Lung Cancer

Lung Cancer

Single-Cell Sequencing, an Advanced Technology in Lung Cancer Research

This review summarizes lung cancer research using SCS and their research achievements.

OncoTargets and Therapy
Severity of COVID-19 in Patients With Lung Cancer: Evidence and Challenges

This review summarizes available evidence regarding the direct and indirect impact of the COVID-19 pandemic on lung cancer care and patients.

Journal for ImmunoTherapy of Cancer
Some Patients With Lung Cancer Report Feeling Uninformed About Their Disease, Uninvolved With Their Treatment

More than 1 in 10 patients with lung cancer do not know what type of tumor they have, according to data from a 17-country study carried out by the GLCC presented at the European Lung Cancer Virtual

The ASCO Post

The Incidence and Risk Analysis of Lung Cancer Development in Patients with Chronic Obstructive Pulmonary Disease: Possible Effectiveness of Annual CT-Screening

This study examines the incidence of lung cancer and the lung cancer mortality rate in Japanese COPD patients, as well as factors that are associated with the development of lung cancer in COPD pat

Optimal Treatment Strategies for Stage I Non–Small-Cell Lung Cancer in Veterans With Pulmonary and Cardiac Comorbidities

Study investigators use use simulation modeling to assess projected outcomes associated with different management strategies of Veterans with stage I NSCLC with COPD and/or CAD.

Quantitative Assessment of CD200 and CD200R Expression in Lung Cancer

This study uses quantitative immunofluorescence to characterize the CD200/CD200R immune checkpoint in lung cancer. 

GOECP/SEOR Radiotherapy Guidelines for Small-Cell Lung Cancer

These guidelines emphasize treatment fields, radiation techniques, fractionation, concomitant treatment, and the optimal timing of Ch and radiotherapy.

RNA-Based Therapies: A Cog in the Wheel of Lung Cancer Defense

This article describes the current understanding of various aspects of RNA-based therapeutics, including modern platforms, modifications, and combinations with chemo-/immunotherapies...

Molecular Cancer
Non-Coding RNAs in Cancer Diagnosis and Therapy: Focus on Lung Cancer

This review is structured to provide an overview of non-coding RNAs in cancer biology, diagnostics, and therapeutics, focusing on lung cancer.

Tackling Drug Resistance in EGFR Exon 20 Insertion Mutant Lung Cancer

This literature reviews the current understanding of the mechanisms of resistance to these compounds, which include on-target EGFR secondary mutations, compensatory bypass pathway...

Pharmacogenomics and Personalized Medicine
Neoadjuvant Atezolizumab in Stage IB/IIIB Resectable Lung Cancer

Neoadjuvant atezolizumab is well-tolerated by patients with stage IB-IIIB lung cancer, according to the primary analysis of the Lung Cancer Mutation Consortium (LCMC) 3 study.

Oncology Times - Latest Articles
Successful Bronchial Arterial Infusion Chemotherapy Combined With Radiotherapy for an Endobronchial Metastasis After Resection of Small Cell Lung Cancer

Bronchial arterial infusion chemotherapy has been reported to be an effective treatment option for centrally located early‐stage SCC and has a favorable response rate for patients with...

Respirology Case Reports
Nivolumab and Ipilimumab as Maintenance Therapy in Extensive-Disease Small-Cell Lung Cancer

CheckMate 451, a double-blind phase III trial, evaluated nivolumab plus ipilimumab and nivolumab monotherapy as maintenance therapy following first-line chemotherapy for ED-SCLC.

Journal of Clinical Oncology
Improving Social Support to Increase QoL in Lung Cancer Patients

The purpose of this study is to analyze original papers in order to determine whether an increase in social support is important in improving QoL for lung cancer patients. 

Cancer Management and Research
Risk Factors for Brain Metastases from Non—Small-Cell Lung Cancer

This study explores the correlation between different clinical factors and secondary brain metastases in NSCLC in an attempt to identify NSCLC patient populations at...

Expression of Inflammatory Interleukins and Selected miRNAs in Non-Small Cell Lung Cancer

Study investigators examine the mRNA expression of interleukins IL-1β, IL-6, IL-17 and miR-9, miR-122 as potential useful biomarkers of NSCLC.

Scientific Reports
Deep Learning for COVID-19 Chest CT Image Analysis: A Lesson From Lung Cancer

To build a reliable deep learning model trained and tested with a larger scale dataset, the proposed model builds a public COVID-19 CT dataset, containing 1186 CT images synthesized from...

