Frontiers in Immunology

Frontiers in Immunology
Association Analyses of TP53 Mutation With Prognosis, Tumor Mutational Burden, and Immunological Features in Acute Myeloid Leukemia

Somatic mutations in AML patients were found using The Cancer Genome Atlas dataset and BeatAML dataset and then researchers identified the common mutant genes in the two cohorts. 

Frontiers in Immunology
Integrative Characterization of the Role of IL27 In Melanoma Using Bioinformatics Analysis

Scientists work to uncover the multifaceted roles of IL27 and provide evidence for future cytokine-based immunotherapy against melanoma.

Frontiers in Immunology
PTP4A3 Is a Prognostic Biomarker Correlated With Immune Infiltrates in Papillary Renal Cell Carcinoma

Scientists developed a comprehensive analysis across multiple databases to elucidate the role of PTP4A3 in ccRCC and pRCC & analyzed PTP4A3 and immune cell tumor infiltration (TIMER). 

Frontiers in Immunology
Predictive Value of High ICAM-1 Level for Poor Treatment Response to Low-Dose Decitabine in Adult Corticosteroid Resistant ITP Patients

This study attempts to elucidate the correlation between endothelial dysfunction and disease severity of ITP and find related markers to predict response to low-dose decitabine treatment.

Frontiers in Immunology
In Situ Overexpression of Matricellular Mechanical Proteins Demands Functional Immune Signature and Mitigates Non–Small-Cell Lung Cancer Progression

This study investigates 120 patients with NSCLC to describe the immune-matricellular phenotypes of their TME and their relationship with malignant cells.

Frontiers in Immunology
Multi-Omics Profiling Identifies Risk Hypoxia-Related Signatures for Ovarian Cancer Prognosis

Hypoxia is a driver of the malignant progression in ovarian cancer, which results in poor prognosis.

Frontiers in Immunology
γδ T Cells May Aggravate Acute GvHD Through CXCR4 Signaling After Allogeneic Hematopoietic Transplantation

The identification of immune cells that correlate with aGVHD is important and intriguing. To date, the involvement of innate-like γδ T cells in the pathogenesis of aGVHD is unclear. 

Frontiers in Immunology
Identification and Validation of the Immune Regulator CXCR4 as a Novel Promising Target for Gastric Cancer

This study has determined the prognostic value of 11 immunomodulatory factors in gastric cancer.

Frontiers in Immunology
Comprehensive Transcriptomic Analysis Reveals the Role of the Immune Checkpoint HLA-G Molecule in Cancers

The aim of this study is to systematically identify the roles of checkpoint HLA-G molecules across various types of cancer.

Frontiers in Immunology
Inflammatory Pathophysiology as a Contributor to Myeloproliferative Neoplasms

In myelofibrosis, elevated levels of individual cytokines in plasma are adverse prognostic indicators: elevated IL-8/CXCL8, in particular, predicts risk of transformation of MF to secondary AML. 

Frontiers in Immunology
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