Pediatric Oncology

Pediatric Oncology

Incidence of Suicide Among Adolescent and Young Adult Cancer Patients

As the survival rates of cancer patients continue to increase, most cancer patients now die of non-cancer causes, this study characterizes suicide mortality among AYA patients in the US...

Cancer Cell International
Extracorporeal Photopheresis in Pediatric Chronic Graft vs Host Disease

ECP is a safe treatment approach for kids who have steroid-refractory cGVHD, while enabling high response rates but with further immunosuppressive treatment required for some patients.

Hematology Advisor
Characteristics of Genomically Targeted Single-Patient Use Requests for Pediatric Cancers

Scientists analyzed characteristics of genomically targeted single-patient use requests for investigational agents for the treatment of pediatric cancers.

The ASCO Post

Effects of Immersive Virtual Reality for Preventing and Managing Anxiety, Nausea and Vomiting Among Pediatric Cancer Patients Receiving Their First Chemotherapy

This exploratory trial aims to assess the feasibility of IVR as a relaxation & distraction intervention for reducing anxiety and CINV patients receiving their first chemotherapy.

SARS-CoV-2 in Children with Cancer or Following Haematopoietic Stem Cell Transplant

Research describes the severity and outcomes of SARS-COV-2 in children with cancer or following HSCT and identifies factors associated with severe disease.

European Journal of Cancer
A Systematic Analysis of Genetic Interactions and Their Underlying Biology in Childhood Cancer

Scientists present a robust pipeline that implements two statistical tests to detect with high confidence significantly co-occurring and mutually exclusive gene pairs.

Communications Biology
Factors Associated With Risk of Hearing Loss in Pediatric Patients Receiving Radiation and Chemotherapy

This study explores factors associated with an increased risk of hearing loss in pediatric patients receiving radiation therapy and chemotherapy for central nervous system and head and neck tumors.

The ASCO Post
Researchers ‘Extraordinarily Optimistic’ About Potential of CAR-T for Pediatric Brain Cancer

Scientists explore strategies to provide CAR T-cell therapy to treat advanced and high-risk brain and CNS tumors among younger patients.

Comparison of the Blood, Bone Marrow, and Cerebrospinal Fluid Metabolomes in Children with B-Cell Acute Lymphoblastic Leukemia

Scientists aim to create a resource that will accelerate ALL research by facilitating translation of findings from bone marrow and CSF.

Scientific Reports
A Supervised Exercise Intervention During Cancer Treatment for Adolescents and Young Adults—FiGHTING F!T

Scientists determine whether a 10-week individualised exercise intervention is associated with a reduction in the decline of physical fitness (V02peak) experienced by AYAs during cancer treatment..

DexaDays-2, Hydrocortisone for Treatment of Dexamethasone-Induced Neurobehavioral Side Effects in Pediatric Leukemia Patients

Researchers aim to replicate the NTR3280 trial results in a targeted larger sample before further implementing this intervention into standard of care.

BMC Pediatrics
Children With Cancer More Likely to Have Severe COVID-19 Illness

Data suggests that children with cancer who contracted COVID-19 developed more serious infections and had a greater likelihood of hospitalization or death than the general pediatric population.

Irinotecan Plus Doxorubicin Hydrochloride Liposomes for Relapsed or Refractory Wilms Tumor

Scientists retrospectively analyzed the efficacy and toxicity of the AI regimen in 16 patients with relapsed or refractory WT from July 2018 to September 2020.

Frontiers in Oncology
Effect of Concurrent Focal 22q11.22 Deletions and IKZF1 Alterations on Outcomes in Pediatric Patients With B-Cell ALL

Mangum et al find that focal deletions in chromosome 22q11.22 are associated with poor outcomes in pediatric patients with B-cell ALL with IKZF1 alterations.

The ASCO Post
Genetic Variant Linked to Hearing Loss in Children Treated With Chemotherapy

With significant advances in pediatric cancer care in recent decades, the 5-year survival rate for childhood cancer is now almost 80 percent.

Oncology Times - Latest Articles
Genetic Testing Options for Children With Rhabdomyosarcoma

In children with rhabdomyosarcoma, the presence of mutations in several genes, including TP53, MYOD1, and CDKN2A, appears to be associated with a more aggressive form...