Computational and Structural Biotechnology Journal
Integrative Genomic Expression Analysis Reveals Stable Differences Between Lung Cancer and Systemic Sclerosis

Patients with systemic sclerosis show a four-fold greater risk of lung cancer than the general population. 

BMC Cancer
Clinical Outcomes of Extensive-Stage Small Cell Lung Cancer Patients Treated With Thoracic Radiotherapy at Different Times and Fractionations

The purpose of this study is to assess whether thoracic radiotherapy combined with chemotherapy shows promising anti-tumour activity in extensive-stage small cell lung cancer, and to...

Radiation Oncology
Delay to Surgical Treatment in Lung Cancer Patients and its Impact on Survival in a Video-Assisted Thoracoscopic Lobectomy Cohort

This study aims to investigate the impact patient pathways from first suspicious imaging until final surgical treatment delays have on survival of lung cancer patients. 

Scientific Reports
Predicting Recurrence in Patients With Completely Resected Lung Cancer

The integration of tumor genomics and high-risk clinicopathologic factors performs better than traditional TNM classifications when predicting recurrence after surgical resection...

Oncology Times - Latest Articles
Automated Detection of Lung Nodules and Coronary Artery Calcium Using Artificial Intelligence on Low-Dose CT Scans for Lung Cancer Screening

This study presents findings on the performance of an AI convolutional neural network prototype that automatically detects pulmonary nodules and quantifies coronary artery calcium volume...

BMC Medicine
MiRNA-200C Expression in Fanconi Anemia Pathway Functionally Deficient Lung Cancers

To evaluate downstream effectors of the FA pathway, investigators study the expression of 734 different miRNA using NanoString nCounter miRNA array in two FA defective lung cancer cells...

Scientific Reports
A 10-Year Probability Deep Neural Network Prediction Model for Lung Cancer

In this study, the NHIRDB is used to determine the diseases and symptoms associated with lung cancer, and a 10-year probability deep neural network prediction model for lung cancer is developed.

Asthma and Asthma Symptom Control in Relation to Incidence of Lung Cancer in the HUNT Study

Large prospective studies on asthma, especially asthma symptom control, as a potential risk factor for lung cancer are limited.

Scientific Reports
Current Understanding on Perioperative Management in Lung Cancer: Implications for Anesthetic Considerations

This study summarizes the effects of anesthetic management and its related substances on lung cancer.

Drug Design, Development and Therapy
Advanced Lung Cancer Inflammation Index is a Prognostic Factor of Patients With Small-Cell Lung Cancer Following Surgical Resection

This study explores the relationship between ALI and the prognosis of operable SCLC.

Cancer Management and Research
Beta-Blocker and Survival in Patients With Lung Cancer

The potential influence of beta-blocker use on overall survival in patients with lung cancer remains undetermined.

A Sonosensitiser‐Based Polymeric Nanoplatform for Chemo‐Sonodynamic Combination Therapy of Lung Cancer

The combination of sonodynamic therapy and chemotherapy has attracted attention, particularly in lung cancer treatment.

A Novel Technology to Integrate Imaging and Clinical Markers for Non-Invasive Diagnosis of Lung Cancer

This study presents a non-invasive, automated, clinical diagnostic system for early diagnosis of lung cancer that integrates imaging data from a single computed tomography scan...

Scientific Reports
Impact Analysis of miR-1253 on Lung Cancer Progression Through Targeted Regulation of ANXA3

This study investigates the effect of miR-1253 on lung cancer progression through targeted regulation of ANXA3.

Cancer Management and Research
Front Line Applications and Future Directions of Immunotherapy in Small-Cell Lung Cancer

This article reviews the use of ICIs in SCLC as well as other emerging immunotherapy strategies.

Relationship Between Nutritional Status and Quality of Life in Patients with Lung Cancer

This study assesses the relationship between nutritional status and QoL in patients with lung cancer.

Cancer Management and Research
DNA Methylation Profiles of Bronchoscopic Biopsies for the Diagnosis of Lung Cancer

This study aims at determining the value of DNA methylation analysis applied to specimens obtained by bronchoscopic biopsy for the diagnosis of lung cancer...

