Lung Cancer

Lung Cancer

M6A Associated TSUC7 Inhibition Contributed to Erlotinib Resistance in Lung Adenocarcinoma Through a Notch Signaling Activation Dependent Way

 Researchers tentatively explored the supporting role of TUSC7 in cancer suppression, trying to establish the m6A correlated lncRNA functions in modulating the TKIs therapies resistance.

Journal of Experimental & Clinical Cancer Research
Influence of Autophagy Inhibition on Lung Adenocarcinoma Cell Migration and Invasion Ability, and Efficacy of Gefitinib

3 types of lung adenocarcinoma cells are selected to explore the influence of autophagy inhibition on the migration and invasion of lung adenocarcinoma cells...


Technology in Cancer Research & Treatment
Assessment of the Clinical Utility of Circulating Tumor Cells at Different Time Points in Predicting Prognosis of Patients With Small Cell Lung Cancer

Scientists investigate the prognostic significance of different time points of CTCs in SCLC.

Cancer Control

Identifying Modifiable Risk Factors of Lung Cancer

While lung cancer incidence rate has recently declined, it is still far from satisfactory and its potential modifiable risk factors should be explored.

A Mixed Methods Population Health Approach to Explore Radon-Induced Lung Cancer Risk Perception in Canada

Researchers employe a MM approach to understand determinant perceptions of the risk as well as the micro & macro level factors that motivate residents to adopt preventive actions.

Cancer Control
Challenges in Advanced Lung Cancer Diagnosis During the COVID-19 Pandemic

Doctors and researchers collaborate to create individualized management for lung cancer patients to protect them from COVID-19.

Technology in Cancer Research & Treatment
Protein Co-Expression Network-Based Profiles Revealed from Laser-Microdissected Cancerous Cells of Lung Squamous-Cell Carcinomas

Unveiling disease-related protein networks by proteomic and bioinformatic assessment of laser-microdissected cancerous cells from seven SqCCs compared with eight representative lung adenocarcinomas

Scientific Reports
Cell-Free DNA Blood Test Shows Promise as Assessment to Screen for Lung Cancer

Scientists develop a genome-wide approach to analyze cfDNA “fragmentomes” to increase sensitivity of detection of early-stage cancers.

Hematology Advisor
Construction and Validation of a Novel Nomogram to Predict the Overall Survival of Patients With Combined Small Cell Lung Cancer

Researchers construct a novel nomogram to predict the overall survival of patients with C-SCLC.

Cancer Control
Worsening Depression Cuts Survival in Lung Cancer Patients

Lung cancer patients whose symptoms of depression got worse after diagnosis died significantly earlier than those whose symptoms stayed the same or improved, a new study shows.

Medical Xpress
Clinical Significance of Serum S100A10 in Lung Cancer

Scientists investigate the clinical significance of serum S100A10 in lung cancer with a view to providing a new tumour biomarker for lung cancer.

Journal of International Medical Research
Development and Validation of Nomograms for Predicting Survival of Elderly Patients with Stage I Small-Cell Lung Cancer

Researchers attempt to build and validate a nomogram to identify risk factors affecting CSS in elderly patients with Stage I SCLC based on data derived from the SEER database.

The Landscape of m6A Regulators in Small Cell Lung Cancer: Molecular Characteristics, Immuno-oncology Features, and Clinical Relevance

Researchers highlight the importance of m6A regulators on cancer pathogenesis and shaping of the TIME, and lay a rational foundation and buttress for developing therapeutic strategies...

Molecular Cancer
Integrated Genomics Point to Immune Vulnerabilities in Pleural Mesothelioma

Researchers explored the mutational spectrum with WES in 50 subjects before extending mutation detection to all tumours with a 57-gene TC-NGS panel.

Scientific Reports
Bone Morphogenetic Protein Receptor 2 Inhibition Destabilizes Microtubules Promoting the Activation of Lysosomes and Cell Death of Lung Cancer Cells

Researchers examine whether the inhibition of BMPR2 destabilizes the microtubules in cancer cells and whether this effects survival. 

Cell Communication and Signaling
Durvalumab After Concomitant or Sequential Chemoradiation for Unresectable Stage III Non-Small Cell Lung Cancer

Researchers established a new standard for unresectable stage III NSCLC, introducing immunotherapy maintenance with the anti-PD-L1 agent durvalumab after CRT.

Frontiers in Oncology
Prediction Model for Lung Cancer in High-Risk Nodules Being Considered for Resection

This study aimed to develop a lung cancer risk prediction model for predicting the nature of the nodule in patients’ lungs and deciding whether to perform a surgical intervention.

