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Standardization & Harmonization of Immuno-Oncology Toxicities

A report from the Association of Community Cancer Centers shows that IO treatment is increasingly being given to patients in community settings, not just in academic cancer centers.

Oncology Times - Latest Articles
04/05/2021
https://journals.lww.com/oncology-times/Fulltext/2021/04050/Standardization___Harmonization_of_Immuno_Oncology.2.aspx
Liver Transplant Emerges for Hepatic Mets in Colorectal Cancer

Liver transplant might be the next big thing for extensive hepatic metastases in colorectal cancer.

Medscape
04/05/2021
https://www.medscape.com/viewarticle/948683?src=soc_tw_210407_mscpedt_news_mdscp_crc&faf=1

Head And Neck Cancer

Electrochemotherapy in the Treatment of Head and Neck Cancer: Current Conditions and Future Directions

This review describes current knowledge and data on the use of ECT in various forms of HNCs across different clinical settings, with attention to future clinical and research perspectives.

Cancers
03/19/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003720/
Tipifarnib for Patients With Advanced HRAS-Mutant Head and Neck Cancer and High Variant Allele Frequency

In a phase II trial, Ho et al finds that tipifarnib produces a high response rate among patients with recurrent or metastatic HNSCC with HRAS mutations and high variant allele frequency.

The ASCO Post
04/05/2021
https://ascopost.com/news/april-2021/tipifarnib-for-patients-with-advanced-hras-mutant-head-and-neck-cancer-and-high-variant-allele-frequency/
Effect of Acupuncture in Pain Management of Head and Neck Cancer Radiotherapy

This prospective randomized open-label trial evaluates the role of acupuncture in the treatment of pain related to curative and adjuvant (chemo)radiotherapy of head and neck cancer.

Journal of Clinical Medicine
03/07/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7961644/
Cetuximab, Docetaxel, and Cisplatin versus Platinum, Fluorouracil, and Cetuximab as First-Line Treatment in Patients With Recurrent or Metastatic Head and Neck Squamous-Cell Carcinoma

Results from a phase 2 trial of the TPEx chemotherapy regimen show promising results, with a median overall survival of 14·0 months in first-line recurrent or metastatic HNSCC.

The Lancet Oncology
04/01/2021
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(20)30755-5/fulltext
New Database of HPV-Negative Head & Neck Carcinomas Unveiled

New research clarifies the contributions of genes, proteins, and signaling pathways associated with HPV-negative head and neck squamous cell carcinomas.

Oncology Times - Latest Articles
04/05/2021
https://journals.lww.com/oncology-times/Fulltext/2021/04050/New_Database_of_HPV_Negative_Head___Neck.5.aspx

FDA Approvals

FDA Oncologic Drugs Advisory Committee to Review Status of Six Indications Granted Accelerated Approval

These products are being used under accelerated approval to treat patients with breast, urothelial, gastric, and hepatocellular cancers.

The ASCO Post
03/15/2021
https://ascopost.com/news/march-2021/fda-oncologic-drugs-advisory-committee-to-review-status-of-six-indications-granted-accelerated-approval/
FDA Approves Pembrolizumab Combination for Advanced Esophageal or Gastroesophageal Junction Carcinoma

The FDA has approved pembrolizumab in combination with platinum and fluoropyrimidine-based CT for patients with metastatic or locally advanced esophageal or gastroesophageal junction carcinoma...

The ASCO Post
03/23/2021
https://ascopost.com/news/march-2021/fda-approves-pembrolizumab-combination-for-advanced-esophageal-or-gastroesophageal-junction-carcinoma/
CAR-T Therapy Is Approved for Non-Hodgkin Lymphoma

Lisocabtagene maraleucel is a CAR-T therapy indicated for patients who haven’t responded to or have relapsed after at least 2 other systemic treatments.

