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Anakinra Shows Promise as Steroid-Sparing Agent for CAR T-Cell Therapy-Related Toxicities

Steroids are commonly used to mitigate severe treatment-related adverse events associated with chimeric antigen receptor T-cell therapy.

Healio
04/05/2021
CAR T-Cell Therapy ‘Extremely Effective’ for Advanced Follicular Lymphoma, Early Data Show

Sixty-five percent of patients with R/R FL had an initial complete response to a single infusion of tisagenlecleucel, according to phase 2 study results presented at TCT Meetings Digital Experience

Healio
02/19/2021
Anti-CD22 CAR T-Cell Therapy A ‘Promising Option’ for Advanced B-Cell Malignancies

An investigational CAR T-cell therapy appears safe and demonstrates antitumor activity among patients with R/R B-cell malignancies, according to results presented at TCT Meetings Digital Experience

Healio
02/17/2021
Higher CAR-T Dose Associated With Longer Remission Among Younger Patients With ALL

Children and young adults with ALL who received higher doses of tisagenlecleucel achieved significantly longer OS and RFS, according to study results presented at TCT Meetings Digital Experience.

Healio
02/16/2021
‘On-Your-Toes’ Approach to Managing Infection Risk Needed as CAR T-Cell Therapy Evolves

Chimeric antigen receptor T-cell therapy employs a patient’s immune system to fight cancer and thereby weakens it, leaving the recipient vulnerable to infection.

Healio
03/17/2021
Outpatient CAR T-Cell Therapy Safe, Effective for Advanced Large B-Cell Lymphoma

Patients with relapsed or refractory large B-cell lymphoma who received lisocabtagene maraleucel had similar response rates regardless of the type of center providing the CAR T-cell therapy.

Healio
02/26/2021
FDA Grants Fast Track Designation to Neihulizumab for Acute GVHD

The FDA granted fast track designation to neihulizumab for treatment of steroid-refractory acute graft-versus-host disease, according to the agent’s manufacturer.

Healio
03/15/2021
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