Cancer Undergoing Hysterectomy and Ovarian Transposition Before Pelvic Radiotherapy

Research explores the factors associated with ovarian failure and evaluates the effectiveness of OT before pelvic irradiation for preserving ovarian function in patients with cervical cancer...

Technology in Cancer Research & Treatment

10/09/2021

https://journals.sagepub.com/doi/10.1177/15330338211042140

Cervical Cancer Screening is Overused—and Underused, As Well

Researchers have found that many women are screened too often, leading to unnecessary procedures that may carry their own harms, while some women are not getting tested often enough...

Medical Xpress

10/13/2021

https://medicalxpress.com/news/2021-10-cervical-cancer-screening-overusedand-underused.html

Attenuated Salmonella Carrying Plasmid Co-Expressing HPV16 L1 and siRNA-E6 for Cervical Cancer Therapy

This study suggests that pcDNA3.1-HPV16-L1-siE6 carried by attenuated Salmonella has a synergistic effect of immune regulation and RNA interference in cervical cancer treatment.

Scientific Reports

10/11/2021

https://www.nature.com/articles/s41598-021-99425-3

Clinicopathological Features and Survival of Adolescent and Young Adults with Cervical Cancer

Researchers explore the clinicopathological characteristics and find a meaningful method to predict the prognosis of young women with cervical cancer.

Cancer Control

10/14/2021

https://journals.sagepub.com/doi/10.1177/10732748211051558

Hsp90 Up-Regulates PD-L1 to Promote HPV-Positive Cervical Cancer via HER2/PI3K/AKT Pathway

The therapeutic effect of heat shock protein 90 knockdown on HPV16+ cervical cancer progression and the underlying mechanism is investigated.

Molecular Medicine

10/19/2021

https://molmed.biomedcentral.com/articles/10.1186/s10020-021-00384-2

Spotlight

Salvage Autologous Stem Cell Transplantation May Improve Outcomes for Relapsed/Refractory Multiple Myeloma

Salvage therapy with high-dose chemotherapy followed by ASCT may lead to long-term improvements in survival for MM in some patients.

Hematology Advisor

10/12/2021

https://www.hematologyadvisor.com/home/topics/myeloma/salvage-therapy-multiple-myeloma-high-dose-chemo-treatment-risk/?utm_campaign=hem_daily_posts&utm_content=da5f42fe752846f5aec4678740671967-1019321025555763201&utm_medium=social&utm_source=twitter

News

A Multi-Modal, Physician-Centered Intervention to Improve Guideline-Concordant Prostate Cancer Imaging

Research describes and analyzes the implementation of the PCIS intervention to determine the effect of a physician-focused behavioral intervention on VHA prostate cancer imaging use.

Trials

10/18/2021

https://trialsjournal.biomedcentral.com/articles/10.1186/s13063-021-05645-3

10384

Association Analyses of TP53 Mutation With Prognosis, Tumor Mutational Burden, and Immunological Features in Acute Myeloid Leukemia

Somatic mutations in AML patients were found using The Cancer Genome Atlas dataset and BeatAML dataset and then researchers identified the common mutant genes in the two cohorts.

Frontiers in Immunology

10/21/2021

https://www.frontiersin.org/articles/10.3389/fimmu.2021.717527/full?utm_source=S-TWT&utm_medium=SNET&utm_campaign=ECO_FIMMU_XXXXXXXX_auto-dlvrit

10383

Prognostic Value of Immune-Related lncRNA Pairs in Patients With Bladder Cancer

Research establishes a novel model to predict the efficacy of immunotherapy regardless of expression.

World Journal of Surgical Oncology

10/18/2021

https://wjso.biomedcentral.com/articles/10.1186/s12957-021-02419-8

10382

Extended Letrozole Prolonged Survival in Postmenopausal Patients With Breast Cancer

When compared with the standard 2-3 years of letrozole, 5 years of letrozole treatment improved both disease-free survival and overall survival.

Cancer Therapy Advisor

10/18/2021

https://www.cancertherapyadvisor.com/home/cancer-topics/breast-cancer/breast-cancer-letrozole-prolongs-survival-post-menopause-treatment/?utm_medium=social&utm_source=twitter&utm_content=211e003a8cf2481c8ad776e75273a0cb-429091341&utm_campaign=cta_daily_po

10381

M6A Associated TSUC7 Inhibition Contributed to Erlotinib Resistance in Lung Adenocarcinoma Through a Notch Signaling Activation Dependent Way

Researchers tentatively explored the supporting role of TUSC7 in cancer suppression, trying to establish the m6A correlated lncRNA functions in modulating the TKIs therapies resistance.

Journal of Experimental & Clinical Cancer Research

10/16/2021

https://jeccr.biomedcentral.com/articles/10.1186/s13046-021-02137-9

10380

Hsp90 Up-Regulates PD-L1 to Promote HPV-Positive Cervical Cancer via HER2/PI3K/AKT Pathway

The therapeutic effect of heat shock protein 90 knockdown on HPV16+ cervical cancer progression and the underlying mechanism is investigated.

Molecular Medicine

10/19/2021

https://molmed.biomedcentral.com/articles/10.1186/s10020-021-00384-2

10379

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