JAMA Network
03/16/2021
https://jamanetwork.com/journals/jama/fullarticle/2777452?guestAccessKey=33489aca-451a-4f11-a675-51739436362d&utm_source=twitter&utm_medium=social_jamaonc&utm_term=4691913278&utm_campaign=partnership&linkId=115201487
FDA Updates Highlighting the Latest Cancer Treatments

Oncology Times covers the most recent FDA approvals in cancer treatment.

Oncology Times - Latest Articles
03/20/2021
https://journals.lww.com/oncology-times/Fulltext/2021/03200/FDA_Updates_Highlighting_the_Latest_Cancer.17.aspx
FDA Grants Accelerated Approval to Melphalan Flufenamide for Relapsed or Refractory Multiple Myeloma

The FDA just granted accelerated approval to Pepaxto in combination with dexamethasone for adult patients with R/R multiple myeloma who have received at least four prior lines of therapy...

The ASCO Post
03/01/2021
https://ascopost.com/news/march-2021/fda-grants-accelerated-approval-to-melphalan-flufenamide-for-relapsed-or-refractory-multiple-myeloma/
FDA Updates Highlighting the Latest Cancer Treatments

The latest developments in FDA approvals for cancer treatments.

Oncology Times - Latest Articles
03/05/2021
https://journals.lww.com/oncology-times/Fulltext/2021/03050/FDA_Updates_Highlighting_the_Latest_Cancer.9.aspx

Oncology

Development and Optimization of Clinical Informatics Infrastructure to Support Bioinformatics at an Oncology Center.

Translational bioinformatics for therapeutic discovery requires the infrastructure of clinical informatics.

Methods of Molecular Biology
01/01/2021
Pharmacogenomics in Pediatric Oncology: Mitigating Adverse Drug Reactions While Preserving Efficacy

Major developments in drugs such as thiopurines and optimization in clinical trial protocols for treating cancer in children have led to a remarkable improvement in survival, from approximately...<

Annual Review of Pharmacology and Toxicology
01/06/2021
https://www.annualreviews.org/doi/10.1146/annurev-pharmtox-031320-104151
Selecting Image-Guided Surgical Technologies in Oncology: A Surgeon's Perspective.

This study aimed to select the most promising IG technology per oncologic indication.

Journal of Surgical Research
01/01/2021
https://www.journalofsurgicalresearch.com/article/S0022-4804(20)30543-6/fulltext
The use of Hericium erinaceus and Trametes versicolor extracts in supportive treatment in oncology.

Substances available in nature with potential therapeutic effects are the subject of research that raises tremendous hopes for new challenges medicine.

Acta Pharmaceutica
03/01/2021
https://content.sciendo.com/view/journals/acph/71/1/article-p1.xml?language=en
Review of Oncology and Transplant Literature for the Management of Hepatic and Pancreatic Resections in Jehovah's Witnesses.

Jehovah's Witnesses undergoing liver or pancreas surgery represent a unique medical and ethical challenge.

Cancer medicine journal
04/01/2021
https://www.ncbi.nlm.nih.gov/pubmed/32601622

Lung Cancer

Some Patients With Lung Cancer Report Feeling Uninformed About Their Disease, Uninvolved With Their Treatment

More than 1 in 10 patients with lung cancer do not know what type of tumor they have, according to data from a 17-country study carried out by the GLCC presented at the European Lung Cancer Virtual

The ASCO Post
03/26/2021
https://ascopost.com/news/march-2021/some-patients-with-lung-cancer-report-feeling-uninformed-about-their-disease-uninvolved-with-their-treatment/
Single-Cell Sequencing, an Advanced Technology in Lung Cancer Research

This review summarizes lung cancer research using SCS and their research achievements.

OncoTargets and Therapy
03/16/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7981160/
Severity of COVID-19 in Patients With Lung Cancer: Evidence and Challenges

This review summarizes available evidence regarding the direct and indirect impact of the COVID-19 pandemic on lung cancer care and patients.

