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Cancers

Cancers
Enhancing Therapeutic Efficacy of Double Negative T Cells against Acute Myeloid Leukemia Using Idelalisib

Scientists characterize the in vivo persistence of DNTs in PDX models to improve the efficacy and durability of DNT-mediated activity with PI3Kδ inhibition. 

Cancers
10/09/2021
Activation of Vitamin D Receptor Pathway Enhances Differentiating Capacity in Acute Myeloid Leukemia with Isocitrate Dehydrogenase Mutations

This study demonstrates 2-HG specifically activates vitamin D receptor in IDH mutant AML cells leading to increased sensitivity to the combination of vitamin D (or VDR agonist) and...

Cancers
10/19/2021
Precision Oncology of High-Grade Ovarian Cancer Defined through Targeted Sequencing

Genomic characterization was applied to tumour material from women with ovarian cancer to identify women that might benefit from PARP inhibitor therapy...

Cancers
10/19/2021
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