Frontiers in Oncology
The Prediction Potential of the Pretreatment Lung Immune Prognostic Index for the Therapeutic Outcomes of Immune Checkpoint Inhibitors in Patients With Solid Cancer

Scientists performed a systematic review and meta-analysis, to investigate the significance of the LIPI score as a predictive tool in solid cancer patients receiving ICIs treatment. 

Frontiers in Oncology
Consolidation Nivolumab and Ipilimumab versus Observation in Limited-Disease Small Cell Lung Cancer After Chemo-Radiotherapy

Scientists demonstrate superiority of consolidation combination immunotherapy versus observation after chemo-radiotherapy plus PCI.

Annals of Oncology
Addition of Ramucirumab to Gemcitabine in Second-Line Treatment of Malignant Pleural Mesothelioma

Scientists find that the addition of ramucirumab to gemcitabine improved overall survival in the second-line treatment of malignant pleural mesothelioma.

The ASCO Post
Comparison of Clinical and Pathological Characteristics Between Extremely Multiple GGNs and Single GGN

Scientists aim to compare the clinical and pathological characteristics between patients undergoing surgery for extremely multiple ground-glass nodules (GGNs) and those for single GGN.

Frontiers in Oncology
Downregulated Expression of CLEC9A as Novel Biomarkers for Lung Adenocarcinoma

This study aimed to reveal the role of CLEC9A in LUAD based on bioinformatics and cellular functional experiments.

Frontiers in Oncology
Clinical Utility of Circulating Tumor Cells in the Early Detection of Lung Cancer in Patients with a Solitary Pulmonary Nodule

Researchers investigate the potential of CTCs as a biomarker for early detection of lung cancer.

Prevention, Early Detection, and Interception
The Shared Genetic Architecture Between Epidemiological and Behavioral Traits With Lung Cancer

Scientists quantify the association between genetically influenced epidemiological and behavioral traits and the risk of lung cancer. 

Scientific Reports
Immune Checkpoint Inhibitors Plus Single-Agent Chemotherapy for Advanced Non-Small-Cell Lung Cancer After Resistance to EGFR-TKI

In this study, researchers analyzed real-world outcomes of treatment with ICIs combined with platinum-free chemotherapy in patients with NSCLC after developing resistance to EGFR-TKIs.

Frontiers in Oncology
Characterization of Non–Small-Cell Lung Cancers With MET Exon 14 Skipping Alterations Detected in Tissue or Liquid

Researchers explore METex14-altered NSCLC allowing granular description of diverse alterations activating MET. 

Journal of Clinical Oncology
Several Studies Show Rovalpituzumab Tesirine Is Ineffective Against SCLC

Four independent studies demonstrate that rovalpituzumab tesirine, a first-in-class antibody-drug conjugate directed against delta-like protein 3, is not effective against small cell lung cancer.

The ASCO Post
Evaluation of the Oncogene Function of GOLPH3 and Correlated Regulatory Network in Lung Adenocarcinoma

This study examines the potential biological regulation network of GOLPH3 in lung adenocarcinoma.

Frontiers in Oncology
Randomized Phase III Trial of Prophylactic Cranial Irradiation With or Without Hippocampal Avoidance for Small-Cell Lung Cancer

The key concern using hippocampal avoidance-prophylactic cranial irradiation in patients with SCLC is the incidence of brain metastasis within the hippocampal avoidance zone.

Journal of Clinical Oncology
Lung Cancer Screening Rates Improved in 19 States Despite the COVID-19 Pandemic

A new study shows that although national lung cancer screening rates decreased in some states, 19 states experienced significant improvements in screening rates despite the COVID-19 pandemic.

The ASCO Post
Identification of Tumor Microenvironment-Related Prognostic lncRNAs in Lung Adenocarcinoma

This study aims to find reliable immune microenvironment-related lncRNA biomarkers to improve LUAD prognosis.

Frontiers in Oncology
Immune Microenvironment Signatures as Biomarkers to Predict Early Recurrence of Stage Ia-b Lung Cancer

This study aims to identify immune-related biomarkers that might predict tumor recurrence in stage Ia-b NSCLC within 40 months after curative resection.

Frontiers in Oncology
BMI May Not Be Best Obesity Indicator to Assess Risk for Lung Cancer

New research published in the Journal of Thoracic Oncology suggests the method used to calculate how obesity is measured may affect whether it is considered a risk factor for lung cancer.

Oncology Times - Latest Articles

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