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Phase 3 Trial of Canakinumab for Lung Cancer Misses Primary Endpoints

Although this Phase III trial failed to extend PFS/OS among patients with NSCLC, results showed potentially clinically meaningful improvements in both outcomes among prespecified subgroups.

Healio
10/26/2021
FDA Clears Application for Anti-PD-1 CAR-T to Treat Hematologic, Breast Cancers

The FDA clears investigational new drug application for PRGN-3007, a chimeric antigen receptor T-cell therapy for patients with advanced hematologic malignancies or solid tumors expressing ROR1.

Healio
10/26/2021
Oncopeptides Withdraws Multiple Myeloma Therapy From U.S. Market

The decision came 3 months after the FDA alerted health care providers and patients about clinical trial results that showed increased mortality risk among patients who received the agent.

Healio
10/25/2021
Personalized Interventions Reduce Chemotherapy-Related Toxicity Among Older Adults

A randomized clinical trial showed use of personalized interventions significantly reduced grade 3 or higher chemotherapy-related toxicity among patients with cancer aged 65 years or older. 

Healio
10/20/2021
Nut Consumption Associated With Survival Benefit Among Long-Term Breast Cancer Survivors

Nut consumption appeared associated with higher survival rates among long-term breast cancer survivors and should be emphasized as a modifiable lifestyle factor in survivor guidelines. 

Healio
10/20/2021
Sintilimab Extends PFS for Certain Patients With NSCLC

 After first interim analysis, a statistically significant PFS benefit with sintilimab, bevacizumab biosimilar injection and chemotherapy was shown in the the ORIENT-31 study. 

Healio
10/18/2021
ctDNA Reduction After Tebentafusp Predicts OS in Uveal Melanoma

Reduction in circulating tumor DNA appeared correlated with longer OS among patients with previously treated metastatic uveal melanoma who received tebentafusp. 

Healio
10/18/2021
FDA Grants Orphan Drug Designation to LAVA-051 for CLL

LAVA-051, a bispecific antibody that activates the immune system to attack CD1d-expressing cancer cells, was given orphan drug designation from the FDA. 

Healio
10/18/2021
FDA Approves Tecentriq for New Lung Cancer Indication

The FDA expanded the approval of atezolizumab to include adjuvant treatment of certain patients with NSCLC. 

Healio
10/15/2021
FDA Approves Verzenio for Certain Patients With Early Breast Cancer

The approval applies to use of the agent by adults with hormone receptor-positive, HER2-negative, node-positive disease at high risk for recurrence who have a Ki-67 score of at least 20%.

Healio
10/13/2021
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