Journal for ImmunoTherapy of Cancer
03/18/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7978268/
Optimal Treatment Strategies for Stage I Non–Small-Cell Lung Cancer in Veterans With Pulmonary and Cardiac Comorbidities

Study investigators use use simulation modeling to assess projected outcomes associated with different management strategies of Veterans with stage I NSCLC with COPD and/or CAD.

PLOS ONE
03/18/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7971489/
The Incidence and Risk Analysis of Lung Cancer Development in Patients with Chronic Obstructive Pulmonary Disease: Possible Effectiveness of Annual CT-Screening

This study examines the incidence of lung cancer and the lung cancer mortality rate in Japanese COPD patients, as well as factors that are associated with the development of lung cancer in COPD pat

03/25/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8006963/

Immuno Oncology

Standardization & Harmonization of Immuno-Oncology Toxicities

A report from the Association of Community Cancer Centers shows that IO treatment is increasingly being given to patients in community settings, not just in academic cancer centers.

Oncology Times - Latest Articles
04/05/2021
https://journals.lww.com/oncology-times/Fulltext/2021/04050/Standardization___Harmonization_of_Immuno_Oncology.2.aspx
Immune Regulation of the cGAS-STING Signaling Pathway in the Tumor Microenvironment and Its Clinical Application

STING agonists, as novel agonists, are used in preclinical research and in the treatment of various tumors via clinical trials and have displayed attractive application prospects.

OncoTargets and Therapy
03/01/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7935450/
The Impact of m6A RNA Modification in Therapy Resistance of Cancer: Implication in Chemotherapy, Radiotherapy, and Immunotherapy

This review focuses on m6A-associated regulation, mechanisms, and functions in acquired chemoresistance, radioresistance, and resistance to immunotherapy in cancer.

Frontiers in Oncology
02/25/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7947626/
Clinical Sequencing to Assess Tumor Mutational Burden as a Useful Biomarker to Immunotherapy in Various Solid Tumors

Tumor mutational burden has been considered as a useful marker to indicate patients who benefit from ICIs.

Therapeutic Advances in Medical Oncology
02/26/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7917846/
mRNA in Cancer Immunotherapy: Beyond a Source of Antigen

Many novel immunotherapeutic strategies focus on the use of mRNA beyond its use as the source of tumor antigens. 

Molecular Cancer
03/03/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926200/

Gastrointestinal Cancer

KK-LC-1 May be an Effective Prognostic Biomarker for Gastric Cancer

This study detects the expression of  KK-LC-1 in gastric cancer specimens and analyze the associations between KK-LC-1 expression and clinicopathological parameters and clinical prognosis.

BMC Cancer
03/12/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953676/
MicroRNAs as Predictive Biomarkers of Resistance to Targeted Therapies in Gastrointestinal Tumors

The aim of this review is to summarize the major studies that have investigated the role of microRNAs as mediators of resistance to targeted therapies currently in use in GI neoplasms...

Biomedicines
03/21/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8003870/
Exploring the Attitudes of Health Professionals Providing Care to Patients Undergoing Treatment for Upper Gastrointestinal Cancers to Different Models of Nutrition Care Delivery

This study aims to explore the perspectives of health professionals on providing nutrition care to upper gastrointestinal cancer patients by electronic methods to allow the future scaling-up of acc

03/22/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8004184/
Circulating Hybrid Cells May Help to Monitor Treatment Response in Patients With Rectal and Esophageal Cancers

An analysis of 58 peripheral blood specimens from patients with rectal and esophageal cancers demonstrates that circulating hybrid cells may be a novel, noninvasive biomarker with potential for...<

The ASCO Post
03/18/2021
https://ascopost.com/news/march-2021/circulating-hybrid-cells-may-help-to-monitor-treatment-response-in-patients-with-rectal-and-esophageal-cancers/
HER2 Expression, Test Deviations, and Their Impact on Survival in Metastatic Gastric Cancer

The multicenter VARIANZ study aims to investigate the background of response and resistance to trastuzumab in mGC.

