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Sarcoma

Sarcoma

Here, we use a retrospective cohort of sarcoma patients, treated with neoadjuvant radiotherapy, and TCGA data.

OncoImmunology
05/09/2022

In this analysis, pooled PRO data are reported from patients with advanced or metastatic soft tissue sarcoma enrolled to the ANNOUNCE phase III trial of doxorubicin-based therapy.

Rare Tumors
05/05/2022

This study aimed to characterize patient experiences of symptoms and impacts of mSS and evaluate the content validity and relevance of the novel EORTC IL31 Disease Symptoms...

Journal of Patient-Reported Outcomes
05/04/2022

This retrospective study of 19 cases of pathologically diagnosed angiosarcoma before treatment explored the relationship among the clinical characteristics, laboratory examinations...

Quantitative Imaging in Medicine and Surgery
05/05/2022

We analyzed gene expression and survival data downloaded from the GEO data using a combination of bioinformatics and laboratory validation to determine the role of m6A-related genes in Ewing’s sarc

Scientific Reports
04/29/2022

We demonstrate that in ES, tumor hypoxia selectively exacerbates bone metastasis.

Nature Communications
04/28/2022

Here, we aimed to identify the TC transcriptional targets and signaling mechanisms that underlie EHE tumorigenesis.

AACR
04/20/2022

These findings demonstrate the translational potential of targeting redox homeostasis in ME1 null cancers, and establish the preclinical rational for a phase 1 trial of ACXT-3102...

AACR
04/14/2022

Patients with osteosarcoma at axial sites have an increased risk for local recurrence after surgery relative to peers with osteosarcoma at nonproximal limb sites...

Cancer Therapy Advisor
04/14/2022

This study aimed to explore the prognostic factors for first local recurrent retroperitoneal soft tissue sarcoma (FLR-RPS) and construct predictive nomograms in the Asian population.

Frontiers in Oncology
04/11/2022

In the phase III TAPPAS trial reported in JAMA Oncology, Jones et al found that the addition of carotuximab to pazopanib did not improve progression-free survival in patients...

The ASCO Post
04/07/2022

We evaluated the efficacy of two tetrapeptidic doxo prodrugs (PhAc-ALGP-Dox or CBR-049 and CBR-050) that are locally activated by enzymes expressed in the tumor environment...

Biomedicines
04/06/2022

The study’s findings indicate that the combination of pazopanib plus carotuximab is not superior to pazopanib alone in treating patients with advanced angiosarcoma.

JAMA Oncology
03/31/2022

In this study, we aimed to pooled-analyze the efficacy and safety of the combination of irinotecan and temozolomide in treating patients with relapsed Ewing sarcoma.

BMC Cancer
03/31/2022

Delyon et al found that pembrolizumab produced a high response rate in patients with classic or endemic Kaposi sarcoma with progressive cutaneous extension requiring systemic treatment.

The ASCO Post
03/30/2022

Researchers have published an analysis of strategies for treating retroperitoneal soft-tissue sarcoma, which has historically been understudied due to its rarity. 

The ASCO Post
03/21/2022

Given these outstanding questions we undertook to evaluate patients with advanced sarcoma who were treated with PD-1 blockade at our institution under the auspices of clinical trials. 

Clinical Cancer Research
03/03/2022

Investigators analyzed the clinical data of patients with advanced soft tissue sarcoma who were treated with nab-paclitaxel plus a PD-1 inhibitor to provide...

BMC Cancer
01/12/2022

This study aimed to construct 2 nomograms to predict the risk of lung metastases and overall survival of soft tissue sarcoma patients with lung metastases.

Technology in Cancer Research & Treatment
01/10/2022

Treatment of LA-STS with the radio-enhancer NBTXR3 plus RT did not negatively impact quality of life or long-term morbidity, according to results of the phase 2/3 ACT.IN.SARC trial...

Cancer Therapy Advisor
11/23/2021

Researchers conducted a pooled analysis to comprehensively compare the efficacy and tolerability between AI and ADM in patients with previously untreated ASTS.

Frontiers in Oncology
11/22/2021

This research sought to understand the type and thresholds of clinical evidence required for experts to adopt hypofractionated RT as a standard-of-care option for patients with STS.

Hindawi
10/26/2021

The purpose of this study was to identify novel biomarkers for the prognosis of Ewing's sarcoma based on bioinformatics analysis.

BioMed Research International
10/06/2021

Investigators hypothesized that administration of potent prophylactic anti-emetics and growth factors with dacarbazine would markedly reduce the proportion of patients who experience...

Rare Tumors
10/08/2021

The discovery of biomarker is expected to be the direction of targeted therapy, providing a new direction for the precise treatment of RMS.

Medicine
10/01/2021

This study provided a tractable strategy to therapeutically exploit oncogene overdose in Ewing sarcoma and potentially other fusion-TF-driven cancers.

Cancer Cell
09/13/2021

Investigators determine the recommended phase 2 dose and antitumour activity of lenvatinib with etoposide plus ifosfamide in patients with refractory or relapsed osteosarcoma.

The Lancet Oncology
09/01/2021

This study's purpose is to evaluate the clinical outcomes of the frozen autograft reconstruction focusing on skeletally mature adolescents and young adults ranging from 15 to 39 years of age.

Scientific Reports
08/27/2021

Young adults with extremity soft tissue sarcoma were more likely to receive chemotherapy and less likely to receive radiation compared with their older counterparts.

Cancer Therapy Advisor
08/30/2021

Recommendations outline optimal radiation dosing, techniques, and treatment planning for patients with localized, operable STS of the trunk and extremities, with a focus on...

Oncology Times - Latest Articles
08/20/2021

Study investigators find that the addition of the heterologous prime-boost vaccination regimen CMB305 to atezolizumab did not improve survival outcomes in patients with STS expressing...

The ASCO Post
07/21/2021

This study explores the relationship between ultrasound features and Ki-67 labeling index of soft tissue sarcoma.

Frontiers in Oncology
06/28/2021

While large-scale genomic and epigenomic profiling of soft tissue sarcomas have been undertaken, proteomic analysis has thus far been limited.

Journal of Proteomics
06/15/2021

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