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Nature Communications

Nature Communications

Here we identify oxidative phosphorylation (OxPhos) as a critical pathway for leukemia cell survival and demonstrate a direct relationship between NOTCH1, elevated OxPhos gene expression...

Nature Communications
05/19/2022

 These methods provide an approach for pan-solid tumor comprehensive genomic profiling with high analytical performance. 

Nature Communications
05/20/2022

These results establish key technical considerations for the implementation of cWGTS as an integrated test in clinical oncology.

Nature Communications
05/18/2022

Our results suggest an oncogenic role of TUBB4A and provide a potentially actionable therapeutic target for prostate cancers with TUBB4A overexpression.

Nature Communications
05/19/2022

IDH1 mutation limits the flexibility for citrate utilization in the presence of impaired complex I activity to a degree that is not apparent in IDH2 mutant cells, exposing a mutation-specific...

Nature Communications
05/12/2022

MYC overexpression significantly diminishes the androgen receptor (AR) transcriptional program (the set of genes directly targeted by the AR protein) in luminal prostate cells without altering AR..

Nature Communications
05/13/2022

The EZH2-integrin β1-FAK axis cooperates with the TGFβ signaling pathway to promote bone metastasis of breast cancer.

Nature Communications
05/10/2022

Through a series of chemical iterations and molecular dynamics simulations, we synthesize a library of FRET peptides and identify probe H5 with an optimal fit into granzyme B.

Nature Communications
05/02/2022

These results provide a preclinical proof-of-principle that allogeneic UCART123 cells have potent anti-BPDCN activity.

Nature Communications
04/28/2022

Treatment with androgen receptor pathway inhibitors (ARPIs) in prostate cancer leads to the emergence of resistant tumors characterized by lineage plasticity and differentiation toward...

Nature Communications
04/27/2022
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