Journal of Clinical Oncology
03/25/2021
https://ascopubs.org/doi/full/10.1200/JCO.20.02761
Effects of Cooperative Nursing and Patient Education on Postoperative Infection and Self-Efficacy in Gastrointestinal Tumors

This study aims to explore the effect of cooperative nursing care management/self-efficacy education on postoperative infection and self-efficacy in gastrointestinal tumor surgery patients.

World Journal of Clinical Cases
03/06/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7942033/

Skin Cancer

Muffin Technique Micrographic Surgery for Non-Melanoma Skin Cancer

This study describes the implementation and the preliminary results of MTMS in an academic dermatology center.

Frontiers in Medicine
01/21/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7859636/
Systemic Photoprotection in Skin Cancer Prevention: Knowledge Among Dermatologists

The aim of this study is to summarize the current state of knowledge of systemic photoprotection and to evaluate the knowledge and attitude of dermatologists regarding these treatments.

Biomolecules
02/23/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926776/
Patterns in the Development of Melanoma Across Body Sites

An international research team examined patterns in the development of melanoma in patients in Australia and the United Kingdom and shed light on possible relationships by anatomical site.

Cancer Therapy Advisor
03/24/2021
https://www.cancertherapyadvisor.com/home/cancer-topics/skin-cancer/melanoma-nevi-patterns-development-across-body-sites-risk/
Construction and Validation of a Nomogram for Patients with Skin Cancer

Study investigators use patient data collected from the surveillance, epidemiology, and end results program database to construct and validate the model for clinical prediction of skin cancer.

Medicine
01/29/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7850664/
Anti-BRAF/Anti-MEK Targeted Therapies for Metastatic Melanoma Patients During the COVID-19 Outbreak: Experience From an Italian Skin Cancer Unit

Although melanoma has been increasing at a constant rate in the past few decades, mortality has been low, and only a small percentage of patients have developed metastatic disease.

Future Oncology
02/03/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7874884/
Checkpoint Inhibitor Therapy for Skin Cancer May be Safe in Patients With Asymptomatic COVID-19

An ongoing area of uncertainty during the SARS-CoV-2 pandemic is the safety of ICI therapy for cancer, and the theoretical possibility of exacerbated irAEs secondary to COVID-19 inflammatory pathol

Annals of Oncology
02/16/2021
https://www.annalsofoncology.org/article/S0923-7534(21)00125-3/pdf

Gynecologic Cancer

Significance of EZH2 Expression in Endometrial Cancer

To identify new targets, researchers have explored the relevance of epigenetic modifiers in cancer therapeutics. One such potential candidate is enhancer of zeste homolog 2 (EZH2). 

Oncology Times - Latest Articles
04/05/2021
https://journals.lww.com/oncology-times/Fulltext/2021/04050/Significance_of_EZH2_Expression_in_Endometrial.4.aspx
MRI-Guided Adaptive Brachytherapy in Locally Advanced Cervical Cancer (EMBRACE-I)

This study reports on EMBRACE-I, which aims to evaluate local tumor control and morbidity after chemoradiotherapy and MRI-based IGABT.

The Lancet Oncology
04/01/2021
https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(20)30753-1/fulltext
Phase III ARIEL4 Trial Confirms Benefit of Rucaparib in BRCA-Mutated Relapsed Ovarian Cancer

In patients with BRCA-mutated, advanced, relapsed ovarian cancer, treatment with the PARP inhibitor rucaparib led to a significant improvement in progression-free survival compared with...

The ASCO Post
03/21/2021
https://ascopost.com/news/march-2021/phase-iii-ariel4-trial-confirms-benefit-of-rucaparib-in-brca-mutated-relapsed-ovarian-cancer/
Frailty May Impact Surgical Outcomes in Patients With Ovarian Cancer

Frailty may be a better predictor of poor surgical outcomes in patients with ovarian cancer than age, according to two studies reported at the SGO 2021 Virtual Annual Meeting on Women’s Cancer.

