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International Journal of Molecular Sciences

International Journal of Molecular Sciences
SOD2 Enhancement by Long-Term Inhibition of the PI3K Pathway Confers Multi-Drug Resistance and Enhanced Tumor-Initiating Features in Head and Neck Cancer

Researchers developed PII3K inhibitor resistant cancer cells by prolonged culturing of cell lines with BEZ235, a dual PI3K and mTOR inhibitor.

International Journal of Molecular Sciences
10/19/2021
The Hedgehog-GLI Pathway Regulates MEK5-ERK5 Expression and Activation in Melanoma Cells

Researchers find ERK5 is required for Hedgehog-GLI-dependent melanoma cell proliferation, and the combination of GLI and ERK5 inhibitors is more effective than single treatments...

International Journal of Molecular Sciences
10/19/2021
Identification of Tumor Antigens in Ovarian Cancers Using Local and Circulating Tumor-Specific Antibodies

Scientists use antibodies produced locally in tumor-draining lymph nodes (ASC probes) of individual ovarian cancer patients to screen two separate protein microarray platforms...

International Journal of Molecular Sciences
10/18/2021
Expression Profiles of ASIC1/2 and TRPV1/4 in Common Skin Tumors

Study investigators examine the expression profiles of ASIC1, ASIC2, TRPV1 and TRPV4 in malignant melanoma, squamous cell carcinoma, basal cell carcinoma and in nevus cell nevi. 

International Journal of Molecular Sciences
06/02/2021
Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors

Study investigators determine the sensitivity of four patient-derived cSCC cell lines to isoform-specific PI3K inhibitors to start investigating their potential therapeutic value in cSCC.

International Journal of Molecular Sciences
03/30/2021
Immunological Prognostic Factors in Multiple Myeloma

The authors focus on characterizing the components of the immune system that are of prognostic value in MM patients, in order to facilitate the development of...

International Journal of Molecular Sciences
03/30/2021
PI3K Inhibitors in Cancer: Clinical Implications and Adverse Effects

This review focuses on the current landscape of various PI3K inhibitors either as monotherapy or in combination therapies and the treatment outcomes involved in various phases of clinical trials in

International Journal of Molecular Sciences
03/27/2021
Meibomian Gland Dysfunction in Ocular Graft vs. Host Disease: A Need for Pre-Clinal Models and Deeper Insights

Herein, the current state of the etiology and, pathophysiology of oGvHD based on existing pre-clinical models are reviewed.

International Journal of Molecular Sciences
03/29/2021
The Interactome Between Metabolism and Gene Mutations in Myeloid Malignancies

The study of metabolic deregulation in myeloid malignancies has led to the investigation of metabolic-targeted therapies considering that cells undergoing leukemic transformation...

International Journal of Molecular Sciences
03/19/2021
Diabetes, Obesity, and Inflammation: Impact on Clinical and Radiographic Features of Breast Cancer

Here, literature is reviewed that regards the accuracy of conventional imaging modalities in obese and diabetic women, the potential role of anti-inflammatory agents to improve detection, and...

International Journal of Molecular Sciences
03/09/2021
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