Oncology Times - Latest Articles
Three-Platform Sequencing Provides Detailed Picture of Pediatric Cancers

A 3-platform sequencing approach allowed for identification and characterization of genetic drivers across a wide spectrum of pediatric cancers, according to a study published in Cancer Discovery.<

Cancer Therapy Advisor
Disparities Observed in Follow-up Care Among Young Adult Childhood Cancer Survivors

A research team examined gaps and disparities in lifelong follow-up among childhood cancer survivors, including taking a closer look at long-term follow-up care plans, specifically for...

The ASCO Post
Carboplatin Intensification for the Treatment of Pediatric High-Risk Medulloblastoma

In a COG phase III trial reported in JAMA Oncology, investigators found the addition of carboplatin to RT in pediatric patients with newly diagnosed high-risk medulloblastoma improved EFS...

The ASCO Post
More Children With High-Risk Brain Cancer Now Surviving

A study that used molecular testing to distinguish between subtypes of medulloblastoma has shown a significant improvement in survival for children with high-risk disease who underwent treatment...

HER2-Specific CAR T-Cell Trial Addresses Pediatric Brain and Spinal Cord Tumors

The phase I BrainChild-01 trial is assessing the safety and efficacy of delivering repetitive doses of T cells into the brain or the cerebrospinal fluid of children and young adults with R/R tumors

The ASCO Post
Calaspargase Pegol vs Pegaspargase in Pediatric Acute Lymphoblastic Leukemia

Vrooman et al find that the novel pegylated asparaginase formulation calaspargase pegol given every 3 weeks is associated with similar serum asparaginase activity nadir values, survival outcomes...

The ASCO Post
Pediatric Treatment Options for Average-Risk Medulloblastoma

A national study suggests that children with average-risk medulloblastoma can receive a radiation boost to a smaller volume of the brain at the end of a 6-week course of radiation treatment and...<

Oncology Times - Latest Articles
Effects of FOXR2 Expression in Neuroblastoma

Schmitt-Hoffner et al find that FOXR2 expression is associated with poorer survival in neuroblastoma, identifying a subgroup of patients in addition to those with MYCN-amplified tumors...

The ASCO Post
Hypomethylating Agents in Children With Relapsed/Refractory AML

Hypomethylating agents also can serve as a bridge to transplant for children and young adults with relapsed or refractory acute myeloid leukemia.

Maternal and Perinatal Factors are Associated With Risk of Pediatric Central Nervous System Tumors and Poorer Survival After Diagnosis

Study investigators examine the association between these early-life factors, risk, and survival of pediatric CNS tumors, using data from one of the world’s largest and most diverse cancer...

Scientific Reports
Survival Benefit for Individuals With Constitutional Mismatch Repair Deficiency Undergoing Surveillance

Constitutional mismatch repair deficiency syndrome is a lethal cancer predisposition syndrome characterized by early-onset synchronous and metachronous multiorgan tumors.

Journal of Clinical Oncology
Pediatric Cancer Survivors at Risk for Opioid Misuse

Survivors of childhood cancers are at increased risk for prescription opioid misuse compared with their peers, a review of a claims database revealed.

Expert Panel–Endorsed Quality Measures for End-of-Life Care for Children With Cancer

There is currently no consensus on what quality end-of-life care for children with cancer looks like, or how to measure and deliver it; however, investigators recently assembled an expert panel...<

The ASCO Post
Heritability Genes Identified in Childhood Neuroblastoma

An important finding is that the heritability of pathogenic or likely pathogenic germline variants accounts for about 16% of neuroblastomas, whereas previous estimates were less than 10%.

The ASCO Post
Integration of Brentuximab Vedotin Into Front-Line Treatment for Pediatric Patients With High-Risk Hodgkin Lymphoma

Metzger et al finds that the integration of brentuximab vedotin into front-line treatment of pediatric patients with high-risk classical Hodgkin lymphoma results in avoidance of RT in many patients

The ASCO Post
Diet and Exercise Intervention May Increase Efficacy of Chemotherapy in Pediatric Patients With Leukemia

Research published by Orgel et al shows that restricting calories, reducing fat and sugar intake, and increasing physical activity may boost the effectiveness of chemotherapy for older children and

The ASCO Post
Safety and Family Satisfaction of a Home-Delivered Chemotherapy Program for Children With Cancer

Home chemotherapy programs for children with cancer are safe and feasible, and their impact on the quality of life has been reported in different countries.

Italian Journal of Pediatrics

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