Clinical Epigenetics
Competing Endogenous RNAs in Lung Cancer

This study reviews the research progress in the field of non-coding and protein-coding RNAs as ceRNAs in lung cancer, and highlighted validated ceRNAs involved in biological lung cancer functions.<

Cancer Biology & Medicine
Identification of Primary and Metastatic Lung Cancer-Related lncRNAs and Potential Targeted Drugs Based on ceRNA Network

This study analyzes the competitive relationships and regulatory mechanism of the repeatedly dysregulated lncRNAs in lung cancer carcinogenesis and metastasis, and provided...

Frontiers in Oncology
A Multi-Omics-Based Serial Deep Learning Approach to Predict Clinical Outcomes of Single-Agent Anti-PD-1/PD-L1 Immunotherapy in Advanced Stage Non-Small-Cell Lung Cancer

The SimTA-based multi-omics serial deep learning provides a promising methodology for predicting response of advanced NSCLC patients to anti-PD-1/PD-L1 monotherapy.

American Journal of Translational Research
POU2F1 Induces the Immune Escape in Lung Cancer by Up-Regulating PD-L1

The aim is to research the POU2F1 related genes and mechanism during the progress of immune escape of lung cancer. 

American Journal of Translational Research
Dynamic Perfusion Digital Radiography for Predicting Pulmonary Function After Lung Cancer Resection

This study confirms whether dynamic perfusion digital radiography can be evaluated in comparison with pulmonary perfusion scintigraphy in predicting early postoperative pulmonary function...

World Journal of Surgical Oncology
Feasibility of a Multimodal Exercise, Nutrition, and Palliative Care Intervention in Advanced Lung Cancer

Study investigators assess the feasibility of a multimodal physical activity, nutrition, and palliative symptom management intervention in advanced lung cancer.

BMC Cancer
Baicalin Induces Apoptosis and Suppresses the Cell Cycle Progression of Lung Cancer Cells Through Downregulating Akt/mTOR Signaling Pathway

The therapeutic effects and molecular mechanisms of baicalin on lung cancer cell lines H1299 and H1650 are investigated.

Evaluation of the Susceptibility and Fatality of Lung Cancer Patients Towards the COVID-19 Infection

To evaluate the probable reasons behind the excessive susceptibility and fatality of lung cancer patients to COVID-19, this study targets the two most crucial agents, ACE2 and CXCL10.

Pulmonary Micro-Ecological Changes and Potential Microbial Markers in Lung Cancer Patients

This review summarizes microbiome studies of lung cancer, potential mechanisms, potential microbial markers, and the influence of the microbiome on the diagnosis and treatment of lung cancer.

Frontiers in Oncology
A Nationwide Population-Based Study of Incidence and Mortality of Lung Cancer in Idiopathic Pulmonary Fibrosis

This study aims to investigate the cumulative incidence and survival outcomes of lung cancer in idiopathic pulmonary fibrosis.

Scientific Reports
Implementation of Shared Decision Making for Lung Cancer Screening Among the Privately Insured Nonelderly

This study examines the implementation of SDM in the context of lung cancer screening among the privately insured.

Tackling Muscle Wasting & Malnutrition Among Lung Cancer Patients

There is a high risk of malnutrition, cancer cachexia, and sarcopenia among patients with advanced lung cancer.

Oncology Times - Latest Articles
Evolution of DNA Methylome From Precancerous Lesions to Invasive Lung Adenocarcinomas

Study investigators perform reduced representation bisulfite sequencing of invasive lung adenocarcinoma and its precursors, atypical adenomatous hyperplasia, adenocarcinoma...

Differentiation of Primary Lung Cancer from Solitary Lung Metastasis in Patients With Colorectal Cancer

This study aims to evaluate the CT features of solitary pulmonary nodule, which can be a non-invasive diagnostic tool to differentiate between primary lung cancer and solitary lung metastasis...

Treatment Burden Experienced by Patients With Lung Cancer

Patients’ burden from lung cancer treatment is not well researched, but this understanding can facilitate a patient-centered treatment approach.

Advances in Nanocarriers for Effective Delivery of Docetaxel in the Treatment of Lung Cancer

This review focuses on docetaxel as one of the most commonly used drugs for lung cancer treatment, the properties of the drug and the application of nanotechnology in delivering...

Risk Factors for Short-Term Lung Cancer Survival

Models for classifying less than one year survival for patients diagnosed with lung cancer which are able to identify risk factors and quantify their effect for prognosis are analyzed.

