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Immuno Oncology

Immuno Oncology

Researchers are now investigating whether immunotherapy benefits patients who do not have stage 4 metastatic disease. In these patients, tumors have not spread to distant organs.

Medical Xpress
05/16/2022

Adding oleclumab or monalizumab to consolidation with durvalumab can improve clinical outcomes in patients with unresectable stage III non-small cell lung cancer...

Cancer Therapy Advisor
05/13/2022

Investigators at Memorial Sloan Kettering Cancer Center are developing a variety of tactics for creating new immunotherapy treatments.

Memorial Sloan Kettering Cancer Center News
04/29/2022

Researchers at The University of Texas MD Anderson Cancer Center have identified a novel strategy to reduce immune-related adverse events from immunotherapy treatment...

Medical Xpress
05/09/2022

Through a series of chemical iterations and molecular dynamics simulations, we synthesize a library of FRET peptides and identify probe H5 with an optimal fit into granzyme B.

Nature Communications
05/02/2022

We revealed a robust link between cancer stemness and immunotherapy resistance and developed a promising signature, Stem.Sig, which showed increased performance in comparison...

Genome Medicine
04/29/2022

We sought to exploit the anti-tumor mediators in MC granules to selectively target them to tumor cells using tumor specific immunoglobin E and controllably trigger release of anti-tumor mediators u

Frontiers in Oncology
04/22/2022

The study reported a landmark finding that describes how male sex hormones contribute to cancer-related sex bias via the modulation of CD8+ T cells...

Medical Xpress
04/15/2022

Our data provide insights into the mechanisms, predictive biomarkers, and therapeutic targets for arthritis-irAE.

Nature Communications
04/12/2022

This study aimed to predict immunotherapy response and prognosis using immunologic gene sets. 

Frontiers in Immunology
04/14/2022

A new type of immunotherapy making use of the immune system's "natural killer cells" could offer potential against a range of cancers that can evade current treatments...

Medical Xpress
04/11/2022

 CoCAR can increase the activity of T cells expressing both native and transgenic TCRs and enhance antitumor responses.

Cancer Immunology Research
04/01/2022

This work supports further investigation using isolate-driven models to characterize the mechanisms underlying this phenomenon.

Genome Medicine
03/29/2022

TU Dresden scientists led by Prof. Sebastian Zeissig have now identified proteins that are promising targets for new immunotherapies against colon cancer. 

Medical Xpress
03/31/2022

We show for the first time that nPKC-θ mediates immunotherapy resistance via its activity in circulating tumor cells and dysfunctional CD8+ T cells.

Cancers
03/21/2022

We demonstrate a higher rate of ICI-induced hypophysitis than previously reported, which may be reflective of real-world practice due to increased awareness as experience with ICI has grown.

Frontiers in Oncology
03/08/2022

In this study, we established a comprehensive mutation-based gene set across different tumor types to predict the efficacy of ICI therapy.

Genome Medicine
02/24/2022

Women are at higher risk of severe adverse events from cancer therapy than men, and this is seen with chemotherapy, targeted agents, and especially with immunotherapy.

Medscape
02/17/2022

Researchers found unique expression profiles in 50 genes that help identify rare anti-tumor lymphocytes that can infiltrate and help defeat metastatic solid epithelial tumors.

Medical Xpress
02/04/2022

A new French study raises the possibility that immunotherapy can help some people with stomach cancer avoid surgery.

Medscape
01/27/2022

Combination durvalumab, gemcitabine, and cisplatin may be a new first-line standard of care for patients with advanced biliary tract cancer, according to researchers.

Cancer Therapy Advisor
01/22/2022

A new data portal called Cancer-Immu can help cancer clinicians and researchers predict which patients will respond to immune checkpoint inhibitors.

Medical Xpress
01/18/2022

This research aimed to investigate the correlation between LCN2 expression and immunity and visualize its prognostic landscape in pan-cancer.

Frontiers in Oncology
12/23/2021

New trial results show no improvement in EFS with second-line tisagenlecleucel vs standard of care including salvage chemotherapy and autologous HSCT in patients with aggressive B-cell lymphoma.

The ASCO Post
12/23/2021

Yale scientists helped identify crucial ways that immune system cells congregate and communicate with each other to identify and eradicate tumors, an insight that can help improve these outcomes.

Medical Xpress
12/09/2021

The use of immune checkpoint inhibitors for cancer patients with advanced disease may be contradictory and cause more harm than good, according to a new study in JAMA Oncology. 

Medscape
12/08/2021

Researchers suggests that identification of the membrane targets for the promising anticancer HDPs might lead to the identification of new drugs for targeted therapy.

Frontiers in Immunology
11/19/2021

Study investigators report results from clinical trials using single agent ICI, ICI/ICI and ICI/chemo combination therapies in the neoadjuvant setting for non-metastatic MIBC. 

Therapeutic Advances in Medical Oncology
09/22/2021

Tumor response endpoints are “poor surrogate endpoints” for OS in trials of immune checkpoint inhibitors, according to research published in JCO Precision Oncology.

Cancer Therapy Advisor
08/05/2021

The aim of this study is to systematically identify the roles of checkpoint HLA-G molecules across various types of cancer.

Frontiers in Immunology
07/01/2021

Leveraging the immune system to treat cancer, however, also increases the potential for serious off-target effects.

The ASCO Post
04/10/2021

A report from the Association of Community Cancer Centers shows that IO treatment is increasingly being given to patients in community settings, not just in academic cancer centers.

Oncology Times - Latest Articles
04/05/2021

Many novel immunotherapeutic strategies focus on the use of mRNA beyond its use as the source of tumor antigens. 

Molecular Cancer
03/03/2021

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