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Biochimica et Biophysica Acta

Biochimica et Biophysica Acta
MCM family in gastrointestinal cancer and other malignancies: From functional characterization to clinical implication.

This review summarizes the current knowledge on the oncogenic role of MCM proteins and highlights their clinical implications in various malignancies, especially in GI cancers.

Biochimica et Biophysica Acta
12/01/2020
AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells.

In this study, CRISPR/Cas9-mediated loss-of-function screen revealed that PPP2R2A downregulation suppressed cell growth in NSCLC cells.

Biochimica et Biophysica Acta
01/01/2021
The high expression of MTH1 and NUDT5 promotes tumor metastasis and indicates a poor prognosis in patients with non-small-cell lung cancer.

The present study reported that MTH1 and NUDT5 were upregulated in NSCLC cell lines and tissues, and higher levels of MTH1 or NUDT5 were associated with tumor metastasis and...

Biochimica et Biophysica Acta
01/01/2021
NIR promotes progression of colorectal cancer through regulating RB.

Here, the authors report that NIR promotes progression of colorectal cancer through regulating RB function.

Biochimica et Biophysica Acta
01/01/2021
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