Genomic Profiling in Non-Small-Cell Lung Cancer in Young Patients

Lung cancer in young patients is an uncommon and understudied entity that harbors distinctive epidemiological, clinic-demographic, and genomic features.

Advances in Lung Cancer Driver Genes Associated With Brain Metastasis

This article reviews the relationship between lung cancer driver genes and brain metastasis, and summarizes the mechanism of driver gene-associated pathways in brain metastasis.

Frontiers in Oncology
Study Identifies Four Unique Subtypes of Small Cell Lung Cancer

Researchers develop the first comprehensive framework to classify SCLC into four unique subtypes based on gene expression and identify potential therapeutic targets for each type.

The ASCO Post
Inflammation Scores as Prognostic Biomarkers in Small Cell Lung Cancer

This study highlights a systematic review and meta-analysis investigating reported associations between inflammation scores and overall survival in SCLC.

Lung Cancer Presenting as an Acute Appendicitis

Appendiceal metastasis is a rare complication of primary lung cancer and an extremely rare cause of appendicitis.

Protein Glycopatterns in Bronchoalveolar Lavage Fluid as Novel Potential Biomarkers for Diagnosis of Lung Cancer

This study systematically investigates and assesses the alterations of protein glycopatterns in BALF and possibility as biomarkers for diagnosis of lung cancer.

Frontiers in Oncology
Progress on Pivotal Role and Application of Exosome in Lung Cancer Carcinogenesis, Diagnosis, Therapy and Prognosis

Current status of lung cancer and extensive applicability of LCCDEs are illustrated in this review.

Plausible Role of Estrogens in Pathogenesis, Progression and Therapy of Lung Cancer

This study summarizes the current knowledge on the role of estrogens in the etiopathogenesis of lung cancer, as well as biological, hormonal and genetic sex-related differences in this neoplasm.

Molecular Epidemiology of the Main Druggable Genetic Alterations in Non-Small Cell Lung Cancer

This study discusses the molecular epidemiology of the main druggable genetic alterations in non-small cell lung cancer, namely EGFR, KRAS, BRAF, MET, and HER2 mutations...

International Journal of Molecular Sciences
Current Status and Future Perspectives of Liquid Biopsy in Small Cell Lung Cancer

This study discusses the recent SCLC studies of CTCs, cfDNA and other liquid biopsy biomarkers, and discusses the future utility of liquid biopsy in the clinical management of SCLC.

Role of Omentin in Obesity Paradox in Lung Cancer

This study warrants further mechanistic studies on the role of omentin in lung cancers.

Perspectives of Family Physicians Towards Access to Lung Cancer Screening for Individuals Living With Low Income

This study seeks to understand FPs perspectives on access to lung cancer screening for individuals living with low income in order to improve equity in access to LCS.

An Update in Clinical Utilization of Photodynamic Therapy for Lung Cancer

Despite the clinical success reported, photodynamic therapy is still currently underutilized to treat lung cancer and other tumors.

Comprehensive Perspective for Lung Cancer Characterisation Based on AI Solutions Using CT Images

This study explores the need to combine the information from tumors with other lung structures for the next generation of computer-aided decision, which could create...

Current Lung Cancer Screening Guidelines May Miss High-Risk Population: A Real-World Study

Despite much research published on lung cancer screening, China has had no large-scale study on the missed diagnosis of lung cancer in a health examination population.

BMC Cancer
Duration of Lead Time in Screening for Lung Cancer

Screening for lung cancer has used chest radiography, low dose computed tomography and sputum cytology.

Bisphosphonates and Risk of Lung Cancer

This study conducts a meta-analysis to figure out the relationship between bisphosphonates and lung cancer.

Comparative Analysis of Target Gene Exon Sequencing by Cognitive Technology Using a Next Generation Sequencing Platform in Patients with Lung Cancer

Next generation sequencing technology is an increasingly important clinical tool for therapeutic decision-making.

Infections and Immunotherapy in Lung Cancer: A Bad Relationship?

This analysis aims to review the current evidence in order to clarify the complex correlation between infections and lung cancer.

International Journal of Molecular Sciences
Immunogenomic Gene Signature of Cell-Death Associated Genes with Prognostic Implications in Lung Cancer

In this study, variations in the expression of genes involved in cell death pathways and resulting infiltration of immune cells are explored in lung adenocarcinoma.

The Lung Microbiome: A Central Mediator of Host Inflammation and Metabolism in Lung Cancer Patients?

