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Journal of Clinical Investigation

Journal of Clinical Investigation
Zeb1 modulates hematopoietic stem cell fates required for suppressing acute myeloid leukemia

ZEB1 expression was downregulated in AML patients, and Zeb1 KO in the malignant counterparts of HSCs—leukemic stem cells— accelerated MLL-AF9– and Meis1a/Hoxa9-d

Journal of Clinical Investigation
01/04/2021
mRNA vaccine–induced neoantigen-specific T cell immunity in patients with gastrointestinal cancer

Here, validated, defined neoantigens, predicted neoepitopes, and mutations of driver genes were concatenated into a single mRNA construct to vaccinate patients with metastatic...

Journal of Clinical Investigation
10/05/2020
Germ cell tumors and associated hematologic malignancies evolve from a common shared precursor.

GCTs are the most common cancer in men between the ages of 15-40. While most patients are cured, those with disease arising in the mediastinum have distinctly poor outcomes.

Journal of Clinical Investigation
09/08/2020
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