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Genome Biology

Genome Biology
Comprehensive Integrative Profiling of Upper Tract Urothelial Carcinomas

Crosstalk between genetic, epigenetic, and immune alterations in upper tract urothelial carcinomas and their role in shaping muscle invasiveness and patient outcome are poorly understood.

Genome Biology
01/04/2021
Aberrant Splicing Isoforms Detected by Full-Length Transcriptome Sequencing as Transcripts of Potential Neoantigens in Non-Small Cell Lung Cancer

This study uses a long-read sequencer to construct a comprehensive catalog of aberrant splicing isoforms in non-small-cell lung cancers...

Genome Biology
01/04/2021
Multiomics profiling of primary lung cancers and distant metastases reveals immunosuppression as a common characteristic of tumor cells with metastatic plasticity

This study performed whole exome sequencing, RNA sequencing, methylation microarray, and immunohistochemistry on 8 pairs of NSCLC primary tumors and matched distant metastases.

Genome Biology
11/04/2020
Distinct epigenetic features of tumor-reactive CD8 T cells in colorectal cancer patients revealed by genome-wide DNA methylation analysis

Tumor-reactive CD8 tumor-infiltrating lymphocytes (TILs) represent a subtype of T cells that can recognize and destroy tumor specifically.

Genome Biology
12/01/2020
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