This article discusses the links between the lung microbiota and cancer, with particular focus on immune responses, metabolism and strategies to target the lung microbiome for cancer prevention.

Volatile Organic Compounds in Exhaled Breath as Fingerprints of Lung Cancer, Asthma and COPD

Lung cancer, chronic obstructive pulmonary disease and asthma are inflammatory diseases that have risen worldwide, posing a major public health issue...

Sex Difference and Smoking Effect of Lung Cancer Incidence in Asian Population

This study analyzes the sex difference in the effect of smoking exposure on lung cancer in terms of absolute and relative risks despite the increasing lung cancer...

A Population-Based Analysis of Spirometry Use and the Prevalence of Chronic Obstructive Pulmonary Disease in Lung Cancer

This study assesses the diagnosis of COPD with lung cancer in a large public healthcare system.

BMC Cancer
Connexins in Lung Cancer and Brain Metastasis

This review discusses junctional or non-junctional hemichannel studies in lung cancer development and brain metastasis, highlighting important unanswered questions...

Frontiers in Oncology
Durvalumab and Tremelimumab With or Without Stereotactic Body Radiation Therapy in Relapsed Small Cell Lung Cancer

Study investigators conducted this signal-finding study to assess the efficacy of ICB with or without radiation in relapsed SCLC.

Predictive value of tumor mutation burden with targeted next-generation sequencing in immunocheckpoint inhibitors for non-small cell lung cancer

This study evaluates the clinical predictive value of tumor mutation burden for immune checkpoint inhibitor therapy in patients with NSCLC.

Overexpression of CENPF is Associated With Progression and Poor Prognosis of Lung Adenocarcinoma

This study explored the role of Centromere protein F in lung adenocarcinoma. 

Acquired Resistance to PD-1/PD-L1 Blockade in Lung Cancer: Mechanisms and Patterns of Failure

This review discusses mechanisms and clinical outcomes of acquired resistance in NSCLCs and explores future directions for research to understand and address this important question.

GINS2 attenuates the development of lung cancer by inhibiting the STAT signaling pathway

This study's results suggest that GINS2 inhibits the proliferation of lung cancer cells by inhibiting the STAT signaling pathway, which may be a potential biomarker for the diagnosis or prognosis..

Cutaneous Metastasis as the First Presentation of Non-Small-Cell Lung Cancer with a BRAF Mutation

Distant metastases at the time of non-small-cell lung cancer presentation are a frequent clinical problem.

Three metachronous primary lung cancers in a chronic smoker

This report involves a rare case of triple metachronous lung cancer and review of literature of patients with triple metachronous cancers.

Clinical significance and prognostic value of Porphyromonas gingivalis infection in lung cancer

This study analyzed the correlation between P. gingivalis infection and clinicopathological features and survival prognosis of patients with lung cancer.

Translational Oncology
Response evaluation after immunotherapy in NSCLC

The present study aimed to evaluate the role of early FDG PET/CT in non-small cell lung cancer patients undergoing immune checkpoint inhibitor treatment.

Microbiome Dysbiosis in Lung Cancer: From Composition to Therapy

This study summarized the recent progresses about microbiome in lung cancer and further discussed the role of microbial communities in promoting lung cancer progression...

Evolution of Systemic Treatment Uptake and Survival in Advanced Non-Small Cell Lung Cancer

Non-small cell lung cancer commonly presents at advanced stage.

Current Oncology
Germline variation networks in the PI3K/AKT pathway corresponding to familial high-incidence lung cancer pedigrees

Investigators conducted a study with whole-exome sequencing of pedigrees with familial lung cancer to analyze the potential genetic susceptibility.

BMC Cancer
Tumor Differentiation and EGFR Mutation Associated with Disease-Free Survival in Stage IA Lung Adenocarcinoma Patients with Curative Surgery

This study aimed to predict stage IA lung adenocarcinoma patients who underwent radical resection with a high risk of recurrence or metastasis.

Clinically relevant prognostic and predictive markers for immune-checkpoint-inhibitor (ICI) therapy in non-small cell lung cancer (NSCLC)

ICI either alone or in combination with chemotherapy have expanded our choice of agents for the palliative treatment of non-small cell lung cancer patients.

BMC Cancer
Multi-Window CT Based Radiological Traits for Improving Early Detection in Lung Cancer Screening

This study evaluated the ability of radiological semantic traits assessed on multi-window computed tomography to predict lung cancer risk.