The ASCO Post
03/21/2021
https://ascopost.com/news/march-2021/frailty-may-impact-surgical-outcomes-in-patients-with-ovarian-cancer/
Hormonal IUD May Be a Potential Nonsurgical Treatment for Early Endometrial Cancer or Precancer

An intrauterine device, or IUD, that releases the hormone levonorgestrel appears to be an effective treatment for endometrial precancer and early-stage endometrial cancer. 

The ASCO Post
03/21/2021
https://ascopost.com/news/march-2021/hormonal-iud-may-be-a-potential-nonsurgical-treatment-for-early-endometrial-cancer-or-precancer/
Overall Survival With Olaparib vs Placebo Maintenance in Patients With Platinum-Sensitive Relapsed Ovarian Cancer and BRCA1/2 Mutation

The phase III SOLO2/ENGOT-Ov21 trial has shown a large numeric but statistically nonsignificant improvement in the secondary endpoint of overall survival with olaparib tablet maintenance therapy vs

The ASCO Post
04/06/2021
https://ascopost.com/news/april-2021/overall-survival-with-olaparib-vs-placebo-maintenance-in-patients-with-platinum-sensitive-relapsed-ovarian-cancer-and-brca12-mutation/
Spotlight
Patterns in the Development of Melanoma Across Body Sites

An international research team examined patterns in the development of melanoma in patients in Australia and the United Kingdom and shed light on possible relationships by anatomical site.

Cancer Therapy Advisor
03/24/2021
https://www.cancertherapyadvisor.com/home/cancer-topics/skin-cancer/melanoma-nevi-patterns-development-across-body-sites-risk/

News

Targeted Treatment of Follicular Lymphoma

Recent advances in understanding of the unique genetic and immune biology of FL have led to increasingly potent and precise novel targeted agents, suggesting that a CT-future...

02/22/2021
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7926563/
8292
Melphalan Flufenamide Receives Accelerated Approval for Relapsed/Refractory Multiple Myeloma

Melphalan flufenamide, in combination with dexamethasone, has received accelerated approval from the FDA for the treatment of adult patients with relapsed or refractory MM who have received...

ASH Clinical News
04/01/2021
https://www.ashclinicalnews.org/online-exclusives/melphalan-flufenamide-receives-accelerated-approval-relapsed-refractory-multiple-myeloma/
8661
HER2 Expression, Test Deviations, and Their Impact on Survival in Metastatic Gastric Cancer

The multicenter VARIANZ study aims to investigate the background of response and resistance to trastuzumab in mGC.

Journal of Clinical Oncology
03/25/2021
https://ascopubs.org/doi/full/10.1200/JCO.20.02761
8663
Final Results From the International Tailored Chemotherapy Adjuvant Trial

Findings from a Phase III study found that evaluating mRNA expression of selected genes to tailor adjuvant chemotherapy did not improve survival outcomes among patients with resected stage II-III NSCLC.

Oncology Times - Latest Articles
04/01/2021
http://know.lww.com/nsclc/articles/adjuvant-trial.html
8662
Diet and Exercise Intervention May Increase Efficacy of Chemotherapy in Pediatric Patients With Leukemia

Research published by Orgel et al shows that restricting calories, reducing fat and sugar intake, and increasing physical activity may boost the effectiveness of chemotherapy for older children and adolescents with leukemia.

The ASCO Post
04/07/2021
https://ascopost.com/news/april-2021/diet-and-exercise-intervention-may-increase-efficacy-of-chemotherapy-in-pediatric-patients-with-leukemia/
8660
New ASH Guidelines: VTE Prevention and Treatment in Cancer Patients

New ASH guidelines "strongly recommend" using no thromboprophylaxis over using parenteral thromboprophylaxis in ambulatory patients receiving cancer CT who have low VTE risk.

Medscape
03/03/2021
https://www.medscape.com/viewarticle/946777?src=soc_tw_210307_mscpedt_news_mdscp_vte&faf=1
8275

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