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Blood Advances

Blood Advances
Diffuse Large B-Cell Lymphomas in Adults With Aberrant Coexpression of CD10, BCL6, and MUM1 are Enriched in IRF4 Rearrangements

DLBCL in adults aberrantly coexpressing CD10, BCL6, and MUM1 are genetically heterogeneous and enriched in IRF4-rearranged cases.

Blood Advances
10/15/2021
Zanubrutinib Monotherapy for Relapsed or Refractory Non-Germinal Center Diffuse Large B-Cell Lymphoma

Potential antitumor activity was observed in DLBCL with mutations in both CD79B and MYD88 genes.

Blood Advances
10/12/2021
Early Detection of WT1 Measurable Residual Disease Identifies High-Risk Patients Independently of Transplantation in AML

Post-induction WT1 measurable residual disease is associated with shorter survival and higher risk of relapse in younger AML patients.

Blood Advances
10/08/2021
Frequent Mutated B2M, EZH2, IRF8, and TNFRSF14 in Primary Bone DLBCL Reflect a GCB Phenotype

These features indicate PB-DLBCL as a distinct extranodal DLBCL entity, and its specific mutations offer potential for targeted therapies.

Blood Advances
10/01/2021
Tissue-Resident Macrophages Promote Early Dissemination of Multiple Myeloma via IL-6 and TNFα

Researchers propose that egress of myeloma cells from BM is regulated by localized inflammation in foci, driven in part by CD169+ MPs.

Blood Advances
09/22/2021
Impact of PTPN11 Mutations on Clinical Outcome Analyzed in 1529 Patients With Acute Myeloid Leukemia

Researchers found a profound new association of the clonal rank of PTPN11 mutations with the comutational spectrum and clinical outcome...

Blood Advances
08/30/2021
Detection of Clonotypic DNA in the Cerebrospinal Fluid as a Marker of Central Nervous System Invasion in Lymphoma

Researchers studied a NGS-based assay that detects tumor-derived DNA for clonotypic immunoglobulin gene rearrangements in the CSF of patients with lymphomas.

Blood Advances
09/22/2021
Extrinsic Interactions in the Microenvironment In Vivo Activate an Antiapoptotic Multidrug-Resistant Phenotype in CLL

Scientists demonstrate that antiapoptotic multidrug-resistant CLL cells exist in patients de novo and show that these cells persist during proapoptotic treatment, such as venetoclax.

Blood Advances
09/13/2021
Autologous and Allogeneic Hematopoietic Cell Transplantation for DLBCL–Type Richter Syndrome

This study shows that allo-HCT and auto-HCT produce durable remissions in patients with DLBCL-RS.

Blood Advances
09/17/2021
Bortezomib and Rituximab in de novo Adolescent/Adult CD20-Positive, Ph-Negative Pre-B-Cell Acute Lymphoblastic Leukemia

Scientists evaluate the activity of this combination during induction in adolescents and adults with CD20+ Ph– precursor B-ALL...

Blood Advances
09/09/2021
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