Evaluation of the association between vitamin D and lung cancer skin metastasis

This study aims to investigate the association between vitamin D and lung cancer skin metastasis.

EZH2 inhibitors reverse resistance to gefitinib in primary EGFR wild-type lung cancer cells

This study aimed to investigate whether the EZH2 inhibitors, GSK343 and DZNep when combined with gefitinib can reverse EGFR-TKIs resistance in EGFR wild-type NSCLC cells.

BMC Cancer
Lung cancer screening by low-dose computed tomography: a cost-effectiveness analysis of alternative programmes in the UK using a newly developed natural history-based economic model

This systematic review of economic evaluations for lung cancer identified no economic models of the UK setting based on disease natural history.

Association of Mutation Profiles with Postoperative Survival in Patients with Non–Small Cell Lung Cancer

This study comprehensively and synthetically analyzed mutations in lung cancer based on the next generation sequencing data of lung tumors surgically removed...

Increased PARP Activity and DNA Damage in NSCLC Patients: The Influence of COPD

This study aimed to assess PARP-1 and PARP-2 expression and activity and DNA damage in tumors and non-tumor lungs from patients with/without COPD.

Continuous Versus 1-Year Fixed-Duration Nivolumab in Previously Treated Advanced Non–Small-Cell Lung Cancer: CheckMate 153

This study presents an exploratory analysis of CheckMate 153, a largely community-based phase IIIb/IV study, to evaluate the impact of 1-year fixed-duration...

Journal of Clinical Oncology
Approach to Resectable N1 Non-Small Cell Lung Cancer: An Analysis of the National Cancer Database

In patients with clinical N1 disease, minimally invasive surgery has potentially better perioperative outcome compared to open thoracotomy. 

Journal of Surgical Research
Blood cadmium levels as a marker for early lung cancer detection.

This study assessed whether blood cadmium levels were associated with incident lung cancer and could be used in the context of a screening program for early-stage lung cancer.

Journal of Trace Elements in Medicine and Biology
Long Noncoding RNA PTPRG Antisense RNA 1 Reduces Radiosensitivity of Nonsmall Cell Lung Cancer Cells Via Regulating MiR-200c-3p/TCF4

This is an in-depth investigation into the underlying mechanism of radioresistance in NSCLC cells is highly desirable to improve survival rate and help to determine optimized treatment for NSCLC.

MicroRNA-126: A new and promising player in lung cancer

In the present review, the current knowledge of the role of miR-126 in lung cancer growth, metastasis, diagnosis and prognosis as well as therapy was summarized...

Defining timeliness in care for patients with lung cancer: protocol for a scoping review

The aim of this scoping review is to identify and critically synthesise the operational definitions and terminologies used to describe the timely initiation of care and consequent treatments...

BMJ Open
Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity

This study performed whole exome sequencing, RNA sequencing, methylation microarray, and immunohistochemistry on 8 pairs of NSCLC primary tumors and matched distant metastases.

Genome Biology
9G TestTM Cancer/Lung: A Desirable Companion to LDCT for Lung Cancer Screening

The present study evaluated the applicability of 9G testTM Cancer/Lung test to detect stage 0~IV lung cancer.

Licochalcone A inhibits interferon-gamma-induced programmed death-ligand 1 in lung cancer cells.

The aim of this study is to further clarify the effect and the mechanism of LCA on inhibiting IFN-γ-induced PD-L1 in lung cancer cells.

Combination therapy: Future directions of immunotherapy in small cell lung cancer.

This review focused on the completed and ongoing trials of the combination therapy for immunotherapy of SCLC to find out the rational combination strategies which may improve the outcomes for SCLC.

Translational Oncology
Functional proteomic analysis reveals that fungal immunomodulatory protein reduced expressions of heat shock proteins correlates to apoptosis in lung cancer cells.

This study determines the changes in the proteomic profile for tumor lesions of LLC1 cell-bearing mouse received with LZ-8 and the potential mechanism for FIPs in anti-lung cancer cells.

Stress-induced upregulation of TNFSF4 in cancer-associated fibroblast facilitates chemoresistance of lung adenocarcinoma through inhibiting apoptosis of tumor cells

The present study explored transcriptome changes in lung fibroblasts under chemotherapeutics, irradiation, and hypoxia, which were induced by chemotherapy, radiotherapy, and...

