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JCO Precision Oncology

JCO Precision Oncology
Clinical Outcomes in Non–Small-Cell Lung Cancer Patients Treated With EGFR-Tyrosine Kinase Inhibitors and Other Targeted Therapies Based on Tumor Versus Plasma Genomic Profiling

This study compares clinical outcomes in a cohort of patients with advanced NSCLC with targetable genomic alterations detected using plasma-based ctDNA or tumor-based...

JCO Precision Oncology
08/05/2021
Differential Activity of PARP Inhibitors in BRCA1- Versus BRCA2-Altered Metastatic Castration-Resistant Prostate Cancer

This study examines the relative efficacy of PARP inhibition in BRCA1- versus BRCA2-altered mCRPC. 

JCO Precision Oncology
07/22/2021
Detection of Molecular Residual Disease Using Personalized Circulating Tumor DNA Assay in Patients With Colorectal Cancer Undergoing Resection of Metastases

This study evaluates the prognostic value of ctDNA, correlating MRD status postsurgery with clinical outcomes by using a personalized and tumor-informed ctDNA assay.

JCO Precision Oncology
07/21/2021
ctDNA Predicts Overall Survival in Patients With NSCLC Treated With PD-L1 Blockade or With Chemotherapy

Investigators assess the association between ctDNA metrics and the primary end point of OS in a subset of previously treated patients with locally advanced or metastatic NSCLC, who...

JCO Precision Oncology
05/12/2021
Long-Term Outcomes in a Multicenter, Prospective Cohort Evaluating the Prognostic 31-Gene Expression Profile for Cutaneous Melanoma

Current guidelines for postoperative management of patients with stage I-IIA cutaneous melanoma do not recommend routine cross-sectional imaging...

JCO Precision Oncology
04/06/2021
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