Cancer Letters
DFD-Net: lung cancer detection from denoised CT scan image using deep learning

The availability of pulmonary nodules in CT scan image of lung does not completely specify cancer.

Frontiers of Computer Science in China
Risk Prediction Model Versus United States Preventive Services Task Force Lung Cancer Screening Eligibility Criteria: Reducing Race Disparities

This study evaluated whether the PLCOm2012 risk prediction model more effectively selects African American ever-smokers for screening.

Anti-epidermal growth factor vaccine antibodies increase the antitumor activity of kinase inhibitors in ALK and RET rearranged lung cancer cells

This study investigated the effects of anti-EGF antibodies generated by vaccination, TKIs and combinations in EML4-ALK and CCDC6-RET NSCLC cell lines.

Translational Oncology
The high expression of MTH1 and NUDT5 promotes tumor metastasis and indicates a poor prognosis in patients with non-small-cell lung cancer.

The present study reported that MTH1 and NUDT5 were upregulated in NSCLC cell lines and tissues, and higher levels of MTH1 or NUDT5 were associated with tumor metastasis and...

Biochimica et Biophysica Acta
Synergistic co-loading of vincristine improved chemotherapeutic potential of pegylated liposomal doxorubicin against triple negative breast cancer and non-small cell lung cancer.

The current work aims to explore the biological characteristics of vincristine synergistic co-loading into pegylated liposomal doxorubicin in non-indicated modalities of NSCLC and TNBC.

Nanomedicine: Nanotechnology, Biology and Medicine
Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer

Cisplatin is the first-in-class drug for advanced and non-targetable NSCLC.

AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.

In this study, CRISPR/Cas9-mediated loss-of-function screen revealed that PPP2R2A downregulation suppressed cell growth in NSCLC cells.

Biochimica et Biophysica Acta
Mechanisms of Fritillariae Thunbergii Flos in lung cancer treatment from a systems pharmacology perspective.

Fritillariae Thunbergii Flos included in the Chinese Pharmacopoeia (1977 Edition) is a Chinese medicinal herb traditionally used to treat bronchitis.

Journal of Ethnopharmacology
Rova-T enhances the anti-tumor activity of anti-PD1 in a murine model of small cell lung cancer with endogenous Dll3 expression.

Rovalpituzumab tesirine offers a targeted therapy for ~85% of SCLC patients whose tumors express DLL3, but clinical dosing is limited due to off-target toxicities.

Translational Oncology
Interprovincial trade driven relocation of polycyclic aromatic hydrocarbons and lung cancer risk in China

This study assesses the PAHs environmental contamination and associated lung cancer risk attributable to interprovincial trade in goods and services in China.

Journal of Cleaner Production
Sericin microparticles enveloped with metal-organic networks as a pulmonary targeting delivery system for intra-tracheally treating metastatic lung cancer.

Chemotherapy is one of the major approaches for the treatment of metastatic lung cancer. However, systemic chemotherapy is limited by poor therapeutic efficiency...

Bioactive Materials
Usefulness of Rapid Desensitization Therapy for Severe Rash Caused by Molecularly Targeted Drugs Used in the Treatment of Non-small-cell Lung Cancer.

Molecular-targeted drugs, such as epidermal growth factor receptor tyrosine kinase inhibitors and anaplastic lymphoma kinase inhibitors, are used to treat NSCLC. 

Internal Medicine
Targeted inhibition of c-MET by podophyllotoxin promotes caspase-dependent apoptosis and suppresses cell growth in gefitinib-resistant non-small cell lung cancer cells.

In the present study, the authors investigated the underlying mechanisms of PPT-induced apoptosis in NSCLC cells and found that the inhibition of c-MET kinase activity...

A Case of Anti-CRMP5 Paraneoplastic Neurological Syndrome Induced by Atezolizumab for Small Cell Lung Cancer.

This case report discusses a 76-year-old man who developed irritability and forgetfulness 5 months after the introduction of atezolizumab for the treatment of small cell lung cancer.

Internal Medicine
Pre-treatment CT imaging in stage IIIA lung cancer: Can we predict local recurrence after definitive chemoradiotherapy?

The aim of this study was to delineate computed tomography features of stage IIIA non-small cell lung cancers on pre-treatment staging studies and identify features that could...

Clinical Imaging
Relationship between Patient Characteristics and the Timing of Provision of Explanation about DNAR to Patients with Advanced Lung Cancer.

The aim of the present study was to analyze the relationship between the patient characteristics and the timing of provision of an explanation about “Do Not Attempt Resuscitation”...

Internal Medicine
Surface plasmon resonance signal enhancement based on erlotinib loaded magnetic nanoparticles for evaluation of its interaction with human lung cancer cells

In the present study, signal enhancement of erlotinib conjugated magnetic nanoparticles compared to erlotinib was evaluated...

Optics and Laser Technology
Fucoxanthin extracted from Laminaria Japonica inhibits metastasis and enhances the sensitivity of lung cancer to Gefitinib.

The aim of this study was to demonstrate the effects of Fucoxanthin, a major active component extracted from Laminaria japonica on metastasis and Gefitinib sensitivity in...

Journal of Ethnopharmacology
Targeted Delivery of Quercetin by Nanoparticles Based on Chitosan Sensitizing Paclitaxel-Resistant Lung Cancer Cells to Paclitaxel

This study explores whether QUE could reverse the resistance of NSCLC to paclitaxel-based therapy.

Materials Science and Engineering: C
A k-NN Method for Lung Cancer Prognosis with the Use of a Genetic Algorithm for Feature Selection

In this paper, a k-Nearest-Neighbors technique, for which a genetic algorithm is applied for the efficient feature selection to reduce the dataset dimensions and enhance the classifier pace...

Expert Systems With Applications
Polydopamine nanoparticles-assisted impedimetric sensor towards label-free lung cancer cell detection

Herein, this study demonstrated the first evaluation of the PDA NPs for the electrochemical determination of lung cancer cells.

Materials Science and Engineering: C
Differential expression profiling of transcripts of IDH1, CEA, Cyfra21-1, and TPA in stage IIIa non-small cell lung cancer (NSCLC) of smokers and non-smokers cases with air quality index

The aim of the study is to compare chronic smokers and non-smokers living in areas with air quality categorized as poor or moderate.

Artesunate exhibits synergistic anti-cancer effects with cisplatin on lung cancer A549 cells by inhibiting MAPK pathway.

This study was aimed to explore the anti-cancer activity of ART in combination with CIS on A549 cells.

Complementary and integrative medicine mention and recommendations: A systematic review and quality assessment of lung cancer clinical practice guidelines.

The purpose of this study was to identify the quantity and assess the quality of CIM recommendations in clinical practice guidelines (CPGs) for the treatment and/or management of lung cancer.

Integrative medicine research
The More, The Better?
ASCO: Journal of Clinical Oncology: Table of Contents
Hybrid Screening Model Proves Beneficial for Lung Cancer Patient Outcomes
Journal of Clinical Pathways
Volume-Based Care Regionalization: Pitfalls and Challenges
ASCO: Journal of Clinical Oncology: Table of Contents
RET Inhibitor Selpercatinib Achieves Durable Responses in Lung Cancer
Oncology Times - Latest Articles
Even 'Light' Smoking Ups Lung Cancer Risk
MedPage Today
Decreases in Lung Cancer Deaths May Be Due to Advances in Treatment
MedPage Today
BMS' Opdivo Garners Positive Draft Recommendation From UK's NICE in Second-Line NSCLC
Precision Oncology News
Precision Therapy in Lung Cancer
Oncology Times - Latest Articles
Second Liquid Biopsy OK'd for Tumor Profiling in All Solid Cancers
MedPage Today
FDA Approves Pralsetinib for Lung Cancer With RET Gene Fusions
Oncology Nursing Society
Selective MET Inhibitor Tepotinib in Patients With Advanced NSCLC and MET Exon 14–Skipping Mutation
The ASCO Post
Research Shows ‘Social Smoking’ Raises Risk of Death From Lung Disease and Lung Cancer
The ASCO Post
Pralsetinib: Second Drug for RET+ NSCLC Approved in US
UK's NICE Backs Tagrisso for First-, Second-Line EGFR-Positive Lung Cancer
Precision Oncology News
FDA Approves Gavreto for Treatment of RET-Positive, Metastatic NSCLC
Clinical Oncology News
Libtayo First-line Treatment Prolongs Survival in Advanced NSCLC, Early Trial Data Show
Immuno-Oncology News
First-line Keytruda Doubles 5-Year Survival in Certain Lung Cancer Patients, Data Show
Immuno-Oncology News
Barriers to Guideline-Concordant Treatment for Lung Cancer
Journal of Clinical Pathways

source list reference